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Golgi-SNARE GS28 potentiates cisplatin
Golgi-SNARE GS28 potentiates cisplatin

... as well as the pro-apoptotic phosphorylation of p53 on Ser46 . Further experiments showed that these cellular responses could be ...
Volume 94, issue 2  July 2011   ...
Volume 94, issue 2 July 2011 ...

... induce axonal elongation. In the context of this problem the work from Smith’s group is particularly interesting. In an effort to design strategies for improved axonal regeneration following injury, they developed a specialized chamber system in which neurons are cultured on two initially contiguous ...
The Development of Radial and Biradial Symmetry: The Evolution of
The Development of Radial and Biradial Symmetry: The Evolution of

... Both phyla are "diploblastic" and possess an outer epidermis and inner gastrodermis (darkly shaded) separated by a largely acellular mesoglea. The cnidarians generally have multiple planes of mirror symmetry which pass through the major longitudinal axis, the oral-aboral axis. A. Cross section of th ...
The functional diversity of essential genes required for mammalian
The functional diversity of essential genes required for mammalian

... so cardiac essential genes may also affect the development of the early embryo or other organ systems. This review predominantly covers genes and genetic pathways specific to cardiogenesis. CARDIAC INDUCTION AND MIGRATION During the first stages of cardiac development, after gastrulation, at embryon ...
Current Status and Future Prospectives of C1 Domain Ligands as
Current Status and Future Prospectives of C1 Domain Ligands as

... At present, the disease models (both in vitro and in vivo) in which the effects of C1 domain ligands have been characterized are mainly based on the proposed role of PKC in the pathophysiology of cancer and AD. In cancer, the differential effects of PKC isoforms on cell proliferation and apoptosis f ...
PDF
PDF

... An epithelium is a coherent sheet of cells that functions as a barrier, separating an organism or tissue from its environment. Any wounds that arise in an epithelium must be closed rapidly and completely to maintain barrier function. Closure of epithelial wounds is primarily driven by the cells bord ...
file
file

... Pterygoid muscles: function of lateral vs. medial "Look at how your jaw ends up when saying first syllable of 'Lateral' or 'Medial' ": "La": your jaw is now open, so Lateral opens mouth. "Me": your jaw is still closed, so medial closes the mandible. Supine vs. prone body position"Supine is on your s ...
Arabinogalactan proteins are involved in root hair development in
Arabinogalactan proteins are involved in root hair development in

... root growth (Willats and Knox, 1996). AGPs are known to influence the organization of cortical microtubules, which control the elongation of epidermal cells (Nguema-Ona et al., 2007). Periplasmic AGPs can also act as calcium capacitors, which is significant because calcium ion gradients are importan ...
golgi apparatus, gerl, and lysosomes of neurons in rat dorsal root
golgi apparatus, gerl, and lysosomes of neurons in rat dorsal root

... this organelle is still lacking in cells generally, including the cells which have provided the bulk of the biochemical and radioautographic evidence . The precise localizations of phosphatases (the functional roles of these phosphatases are currently unknown) in the Golgi apparatus and GERL (14) ar ...
Further analysis on lidocaine-induced increase in intracellular Zn2+
Further analysis on lidocaine-induced increase in intracellular Zn2+

... Milimolar concentrations (1–10 mM) of lidocaine significantly increased the intensity of FluoZin-3 in a concentration-dependent manner (Fig. 1). The result indicated the lidocaine-induced increase in intracellular Zn2+ concentration (Nishimura and Oyama, 2010; Kimura et al., 2011). Removal of extern ...
In tobacco leaf epidermal cells, the integrity of protein export from
In tobacco leaf epidermal cells, the integrity of protein export from

... apparatus in living plant cells has yet to emerge. It has been shown that Arf1 localizes at the Golgi apparatus (Takeuchi et al., 2002) with the coatomer (Movafeghi et al., 1999; Pimpl et al., 2000; Ritzenthaler et al., 2002). However, a distribution of Arf1 on non-Golgi structures has also been ver ...
Gap Junctional Communication in the Extraembryonic Tissues of the
Gap Junctional Communication in the Extraembryonic Tissues of the

... <1,000-1,500 daltons (13). They can be detected functionally by either monitoring for the intercellular passage of ions (ionic coupling), or by observing the cell-to-cell spread of membrane impermeant fluorescent tracers (dye coupling). Using these two techniques, gap junctional communication has be ...
The Development of Radial and Biradial Symmetry: The Evolution of
The Development of Radial and Biradial Symmetry: The Evolution of

... Both phyla are "diploblastic" and possess an outer epidermis and inner gastrodermis (darkly shaded) separated by a largely acellular mesoglea. The cnidarians generally have multiple planes of mirror symmetry which pass through the major longitudinal axis, the oral-aboral axis. A. Cross section of th ...
Bacteriochlorophyll-Synthesizing Budding Bacterium
Bacteriochlorophyll-Synthesizing Budding Bacterium

... Tubes were also incubated anaerobically under dark conditions in a metal container and aerobically in the dark at the same temperature. Growth was determined against a distilled water blank. For antibiotic sensitivity tests, inoculum was spread onto 20-ml PYG agar plates by using sterile glass sprea ...
Naive CD8 T cells differentiate into protective memory
Naive CD8 T cells differentiate into protective memory

... Fc␥ receptors are dispensable for the action of IL-2–anti– IL-2 complexes Why IL-2–anti–IL-2 complexes are so potent in vivo is still unclear. One possible mechanism that has been proposed is the presentation of IL-2–anti–IL-2 complexes by Fc receptor–bearing cells to cells expressing CD122/CD132 ( ...
In tobacco leaf epidermal cells, the integrity of protein export from
In tobacco leaf epidermal cells, the integrity of protein export from

... apparatus in living plant cells has yet to emerge. It has been shown that Arf1 localizes at the Golgi apparatus (Takeuchi et al., 2002) with the coatomer (Movafeghi et al., 1999; Pimpl et al., 2000; Ritzenthaler et al., 2002). However, a distribution of Arf1 on non-Golgi structures has also been ver ...
aplicaciones clínicas de modelos de dinámica de fluidos en
aplicaciones clínicas de modelos de dinámica de fluidos en

... parameters of inhaled drugs on the total and regional deposition in the lungs". In particular, one of the main goals of this project was to improve the existing models by developing a geometry that can be used to investigate the drug deposition in the lower respiratory tract including the alveolar r ...
Main component of spongy bone: _Trabeculae
Main component of spongy bone: _Trabeculae

... ends, usually somewhat curved for strength. Examples: thigh (femur), leg (tibia and fibula), arm (humerus), forearm (ulna and radius), and fingers and toes (phalanges) b. Short bones: somewhat cube-shaped and nearly equal in length and width. Examples: most wrist and ankle bones c. Flat bones: gener ...
Multiple Wnts and Frizzled Receptors Regulate Anteriorly Directed
Multiple Wnts and Frizzled Receptors Regulate Anteriorly Directed

... and 3I; data not shown). To reveal the relationship between migrating HSNs and EGL-20-expressing cells, we stained embryos carrying both muIs49 and muIs13 (Pegl-5::lacZ) transgenes with antisera against GFP and LacZ. The Hox gene egl-5 is expressed in HSNs and a few cells in the tail (Wang et al., 1 ...
glossary for basic cancer terminology in the navajo
glossary for basic cancer terminology in the navajo

... Local anesthesia – numbing only the area involved in the treatment Regional anesthesia – The patient remains awake but usually will receive medication to help relax. Regional anesthesias interfere with the feeling in a part of the body larger than the spot where the treatment is going to take place, ...
Association of FMRP with Ribosomal Precursor Particles in the
Association of FMRP with Ribosomal Precursor Particles in the

... since in cells from fragile X patients, lacking FMRP, a normal transport of ribosomes from the nucleus to the cytoplasm occurs. On the other hand, the RNA binding properties of FMRP and the in vitro association with ribosomes led to different proposals for a theoretical function for FMRP. One possib ...
The Role of PME-1 in Cancer: Therapeutic Implications
The Role of PME-1 in Cancer: Therapeutic Implications

... by conveying cell proliferation, survival, and death signals across the cellular machinery. Protein kinases and phosphatases regulate the phosphorylation status of thousands of proteins in a cell, and thereby maintain a state of homeostasis necessary for normal cell function (Brautigan, 2013; Shi, 2 ...
Role of glutamate on T-cell mediated immunity
Role of glutamate on T-cell mediated immunity

... The pivotal role that glutamate plays in the functioning of the central nervous system is well established. Several glutamate receptors and glutamate transporters have been extensively described in the central nervous system where they, respectively mediate glutamate effects and regulates extracellu ...
Evolution of the Cardiovascular System in
Evolution of the Cardiovascular System in

... present in an animal are probably derived from the ancestral segmental ones rather than de novo structures, given their embryonic origin. Thus, the number of pairs of ostia, unless they were secondarily lost, could indicate the number of segments of the ancestral heart tube that have been retained. ...
Extracellular ATP signaling in plants
Extracellular ATP signaling in plants

... By analogy with animals, the mechanism of plant purinergic signaling should include systems for cellular release and removal of the compound from the extracellular space. In mammalian cells, release of ATP and other nucleotides is mediated by anion channels, gap-junction hemichannels, ATP-binding ca ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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