A leucine aminopeptidase is involved in kinetoplast DNA
... single flagellum, to which it is physically attached via the tripartite attachment complex (TAC). The TAC is a structure comprised of both exclusion zone and unilateral filaments, which are assembled with a region of non-corrugated inner mt membrane between them [2]. Unlike the mt DNA of most eukary ...
... single flagellum, to which it is physically attached via the tripartite attachment complex (TAC). The TAC is a structure comprised of both exclusion zone and unilateral filaments, which are assembled with a region of non-corrugated inner mt membrane between them [2]. Unlike the mt DNA of most eukary ...
Epididymis, Epithelium – Degeneration
... there is a breach of the epithelial lining, it is generally accompanied by an inflammatory infiltrate due to breakdown in the blood-epididymal barrier resulting in exposure of immune cells to the antigenically foreign sperm. Epithelial degeneration has been described in response to methyl chloride i ...
... there is a breach of the epithelial lining, it is generally accompanied by an inflammatory infiltrate due to breakdown in the blood-epididymal barrier resulting in exposure of immune cells to the antigenically foreign sperm. Epithelial degeneration has been described in response to methyl chloride i ...
Role of Sodium Channel Deglycosylation in the Genesis of Cardiac
... To investigate the arrhythmogenic potential of the prolonged APs in MLP"/" animals, myocytes were stimulated at 1 Hz for periods of 1 min. Clusters of 5 APs from WT and MLP"/" records are shown in Fig. 1C. Arrhythmogenic voltage fluctuations called early afterdepolarization (EADs, Fig. 1C) were freq ...
... To investigate the arrhythmogenic potential of the prolonged APs in MLP"/" animals, myocytes were stimulated at 1 Hz for periods of 1 min. Clusters of 5 APs from WT and MLP"/" records are shown in Fig. 1C. Arrhythmogenic voltage fluctuations called early afterdepolarization (EADs, Fig. 1C) were freq ...
- the University of Huddersfield Repository
... the wound edge by local antioxidant release, SOD, GPx, and phospholipid hydroperoxide glutathione peroxidase; this has been well demonstrated in models of mouse-based cutaneous injury [31]. In fact, the overall evidence for H2O2 having an integral role in stress/inflammatory responses and the subseq ...
... the wound edge by local antioxidant release, SOD, GPx, and phospholipid hydroperoxide glutathione peroxidase; this has been well demonstrated in models of mouse-based cutaneous injury [31]. In fact, the overall evidence for H2O2 having an integral role in stress/inflammatory responses and the subseq ...
Phototropism: Growing towards an Understanding of
... NONPHOTOTROPIC HYPOCOTYL3 (NPH3) was originally identified as a phototropic loss-of-function mutant in Arabidopsis (Liscum and Briggs, 1995). NPH3 encodes a protein containing an N-terminal Broad-complex, Tramtrack, and Bric-á-brac (BTB) domain, a central NPH3 domain (Pfam, PF03000), and a C-terminal ...
... NONPHOTOTROPIC HYPOCOTYL3 (NPH3) was originally identified as a phototropic loss-of-function mutant in Arabidopsis (Liscum and Briggs, 1995). NPH3 encodes a protein containing an N-terminal Broad-complex, Tramtrack, and Bric-á-brac (BTB) domain, a central NPH3 domain (Pfam, PF03000), and a C-terminal ...
PDF
... large amount of unglycosylated protein for structural studies, glycosylation-deficient mutants were generated in which Asn residues at positions 91, 94 and 99 were either replaced with Gln (Gly−), Asp (Gly− D), or all three Asn were deleted (Gly− ⌬). The biochemical properties of the mutant protein, ...
... large amount of unglycosylated protein for structural studies, glycosylation-deficient mutants were generated in which Asn residues at positions 91, 94 and 99 were either replaced with Gln (Gly−), Asp (Gly− D), or all three Asn were deleted (Gly− ⌬). The biochemical properties of the mutant protein, ...
Understanding Skin Colour
... deposits more melanin in all the keratinocytes and/or fibroblasts that comprise the melanocyte unit. Progressively, with time, more melanocytes in the area are affected and the mark gradually becomes perceptible. This may happen years after the initial insult. One thing for certain is that with the ...
... deposits more melanin in all the keratinocytes and/or fibroblasts that comprise the melanocyte unit. Progressively, with time, more melanocytes in the area are affected and the mark gradually becomes perceptible. This may happen years after the initial insult. One thing for certain is that with the ...
Cytokinins regulate vascular morphogenesis in the Arabidopsis
... terrestrial plants were able to cope with occasional drying, when growing on streams or mudflats, but they were still tightly depended on living on water. To successfully accomplish the transition from aquatic to terrestrial life, several structural and functional changes had to occur in plants. Ada ...
... terrestrial plants were able to cope with occasional drying, when growing on streams or mudflats, but they were still tightly depended on living on water. To successfully accomplish the transition from aquatic to terrestrial life, several structural and functional changes had to occur in plants. Ada ...
MAPK-mediated Phosphorylation of GATA-1 Promotes Expression and Cell Survival* Bcl-X □
... influencing its DNA binding or transcriptional activity. In one study, no effect of phosphorylation of GATA-1 was found (14). However, in another study, the DNA binding of baculovirusexpressed human GATA-1 was reported to be sensitive to treatment by alkaline phosphatase (15). A more recent study sh ...
... influencing its DNA binding or transcriptional activity. In one study, no effect of phosphorylation of GATA-1 was found (14). However, in another study, the DNA binding of baculovirusexpressed human GATA-1 was reported to be sensitive to treatment by alkaline phosphatase (15). A more recent study sh ...
Compare TIRF Geometries
... TIRF is a powerful analytical technique with numerous applications in the area of life sciences [1-3]. In particular, TIRF is “...a method uniquely suited to image the plasma membrane with its associated organelles and macromolecules in living cells. The method shows even the smallest vesicles made ...
... TIRF is a powerful analytical technique with numerous applications in the area of life sciences [1-3]. In particular, TIRF is “...a method uniquely suited to image the plasma membrane with its associated organelles and macromolecules in living cells. The method shows even the smallest vesicles made ...
Role of chick cux1 and cux2 during limb development
... directing the initial positioning of the AER (Laufer et al., 1997; Rodriguez-Esteban et al., 1997). The ridge forms at the boundary between cells that express R-fng (dorsal ectoderm) and those that do not (ventral ectoderm). However, loss-offunction of mouse R-fng does not result in any limb defects ...
... directing the initial positioning of the AER (Laufer et al., 1997; Rodriguez-Esteban et al., 1997). The ridge forms at the boundary between cells that express R-fng (dorsal ectoderm) and those that do not (ventral ectoderm). However, loss-offunction of mouse R-fng does not result in any limb defects ...
Situs inversus and ciliary abnormalities: 20Łyears later, what is the
... inversus viscerum (iv) displaying random LR-asymmetry [39] and the inversion of embryonic turning (inv) developing situs inversus [40]. Both mouse models were extensively used for the analysis of LR-development. It was anticipated that these mutant mice would provide important insights into the unde ...
... inversus viscerum (iv) displaying random LR-asymmetry [39] and the inversion of embryonic turning (inv) developing situs inversus [40]. Both mouse models were extensively used for the analysis of LR-development. It was anticipated that these mutant mice would provide important insights into the unde ...
aureus and Enterococcus faecalis exposed to
... Summary. The novel lipopeptide antibiotic, daptomycin, at a concentration of 8 mg/L, caused gross morphological changes in both a methicillin-sensitive and a methicillin-resistant strain of Staphylococcus aureus and in a strain of Enterococcus faecalis. The earliest (after 1 h) surface lesion observ ...
... Summary. The novel lipopeptide antibiotic, daptomycin, at a concentration of 8 mg/L, caused gross morphological changes in both a methicillin-sensitive and a methicillin-resistant strain of Staphylococcus aureus and in a strain of Enterococcus faecalis. The earliest (after 1 h) surface lesion observ ...
Science Mystery Detectives
... substance, found only in animal products, that is an important part of your body's cells; can build up on artery walls Question 59 - ...
... substance, found only in animal products, that is an important part of your body's cells; can build up on artery walls Question 59 - ...
12 October 2000
... in humans; about two-thirds of these have been suggested to function in apoptosis7, 8. All known caspases possess an active-site cysteine, and cleave substrates at Asp-Xxx bonds (that is, after aspartic acid residues); a caspase's distinct substrate specificity is determined by the four residues ami ...
... in humans; about two-thirds of these have been suggested to function in apoptosis7, 8. All known caspases possess an active-site cysteine, and cleave substrates at Asp-Xxx bonds (that is, after aspartic acid residues); a caspase's distinct substrate specificity is determined by the four residues ami ...
PROPERTIES OF ANTI-MYCOLIC ACID ANTIBODIES IN HUMAN TUBERCULOSIS PATIENTS Master of Science
... antigens in a country with a high prevalence of tuberculosis leads to false positive test results. Serodiagnosis would have been ideal, but was hitherto not successful. Mycolic acid (MA) is the major lipid cell wall constituent of Mycobacterium tuberculosis, the etiological agent of this disease. In ...
... antigens in a country with a high prevalence of tuberculosis leads to false positive test results. Serodiagnosis would have been ideal, but was hitherto not successful. Mycolic acid (MA) is the major lipid cell wall constituent of Mycobacterium tuberculosis, the etiological agent of this disease. In ...
Spatiotemporal Patterns of Expression of NGF and the Low
... ends of the limb persisted throughout limb development, with some of the highest levels of expression occurring at the limb axillary sites, which were not highly innervated. We have also found ~75”” expression at sites of mesenchymal/epithelial interactions in several developing organs that do not a ...
... ends of the limb persisted throughout limb development, with some of the highest levels of expression occurring at the limb axillary sites, which were not highly innervated. We have also found ~75”” expression at sites of mesenchymal/epithelial interactions in several developing organs that do not a ...
Shaping mitotic chromosomes: From classical concepts to molecular
... account the difficulties in obtaining synchronous cell cycle populations by nocodazole washout, one would have expected to observe H4K16 deacetylation and H2A–H4 cross-linking when chromosomes condense as cells proceeded from the arrest into anaphase [45], which was not the case [43]. While it is li ...
... account the difficulties in obtaining synchronous cell cycle populations by nocodazole washout, one would have expected to observe H4K16 deacetylation and H2A–H4 cross-linking when chromosomes condense as cells proceeded from the arrest into anaphase [45], which was not the case [43]. While it is li ...
The System of the Cockroach
... body through the spiracles. The spiracles are found in each of the cockroach’s segments. The larger tubes are called trachea. Trachea are found close to the cockroach’s dorsal vessel, or heart. The trachea branch into smaller tubes, called tracheoles. The tracheoles surround all of the insect’s orga ...
... body through the spiracles. The spiracles are found in each of the cockroach’s segments. The larger tubes are called trachea. Trachea are found close to the cockroach’s dorsal vessel, or heart. The trachea branch into smaller tubes, called tracheoles. The tracheoles surround all of the insect’s orga ...
The role of mitochondria in aging
... create RC dysfunction (see further discussion below). However, when considering the contribution of mitochondrial dysfunction to aging, it is important to note that mitochondrial biogenesis is controlled simultaneously at many different levels. ...
... create RC dysfunction (see further discussion below). However, when considering the contribution of mitochondrial dysfunction to aging, it is important to note that mitochondrial biogenesis is controlled simultaneously at many different levels. ...
Platelet Dense Granule Membranes Contain Both
... cells, and the vessel wall. These secreted components contribute to promotion of hemostasis, wound healing, and formation of atherosclerotic plaques. In particular, secretion of dense granule contents plays a pivotal role in formation of platelet thrombi. These storage organelles (also called dense ...
... cells, and the vessel wall. These secreted components contribute to promotion of hemostasis, wound healing, and formation of atherosclerotic plaques. In particular, secretion of dense granule contents plays a pivotal role in formation of platelet thrombi. These storage organelles (also called dense ...
me337_s17
... involves changes in material properties. These changes, which often are adaptive, may be brought about by alterations in modulus, internal structure, strength, or density. for example, bones, and heart muscle may change their internal structures through reorientation of trabeculae and muscle fibers, ...
... involves changes in material properties. These changes, which often are adaptive, may be brought about by alterations in modulus, internal structure, strength, or density. for example, bones, and heart muscle may change their internal structures through reorientation of trabeculae and muscle fibers, ...
Mercury Detox Instructions (and other Heavy Metals)
... remove toxic Heavy metals from the body and restore proper functioning of the ANS and the organs/ structures affected by it. Mercury in particular (as well as other toxic heavy metals) have a devastating impact on the ANS, promote excessive oxidative damage and alter enzymes and detoxification syste ...
... remove toxic Heavy metals from the body and restore proper functioning of the ANS and the organs/ structures affected by it. Mercury in particular (as well as other toxic heavy metals) have a devastating impact on the ANS, promote excessive oxidative damage and alter enzymes and detoxification syste ...
Development of the lymphatic system: new questions and paradigms
... system and provide a thorough historical analysis of the evolution of this field of research, with a special focus on the animal models and experimental approaches utilized. Finally, we discuss exciting findings from the past year highlighting novel potential sources for lymphatic endothelial cells. ...
... system and provide a thorough historical analysis of the evolution of this field of research, with a special focus on the animal models and experimental approaches utilized. Finally, we discuss exciting findings from the past year highlighting novel potential sources for lymphatic endothelial cells. ...
Full Text
... increased. the time required to cause defects is reduced logarithmically. Also, as time at a given temperature increases. the severity of defects is increased (Fig. 1). These findings match those of Germain et al. (1985) who used similar temperature and duration combinations in rat embryos in vivo. ...
... increased. the time required to cause defects is reduced logarithmically. Also, as time at a given temperature increases. the severity of defects is increased (Fig. 1). These findings match those of Germain et al. (1985) who used similar temperature and duration combinations in rat embryos in vivo. ...