Obesity - PHG Foundation
... obesity is the primary feature. These gene discoveries have contributed to our understanding of the biological mechanisms involved in the development of obesity, as all play a role in the central regulation of energy intake. Mutations in the identified genes disrupt appetite and satiety mechanisms, ...
... obesity is the primary feature. These gene discoveries have contributed to our understanding of the biological mechanisms involved in the development of obesity, as all play a role in the central regulation of energy intake. Mutations in the identified genes disrupt appetite and satiety mechanisms, ...
Phylogenetic analysis of three complete gap
... transfer of small molecules (<1 kDa) between neighboring cells [1]. Cell –cell communication via gap junctions is critical for normal cellular function and homeostasis as evidenced by the wide variety of connexin mutations that lead to human disease [2]. A single connexin protein folds into four con ...
... transfer of small molecules (<1 kDa) between neighboring cells [1]. Cell –cell communication via gap junctions is critical for normal cellular function and homeostasis as evidenced by the wide variety of connexin mutations that lead to human disease [2]. A single connexin protein folds into four con ...
π, γ
... 1. Remove all circular singletons of Π and Γ. 2. Lemma 1 Close every {π, π}-path ({γ, γ}-path) into a cycle by adding a single new adjacency to Π* (Γ*). 3. Form a maximum set of 2-bracelets (only chains remaining). 4. Form a maximum set of even 2-chains by linking pairs of πpaths (γ-paths) having ...
... 1. Remove all circular singletons of Π and Γ. 2. Lemma 1 Close every {π, π}-path ({γ, γ}-path) into a cycle by adding a single new adjacency to Π* (Γ*). 3. Form a maximum set of 2-bracelets (only chains remaining). 4. Form a maximum set of even 2-chains by linking pairs of πpaths (γ-paths) having ...
1. Introduction
... 1.1. Chromosomes, karyotypes and theirs variations 1.1.1. Historical background: the chromosome discovery In 1888, Heinrich von Waldeyer (1888) introduced the term “chromosome”, from the Greek chroma for colored and soma for body, to designate the filaments present in the cell nucleus and previously ...
... 1.1. Chromosomes, karyotypes and theirs variations 1.1.1. Historical background: the chromosome discovery In 1888, Heinrich von Waldeyer (1888) introduced the term “chromosome”, from the Greek chroma for colored and soma for body, to designate the filaments present in the cell nucleus and previously ...
Supplementary Information (doc 408K)
... fulfilling the DSM-IV criteria of schizophrenia for proband recruitment based on clinical observation and interview by the attending psychiatrist providing the psychiatric services. (2) After identifying the potential proband, the parents were informed about the details of this study, and initial o ...
... fulfilling the DSM-IV criteria of schizophrenia for proband recruitment based on clinical observation and interview by the attending psychiatrist providing the psychiatric services. (2) After identifying the potential proband, the parents were informed about the details of this study, and initial o ...
DNA cytosine methylation in plant development
... Locus-specific histone modifications that are catalyzed by HDA6 and SUVH4/KYP, and variation in methylation 1 (VIM1) and decrease in DNA methylation 1 (DDM1) help to maintain cytosine methylation. Cytosine methylation can be lost in nondividing cells by a base excision repair-type mechanism that inv ...
... Locus-specific histone modifications that are catalyzed by HDA6 and SUVH4/KYP, and variation in methylation 1 (VIM1) and decrease in DNA methylation 1 (DDM1) help to maintain cytosine methylation. Cytosine methylation can be lost in nondividing cells by a base excision repair-type mechanism that inv ...
Polygenes and Modifier Genes for Tetracycline and
... genes, shows that no more than one Tet resistance gene can beltransformed by this rapid technique. DNA from 49191 is the negative control. In all cases DNA from one strain spotted on a lawn of that same strain did not increase its level of resistance to Tet. This means that a ‘double dose effect’ do ...
... genes, shows that no more than one Tet resistance gene can beltransformed by this rapid technique. DNA from 49191 is the negative control. In all cases DNA from one strain spotted on a lawn of that same strain did not increase its level of resistance to Tet. This means that a ‘double dose effect’ do ...
Predictions of Patterns of Response to Artificial Selection
... give the environmental deviation and thus the phenotypic value; (iii) individuals were ranked on phenotypic value and the highest Np was selected; (iv) each offspring was drawn independently by random mating without random selfing (i.e., no family structure or sexes); and (v) Mo offspring genotypes ...
... give the environmental deviation and thus the phenotypic value; (iii) individuals were ranked on phenotypic value and the highest Np was selected; (iv) each offspring was drawn independently by random mating without random selfing (i.e., no family structure or sexes); and (v) Mo offspring genotypes ...
Stumps, a Drosophila gene required for FGF-directed migrations of tracheal and mesodermal cells. Genetics 152, 307-318. pdf
... caused a striking arrest in tracheal cell migration, resulting in a tracheal phenotype resembling that of null mutations in breathless (btl) or branchless (bnl; Sutherland et al. 1996). Here we present the genetic characterization of the gene. The gene was named stumps because no tracheal branches f ...
... caused a striking arrest in tracheal cell migration, resulting in a tracheal phenotype resembling that of null mutations in breathless (btl) or branchless (bnl; Sutherland et al. 1996). Here we present the genetic characterization of the gene. The gene was named stumps because no tracheal branches f ...
"Nitrogen Fixation: 1888-2001"
... Both uridylylation and deuridylylation of GlnB are effected by the GlnD protein which responds to the intracellular glutamine concentration in such a way that glutamine specifically inhibits the uridylylation reaction (Jiang et al., 1998). Consequently GlnB is uridylylated under nitrogen-limiting (l ...
... Both uridylylation and deuridylylation of GlnB are effected by the GlnD protein which responds to the intracellular glutamine concentration in such a way that glutamine specifically inhibits the uridylylation reaction (Jiang et al., 1998). Consequently GlnB is uridylylated under nitrogen-limiting (l ...
Pom-Pom_Genetics
... Yes, eye color is complicated. Not only are there three main colors, but there are many shades of those colors and some eyes have rings around the pupil while others have rays coming out from the iris (the black part). Much of this genetics has not been worked out. However, this much is known: eye c ...
... Yes, eye color is complicated. Not only are there three main colors, but there are many shades of those colors and some eyes have rings around the pupil while others have rays coming out from the iris (the black part). Much of this genetics has not been worked out. However, this much is known: eye c ...
Early frameshift alleles of zebrafish tbx5a that fail to
... dominant-negative conditions arising from truncated residual protein or lower protein concentration. The introduction of CRISPR-Cas9 for genome editing has provided the zebrafish field with an easily accessible tool for generating mutant alleles for any gene of choice. Targeted mutagenesis using CRI ...
... dominant-negative conditions arising from truncated residual protein or lower protein concentration. The introduction of CRISPR-Cas9 for genome editing has provided the zebrafish field with an easily accessible tool for generating mutant alleles for any gene of choice. Targeted mutagenesis using CRI ...
Monitoring BCR-ABL transcript levels by real-time
... adopted to monitor residual disease in clinical studies. An attempt to standardize this methodology was made by the comprehensive work of a European network of experienced laboratories,2 resulting in the suggestion to use three different control genes, glucuronidase (GUS), Abelson (ABL) and β-2 micr ...
... adopted to monitor residual disease in clinical studies. An attempt to standardize this methodology was made by the comprehensive work of a European network of experienced laboratories,2 resulting in the suggestion to use three different control genes, glucuronidase (GUS), Abelson (ABL) and β-2 micr ...
Genotype Discrimination: The complex case for some legislative protection. Henry T. Greely. 149 U. Pa. L. Rev. 1483 (May 2001)
... all humans have the same set of genes, about 32,000 of them, n1 except for those few genes on the Y chromosome, found in men and not in women. n2 Those genes come in many variations; indeed, for the most part, the human genes are just human variations of genes found in other primates, mammals, anima ...
... all humans have the same set of genes, about 32,000 of them, n1 except for those few genes on the Y chromosome, found in men and not in women. n2 Those genes come in many variations; indeed, for the most part, the human genes are just human variations of genes found in other primates, mammals, anima ...
December 8, 2006 - Brandeis University
... Experimental errors might have also influenced the progeny count. Incubation conditions may not have allowed for proper fly development. An incubation temperature set too high, for example, may have made female flies sterile, affecting the progeny count. It is also still possible that some female fl ...
... Experimental errors might have also influenced the progeny count. Incubation conditions may not have allowed for proper fly development. An incubation temperature set too high, for example, may have made female flies sterile, affecting the progeny count. It is also still possible that some female fl ...
Feline Genetics: a Combinatorial Approach
... Introduction: combinatorial models for feline genetics. These notes are aimed to give a simplified and synthetic account of feline genetics, whose biological and biochemical prerequisites are reduced to a minimum. This goal is achieved by systematically using Mendelian models of genetic transmission ...
... Introduction: combinatorial models for feline genetics. These notes are aimed to give a simplified and synthetic account of feline genetics, whose biological and biochemical prerequisites are reduced to a minimum. This goal is achieved by systematically using Mendelian models of genetic transmission ...
Chapter 44 Self Test (EOC)
... 1. Several examples of genes being co-opted for new functions were given in the chapter. Cite two and explain what is meant by co-opted. Answer—Brachyury, Tbx5, and others, are examples of genes that have a defined function in a basal set of taxa, and in more derived taxa the function switches. In t ...
... 1. Several examples of genes being co-opted for new functions were given in the chapter. Cite two and explain what is meant by co-opted. Answer—Brachyury, Tbx5, and others, are examples of genes that have a defined function in a basal set of taxa, and in more derived taxa the function switches. In t ...
Biological data integration using semantic Web technology
... Various sources of biological data must be combined in order to obtain a full picture and to build new knowledge, for example data stored in an organism’s specific database (such as FlyBase) with results of microarray experiments and information available on related species. However, a large majorit ...
... Various sources of biological data must be combined in order to obtain a full picture and to build new knowledge, for example data stored in an organism’s specific database (such as FlyBase) with results of microarray experiments and information available on related species. However, a large majorit ...
17. Prof. K. P. Bhatia: Paroxysmal Movement Disorders
... family, all with typical PNKD with autosmal dominant inhertitance.53-55 It appears that there is genetic homogeneity for typical familial PNKD/PDC. The gene for this disorder was recently identified and is called the myofibrillogenesis regulator 1 gene.56 Mis-sense mutations were identified in the a ...
... family, all with typical PNKD with autosmal dominant inhertitance.53-55 It appears that there is genetic homogeneity for typical familial PNKD/PDC. The gene for this disorder was recently identified and is called the myofibrillogenesis regulator 1 gene.56 Mis-sense mutations were identified in the a ...
Document
... as question-asker, not just as infrastructure-builder or assistant to a biologist.” ...
... as question-asker, not just as infrastructure-builder or assistant to a biologist.” ...
Telomereled bouquet formation facilitates homologous chromosome
... formed between sister chromatids that were produced by a mechanism coupled with semiconservative DNA replication (Skibbens et al., 1999; Toth et al., 1999). In meiosis, however, the link is typically formed between homologous chromosomes, each of which was brought into the same cell from previously ...
... formed between sister chromatids that were produced by a mechanism coupled with semiconservative DNA replication (Skibbens et al., 1999; Toth et al., 1999). In meiosis, however, the link is typically formed between homologous chromosomes, each of which was brought into the same cell from previously ...
SHORT COMMUNICATION One-step multiplex RT-PCR
... The patient who was negative for BCR/ABL had clinical features and peripheral blood film suggestive of chronic myeloproliferative disease. Her condition was complicated by carcinoma of the breast that developed later. The use of conventional cytogenetic analysis has complemented PCR at initial diagn ...
... The patient who was negative for BCR/ABL had clinical features and peripheral blood film suggestive of chronic myeloproliferative disease. Her condition was complicated by carcinoma of the breast that developed later. The use of conventional cytogenetic analysis has complemented PCR at initial diagn ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse