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Regulation of chromatin by histone modifications
Regulation of chromatin by histone modifications

... now know that this is indeed the case. Modifications not only regulate chromatin structure by merely being there, but they also recruit remodelling enzymes that utilize the energy derived from the hydrolysis of ATP to reposition nucleosomes. The recruitment of proteins and complexes with specific en ...
Daclatasvir Prevents Hepatitis C Virus by Blocking Transfer of
Daclatasvir Prevents Hepatitis C Virus by Blocking Transfer of

... association of structural proteins with non-structural proteins from RCs. Thus, we investigated by confocal microscopy the effect of short-time DCV treatments on HCV proteins that mark either component of viral particles20, i.e., core and E2, or RCs10,21, i.e., NS5A (Figure 1) and NS4B (Figure 2). I ...
Fashioning the vertebrate heart: earliest
Fashioning the vertebrate heart: earliest

... means by which the embryo can compare field size to the dimensions of neighboring fields or to that of the whole animal? Currently there are no definitive answers to these questions, but they nevertheless serve as a framework to discuss issues related to organ development and to assist in the interp ...
New insights into root gravitropic signalling
New insights into root gravitropic signalling

... water, temperature, and gravity. These responsive plant growth movements are called tropisms and they contribute to the plant’s survival and reproduction. Roots modulate their growth towards gravity to exploit the soil for water and nutrient uptake, and to provide anchorage. The physiological proces ...
Paramecium as a bioassay system for elucidation of cytotoxicity and
Paramecium as a bioassay system for elucidation of cytotoxicity and

... The safety of materials to living organisms usually depends upon particle size: substances that are safe in macroscopic quantities can become dangerous when reduced to microscopic particles (Brown et al, 2001). As the behavior of nanoparticles in the environment and in cells is not well understood, ...
Transcriptional mechanisms regulating skeletal muscle
Transcriptional mechanisms regulating skeletal muscle

... transcription factors, such as paired box, homeobox and T-box proteins, have been identified as binding upstream of MRF genes. None of these factors is exclusively expressed in the muscle progenitor cells that give rise to differentiated muscl­e cells, which suggests that these trans­cription factor ...
Telomeres do the (un)twist: helicase actions at chromosome termini
Telomeres do the (un)twist: helicase actions at chromosome termini

... archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. ...
File produced at level 10
File produced at level 10

... structure, release of cytochrome c, and subsequent activation of the destructive caspase enzymes (reviewed in Suen et al. 2008), indicating that inner mitochondrial membrane structure is intertwined with regulatory pathways influencing cell life and death. Regulation of these three mitochondrial sha ...
Gut microbiota translocation to the pancreatic lymph nodes
Gut microbiota translocation to the pancreatic lymph nodes

... The intestinal microbiota has also been considered an important component of T1D development (van Belle et al., 2011; Sorini and Falcone, 2013). However, whether it plays a protective or pathogenic role in the disease remains controversial. In this context, it has been shown that, in rodent models, ...
Recent developments in the cell and molecular biology of root hairs
Recent developments in the cell and molecular biology of root hairs

... Growing root hairs of Arabidopsis have been shown to have two ion transport processes (Lew 1991, using micropipette techniques). One of these is a tetra ethyl ammonium-sensitive potassium ion current, and experiments showed that at resting potential there is a net inward potassium current. This pota ...
FOG1 recruits the NuRD repressor complex to mediate
FOG1 recruits the NuRD repressor complex to mediate

Distribution and Cellular Uptake of PEGylated Polymeric Particles in
Distribution and Cellular Uptake of PEGylated Polymeric Particles in

... their large (>5 μm) geometric size. Alternatively, it has been suggested that nanoparticles can avoid the rigorous AM clearance faced by microparticles, as nanoparticles are not as rapidly internalized by AMs (6). Any such therapeutic carriers which could avoid macrophage uptake offer the potential ...
ANALYSIS OF THE BACTERIOPHAGE P22 VIRAL SPREAD CHARACTERIZATION AS IMMUNOBIOSENSOR
ANALYSIS OF THE BACTERIOPHAGE P22 VIRAL SPREAD CHARACTERIZATION AS IMMUNOBIOSENSOR

... maximizing per-infection phage productivity and minimizing the phage generation time (Abedon, S.T. et al., 2001). So long as virus particle remains inside an infected bacterium then it is not free to acquire a new host. 2.1.2. temporarily or greatly extended, as observed, respectively, with pseudoly ...
Pseudomonas putida in the wheat Detection of recombinant
Pseudomonas putida in the wheat Detection of recombinant

... reports on the application of in situ hybridization targeting ribosomal rRNA has enabled distinctions between bacteria and non-bacteria species in soil (Christensen et al. 1999; Dorn et al. 2003) and type I and II methanotrophs in lake sediments (Kalyuzhnaya et al. 2006). Previous studies have repor ...
m o lo
m o lo

... Predatory bacteria were isolated from Microcystis algal blooms and were evaluated for lytic activity. The hypothesis that the plaque developments on Microcystis lawns were due to bacteria and not to cyanophage activity was tested with the chloroform test. The water samples that were treated with chl ...
ANTAGONISM OF Bacillus spp. TOWARDS  Microcystis aeruginosa Philosophiae Doctor
ANTAGONISM OF Bacillus spp. TOWARDS Microcystis aeruginosa Philosophiae Doctor

... have been proposed and implemented to manage HABs with varying levels of success. These control measures include the use of flocculants, mechanical removal of hyperscums and chemical algicides. The use of flocculants such as PhoslockTM is effective in reducing the phosphates in a water body thus dep ...
The role of mitochondria in aging
The role of mitochondria in aging

... mutations can lead to a premature aging phenotype was obtained by the creation of mtDNA mutator mice (58, 59). The mtDNA mutator mice are homozygous for a knock-in mutation that leads to the expression of a proofreading-deficient catalytic subunit of mtDNA polymerase (PolgAmut). The expression of Po ...
S3.03 The maximum degree of local invasion into or through the
S3.03 The maximum degree of local invasion into or through the

... breached the serosal elastic lamina but not appear on the surface of the colon as it elicits a fibroblastic reaction that forms a cap over the tumour. This finding appears to have adverse significance and tumours showing this feature may have the significance of a pT4a stage. An elastic tissue stain ...
Regulation of Metabolic Events during Embryo Development
Regulation of Metabolic Events during Embryo Development

... The overall aim of this thesis was to identify and characterize metabolic and biochemical events that are involved in regulation of embryo development in Norway spruce. Embryogenesis involves coordination of multicellular patterning events which are critical for establishment of the apical-basal pla ...
Autoantibody Explosion in Systemic Lupus Erythematosus: More
Autoantibody Explosion in Systemic Lupus Erythematosus: More

... and Comments ...
Additional file 1
Additional file 1

... biological interest” and which are not can also be ambiguous: Atoms of all named elements are represented, including the lanthanides and actinides, most of which have little biological relevance, as are xenobiotic chemicals; indeed, any chemical could be considered xenobiotic if it found its way int ...
Specialization of Oleosins in Oil Body Dynamics
Specialization of Oleosins in Oil Body Dynamics

... (Brasaemle and Wolins, 2012; Chapman et al., 2012), little is known about OB dynamics during seed maturation. In this article, we investigate this question by monitoring the evolution of OBs in living Arabidopsis embryos over time. This analysis showed a marked change in OB size at 9 to 10 d after fl ...
Active Hair Bundle Movements and the Cochlear Amplifier
Active Hair Bundle Movements and the Cochlear Amplifier

... These mechanisms can vary between species, but there are some fundamental similarities used by hair cells to overcome difficulties that are common to each. One common problem faced by all hair cells is that the energy associated with sound at threshold is small. In order to obtain such low threshold ...
Handout
Handout

... •  Actin-based motor proteins are members of the myosin superfamily. •  Myosin generates mechanical force by coupling ATP hydrolysis to conformational changes. •  Myosin II is the first motor protein discovered in muscle. Sliding of myosin II along actin filaments causes muscles to contract. •  Myos ...
a va i l a b l e a t... w w w. e l s e v i e...
a va i l a b l e a t... w w w. e l s e v i e...

... previously reported sites. Proteolysis requires Kuzbaniandependent metalloprotease activity and a novel thiol-sensitive aspartyl protease activity. In addition, we show that Delta proteolysis differs from the RIP mechanism by two fundamental criteria: 1) TM-domain processing of Delta is not sensitiv ...
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Amitosis

Amitosis (a- + mitosis) is absence of mitosis, the usual form of cell division in the cells of eukaryotes. There are several senses in which eukaryotic cells can be amitotic. One refers to capability for non-mitotic division and the other refers to lack of capability for division. In one sense of the word, which is now mostly obsolete, amitosis is cell division in eukaryotic cells that happens without the usual features of mitosis as seen on microscopy, namely, without nuclear envelope breakdown and without formation of mitotic spindle and condensed chromosomes as far as microscopy can detect. However, most examples of cell division formerly thought to belong to this supposedly ""non-mitotic"" class, such as the division of unicellular eukaryotes, are today recognized as belonging to a class of mitosis called closed mitosis. A spectrum of mitotic activity can be categorized as open, semi-closed, and closed mitosis, depending on the fate of the nuclear envelope. An exception is the division of ciliate macronucleus, which is not mitotic, and the reference to this process as amitosis may be the only legitimate use of the ""non-mitotic division"" sense of the term today. In animals and plants which normally have open mitosis, the microscopic picture described in the 19th century as amitosis most likely corresponded to apoptosis, a process of programmed cell death associated with fragmentation of the nucleus and cytoplasm. Relatedly, even in the late 19th century cytologists mentioned that in larger life forms, amitosis is a ""forerunner of degeneration"".Another sense of amitotic refers to cells of certain tissues that are usually no longer capable of mitosis once the organism has matured into adulthood. In humans this is true of various muscle and nerve tissue types; if the existing ones are damaged, they cannot be replaced with new ones of equal capability. For example, cardiac muscle destroyed by heart attack and nerves destroyed by piercing trauma usually cannot regenerate. In contrast, skin cells are capable of mitosis throughout adulthood; old skin cells that die and slough off are replaced with new ones. Human liver tissue also has a sort of dormant regenerative ability; it is usually not needed or expressed but can be elicited if needed.
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