Relationships Between RNA Polymerase II Activity and Spt
... yeast genome and many of these exhibit modulation by many factors (Martens et al. 2004, 2005; Hainer et al. 2011; Bird et al. 2006). Furthermore, widespread antisense transcription is being revealed as a mechanism for shaping gene regulation in a number of ways, including transcription over promoter ...
... yeast genome and many of these exhibit modulation by many factors (Martens et al. 2004, 2005; Hainer et al. 2011; Bird et al. 2006). Furthermore, widespread antisense transcription is being revealed as a mechanism for shaping gene regulation in a number of ways, including transcription over promoter ...
Testing Guidelines for molecular diagnosis of Cystic Fibrosis.
... believed that there might be another half dozen mutations that would account for the remaining 30% or so of CF mutations. Perhaps that was founded more on wishful thinking than on sound scientific evidence (and, after all, there were not that many genes which had been extensively characterised at th ...
... believed that there might be another half dozen mutations that would account for the remaining 30% or so of CF mutations. Perhaps that was founded more on wishful thinking than on sound scientific evidence (and, after all, there were not that many genes which had been extensively characterised at th ...
Specific PCR Primers for the Identification of Salmonella enterica
... Salmonella is one of the most common pathogens and a major cause of foodborne diseases in human worldwide (1,2,3). Contaminated poultry products have been identified as the principal sources of Salmonella leading to foodborne illness in human(4.5). The most common serotypes of Salmonella isolated fr ...
... Salmonella is one of the most common pathogens and a major cause of foodborne diseases in human worldwide (1,2,3). Contaminated poultry products have been identified as the principal sources of Salmonella leading to foodborne illness in human(4.5). The most common serotypes of Salmonella isolated fr ...
Standards and guidelines for the interpretation of sequence
... A mutation is defined as a permanent change in the nucleotide sequence, whereas a polymorphism is defined as a variant with a frequency above 1%. The terms “mutation” and “polymorphism,” however, which have been used widely, ...
... A mutation is defined as a permanent change in the nucleotide sequence, whereas a polymorphism is defined as a variant with a frequency above 1%. The terms “mutation” and “polymorphism,” however, which have been used widely, ...
Y11 Revision material - Biology - Whitworth Community High School
... environmental factors in determining attributes. □ Explain the link between dominant and recessive characteristics and alleles. □ Explain a monohybrid cross. □ Use and explain the terms homozygous, heterozygous, genotype and phenotype. □ Explain s ex inheritance using genetic diagrams □ Recall t ...
... environmental factors in determining attributes. □ Explain the link between dominant and recessive characteristics and alleles. □ Explain a monohybrid cross. □ Use and explain the terms homozygous, heterozygous, genotype and phenotype. □ Explain s ex inheritance using genetic diagrams □ Recall t ...
Control of human β-globin mRNA stability and its impact on beta
... in the elongation of the b-chain by 11 aminoacid residues at its C-terminus generating hemoglobin Tak.23 This hemoglobin has a high oxygen affinity24,25 causing secondary polycythemia. Most individuals with this condition have asymptomatic erythrocytosis, but a homozygote for the Tak mutation has al ...
... in the elongation of the b-chain by 11 aminoacid residues at its C-terminus generating hemoglobin Tak.23 This hemoglobin has a high oxygen affinity24,25 causing secondary polycythemia. Most individuals with this condition have asymptomatic erythrocytosis, but a homozygote for the Tak mutation has al ...
Affymetrix Software User Manuals
... written instructions provided by Affymetrix. You understand and agree that, except as expressly set forth in the Affymetrix terms and conditions, no right or license to any patent or other intellectual property owned or licensable by Affymetrix is conveyed or implied by this Affymetrix product. In p ...
... written instructions provided by Affymetrix. You understand and agree that, except as expressly set forth in the Affymetrix terms and conditions, no right or license to any patent or other intellectual property owned or licensable by Affymetrix is conveyed or implied by this Affymetrix product. In p ...
PDF - Albinism Fellowship
... but even some people in this group have red or brown hair, and some pigment in their skin so that they do tan. The estimate most commonly used is one in 17,000 children in the UK. In other cultures it may be more or less common, depending partly on whether close relatives produce children together; ...
... but even some people in this group have red or brown hair, and some pigment in their skin so that they do tan. The estimate most commonly used is one in 17,000 children in the UK. In other cultures it may be more or less common, depending partly on whether close relatives produce children together; ...
MOLECULAR RECOGNITION AND RESPONSE IN POLLEN AND
... mechanisms are collectively termed self-incompatibility (SI). SI enables the pistil to distinguish between self (genetically related) and non-self (genetically unrelated) pollen of the same species. Depending on the type of mechanism, rejection of self pollen (tubes) by the pistil occurs either at t ...
... mechanisms are collectively termed self-incompatibility (SI). SI enables the pistil to distinguish between self (genetically related) and non-self (genetically unrelated) pollen of the same species. Depending on the type of mechanism, rejection of self pollen (tubes) by the pistil occurs either at t ...
Ordered subset analysis in genetic linkage mapping of complex traits
... because of etiologic complexity. The presence of multiple independent and/or interacting disease genes and environmental factors causes significant problems for genetic linkage analysis. Etiologic heterogeneity reduces power to detect linkage, but explicitly taking heterogeneity into account can hel ...
... because of etiologic complexity. The presence of multiple independent and/or interacting disease genes and environmental factors causes significant problems for genetic linkage analysis. Etiologic heterogeneity reduces power to detect linkage, but explicitly taking heterogeneity into account can hel ...
as Adobe PDF - Edinburgh Research Explorer
... vivo bound enhancers and direct target genes. While Biniou is broadly expressed, it regulates enhancers driving temporally and spatially restricted expression. In vivo reporter assays indicate that the timing of Biniou binding is a key trigger for the time span of enhancer activity. Although bagpipe ...
... vivo bound enhancers and direct target genes. While Biniou is broadly expressed, it regulates enhancers driving temporally and spatially restricted expression. In vivo reporter assays indicate that the timing of Biniou binding is a key trigger for the time span of enhancer activity. Although bagpipe ...
The enhancement of ribosomal transcription by the recycling of RNA
... eukaryotes may be subject to a special mechanism of transcriptional enhancement, called Readthrough Enhancement, in which transcription factors are recycled. Recent experiments with the mouse ribosomal genes, although consistent with this possibility, were unable to distinguish between true Readthro ...
... eukaryotes may be subject to a special mechanism of transcriptional enhancement, called Readthrough Enhancement, in which transcription factors are recycled. Recent experiments with the mouse ribosomal genes, although consistent with this possibility, were unable to distinguish between true Readthro ...
Swartzlander_ku_0099D_15051_DATA_1
... elongation and desaturation in D. melanogaster females: (1) DESATF, a desaturase; and (2) ELOF, an elongase. The genes for DESATF and ELOF are not expressed in D. melanogaster males, but are expressed in females, leading to sexual differentiation of CHCs (Chertemps et al. 2007; Legendre et al. 2008) ...
... elongation and desaturation in D. melanogaster females: (1) DESATF, a desaturase; and (2) ELOF, an elongase. The genes for DESATF and ELOF are not expressed in D. melanogaster males, but are expressed in females, leading to sexual differentiation of CHCs (Chertemps et al. 2007; Legendre et al. 2008) ...
Useful Information for Lay People
... Since the early 90’s, many research teams throughout the world have been involved in intensive research in an effort to locate and isolate the rogue gene. In 1996, it was finally discovered on chromosome 9 – by Massimo Pandolfo (an Italian scientist working in Houston, Texas) and confirmed by Michel ...
... Since the early 90’s, many research teams throughout the world have been involved in intensive research in an effort to locate and isolate the rogue gene. In 1996, it was finally discovered on chromosome 9 – by Massimo Pandolfo (an Italian scientist working in Houston, Texas) and confirmed by Michel ...
Early Onset of Severe Familial Amyotrophic Lateral Sclerosis with a
... Motoneuron disease in mice with combined CNTF and SOD-1 gene defects. A, CNTF genotyping of mice. Ethidium bromide–stained 2% agarose gel reveals bands of 97 bp for the wild-type allele (CNTF⫹/⫹) and 1.197 bp for the mutated allele (CNTF⫺/⫺). Heterozygous mice (CNTF⫹/⫺) show both bands. “M” denotes ...
... Motoneuron disease in mice with combined CNTF and SOD-1 gene defects. A, CNTF genotyping of mice. Ethidium bromide–stained 2% agarose gel reveals bands of 97 bp for the wild-type allele (CNTF⫹/⫹) and 1.197 bp for the mutated allele (CNTF⫺/⫺). Heterozygous mice (CNTF⫹/⫺) show both bands. “M” denotes ...
Richard Goldschmidt: hopeful monsters and other `heresies`
... rearrangements that affect several loci. Goldschmidt’s mutability experiments involved crossing a fly stock of BLISTERED mutants with wild-type flies. Progeny from the crosses did not show the blistered phenotype; instead, each individual showed the PLEXUS, DUMPY VORTEX THORAXATE and PURPLE phenotyp ...
... rearrangements that affect several loci. Goldschmidt’s mutability experiments involved crossing a fly stock of BLISTERED mutants with wild-type flies. Progeny from the crosses did not show the blistered phenotype; instead, each individual showed the PLEXUS, DUMPY VORTEX THORAXATE and PURPLE phenotyp ...
Genetic Determinants Differences between Vibrio cholerae Biotypes
... Classical and El Tor are differentiated primarily based on a number of phenotypic properties such as susceptibility to polymyxin B, chicken cell (erythrocytes) agglutination (CCA), haemolysis of sheep erythrocytes, Voges-Proskauer (VP) test and phage susceptibilities (2, 9). The V. cholerae biotypes ...
... Classical and El Tor are differentiated primarily based on a number of phenotypic properties such as susceptibility to polymyxin B, chicken cell (erythrocytes) agglutination (CCA), haemolysis of sheep erythrocytes, Voges-Proskauer (VP) test and phage susceptibilities (2, 9). The V. cholerae biotypes ...
paramecium tetraurelia
... Genetic analysis was carried out according to the methods developed and reviewed by SONNEBORN (1970). The two main features of the analysis are: (1) i n a cross A x B the two exconjugants of each pair represent respectively the two reciprocal crosses OB x $ A and $ B x OA; (2) : the F, generation is ...
... Genetic analysis was carried out according to the methods developed and reviewed by SONNEBORN (1970). The two main features of the analysis are: (1) i n a cross A x B the two exconjugants of each pair represent respectively the two reciprocal crosses OB x $ A and $ B x OA; (2) : the F, generation is ...
A surge of late-occurring meiotic double
... wild-type levels, it supports proper DSB formation and synapsis of all chromosomes, with the exception of the XY pair (Kauppi et al. 2011, 2013a). In contrast, when SPO11βbclI expression is reduced relative to that of Spo11+/− mice, proper synapsis of short autosomes and sex chromosomes fails, with ...
... wild-type levels, it supports proper DSB formation and synapsis of all chromosomes, with the exception of the XY pair (Kauppi et al. 2011, 2013a). In contrast, when SPO11βbclI expression is reduced relative to that of Spo11+/− mice, proper synapsis of short autosomes and sex chromosomes fails, with ...
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... partner had 46,XX,9qh+ karyotype, inferring the increased presence of heterochromatin region in the long arm of one of the chromosome 9. Heterochromatin polymorphisms are microscopically visible regions on chromosomes 1, 9, 16, the distal two thirds of the long arm of the Y chromosome and the satell ...
... partner had 46,XX,9qh+ karyotype, inferring the increased presence of heterochromatin region in the long arm of one of the chromosome 9. Heterochromatin polymorphisms are microscopically visible regions on chromosomes 1, 9, 16, the distal two thirds of the long arm of the Y chromosome and the satell ...
PDF - NIMH Genetics
... Model-free linkage analysis can be a favorable method of analysis for complex disease traits since there are no assumptions about mode of inheritance, disease allele frequencies, and penetrance. However, even without specifying models correctly, parametric analyses can be a more powerful test given ...
... Model-free linkage analysis can be a favorable method of analysis for complex disease traits since there are no assumptions about mode of inheritance, disease allele frequencies, and penetrance. However, even without specifying models correctly, parametric analyses can be a more powerful test given ...
LATHYROIDES, encoding a WUSCHEL
... During organ development, many key regulators have been identified in plant genomes, which play conserved role among plant species to control the organ identities and/or determine the organ size and shape. It is intriguing that whether these key regulators can acquire diverse function and be integra ...
... During organ development, many key regulators have been identified in plant genomes, which play conserved role among plant species to control the organ identities and/or determine the organ size and shape. It is intriguing that whether these key regulators can acquire diverse function and be integra ...
Simple identification of dominant p53 mutants by
... impaired degradation model provides a satisfactory explanation for the high level p53 expression seen in tumours (5,6), it does not rule out the possibility that a selective growth advantage may be conferred by mutated p53 proteins, either because dominant inhibition of wild-type protein could facil ...
... impaired degradation model provides a satisfactory explanation for the high level p53 expression seen in tumours (5,6), it does not rule out the possibility that a selective growth advantage may be conferred by mutated p53 proteins, either because dominant inhibition of wild-type protein could facil ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse