Mice 2 NZW)F Genetic Complementation in Female (BXSB ×
... incidence in XWF1 hybrids, including myocardial infarction (MI), degenerative vascular disease (DVD), arteritis, and thymic atrophy (13). For all traits, disease was significantly worse in XWF1 hybrid mice than in one or both parental strains. The 1-year survival for female BXSB mice was 100% (14 mi ...
... incidence in XWF1 hybrids, including myocardial infarction (MI), degenerative vascular disease (DVD), arteritis, and thymic atrophy (13). For all traits, disease was significantly worse in XWF1 hybrid mice than in one or both parental strains. The 1-year survival for female BXSB mice was 100% (14 mi ...
A survey on computational methods for enhancer and
... It is also important to note that these high-throughput experimental methods have been mainly used for testing enhancer candidates already defined by some other means, but not for discovering enhancers ab initio. In theory it should be possible to tile a major portion of a genome for testing the en ...
... It is also important to note that these high-throughput experimental methods have been mainly used for testing enhancer candidates already defined by some other means, but not for discovering enhancers ab initio. In theory it should be possible to tile a major portion of a genome for testing the en ...
This document has been downloaded from Tampub – The
... where it can be processed by two specific proteases and then release the amino-terminal transcription-activation domain of the SREBF. The active form of SREBF can then travel to the nucleus where it binds to the promoters of target genes [1]. The SREBFs consist of three different SREBF isoforms, SRE ...
... where it can be processed by two specific proteases and then release the amino-terminal transcription-activation domain of the SREBF. The active form of SREBF can then travel to the nucleus where it binds to the promoters of target genes [1]. The SREBFs consist of three different SREBF isoforms, SRE ...
8 VARIATION IN CHROMOSOME STRUCTURE AND NUMBER
... metaphase, and the right chromatid shows the banding pattern as it would appear during prometaphase. Why is the banding pattern of eukaryotic chromosomes useful? First, when stained, individual chromosomes can be distinguished from each other, even if they have similar sizes and centromeric location ...
... metaphase, and the right chromatid shows the banding pattern as it would appear during prometaphase. Why is the banding pattern of eukaryotic chromosomes useful? First, when stained, individual chromosomes can be distinguished from each other, even if they have similar sizes and centromeric location ...
Insulin-like growth factor (IGF) signalling is required for early dorso
... zebrafish IGF-1Rs in the vertebrate IGF-1R clade, distinct from the insulin receptor or insulin-related receptor clades. IGF-1Ra and IGF-1Rb mRNAs and proteins are expressed in overlapping spatial domains in vivo, but exhibit distinct temporal expression patterns in specific tissues and organs. Stro ...
... zebrafish IGF-1Rs in the vertebrate IGF-1R clade, distinct from the insulin receptor or insulin-related receptor clades. IGF-1Ra and IGF-1Rb mRNAs and proteins are expressed in overlapping spatial domains in vivo, but exhibit distinct temporal expression patterns in specific tissues and organs. Stro ...
CHAPTER e18 Mitochondrial DNA and Heritable Traits and Diseases
... As a result of its circular structure and extranuclear location, the replication and transcription mechanisms of mtDNA differ from the corresponding mechanisms in the nuclear genome, whose nucleosomal packaging and structure are more complex. Since each mitochondrion contains many copies of mtDNA an ...
... As a result of its circular structure and extranuclear location, the replication and transcription mechanisms of mtDNA differ from the corresponding mechanisms in the nuclear genome, whose nucleosomal packaging and structure are more complex. Since each mitochondrion contains many copies of mtDNA an ...
Identification of the mRNA targets of tRNA
... stability and translational decoding properties, may be central to regulating particular genes, or groups of genes. Mutations in the yeast TRM9 tRNA modification gene drive altered expression of genes enriched in codons targeted by Trm9-modified tRNAs (39). Similarly, mutations in the eukaryotic Elo ...
... stability and translational decoding properties, may be central to regulating particular genes, or groups of genes. Mutations in the yeast TRM9 tRNA modification gene drive altered expression of genes enriched in codons targeted by Trm9-modified tRNAs (39). Similarly, mutations in the eukaryotic Elo ...
Review: Is genetic screening for hemochromatosis worthwhile?
... metal transporter called ferroportin (FPN1) alias, iron regulated transporter (IREG1) or metal transporter protein (MTP1) on human chromosome 2q [43–47]. The exact mechanism by which mutations in the SLC11A3 gene causes autosomal dominant iron overload is still not known. Gain of function and loss o ...
... metal transporter called ferroportin (FPN1) alias, iron regulated transporter (IREG1) or metal transporter protein (MTP1) on human chromosome 2q [43–47]. The exact mechanism by which mutations in the SLC11A3 gene causes autosomal dominant iron overload is still not known. Gain of function and loss o ...
Rh phenotype prediction by DNA typing and its
... 1997). No consensus has yet been achieved as to which polymorphism may be most reliable for testing of any given population. RH and particularly RHD DNA typing is much confounded by the presence of two highly homologous genes, RHCE and RHD, and the complex polymorphisms between both genes. In contra ...
... 1997). No consensus has yet been achieved as to which polymorphism may be most reliable for testing of any given population. RH and particularly RHD DNA typing is much confounded by the presence of two highly homologous genes, RHCE and RHD, and the complex polymorphisms between both genes. In contra ...
DNA structure, function and metabolism. File
... by removing genetic information from an organism, manipulating it in the laboratory and then transferring it into a plant to change certain of its characteristics . Now use a molecular approach to manipulation: molecular markers & mapping ...
... by removing genetic information from an organism, manipulating it in the laboratory and then transferring it into a plant to change certain of its characteristics . Now use a molecular approach to manipulation: molecular markers & mapping ...
Genetics Principles And Analysis
... Ph.D. from the University of Wisconsin. His research interests include molecular genetics, molecular evolution, and population genetics. Elizabeth W. Jones is a Professor of Biological Sciences at Carnegie Mellon University. She received her B.S. degree and Ph.D. from the University of Washington in ...
... Ph.D. from the University of Wisconsin. His research interests include molecular genetics, molecular evolution, and population genetics. Elizabeth W. Jones is a Professor of Biological Sciences at Carnegie Mellon University. She received her B.S. degree and Ph.D. from the University of Washington in ...
Trans-acting siRNA-mediated repression of ETTIN
... studied in F2 families generated by the self-pollination of plants heterozygous for both mutations. The genotype of the plants in these families was determined by PCR, using allele-specific primers. The first two leaves of double mutants are both flatter and rounder than the first two leaves of zip- ...
... studied in F2 families generated by the self-pollination of plants heterozygous for both mutations. The genotype of the plants in these families was determined by PCR, using allele-specific primers. The first two leaves of double mutants are both flatter and rounder than the first two leaves of zip- ...
Interleukin?1 gene cluster variants with innate cytokine production
... OA contributes to symptoms and augments many pathologic changes has become generally accepted (16,17); however, it is unclear whether this is a causal association or marks the ongoing disease process. Furthermore, the interplay between secreted IL-1 and IL-1Ra levels must be taken into account, sin ...
... OA contributes to symptoms and augments many pathologic changes has become generally accepted (16,17); however, it is unclear whether this is a causal association or marks the ongoing disease process. Furthermore, the interplay between secreted IL-1 and IL-1Ra levels must be taken into account, sin ...
Severe Combined Immunodeficiency (SCID)
... • One form of SCID became the first human illness treated by human gene therapy in 1990. • About 1 out of every 100,000 babies is born with SCID. • SCID is sometimes called Bubble Boy disease. In the 1970s, a boy named David Vetter had to live in a plastic bubble for 12 years because of SCID. ...
... • One form of SCID became the first human illness treated by human gene therapy in 1990. • About 1 out of every 100,000 babies is born with SCID. • SCID is sometimes called Bubble Boy disease. In the 1970s, a boy named David Vetter had to live in a plastic bubble for 12 years because of SCID. ...
Taxonomic evaluation of the Streptomyces griseus clade using
... genes (atpD, gyrB, recA, rpoB and trpB) is better than the previous six-gene scheme, as it provides equally good resolution and stability and is more cost-effective; MLSA using three or four of the genes also shows good resolution and robustness for differentiating most of the strains and is therefo ...
... genes (atpD, gyrB, recA, rpoB and trpB) is better than the previous six-gene scheme, as it provides equally good resolution and stability and is more cost-effective; MLSA using three or four of the genes also shows good resolution and robustness for differentiating most of the strains and is therefo ...
Crossover and Diploid Dominance with Deceptive Fitness
... can also be viewed as a genetic operator, although its utility has been difficult to establish. An approach to diploidy was described by Greene (1996) that follows a specific model known as complete dominance. Partial and "complete" dominance are well established mechanisms from biology that provide ...
... can also be viewed as a genetic operator, although its utility has been difficult to establish. An approach to diploidy was described by Greene (1996) that follows a specific model known as complete dominance. Partial and "complete" dominance are well established mechanisms from biology that provide ...
REVIEWS
... the study of MESODERM formation is a must for developmental biologists. To put it in more conventional terms, the formation of the third embryonic layer in TRIPOBLASTIC animals is, indeed, the time at which the embryonic axes are coordinated and when the important morphogenetic movements that shape ...
... the study of MESODERM formation is a must for developmental biologists. To put it in more conventional terms, the formation of the third embryonic layer in TRIPOBLASTIC animals is, indeed, the time at which the embryonic axes are coordinated and when the important morphogenetic movements that shape ...
redundancy and regulatory interactions between two
... FAR cDNA clones showed that four utilized the alternative splice site. The variation occurs within a region of the MADS-box protein known as the I-domain (Ma et al., 1991), the length and sequence composition of which have been postulated to affect the heterodimerization specificity amongst MADS-box ...
... FAR cDNA clones showed that four utilized the alternative splice site. The variation occurs within a region of the MADS-box protein known as the I-domain (Ma et al., 1991), the length and sequence composition of which have been postulated to affect the heterodimerization specificity amongst MADS-box ...
Athymic Nude Mice
... of CD4+ and CD8+ T-cell(s) associated with bright CD3 expression increases with age, at no age are significant numbers of CD4+8+ cells observed, in contrast to intrathymic T-cell maturation. In addition to the frequently observed inversion in the ratio of CD4 to CD8, the CD8 T-cell subpopulation in ...
... of CD4+ and CD8+ T-cell(s) associated with bright CD3 expression increases with age, at no age are significant numbers of CD4+8+ cells observed, in contrast to intrathymic T-cell maturation. In addition to the frequently observed inversion in the ratio of CD4 to CD8, the CD8 T-cell subpopulation in ...
... the ability to bind to specific molecules on the surfaces of their target bacteria (Figure 112-2). The viral DNA is then ejected through the tail into the host cell, where it directs the production of progeny phages; often more than 100 are produced in just half an hour from each bacterial cell. Eac ...
Chromosomes in Saccharomyces cerevisiae
... constructed from the bacterial plasmid A9Op2 and the terminal fragment of the Tetrahymena ribosomal DNA plasmid (hereafter called the Tr end). A9Op2 is a progenitor of the plasmid A164p2 (Fig. lb), but lacks the inverted repeat of the Tr ends flanking the yeast HIS3 gene present in A164p2. A9Op2 was ...
... constructed from the bacterial plasmid A9Op2 and the terminal fragment of the Tetrahymena ribosomal DNA plasmid (hereafter called the Tr end). A9Op2 is a progenitor of the plasmid A164p2 (Fig. lb), but lacks the inverted repeat of the Tr ends flanking the yeast HIS3 gene present in A164p2. A9Op2 was ...
19. - 21. März 2014 in Essen - Deutsche Gesellschaft für
... Vorsitzender: Univ. Prof. Dr. M. Speicher, Graz Stellvertr. Vorsitzender: Univ. Doz. Dr. H.-Ch. Duba, Linz Schriftführer: Dr. G. Webersinke, Linz Stellvertr. Schriftführer: Priv. Doz. Dr. F. Laccone, Wien Kassier: Univ. Prof. Dr. P. Kroisel, Graz Stellvertr. Kassier: Dr. I. Vlasak, Salzburg Beisitze ...
... Vorsitzender: Univ. Prof. Dr. M. Speicher, Graz Stellvertr. Vorsitzender: Univ. Doz. Dr. H.-Ch. Duba, Linz Schriftführer: Dr. G. Webersinke, Linz Stellvertr. Schriftführer: Priv. Doz. Dr. F. Laccone, Wien Kassier: Univ. Prof. Dr. P. Kroisel, Graz Stellvertr. Kassier: Dr. I. Vlasak, Salzburg Beisitze ...
Altered Pax gene expression in murine notochord mutants: the
... Theiler, 1990). The somite also produces a second tissue, the dermomyotome, which will subdivide into dermatome and myotome to form dermis and skeletal muscle. With respect to their position, somite cells have to acquire a dorsolateral identity to become dermomyotome, whereas a ventromedial identity ...
... Theiler, 1990). The somite also produces a second tissue, the dermomyotome, which will subdivide into dermatome and myotome to form dermis and skeletal muscle. With respect to their position, somite cells have to acquire a dorsolateral identity to become dermomyotome, whereas a ventromedial identity ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse