Recurrent Pregnancy Loss and Its Relation to Combined Parental
... RPL is classically defined as the occurrence of three or more consecutive losses of clinically recognized pregnancies prior to the 20th week of gestation (ectopic and molar pregnancies are not included). The ASRM defines RPL as two or more failed pregnancies (by ultrasound or histopathological exami ...
... RPL is classically defined as the occurrence of three or more consecutive losses of clinically recognized pregnancies prior to the 20th week of gestation (ectopic and molar pregnancies are not included). The ASRM defines RPL as two or more failed pregnancies (by ultrasound or histopathological exami ...
Depleting Gene Activities in Early Drosophila Embryos
... the later function of EGFR signaling. The D-raf example illustrates how different embryonic phenotypes can be observed depending on the level of either maternal or zygotic gene activity present at a specific developmental stage. Recently, we established an alternative approach to GLCs based on RNA in ...
... the later function of EGFR signaling. The D-raf example illustrates how different embryonic phenotypes can be observed depending on the level of either maternal or zygotic gene activity present at a specific developmental stage. Recently, we established an alternative approach to GLCs based on RNA in ...
An Overview of Genetic Algorithms: Part 2, Research Topics 1
... When GA researchers use the term epistasis , they would generally be talking only about level 2. This is how we shall use the term, unless otherwise stated. Tasks in which all genes are of type 0 or 1 can be solved eciently by various simple techniques, such as hillclimbing, and do not require a G ...
... When GA researchers use the term epistasis , they would generally be talking only about level 2. This is how we shall use the term, unless otherwise stated. Tasks in which all genes are of type 0 or 1 can be solved eciently by various simple techniques, such as hillclimbing, and do not require a G ...
Sheared DNA fragment sizing: comparison of techniques
... Fig. 4 Size Distribution of Sheared DNA Fragments. Panels a, b and c show the relative number of DNA molecules corresponding to given length increments (base pairs) as determined by Kleinschmidt EM, Adsorption EM and gel electrophoresis procedures, respectively. Panels d, e and f show the relative m ...
... Fig. 4 Size Distribution of Sheared DNA Fragments. Panels a, b and c show the relative number of DNA molecules corresponding to given length increments (base pairs) as determined by Kleinschmidt EM, Adsorption EM and gel electrophoresis procedures, respectively. Panels d, e and f show the relative m ...
Genetic Analysis of Variation in Human Meiotic Recombination
... analysis, we used the genotype data from members of twogeneration families that have two or more children to infer recombination phenotypes of the parents in these families. The 511 AGRE families have an average of 2.26 children (median = 2; range: 2 to 7) and provided data for 1,155 female and 1,15 ...
... analysis, we used the genotype data from members of twogeneration families that have two or more children to infer recombination phenotypes of the parents in these families. The 511 AGRE families have an average of 2.26 children (median = 2; range: 2 to 7) and provided data for 1,155 female and 1,15 ...
Will my baby have PKU? pp PP Pp Pp Pp Pp pp Pp Pp Pp pp pp Pp
... If you have PKU, the chance that any of your children will have PKU depends on whether your partner is a carrier. If your partner is not a carrier (see Figure 2) he/she has only normal PKU genes to pass on. All of your children inherit a mutation from you and will be carriers. If your partner is a c ...
... If you have PKU, the chance that any of your children will have PKU depends on whether your partner is a carrier. If your partner is not a carrier (see Figure 2) he/she has only normal PKU genes to pass on. All of your children inherit a mutation from you and will be carriers. If your partner is a c ...
Defining the biological bases of individual differences in musicality
... causal connections between particular genes and phenotypes of interest, in this case key features of musicality. Once relevant genes have been pinpointed, they can be used as entry points into the critical neurobiological pathways and can potentially complement other approaches to understanding musi ...
... causal connections between particular genes and phenotypes of interest, in this case key features of musicality. Once relevant genes have been pinpointed, they can be used as entry points into the critical neurobiological pathways and can potentially complement other approaches to understanding musi ...
Genes Involved in Sister Chromatid Separation and Segregation in
... 1997). In addition to CBF3, the yeast kinetochore contains homologs of higher eukaryotic centromere proteins such as the Cse4, Mif2, and Ipl1 proteins (Meluh and Koshland 1995, 1997; Meluh et al. 1998; S. Biggins and A. W. Murray, unpublished data). Cse4p is a conserved Histone H3 variant that is th ...
... 1997). In addition to CBF3, the yeast kinetochore contains homologs of higher eukaryotic centromere proteins such as the Cse4, Mif2, and Ipl1 proteins (Meluh and Koshland 1995, 1997; Meluh et al. 1998; S. Biggins and A. W. Murray, unpublished data). Cse4p is a conserved Histone H3 variant that is th ...
Wheat biotechnology: A minireview
... Initial steps for genetic transformation involves delivery of a gene cassette into recipient cells followed by analysis of the expression of delivered gene. The results of the above events can be detected by assaying the expression of a reporter gene introduced into plant cell cultures or intact tis ...
... Initial steps for genetic transformation involves delivery of a gene cassette into recipient cells followed by analysis of the expression of delivered gene. The results of the above events can be detected by assaying the expression of a reporter gene introduced into plant cell cultures or intact tis ...
The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system. Development 122, 1353-1362. pdf
... blood to the sites of utilization. In both the mammalian circulatory system and the insect tracheal (respiratory) system, fine branches ramify on or near the oxygen-requiring tissues, with the extent of branching matched to the oxygen needs of the tissue. Angiogenesis has been intensively studied, a ...
... blood to the sites of utilization. In both the mammalian circulatory system and the insect tracheal (respiratory) system, fine branches ramify on or near the oxygen-requiring tissues, with the extent of branching matched to the oxygen needs of the tissue. Angiogenesis has been intensively studied, a ...
Hierarchical Text Categorization and Its Evaluation
... What is hierarchical text categorization (HTC) Functional gene annotation requires HTC Ensemble-based learning and AdaBoost Multi-class multi-label AdaBoost Generalized local hierarchical learning method • New global hierarchical learning algorithm • New hierarchical evaluation measure • Application ...
... What is hierarchical text categorization (HTC) Functional gene annotation requires HTC Ensemble-based learning and AdaBoost Multi-class multi-label AdaBoost Generalized local hierarchical learning method • New global hierarchical learning algorithm • New hierarchical evaluation measure • Application ...
Genetic variation of ApoB 3′ hyper variable region polymorphism
... groups. The average observed heterozygosity was quite high (0.717), suggesting high diversity at the ApoB 3′′ HVR locus. Low value of average GST (0.0126) and FST (0.002) reflects non-significant deviation of heterozygosity between the three subgroups. On comparing the three study groups with ApoB 3 ...
... groups. The average observed heterozygosity was quite high (0.717), suggesting high diversity at the ApoB 3′′ HVR locus. Low value of average GST (0.0126) and FST (0.002) reflects non-significant deviation of heterozygosity between the three subgroups. On comparing the three study groups with ApoB 3 ...
LAB 9 – Principles of Genetic Inheritance
... don’t give birth to lizards and apple trees don’t give rise to pine trees. So what is the biological basis for this obvious reality? You probably already know this has to do with genes, genes one inherits from one’s parents. However the process of passing on genes from one generation to the next is ...
... don’t give birth to lizards and apple trees don’t give rise to pine trees. So what is the biological basis for this obvious reality? You probably already know this has to do with genes, genes one inherits from one’s parents. However the process of passing on genes from one generation to the next is ...
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... abnormal bone metabolic features and the strong genetic component, osteoporosis is a related disorder with OPLL. Three polymorphisms on chromosome 20p12 were identified associated with the risk of osteoporosis and osteoporotic fracture. The rs996544 (C/T) “TT” and rs965291 (G/A) “AA” genotypes confe ...
... abnormal bone metabolic features and the strong genetic component, osteoporosis is a related disorder with OPLL. Three polymorphisms on chromosome 20p12 were identified associated with the risk of osteoporosis and osteoporotic fracture. The rs996544 (C/T) “TT” and rs965291 (G/A) “AA” genotypes confe ...
TAS2R38 - GenoVive
... As with all TAS2R proteins, TAS2R38 utilizes the Gand alcoholism protein gustducin as its primary method of signal transduction. Both the α- and βγ-subunits are crucial to the transmission of the taste signal.[5] See: taste receptor. The TAS2R38 protein also confers sensitivity to the bitter compoun ...
... As with all TAS2R proteins, TAS2R38 utilizes the Gand alcoholism protein gustducin as its primary method of signal transduction. Both the α- and βγ-subunits are crucial to the transmission of the taste signal.[5] See: taste receptor. The TAS2R38 protein also confers sensitivity to the bitter compoun ...
wsp Gene Sequences from the Wolbachia of Filarial Nematodes
... The PCR products obtained with primers WSPintF and WSPintR from nematode Wolbachia were sequenced directly, and the sequences were aligned to the wsp gene available for arthropod Wolbachia. We also tried to align wsp to the gene sequences available for the major outer membrane proteins of Anaplasma, ...
... The PCR products obtained with primers WSPintF and WSPintR from nematode Wolbachia were sequenced directly, and the sequences were aligned to the wsp gene available for arthropod Wolbachia. We also tried to align wsp to the gene sequences available for the major outer membrane proteins of Anaplasma, ...
Mechanoreception-Defective Mutations of Drosophila
... motor response to touch, but they could also result from altered mechanosensory input and therefore did not alone disqualify a line from further study. Twenty-six of the 28 lines that showed reduced larval touch response also are lethal or showed greatly reduced viability as adults (Table 1). In eac ...
... motor response to touch, but they could also result from altered mechanosensory input and therefore did not alone disqualify a line from further study. Twenty-six of the 28 lines that showed reduced larval touch response also are lethal or showed greatly reduced viability as adults (Table 1). In eac ...
Long Noncoding RNA as a Regulator for Transcription
... liposarcoma) inhibits histone acetyltransferase (HAT) activity of CBP and p300 (Wang et al. 2008b). The HAT inhibitor, TLS, turns out to have specific target genes, cyclin D1 and E1, and represses the expression of cyclin D1 upon binding the RNA containing the GGUG-consensus sequence (Lerga et al. 2 ...
... liposarcoma) inhibits histone acetyltransferase (HAT) activity of CBP and p300 (Wang et al. 2008b). The HAT inhibitor, TLS, turns out to have specific target genes, cyclin D1 and E1, and represses the expression of cyclin D1 upon binding the RNA containing the GGUG-consensus sequence (Lerga et al. 2 ...
Non-conflict theories for the evolution of genomic imprinting
... Genomic imprinting violates the usual rules of Mendelian expression in a diploid individual by privileging the expression of one of the two copies of a gene, depending on its parental origin. The degree of unequal expression, usually but not always manifested as the complete silencing of one copy, o ...
... Genomic imprinting violates the usual rules of Mendelian expression in a diploid individual by privileging the expression of one of the two copies of a gene, depending on its parental origin. The degree of unequal expression, usually but not always manifested as the complete silencing of one copy, o ...
F 2
... inheritance of a trait How do we know if a trait is caused by one gene or by two genes that interact? Example: dihybrid cross of pure-breeding parents produces three phenotypes in F2 progeny • If single gene with incomplete dominance, then F2 progeny should be in 1:2:1 ratio • If two independently a ...
... inheritance of a trait How do we know if a trait is caused by one gene or by two genes that interact? Example: dihybrid cross of pure-breeding parents produces three phenotypes in F2 progeny • If single gene with incomplete dominance, then F2 progeny should be in 1:2:1 ratio • If two independently a ...
LIN-5 Is a Novel Component of the Spindle Apparatus
... MTOCs contribute to the bipolar nature of the spindle, as well as to rapid and directional assembly of microtubules. The mitotic functions of the spindle apparatus include separation of the centrosomes, segregation of sister chromatids, and specification of the cleavage-plane position. These differe ...
... MTOCs contribute to the bipolar nature of the spindle, as well as to rapid and directional assembly of microtubules. The mitotic functions of the spindle apparatus include separation of the centrosomes, segregation of sister chromatids, and specification of the cleavage-plane position. These differe ...
Silent polymorphisms in the RYR1 gene do not modify the
... As our patient is presenting a relatively benign clinical course, probably there is no significant association between her pathogenic mutation and the p.4752 T > T synonymous polymorphism, nor with any of the other silencing mutations later identified in her DNA, that could be acting as a modifier o ...
... As our patient is presenting a relatively benign clinical course, probably there is no significant association between her pathogenic mutation and the p.4752 T > T synonymous polymorphism, nor with any of the other silencing mutations later identified in her DNA, that could be acting as a modifier o ...
Biology Recap
... ■ 1665: Robert Hookes published his textbook “Micrographia” ■ Shared the power of microscopic observations ■ Defined term “cell” using the plant cork ...
... ■ 1665: Robert Hookes published his textbook “Micrographia” ■ Shared the power of microscopic observations ■ Defined term “cell” using the plant cork ...
number of fifty human tumours
... The relation between DNA content and chromosome number Considering first the main group of 30 tumours on which substantial numbers of chromosome counts were made, it is evident that except for Tumour No. 29 there is quite good agreement between basic DNA content and chromosome number. For Tumour No. ...
... The relation between DNA content and chromosome number Considering first the main group of 30 tumours on which substantial numbers of chromosome counts were made, it is evident that except for Tumour No. 29 there is quite good agreement between basic DNA content and chromosome number. For Tumour No. ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse