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... pulmonary obstruction measurement and one of the most significant predictors for chronic obstructive pulmonary disease (COPD), which is a heritable multi-factorial disease. We present genome-wide association study (GWAS) to map the genetic architecture of this trait and investigate the networks betw ...
... pulmonary obstruction measurement and one of the most significant predictors for chronic obstructive pulmonary disease (COPD), which is a heritable multi-factorial disease. We present genome-wide association study (GWAS) to map the genetic architecture of this trait and investigate the networks betw ...
nCounter® Data Analysis Guidelines for Copy Number
... The nCounter® Custom Copy Number Variation (CNV) Assay utilizes NanoString’s unique direct and multiplexed detection of nucleic acids in solution to generate estimates of copy number variation for hundreds of loci in a single reaction. Each NanoString Reporter and Capture Probe pair is complementary ...
... The nCounter® Custom Copy Number Variation (CNV) Assay utilizes NanoString’s unique direct and multiplexed detection of nucleic acids in solution to generate estimates of copy number variation for hundreds of loci in a single reaction. Each NanoString Reporter and Capture Probe pair is complementary ...
Revisiting the Impact of Inversions in Evolution
... Genomes Consortium 2007). Likewise, in yeast, the inversion rate in the clade leading to cryotolerant Debaryomyces hansenii is approximately 10 times that of most other lineages (Fischer et al. 2006). Genomic comparisons across species may assist in identifying inversion polymorphisms within species ...
... Genomes Consortium 2007). Likewise, in yeast, the inversion rate in the clade leading to cryotolerant Debaryomyces hansenii is approximately 10 times that of most other lineages (Fischer et al. 2006). Genomic comparisons across species may assist in identifying inversion polymorphisms within species ...
Genome-wide search for asthma susceptibility loci in a founder
... of molecular biological techniques and the initiation of the Human Genome Project (4–6). The relatively small number of founders and recent ancestries that are characteristic of these populations facilitate the search for human disease genes and make them particularly amenable to novel analytical st ...
... of molecular biological techniques and the initiation of the Human Genome Project (4–6). The relatively small number of founders and recent ancestries that are characteristic of these populations facilitate the search for human disease genes and make them particularly amenable to novel analytical st ...
Discovery and characterization of chromatin states for Please share
... complementary functional annotation of the human genome revealing the genome-wide locations of diverse classes of epigenetic functions, including previously-unsuspected chromatin states enriched in transcription end sites, distinct repeat families, and disease-SNP-associated states. ...
... complementary functional annotation of the human genome revealing the genome-wide locations of diverse classes of epigenetic functions, including previously-unsuspected chromatin states enriched in transcription end sites, distinct repeat families, and disease-SNP-associated states. ...
Genetic Homologies between Flagellar Antigens of
... Two different Salmonella abony Hfr donors were crossed to Escherichia coli strain EH 23 and, as a control, to S . abony strain SH 583, which are arg-mutants of the F- recipient strains used in the previous crosses. In both cases the mutant arg loci lie between his and str. Either his+, arg', or both ...
... Two different Salmonella abony Hfr donors were crossed to Escherichia coli strain EH 23 and, as a control, to S . abony strain SH 583, which are arg-mutants of the F- recipient strains used in the previous crosses. In both cases the mutant arg loci lie between his and str. Either his+, arg', or both ...
Meiosis
... Homologous pairs of chromosomes orient randomly at metaphase I of meiosis In independent assortment, each pair of chromosomes sorts maternal and paternal homologues into daughter cells independently of the other pairs The number of combinations possible when chromosomes assort independently into gam ...
... Homologous pairs of chromosomes orient randomly at metaphase I of meiosis In independent assortment, each pair of chromosomes sorts maternal and paternal homologues into daughter cells independently of the other pairs The number of combinations possible when chromosomes assort independently into gam ...
Discovering the Distribution of Palindromic Sequences in the
... complement of the former half, differ from lexical palindromes which read exactly the same forwards and backwards. Palindromic sequences have a tendency of creating hairpin loops which are secondary RNA structures. These hairpin loops (also known as stem-loops) have many purposes which include prote ...
... complement of the former half, differ from lexical palindromes which read exactly the same forwards and backwards. Palindromic sequences have a tendency of creating hairpin loops which are secondary RNA structures. These hairpin loops (also known as stem-loops) have many purposes which include prote ...
Why we have (only) five fingers per hand: Hox genes
... the anterior-posterior axis. However, the Hox-4 genes are also coordinately expressed in the CNS and elsewhere in the body mesenchyme. Thus to alter their expression would affect more than just the limb. In theory, the effects of a newly derived Hox-4 gene could be limited to the limbs by creating a ...
... the anterior-posterior axis. However, the Hox-4 genes are also coordinately expressed in the CNS and elsewhere in the body mesenchyme. Thus to alter their expression would affect more than just the limb. In theory, the effects of a newly derived Hox-4 gene could be limited to the limbs by creating a ...
Adaptation from standing genetic variation
... There is a strong fixation bias against recessive mutations when adaptation occurs from new mutations because they experience weak selection when rare, a process known as Haldane’s sieve [20–22]. However, the effect vanishes when adaptation occurs from standing variation [18,19]. This happens becaus ...
... There is a strong fixation bias against recessive mutations when adaptation occurs from new mutations because they experience weak selection when rare, a process known as Haldane’s sieve [20–22]. However, the effect vanishes when adaptation occurs from standing variation [18,19]. This happens becaus ...
SB2. Students will analyze how biological traits are passed on to
... Impact on the Phenotype • A very small percentage of all mutations actually have a positive effect these are called beneficial mutations. • These mutations lead to new versions of proteins that help an organism and its future generations better adapt to changes in their environment. • Example: – De ...
... Impact on the Phenotype • A very small percentage of all mutations actually have a positive effect these are called beneficial mutations. • These mutations lead to new versions of proteins that help an organism and its future generations better adapt to changes in their environment. • Example: – De ...
FRIZZY PANICLE Drives Supernumerary
... feature of MRS lines is that they have a large number of spikelets emerging from each rachis node, in most cases in the lower third of the spike (Fig. 1, B and C). The central and upper thirds of the spike generally have only three spikelets per node, similar to the spike architecture of six-rowed b ...
... feature of MRS lines is that they have a large number of spikelets emerging from each rachis node, in most cases in the lower third of the spike (Fig. 1, B and C). The central and upper thirds of the spike generally have only three spikelets per node, similar to the spike architecture of six-rowed b ...
Brooker Chapter 8
... are caused by small chromosomal duplications Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ...
... are caused by small chromosomal duplications Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ...
File
... chromosomes are two chromosomes—one inherited from the mother, one from the father—that have the same length and general appearance. More importantly, these chromosomes have copies of the same genes, although the two copies may differ. For example, if you have a gene that influences blood cholestero ...
... chromosomes are two chromosomes—one inherited from the mother, one from the father—that have the same length and general appearance. More importantly, these chromosomes have copies of the same genes, although the two copies may differ. For example, if you have a gene that influences blood cholestero ...
Site specific insertion of a type I rDNA dement into a unique
... fragment that is cleaved at eight sites by Hindlll. Two of the resulting Hindlll fragments, 8a/5 and 8a/6 are shown on the physical map. The 12.5Kb EcoRI fragment has been re-cloned into pBR322 and Figure 2 shows digests of this recombinant plasmid, pMB8a, with a number of restriction endonucleases. ...
... fragment that is cleaved at eight sites by Hindlll. Two of the resulting Hindlll fragments, 8a/5 and 8a/6 are shown on the physical map. The 12.5Kb EcoRI fragment has been re-cloned into pBR322 and Figure 2 shows digests of this recombinant plasmid, pMB8a, with a number of restriction endonucleases. ...
Transcript - Howard Hughes Medical Institute
... they love their projects but at the same time, everybody is interactive and is happy to help each other. We like people who are interactive because we work on big problems. So one person can't solve that big problem whether it's neurodegeneration or Rett syndrome or the role of MATH1 in neural devel ...
... they love their projects but at the same time, everybody is interactive and is happy to help each other. We like people who are interactive because we work on big problems. So one person can't solve that big problem whether it's neurodegeneration or Rett syndrome or the role of MATH1 in neural devel ...
Phytic Acid and Inorganic Phosphate Composition in Soybean Lines
... substrates in addition to inositol-pentakisphosphate (Caddick et al., 2008; StevensonPaulik et al., 2005; Sun et al., 2007; Sweetman et al., 2006). Soybean is derived from ancient genome duplication events, and the existence of small gene families with members present on different chromosomes provid ...
... substrates in addition to inositol-pentakisphosphate (Caddick et al., 2008; StevensonPaulik et al., 2005; Sun et al., 2007; Sweetman et al., 2006). Soybean is derived from ancient genome duplication events, and the existence of small gene families with members present on different chromosomes provid ...
A Large Pseudoautosomal Region on the Sex Chromosomes of the
... et al. 2011). Many of the other sex-linked AFLPs identified by Olmstead et al. (2010) map to other major or small chromosome/linkage groups (table 1); this is presumably because some scaffolds are chimerical (e.g., a portion of scaffold 2 in version 7.1 is probably actually derived from S. tropicali ...
... et al. 2011). Many of the other sex-linked AFLPs identified by Olmstead et al. (2010) map to other major or small chromosome/linkage groups (table 1); this is presumably because some scaffolds are chimerical (e.g., a portion of scaffold 2 in version 7.1 is probably actually derived from S. tropicali ...
Genetic aspects of chronic pancreatitis
... known so far must be considered in order to understand the relatively rare occurrence of pancreatitis in humans. It appears possible that additional protective mechanisms will be detected. For example, two pancreatic (non-enzymatic) soluble secretory proteins (PAP, pancreatitis-associated protein; P ...
... known so far must be considered in order to understand the relatively rare occurrence of pancreatitis in humans. It appears possible that additional protective mechanisms will be detected. For example, two pancreatic (non-enzymatic) soluble secretory proteins (PAP, pancreatitis-associated protein; P ...
Association of functionally significant Melanocortin
... and Fig. 3). Arg257Ser, found in both case and control subjects, was also classified as a mutation with functional consequence. The prevalence of variants with functional alterations was the same in cases and controls (P ¼ 0.625; Fig. 2). In silico analysis of severe adult obesity-associated MC4R an ...
... and Fig. 3). Arg257Ser, found in both case and control subjects, was also classified as a mutation with functional consequence. The prevalence of variants with functional alterations was the same in cases and controls (P ¼ 0.625; Fig. 2). In silico analysis of severe adult obesity-associated MC4R an ...
B - Dendrome
... Alleles Alternative forms of a gene Alleles arise through mutation A diploid cell has two copies of each gene (i.e. two alleles) at each locus Alleles on homologous chromosomes may be the same or different (homozygous vs. heterozygous) ...
... Alleles Alternative forms of a gene Alleles arise through mutation A diploid cell has two copies of each gene (i.e. two alleles) at each locus Alleles on homologous chromosomes may be the same or different (homozygous vs. heterozygous) ...
Modeling Linkage Disequilibrium and Identifying Recombination
... which these pairwise likelihoods are computed via simulation, assuming an “infinite-sites” mutation model (i.e., no repeat mutation). This method has been modified by McVean et al. (2002) to allow for repeat mutation. Fearnhead and Donnelly’s method is based on dividing data on a large region into s ...
... which these pairwise likelihoods are computed via simulation, assuming an “infinite-sites” mutation model (i.e., no repeat mutation). This method has been modified by McVean et al. (2002) to allow for repeat mutation. Fearnhead and Donnelly’s method is based on dividing data on a large region into s ...
An Overview of Genetic Algorithms: Part 2, Research Topics 1
... When GA researchers use the term epistasis , they would generally be talking only about level 2. This is how we shall use the term, unless otherwise stated. Tasks in which all genes are of type 0 or 1 can be solved eciently by various simple techniques, such as hillclimbing, and do not require a G ...
... When GA researchers use the term epistasis , they would generally be talking only about level 2. This is how we shall use the term, unless otherwise stated. Tasks in which all genes are of type 0 or 1 can be solved eciently by various simple techniques, such as hillclimbing, and do not require a G ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse