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Encapsulation Services
Encapsulation Services

... and size distribution. Microfluidics is an emerging technology for liposome synthesis, because it enables precise control of the lipid hydration process and allows for the production of liposomes ranging from tens of nanometers to tens of micrometers in diameter.  Isopropyl alcohol (IPA) containing ...
PDF
PDF

... and become tightly packed, while retaining their links to both the apical surface and the basement membrane of the epithelium. As the cells pack, their nuclei become stacked, creating a pseudostratified epithelium (Eom et al., 2013). At the same stage, neural tube closure initiates with the formatio ...
Actin machinery: pushing the envelope Gary G Borisy* and Tatyana
Actin machinery: pushing the envelope Gary G Borisy* and Tatyana

... have individualized strategies, taking over the actinbased machinery by intervening at different steps in the overall process. Remarkably, the molecules involved in microbial rocketing have proved also to be involved in lamellipodial and filopodial protrusion. These sheet-like and spike-like process ...
CXCR4 and CXCR7 Have Distinct Functions in Regulating
CXCR4 and CXCR7 Have Distinct Functions in Regulating

... evidence that CXCR7 is a signaling receptor. Unlike traditional seven-transmembrane receptors, which signal through both G proteins and b-arrestin, CXCR7 may only signal through b-arrestin (Rajagopal et al., 2010). b-arrestin activation then leads to stimulation of the MAP kinase casade (Rajagopal e ...
MM2009_Zhang - Australian Institute for Bioengineering and
MM2009_Zhang - Australian Institute for Bioengineering and

... Intercalation of Organic Molecules into Layered Double Hydroxide (LDH): Comparison of Simulation with Experiment H. Zhanga,b, Z. P. Xub, G. Q. Lub and S. C. Smitha,b a) Centre for Computational Molecular Science, Australian Institute for Bioengineering and Nanotechnology The University of Queensland ...
PDF
PDF

... n=137) looping defects (Fig. 1E). Injection of 3-OST-5 MOresistant ‘rescue’ mRNA alone did not alter heart and gut orientation (4% and 5%, respectively, n=171; Fig. 1E). The similar phenotype seen with two distinct morpholinos and the ability to rescue the phenotype indicate that these effects are s ...
Muscle Contraction and Cell Motility
Muscle Contraction and Cell Motility

... Preface This volume provides a comprehensive overview of the current progress in research on muscle contraction and cell motility, not only for investigators in these research fields but also for general readers who are interested in these topics. One of the most attractive features of living orga ...
REVIEW ARTICLE Establishment of the axis in chordates: facts and
REVIEW ARTICLE Establishment of the axis in chordates: facts and

... oblastic cleavage and a relatively late axialization of the blasthe above cytoplasm contains some unique information toderm. Mammals have gone a few steps further in evolution. involved in axis formation. Sardet et al. (1989) found that, The more primitive Monotremata have yolky eggs; the Marsuafter ...
Control of alternative splicing in immune responses: many
Control of alternative splicing in immune responses: many

... couples antigen recognition with intracellular signaling pathways. Thus, the level of CD3f expression determines the ability of a T cell to be activated. Strikingly, AS of exon 8 of CD3f is a primary control point of CD3f expression (10– 12). The 3′ UTR of the CD3f gene contains several AREs (AU-ric ...
Distinct and collaborative roles of Drosophila EXT family proteins in
Distinct and collaborative roles of Drosophila EXT family proteins in

1 - Utrecht University Repository
1 - Utrecht University Repository

... substratum, and several cellular signal transduction pathways are activated that affect cell motility, proliferation, survival, and gene expression, which is called ‘outside-in’ ...
Hepatic Secretion of Conjugated Drugs and Endogenous Substances
Hepatic Secretion of Conjugated Drugs and Endogenous Substances

... of MRP1 mRNA is extremely low31 and the immunoreactive proteins detected at the basolateral hepatocyte membrane by use of antibodies, raised against human MRP1,7,19 could only be fully identified after the more recent cloning of the isoforms MRP320,21 and MRP6.30,65–67 MRP3 and MRP6 have been locali ...
Animal Biology 56(4)
Animal Biology 56(4)

... the most ancient cranial part that, in the traditional view, evolved from pharyngeal arch elements supporting gill slits in a cephalochordate-like animal. Viscerocranial components support the gills and/or contribute to the jaw and hyoid apparatus in gnathostomes, but they probably form parts of the ...
1 An amoeba phagocytosis model reveals a novel developmental
1 An amoeba phagocytosis model reveals a novel developmental

... was not until a study by Margulis et al., looking at boiled intestines of insects ...
Preview the material
Preview the material

... produced by previous contact with the foreign substance - chemical or biological, humoral or bound to fixed tissue - cause a reaction, which may be immediate or delayed. This mechanism is held by many to be involved in most of the common drug reactions, although an antigen-antibody reaction cannot o ...
Phototrophic hydrogen production from glucose by pure and
Phototrophic hydrogen production from glucose by pure and

... of glucose solution to acetate and butyrate by C. butyricum was 200 ml (0.2×24.9×2×(5.5+14.6)=200). As compared to the measured hydrogen production volume of 100 ml, the yield was only 50%. Fig. 4 illustrates that hydrogen was produced after a 10 h lag phase and the production was ceased after 40 h ...
Signalling and neural crest migration pathways - Development
Signalling and neural crest migration pathways - Development

... implies that the crest-free zones are not an intrinsic property of odd-numbered rhombomeres themselves. This suggests that environmental influences adjacent to r3 and r5 may be important in controlling the pathways of hindbrain neural crest migration (Farlie et al., 1999), and distinct mechanisms ma ...
The Ovule and the Embryo Sac
The Ovule and the Embryo Sac

... These unique features of the angiosperm reproductive process illustrate one of the most fundamental problems in plant biology. That is, how does the transition from sporophytic to gametophytic development occur within the context of the flower? How do the gametophytesinteractwith each other and the ...
Gonadotropin-Releasing Hormone Containing Neurons and
Gonadotropin-Releasing Hormone Containing Neurons and

... system towards the brain also is derived from histochemical studies examining particular molecules at successive ages (e.g., [8,32,45,46,68]. Subsets of cells that migrate upon the pathway also maintain selective carbohydrates on their cell surfaces. Evidence suggests that both neurons and glial cel ...
Neuroblast migration along the anteroposterior axis of C. elegans is
Neuroblast migration along the anteroposterior axis of C. elegans is

... 2 expression in the germ cells continued throughout larval development, whereas the tail expression reached a maximum at the mid-L1 stage and disappeared before the L1 to L2 molt (see Fig. S1D in the supplementary material). In addition, one or two mom-2 transcripts were occasionally detected in pos ...
Preview the material
Preview the material

... produced by previous contact with the foreign substance - chemical or biological, humoral or bound to fixed tissue - cause a reaction, which may be immediate or delayed. This mechanism is held by many to be involved in most of the common drug reactions, although an antigen-antibody reaction cannot o ...
THE MOLECULAR PROFILE OF ORAL PLASMABLASTIC
THE MOLECULAR PROFILE OF ORAL PLASMABLASTIC

... 17/41 (42%) and increased IGH gene copy numbers in 6/41 (15%) of cases. The exact role of MYC-rearrangements in the development of PBL is unclear. Many factors may be responsible for MYC deregulation but in the case of PBL of the oral cavity the possible role of Epstein Barr Virus (EBV) infection wa ...
Chapter 16—Probes for Endocytosis, Receptors and Ion Channels
Chapter 16—Probes for Endocytosis, Receptors and Ion Channels

... 16.1 Probes for Following Receptor Binding and Phagocytosis The plasma membrane defines the inside and outside of the cell. It not only encloses the cytosol to maintain the intracellular environment but also serves as a formidable barrier to the extracellular environment. Because cells require input ...
DC-derived exosomes bear molecules involved in
DC-derived exosomes bear molecules involved in

... extracellular exosomes with DC is unknown. Although there is evidence that exosomes may transfer functional MHC-I/peptide complexes to DC 24, it is unclear whether exosomes cluster or fuse with DC, or if they are internalized and processed, as occurs with vesicles derived from apoptotic cells 2-5. H ...
PDF - Wiley Online Library
PDF - Wiley Online Library

... Bacteriophages have developed multiple host cell lysis strategies to promote release of descendant virions from infected bacteria. This review is focused on the lysis mechanisms employed by tailed double-stranded DNA bacteriophages, where new developments have recently emerged. These phages seem to ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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