Transvection and pairing of a Drosophila Hox long noncoding RNA
... highly conserved Hox transcription factors expressed in precise spatial and temporal patterns (McGinnis and Krumlauf 1992). In Drosophila melanogaster, Hox transcription occurs rapidly and is initially directed largely through the combined action of maternally deposited and early expressed transcrip ...
... highly conserved Hox transcription factors expressed in precise spatial and temporal patterns (McGinnis and Krumlauf 1992). In Drosophila melanogaster, Hox transcription occurs rapidly and is initially directed largely through the combined action of maternally deposited and early expressed transcrip ...
Genetic Polymorphisms of Cytochromes P450: CYP2C9, CYP2C19
... be performed to allow a 99% sensitive prediction of poor or ultrarapid metabolizers in the clinical routine. The polymorphism in CYP2C family is important because these enzymes act on some very important drugs: anticonvulsants, antidiabetics, anticoagulants, antidepressants, antimalarial, nonsteroid ...
... be performed to allow a 99% sensitive prediction of poor or ultrarapid metabolizers in the clinical routine. The polymorphism in CYP2C family is important because these enzymes act on some very important drugs: anticonvulsants, antidiabetics, anticoagulants, antidepressants, antimalarial, nonsteroid ...
Binding of Hoechst with nucleic acids using fluorescence spectroscopy
... these flexible sites (not into the rigid double helix) in such samples could occur. While binding to cellular DNA, the Hoechst dye can block the DNA replication during cell division. Consequently, Hoechst at low concentrations could be applied, in principal, as anti-bacterial and anti-tumor drug. At ...
... these flexible sites (not into the rigid double helix) in such samples could occur. While binding to cellular DNA, the Hoechst dye can block the DNA replication during cell division. Consequently, Hoechst at low concentrations could be applied, in principal, as anti-bacterial and anti-tumor drug. At ...
Vernalization Gene Architecture as a Predictor of Growth Habit in
... markers, the assays may need to be repeated in order to have complete confidence in the case of the null allele. The two-locus epistatic genetic model proposed by Von Zitzewitz et al., (2005) was based on comparison of gene sequences between genotypes whose vernalization requirement had been previou ...
... markers, the assays may need to be repeated in order to have complete confidence in the case of the null allele. The two-locus epistatic genetic model proposed by Von Zitzewitz et al., (2005) was based on comparison of gene sequences between genotypes whose vernalization requirement had been previou ...
Genomic variations and distinct evolutionary rate of rare alleles in
... substitutions between these alleles look as grouped SNPs, these loci are defined as gSNP loci, the fixed substitutions as gSNPs, and the non-fixed substitutions as nfSNPs (Fig. 1a-c). Both nfSNPs and dSNPs are essentially the SNPs randomly-distributed within a haplotype, so they are named as rSNPs. ...
... substitutions between these alleles look as grouped SNPs, these loci are defined as gSNP loci, the fixed substitutions as gSNPs, and the non-fixed substitutions as nfSNPs (Fig. 1a-c). Both nfSNPs and dSNPs are essentially the SNPs randomly-distributed within a haplotype, so they are named as rSNPs. ...
Vascular Endothelial Growth Factor and Its Receptors in Embryonic
... postfertilization (Langheinrich, 2003); (3) zebrafish embryos are transparent, allowing visualization of the zebrafish cardiovascular system, including the heart and circulation of the blood; (4) zebrafish embryos are extracorporeal, unlike mice, making it possible to analyze normal and abnormal car ...
... postfertilization (Langheinrich, 2003); (3) zebrafish embryos are transparent, allowing visualization of the zebrafish cardiovascular system, including the heart and circulation of the blood; (4) zebrafish embryos are extracorporeal, unlike mice, making it possible to analyze normal and abnormal car ...
A Pseudomonas syringae pv. tomato DC3000 mutant
... derivative of pRK415 and PCR entry clones that contain an FRT cassette ligated between sequences flanking the deleted target gene. The cassette-marked region can be rapidly ...
... derivative of pRK415 and PCR entry clones that contain an FRT cassette ligated between sequences flanking the deleted target gene. The cassette-marked region can be rapidly ...
Puffs and PCR: the in vivo dynamics of early gene
... ecdysone titres must fall dramatically for the progression of puffing, followed by a second increase in ecdysone titre which regulates the late prepupal ecdysone response from 8 to 14 hours after pupariation. Interestingly, although some of the early puffs of the late prepupal response are in common ...
... ecdysone titres must fall dramatically for the progression of puffing, followed by a second increase in ecdysone titre which regulates the late prepupal ecdysone response from 8 to 14 hours after pupariation. Interestingly, although some of the early puffs of the late prepupal response are in common ...
List of references - UC Davis Plant Sciences
... Leister D; Ballvora A; Salamini F; Gebhardt C. 1996 A PCR-based approach for isolating pathogen resistance genes from potato with potential for wide application in plants. Nature Genetics 14:421-429. Leister, D; Berger, A; Thelen, H; Lehmann, W; Salamini, F; Gebhardt, C. 1997. Construction of a pota ...
... Leister D; Ballvora A; Salamini F; Gebhardt C. 1996 A PCR-based approach for isolating pathogen resistance genes from potato with potential for wide application in plants. Nature Genetics 14:421-429. Leister, D; Berger, A; Thelen, H; Lehmann, W; Salamini, F; Gebhardt, C. 1997. Construction of a pota ...
The Complex Inheritance of Maize Domestication Traits and Gene
... was given to shepherd them to completion. Every day and conversation I have had with John as my advisor has made me into a better scientist and I am extremely thankful for the opportunity I was given six years ago when I joined the Doebley lab. I have been fortunate enough to also work in an outstan ...
... was given to shepherd them to completion. Every day and conversation I have had with John as my advisor has made me into a better scientist and I am extremely thankful for the opportunity I was given six years ago when I joined the Doebley lab. I have been fortunate enough to also work in an outstan ...
PDF
... a multigenerational pedigree in which the "long-haired" phenotype was segregating. The 2 markers that demonstrated the greatest linkage to the long-haired trait (log of the odds 6) flanked an estimated 10-Mb region on cat chromosome B1 containing the Fibroblast Growth Factor 5 (FGF5) gene, a candi ...
... a multigenerational pedigree in which the "long-haired" phenotype was segregating. The 2 markers that demonstrated the greatest linkage to the long-haired trait (log of the odds 6) flanked an estimated 10-Mb region on cat chromosome B1 containing the Fibroblast Growth Factor 5 (FGF5) gene, a candi ...
E20
... significant GE interaction was observed at all measuring stages in the combined analysis over the two environments. The GE interaction variances accounted for 7.3 to 23.4% of the total genetic variances at different stages (data not shown). The average plant height of DH lines in Hangzhou was 8.2 to ...
... significant GE interaction was observed at all measuring stages in the combined analysis over the two environments. The GE interaction variances accounted for 7.3 to 23.4% of the total genetic variances at different stages (data not shown). The average plant height of DH lines in Hangzhou was 8.2 to ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... Preeclampsia is a potentially life-threatening disease that occurs exclusively in pregnant women during late gestation (>20 weeks). The two hallmark symptoms are hypertension and proteinuria, complicating at least 5% of pregnancies and are usually resolved upon delivery of the placenta (Lain and Rob ...
... Preeclampsia is a potentially life-threatening disease that occurs exclusively in pregnant women during late gestation (>20 weeks). The two hallmark symptoms are hypertension and proteinuria, complicating at least 5% of pregnancies and are usually resolved upon delivery of the placenta (Lain and Rob ...
2008 HSC Notes from the Marking Centre Biology
... principles and ideas. Many candidates wrote a lot of information that was not relevant to the question. Some responses showed evidence of rote learning of an anticipated answer based on a single source. These responses did not address the syllabus content and/or outcomes being assessed and hence did ...
... principles and ideas. Many candidates wrote a lot of information that was not relevant to the question. Some responses showed evidence of rote learning of an anticipated answer based on a single source. These responses did not address the syllabus content and/or outcomes being assessed and hence did ...
Role of the distal convoluted tubule in renal Mg handling: molecular
... identiļ¬ed two mutations in the CNNM2 gene: the heterozygous deletion c.117delG and the heterozygous missense mutation c.1703C>T [45]. The deletion c.117delG (p.Ile40SerfsX15) leads to a truncated protein with uncharacterized function, whereas the missense mutation c.1703C>T (p.Thr568Ile) causes a su ...
... identiļ¬ed two mutations in the CNNM2 gene: the heterozygous deletion c.117delG and the heterozygous missense mutation c.1703C>T [45]. The deletion c.117delG (p.Ile40SerfsX15) leads to a truncated protein with uncharacterized function, whereas the missense mutation c.1703C>T (p.Thr568Ile) causes a su ...
O A RIGINAL RTICLE
... of this research was producing transgenic potatoes with more tolerance to salinity stress and studying GMO potato features. To produce GMO plants, new gene (mtlD, mannitol -1- phosphate dehydrogenase, E.C.1.1.1.17) was transferred to a plant by using agrobacterium plasmid. For the production of tran ...
... of this research was producing transgenic potatoes with more tolerance to salinity stress and studying GMO potato features. To produce GMO plants, new gene (mtlD, mannitol -1- phosphate dehydrogenase, E.C.1.1.1.17) was transferred to a plant by using agrobacterium plasmid. For the production of tran ...
Positive and Negative Selection on the Human Genome
... declines as a function of frequency in the population. Advantageous mutations, on the other hand, become enriched relative to neutral mutations in the high frequency portion of the distribution and in fixed differences between species. The effects of positive selection can be distinguished from nega ...
... declines as a function of frequency in the population. Advantageous mutations, on the other hand, become enriched relative to neutral mutations in the high frequency portion of the distribution and in fixed differences between species. The effects of positive selection can be distinguished from nega ...
Developing a Bioassay for Triclosan Toxicity Abstract
... could impair the function of muscles and result in the lock of muscles on one side. The pull of such a deformity would then cause the spine to curl. It is therefore possible that the defects in the spinal cord curvature observed in zebrafish and fathead minnows is more a result of musculature defec ...
... could impair the function of muscles and result in the lock of muscles on one side. The pull of such a deformity would then cause the spine to curl. It is therefore possible that the defects in the spinal cord curvature observed in zebrafish and fathead minnows is more a result of musculature defec ...
... evidence for linkage throughout the genome. Such a strategy was employed by the Collaborative Study of the Genetics of Akoholism (COGA), which ascertained, evaluated, and genotyped 105 pedigrees as part of an initial genome screen (Reich et al., 1998). The initial linkage analyses of the COGA data s ...
Hox patterning of the vertebrate rib cage
... mutants have not been examined for these groups. Mutants in the Hox7, Hox8 and Hox9 genes have also been examined (Chen and Capecchi, 1997; Chen et al., 1998; van den Akker et al., 2001). The reported defects in these mutants also show no clear colinearity. The phenotypes in these animals are report ...
... mutants have not been examined for these groups. Mutants in the Hox7, Hox8 and Hox9 genes have also been examined (Chen and Capecchi, 1997; Chen et al., 1998; van den Akker et al., 2001). The reported defects in these mutants also show no clear colinearity. The phenotypes in these animals are report ...
Age-related macular degeneration: a perspective on genetic studies
... complement pathway could contribute to disease progression. Using candidate gene screening, several different groups have found an association between the CFH gene and AMD in large numbers of patients.29,30 Another study has shown that possession of the variant Y402 H polymorphism significantly incr ...
... complement pathway could contribute to disease progression. Using candidate gene screening, several different groups have found an association between the CFH gene and AMD in large numbers of patients.29,30 Another study has shown that possession of the variant Y402 H polymorphism significantly incr ...
Classification of colorectal cancer based on correlation of clinical
... observed in sporadic adenomas24 and the few such examples found turned out to be mainly derived from patients with Lynch syndrome.25 These findings gave rise to the suggestion that, unlike the adenomas in Lynch syndrome, MSI-H must occur as a relatively late event in sporadic adenomas.21 Why, it may ...
... observed in sporadic adenomas24 and the few such examples found turned out to be mainly derived from patients with Lynch syndrome.25 These findings gave rise to the suggestion that, unlike the adenomas in Lynch syndrome, MSI-H must occur as a relatively late event in sporadic adenomas.21 Why, it may ...
Inhibition of respiration by Nitric Oxide induces a
... regulon genes by NO and low O2 CN-+HYP HYP CN-+NO CNNO ...
... regulon genes by NO and low O2 CN-+HYP HYP CN-+NO CNNO ...
Hox patterning of the vertebrate rib cage
... mutants have not been examined for these groups. Mutants in the Hox7, Hox8 and Hox9 genes have also been examined (Chen and Capecchi, 1997; Chen et al., 1998; van den Akker et al., 2001). The reported defects in these mutants also show no clear colinearity. The phenotypes in these animals are report ...
... mutants have not been examined for these groups. Mutants in the Hox7, Hox8 and Hox9 genes have also been examined (Chen and Capecchi, 1997; Chen et al., 1998; van den Akker et al., 2001). The reported defects in these mutants also show no clear colinearity. The phenotypes in these animals are report ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse