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Microtubule-Associated Protein 1B
Microtubule-Associated Protein 1B

Transforming growth factor–1 in supernatants from stored red blood
Transforming growth factor–1 in supernatants from stored red blood

... Consistent with the possible increased risk of postoperative infections in transfusion patients, various studies suggest that transfusions can induce immunomodulatory effects, including transient reduction in the CD4/CD8 T-cell ratio, reduced natural killer function, impaired lymphocyte mitogenic re ...
Chapter 23
Chapter 23

... NEW AIM: How have different organisms evolved to perform circulation? Circulatory system - system of internal transport Q. What needs to be transported? - oxygen, RBC’s - carbon dioxide - nutrients - waste products of metabolism (CO2 to lungs, urea and other waste to kidneys) ...
human biology
human biology

... An experiment was carried out to determine the optimum size of alginate beads to use in this process. Three bead sizes were prepared and placed in columns. The same volume of milk was run into each column at the same rate of flow. The percentage product for each experiment was calculated. The entire ...
Simvastatin Reduces MMP1 Expression in Human Smooth Muscle
Simvastatin Reduces MMP1 Expression in Human Smooth Muscle

... expression. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been shown to interfere with integrin signaling, but their effects on collagen receptor-mediated MMP expression have not been investigated. Methods and Results—In the present study, we show that simvastatin (3 ...
Calcium homeostasis
Calcium homeostasis

... regulated by calcitonin and PTH activated calcitriol • Calcitriol is released from kidneys. It stimulate cells releasing calcium from bone, increase uptake to gastrointestinal tract and increase reabsorption in renal tubule • Calcitonin is released from thyroid gland and it stimulate calcium deposit ...
Respiratory System
Respiratory System

... The function of the lungs is to exchange gasses As blood flows through the lungs it picks up oxygen from the air & releases carbon dioxide The body needs oxygen from blood & it produces carbon dioxide as a waste product ...
PDF
PDF

... (CGTG to AAAA) were prepared in the context of the full-length Sox9 promoter by PCR using the following primers: forward 5⬘-ATAGGTACCACGGAGACAGCATCGAAAAGTGGGGGTGGGGGGTTGTGGAGGGTCCTAGTCTAGACACGCTCGAAAACACGCGCACACACACAC-3⬘, reverse 5⬘-TCTCTCGAGCGACTTCCAGCTCAGGGTCTCTA3⬘. PCR was performed under the fol ...
Human HL-60 Myeloid Leukemia Cells Transport
Human HL-60 Myeloid Leukemia Cells Transport

... normal and neoplastic cell types. Chronic lymphocytic leukemia cells appear to accumulate higher intracellular concentrations of ascorbate than their normal counterpart^.^ However, the molecular mechanisms that regulate the cellular content of ascorbic acid are poorly understood. Although a correlat ...
In Vivo Release of Mitotic Silencing of Ribosomal Gene
In Vivo Release of Mitotic Silencing of Ribosomal Gene

... very sensitive to roscovitine (IC50 , 7 mM) when tested in vitro. However, because cdk2–cyclin E and cdk2–cyclin A are active at the G1/S transition and during S phase, respectively, the cdc2–cyclin B kinase is the only known kinase inhibited by roscovitine when mitotically synchronized cells are tr ...
Cross-Presentation Proteases in MHC Class I Presentation and
Cross-Presentation Proteases in MHC Class I Presentation and

... in place of the “standard” B1, B2, and B5 subunits to form socalled “immunoproteasomes” (3, 6). These are constitutively expressed in dendritic cells, lymphocytes, and thymic epithelium and are induced in all cells by proinflammatory cytokines such as IFN-g. The net effect of changing these b subuni ...
Mitochondrial Dynamics and the ER: The Plant Perspective
Mitochondrial Dynamics and the ER: The Plant Perspective

... targeting to autophagosomes (Twig et al., 2008b). In mammalian cells mitochondrial fusion triggers fission which in turn is followed by selective fusion (Twig et al., 2008b): differences in membrane potential become evident in daughter mitochondria after a fission event (Twig et al., 2008a). As memb ...
Unit 6 Microorganisms & Fungi
Unit 6 Microorganisms & Fungi

... Algae produce much of earth’s oxygen through photosynthesis Many species are rich in vitamin C & iron Chemicals in algae are used to treat stomach ulcers, high blood pressure, arthritis, & other health problems ...
Applied Kinetics
Applied Kinetics

... • T/F: Intermittent dialysis can last hours to days and is used often in critically ill patients. • T/F: Continuous renal replacement compared to intermittent dialysis is characterized by lower blood and dialysate flow rates. • T/F: Diffusion is more useful than convection at removing drugs with a l ...
Full Text
Full Text

... glycotechnology. As introduced in this short article, important groundwork for glycobiology was made by Japanese researchers. Key words: glycobiology, N-linked sugar chain, O-linked sugar chain, glycoprotein, proteoglycan, glycolipid The early years after World War II On August 15, 1945, World War I ...
ASH1 by Puf6p–Fun12p/eIF5B interaction and released by CK2 phosphorylation Yingfeng Deng,
ASH1 by Puf6p–Fun12p/eIF5B interaction and released by CK2 phosphorylation Yingfeng Deng,

... a plasmid (Supplemental Fig. 2B). Therefore, this truncated Fun12p could form the initiation complex on ASH1 mRNAs, as does the full-length Fun12p in vivo. FUN12 overexpression increased the concentration of Ash1p by twofold in comparison with Pgk1p but had only a marginal difference at the mRNA lev ...
The regulation and plasticity of root hair patterning
The regulation and plasticity of root hair patterning

... roots that play a key role in providing the plant with water and mineral nutrients. Root hairs have been used as a model system for understanding both cell fate determination and the morphogenetic plasticity of cell differentiation. Indeed, many studies have shown that the fate of root epidermal cel ...
High-resolution imaging of cardiomyocyte behavior
High-resolution imaging of cardiomyocyte behavior

... atrial contraction and exhibit reduced flow. We found that, compared with cardiomyocytes in wild-type hearts, those in erbb2 mutants were less likely to form protrusions, those in tnnt2a morphants formed less stable protrusions, and those in myh6 morphants extended fewer protrusions per cell. Thus, ...
Vaccinia Protein F12 Has Structural Similarity to Kinesin
Vaccinia Protein F12 Has Structural Similarity to Kinesin

Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis
Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis

Specific Innervation of Neurons in the Paravertebral
Specific Innervation of Neurons in the Paravertebral

... Innervation of Cl2 and Cl5 ganglia Each ganglion is innervated by preganglionic axons arising from several spinal cord segments. Individual ganglion cells, however, are innervated by only some of the spinal segments that supply each ganglion as a whole. This subset of spinal segments is always conti ...
Archaea - cloudfront.net
Archaea - cloudfront.net

... 1. They both are single-celled, microscopic organisms that can come in a variety of shapes (Figure 1.1). 2. Both archaea and bacteria have a single circular chromosome of DNA and lack membrane-bound organelles. 3. Like bacteria, archaea can have flagella to assist with movement. ...
Full-Text PDF
Full-Text PDF

... target them to the lysosomal pathway; the degradation of pathogens through the autophagy pathway is known as xenophagy [2]. However, most infectious pathogens have evolved strategies to escape autophagy or even to use some properties of this cellular mechanism to optimize their intracellular life cy ...
NCCN Guidelines for MDS
NCCN Guidelines for MDS

... stakeholders. Stakeholders include health providers, patients, businesses, and others. One resource is the series of books for patients called the NCCN Guidelines for Patients®. Each book presents the best practice for a type of cancer. The patient books are based on clinical practice guidelines wri ...
Word - The Open University
Word - The Open University

... their degree of branching depend very much on the type of cell, its shape, and how it is interacting with the extracellular matrix. The great majority of cell adhesion molecules, which allow a cell to bind to the extracellular matrix, interact inside the cell with microfilaments – usually via adapto ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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