Novel p53 mutants selected in BRCA
... 1997). PIG3 is related to a plant gene TED2, implicated in the apoptotic process associated with the formation of meristems, and the mammalian NADPH-quinone oxidoreductase which is a potent inducer of reactive oxygen species (ROS) which are powerful inducers of apoptosis. The importance of transacti ...
... 1997). PIG3 is related to a plant gene TED2, implicated in the apoptotic process associated with the formation of meristems, and the mammalian NADPH-quinone oxidoreductase which is a potent inducer of reactive oxygen species (ROS) which are powerful inducers of apoptosis. The importance of transacti ...
Powerpoint template for scientific posters (Swarthmore College)
... Stony Brook University, Department of Biochemistry and Cell Biology and the Center for Developmental Genetics, Stony Brook University, Stony Brook, NY, 11790 ...
... Stony Brook University, Department of Biochemistry and Cell Biology and the Center for Developmental Genetics, Stony Brook University, Stony Brook, NY, 11790 ...
genetic disorders associated with macrocephaly
... may occasionally be associated with hydrocephalus or true megalencephaly. Noonan syndrome is caused by mutations in the PTPN11 gene (12q24.1) in 50%, KRAS gene (12p12.1) in less than 5%, SOS1 gene (2p22-p21) in 10%, and RAF1 gene (3p25) in 3-17% of cases. Cardiofaciocutaneous (CFC) syndrome is chara ...
... may occasionally be associated with hydrocephalus or true megalencephaly. Noonan syndrome is caused by mutations in the PTPN11 gene (12q24.1) in 50%, KRAS gene (12p12.1) in less than 5%, SOS1 gene (2p22-p21) in 10%, and RAF1 gene (3p25) in 3-17% of cases. Cardiofaciocutaneous (CFC) syndrome is chara ...
12 | mendel`s experiments and heredity
... Genetics is the study of heredity. Johann Gregor Mendel set the framework for genetics long before chromosomes or genes had been identified, at a time when meiosis was not well understood. Mendel selected a simple biological system and conducted methodical, quantitative analyses using large sample s ...
... Genetics is the study of heredity. Johann Gregor Mendel set the framework for genetics long before chromosomes or genes had been identified, at a time when meiosis was not well understood. Mendel selected a simple biological system and conducted methodical, quantitative analyses using large sample s ...
color info - Bedonna`s Performance Horses
... Because I study color genetics, and have lots of color in my breeding program, I get asked LOTS of questions about colors and color possibilities for foals. I used to include most of this info in my breeding agreements, but it added too much length to the contract, so I am going to have it all liste ...
... Because I study color genetics, and have lots of color in my breeding program, I get asked LOTS of questions about colors and color possibilities for foals. I used to include most of this info in my breeding agreements, but it added too much length to the contract, so I am going to have it all liste ...
CIBI3031-070 Midterm Examination III November 2005
... ____ 27. If ALL offspring of a cross have the genotype Aa, the parents of the crosses are most likely a. Aa x aa. b. AA x aa. c. Aa x Aa. ____ 28. The chromatids separate from one another and become individual chromosomes during a. metaphase. b. prophase. c. anaphase. ____ 29. Mendel found that pea ...
... ____ 27. If ALL offspring of a cross have the genotype Aa, the parents of the crosses are most likely a. Aa x aa. b. AA x aa. c. Aa x Aa. ____ 28. The chromatids separate from one another and become individual chromosomes during a. metaphase. b. prophase. c. anaphase. ____ 29. Mendel found that pea ...
CIBI3031-091 Midterm Examination III November 2005
... ____ 47. According to Mendel, what kind of alleles are masked, or "disappear," in F1 pea plants? a. codominant b. dominant c. recessive ____ 48. Crossing over is one of the most important events in meiosis because a. homologous chromosomes must be separated into different daughter cells. b. the num ...
... ____ 47. According to Mendel, what kind of alleles are masked, or "disappear," in F1 pea plants? a. codominant b. dominant c. recessive ____ 48. Crossing over is one of the most important events in meiosis because a. homologous chromosomes must be separated into different daughter cells. b. the num ...
Effect of Proliferating Cell Nuclear Antigen
... that pol is highly mobile in human fibroblasts. Even when localized in replication foci, it is only transiently immobilized. Although ubiquitination of proliferating cell nuclear antigen (PCNA) is not required for the localization of pol in foci, it results in an increased residence time in foci. ...
... that pol is highly mobile in human fibroblasts. Even when localized in replication foci, it is only transiently immobilized. Although ubiquitination of proliferating cell nuclear antigen (PCNA) is not required for the localization of pol in foci, it results in an increased residence time in foci. ...
A Deterministic Analysis of Stationary Diploid/Dominance
... dominance population is complicated with two kinds of recombination. The first is the usual one, between individual, real string positions. In this case, crossover occurs within the gene or dominance locus. The second applies to chromosomes having multiple genes2. Such a situation encourages recombi ...
... dominance population is complicated with two kinds of recombination. The first is the usual one, between individual, real string positions. In this case, crossover occurs within the gene or dominance locus. The second applies to chromosomes having multiple genes2. Such a situation encourages recombi ...
Endoderm development in vertebrates: fate mapping
... The formation of the vertebrate body plan begins with the differentiation of cells into three germ layers: ectoderm, mesoderm and endoderm. Cells in the endoderm give rise to the epithelial lining of the digestive tract, associated glands and respiratory system. One of the fundamental problems in de ...
... The formation of the vertebrate body plan begins with the differentiation of cells into three germ layers: ectoderm, mesoderm and endoderm. Cells in the endoderm give rise to the epithelial lining of the digestive tract, associated glands and respiratory system. One of the fundamental problems in de ...
Document
... Digital PCR provides ultrasensitive and absolute DNA quantification. It is paticulary useful for low abundance targets and for monitoring subtle changes in target levels that cannot be detected with real-time PCR. ...
... Digital PCR provides ultrasensitive and absolute DNA quantification. It is paticulary useful for low abundance targets and for monitoring subtle changes in target levels that cannot be detected with real-time PCR. ...
Multiple Exostoses
... In those with a positive family history, radiologically demonstrable exostoses are virtually always present by 1 year of age. Therefore, in family members at risk we recommend that a complete skeletal survey be obtained at that age in order to determine if a new child is or is not affected. Even pri ...
... In those with a positive family history, radiologically demonstrable exostoses are virtually always present by 1 year of age. Therefore, in family members at risk we recommend that a complete skeletal survey be obtained at that age in order to determine if a new child is or is not affected. Even pri ...
Epigenetics & Chromatin Xist through transcriptional control of Dnmt3a
... upstream region (5') leads to around 20% loss of methylation in both region 1 and region 2. This was also the case for mutants carrying the PGKneo cassette, as well as for neo ES cells (Figure 2C). More severe loss of methylation was observed for SPA+neo mutant (Figure 2D), consistent with the MSR ...
... upstream region (5') leads to around 20% loss of methylation in both region 1 and region 2. This was also the case for mutants carrying the PGKneo cassette, as well as for neo ES cells (Figure 2C). More severe loss of methylation was observed for SPA+neo mutant (Figure 2D), consistent with the MSR ...
Construction of a linkage map based on a Lathyrus sativus
... Conversely, many accessions of Lathyrus sativus L., commonly known as grasspea or chickling pea, were shown to be highly resistant to M. pinodes (Weimer 1947; Gurung et al. 2002). Since L. sativus is also a member of the Vicieae tribe along with Pisum, it may serve as a potential source of resistanc ...
... Conversely, many accessions of Lathyrus sativus L., commonly known as grasspea or chickling pea, were shown to be highly resistant to M. pinodes (Weimer 1947; Gurung et al. 2002). Since L. sativus is also a member of the Vicieae tribe along with Pisum, it may serve as a potential source of resistanc ...
A NEW ALLELE OF THE lpr LOCUS, lpr"9, THAT COMPLEMENTS
... for Thy-1 .2 (11) and GK-1.5 directed against L3T4 (12) were originally supplied by F. Fitch (University of Chicago, Chicago, IL). The 53-6.7 was directed against Lyt-2 (13). The hybridoma that secretes mAb against B220(3A1) was purchased from the American Type Culture Collection (Rockville, MD) . F ...
... for Thy-1 .2 (11) and GK-1.5 directed against L3T4 (12) were originally supplied by F. Fitch (University of Chicago, Chicago, IL). The 53-6.7 was directed against Lyt-2 (13). The hybridoma that secretes mAb against B220(3A1) was purchased from the American Type Culture Collection (Rockville, MD) . F ...
The use of genetic markers in poultry breeding
... plants. For livestock species completely inbred lines are not available. Methods using information from segregating populations have been developed in human genetics (Morton 1955; Ott 1991). Here, the influence oftheresearcher ontheexperimental design is limited. Therefore, emphasis has been on deve ...
... plants. For livestock species completely inbred lines are not available. Methods using information from segregating populations have been developed in human genetics (Morton 1955; Ott 1991). Here, the influence oftheresearcher ontheexperimental design is limited. Therefore, emphasis has been on deve ...
1999 Dekkers: BREEDING IN THE 21st CENTURY
... evaluations, providing best linear unbiased predictors (BLUP) of EBV for identified QTL and for the collective effect of polygenes. Kennedy et al (1992) suggested inclusion of genotype as a fixed effect in an animal model to estimate the effects of known genes, capitalizing on population-wide disequ ...
... evaluations, providing best linear unbiased predictors (BLUP) of EBV for identified QTL and for the collective effect of polygenes. Kennedy et al (1992) suggested inclusion of genotype as a fixed effect in an animal model to estimate the effects of known genes, capitalizing on population-wide disequ ...
selection for the heterozygote
... in a given niche, within the population. The equilibrium will depend on the relative frequencies of the niches and the selection differentials... - can you think of an example?? Papilio butterflies... females mimic different models and an equilibrium is maintained; in fact, an equilibrium at each lo ...
... in a given niche, within the population. The equilibrium will depend on the relative frequencies of the niches and the selection differentials... - can you think of an example?? Papilio butterflies... females mimic different models and an equilibrium is maintained; in fact, an equilibrium at each lo ...
"Antibiotics and the Evolution of Antibiotic Resistance". In
... the challenges suffered by this bacterial species, including the exposure to antibiotics. In this sense, clones might behave as adaptive modules of a hierarchical superior entity, a ‘regional community structure’, integrating ‘optimal clonal compositions’ able to provide alternative stable states if ...
... the challenges suffered by this bacterial species, including the exposure to antibiotics. In this sense, clones might behave as adaptive modules of a hierarchical superior entity, a ‘regional community structure’, integrating ‘optimal clonal compositions’ able to provide alternative stable states if ...
PDF
... activates transcription of genes that promote floral development, including AP1, thus triggering the floral transition. Activation of FT by CO is likely to be mediated through interactions with nuclear factor Y proteins (NF-Y) – also known as heme activator proteins (HAP) or CCAAT binding factors (ref ...
... activates transcription of genes that promote floral development, including AP1, thus triggering the floral transition. Activation of FT by CO is likely to be mediated through interactions with nuclear factor Y proteins (NF-Y) – also known as heme activator proteins (HAP) or CCAAT binding factors (ref ...
Maintenance of genomic integrity by p53: complementary
... described above could be one such mechanism, but other interactions, mediated by the N-terminal prolinerich domain of p53 which serves as a docking place for proteins containing SH3-domains, have also been implicated. Even less understood is what determines the `decision' to induce either a growth a ...
... described above could be one such mechanism, but other interactions, mediated by the N-terminal prolinerich domain of p53 which serves as a docking place for proteins containing SH3-domains, have also been implicated. Even less understood is what determines the `decision' to induce either a growth a ...
Depolarization of the actin cytoskeleton is a specific phenotype in
... (Chowdhury et al., 1992; Lillie and Brown, 1994; Novick et ...
... (Chowdhury et al., 1992; Lillie and Brown, 1994; Novick et ...
Multiple domain structure in a chitinase gene (chic)
... 1992; Kuranda & Robbins, 1991), but these sequences are not always homologous. This suggests that chitinase genes have spread through various organisms in the process of evolution and have formed several gene families. Streptomyces spp. are typical soil inhabitants, and produce various carbohydrases ...
... 1992; Kuranda & Robbins, 1991), but these sequences are not always homologous. This suggests that chitinase genes have spread through various organisms in the process of evolution and have formed several gene families. Streptomyces spp. are typical soil inhabitants, and produce various carbohydrases ...
Hereditary hemorrhagic telangiectasia: genetics and molecular
... 85% of cases submitted to clinical molecular genetics laboratories for clinical suspicion of HHT. Over 750 pathogenic ENG and ACVRL1 mutations have been described to date (HHT mutation databases1, 2 ). The HHT mutation database3 is the most comprehensive database for endoglin and ACVRL1 mutations de ...
... 85% of cases submitted to clinical molecular genetics laboratories for clinical suspicion of HHT. Over 750 pathogenic ENG and ACVRL1 mutations have been described to date (HHT mutation databases1, 2 ). The HHT mutation database3 is the most comprehensive database for endoglin and ACVRL1 mutations de ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse