Inheritance involved in the pathogenesis of idiopathic scoliosis
... idiopathic curvature have not been identified. This is most likely a consequence of several factors, including inconsistent pedigree construction between human studies, an arbitrary consensus threshold for proband curve magnitude that may obscure true heritability, and the lack of a genetic model. I ...
... idiopathic curvature have not been identified. This is most likely a consequence of several factors, including inconsistent pedigree construction between human studies, an arbitrary consensus threshold for proband curve magnitude that may obscure true heritability, and the lack of a genetic model. I ...
Sperm competition and the evolution of spermatogenesis
... hermaphrodites, meaning that they first produce sperm and later eggs from a single gonad (allowing self-fertilization) (reviewed in Ward et al., 1981; L’Hernault, 2006). Both the ca. 160 sperm produced from the fourth larval stage until adulthood, as well as all subsequently produced oocytes, arise f ...
... hermaphrodites, meaning that they first produce sperm and later eggs from a single gonad (allowing self-fertilization) (reviewed in Ward et al., 1981; L’Hernault, 2006). Both the ca. 160 sperm produced from the fourth larval stage until adulthood, as well as all subsequently produced oocytes, arise f ...
It`s All In the Family
... information about inherited conditions. A genetic counselor can help someone with the decision on whether or not to be tested. A genetic counselor can also help someone understand the test results and explain the results to their family. We recommend calling the Alpha-1 Foundation Genetic Counseling ...
... information about inherited conditions. A genetic counselor can help someone with the decision on whether or not to be tested. A genetic counselor can also help someone understand the test results and explain the results to their family. We recommend calling the Alpha-1 Foundation Genetic Counseling ...
The Parasexual Cycle in Candida albicans Provides an
... The parasexual cycle of C. albicans, as currently envisaged, is shown in Figure 1A. Note that no meiotic program has been observed in C. albicans, despite the presence of many genes in the genome whose homologues function specifically in meiosis in other fungi [18]. However, C. albicans strains have ...
... The parasexual cycle of C. albicans, as currently envisaged, is shown in Figure 1A. Note that no meiotic program has been observed in C. albicans, despite the presence of many genes in the genome whose homologues function specifically in meiosis in other fungi [18]. However, C. albicans strains have ...
A physiological overview of the genetics of flowering time control
... essentially perceived by expanded leaves but, in the absence of leaves, they can also be perceived by the stem. However, excised shoot apices of the SD plants Perilla frutescens, Xanthium and Pharbitis and the LD plant Anagallis arvensis respond to day length in the same way as intact plants, sugges ...
... essentially perceived by expanded leaves but, in the absence of leaves, they can also be perceived by the stem. However, excised shoot apices of the SD plants Perilla frutescens, Xanthium and Pharbitis and the LD plant Anagallis arvensis respond to day length in the same way as intact plants, sugges ...
Forche et al. 2008 PLoS Biology
... The parasexual cycle of C. albicans, as currently envisaged, is shown in Figure 1A. Note that no meiotic program has been observed in C. albicans, despite the presence of many genes in the genome whose homologues function specifically in meiosis in other fungi [18]. However, C. albicans strains have ...
... The parasexual cycle of C. albicans, as currently envisaged, is shown in Figure 1A. Note that no meiotic program has been observed in C. albicans, despite the presence of many genes in the genome whose homologues function specifically in meiosis in other fungi [18]. However, C. albicans strains have ...
Pultz, M. A., and Baker, B. S.
... effects. We have also taken advantage of the herl(2)mat allele (Redfield, 1926), which is severely defective in maternal her functions but comparable to wild-type in zygotic her functions (Pultz et al., 1994). Maternal effects of her on female viability The maternal function of her is needed for the ...
... effects. We have also taken advantage of the herl(2)mat allele (Redfield, 1926), which is severely defective in maternal her functions but comparable to wild-type in zygotic her functions (Pultz et al., 1994). Maternal effects of her on female viability The maternal function of her is needed for the ...
Table 2
... Structural variants in the human genome include copy-number variants (CNVs) such as duplications and deletions, as well as copy-neutral events such as inversions and trans- ...
... Structural variants in the human genome include copy-number variants (CNVs) such as duplications and deletions, as well as copy-neutral events such as inversions and trans- ...
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... CGG repeats (28,29). However, the length of CGG repeats on a particular allele in a differentiated cell derived from these carriers is generally mitotically stable although recent studies show that fully expanded FMR1 CGG repeats exhibit a lengthand differentiation-dependent instability in cell hybr ...
... CGG repeats (28,29). However, the length of CGG repeats on a particular allele in a differentiated cell derived from these carriers is generally mitotically stable although recent studies show that fully expanded FMR1 CGG repeats exhibit a lengthand differentiation-dependent instability in cell hybr ...
Multiple genetic loci modify risk for retinoblastoma in
... ectopic sites including the skin and extralenticular portions of the eye. Expression of E6 and E7 in the skin correlated with the high incidence of skin tumors.36 However, expression in other tissues such as the extralenticular portions of the eye did not correlate with tumor formation. In this stud ...
... ectopic sites including the skin and extralenticular portions of the eye. Expression of E6 and E7 in the skin correlated with the high incidence of skin tumors.36 However, expression in other tissues such as the extralenticular portions of the eye did not correlate with tumor formation. In this stud ...
Microbiology of nitrogen cycle in animal manure compost
... Antonyuk et al., 2005). It is possible to distinguish these nitrite reductases in denitrifiers by using diethyldithiocarbamate (DDTC), which chelates copper of the nirK denitrifier and prevents the process. DGGE primers targeting nitrite reductase gene sequences have been developed (Throback et al., ...
... Antonyuk et al., 2005). It is possible to distinguish these nitrite reductases in denitrifiers by using diethyldithiocarbamate (DDTC), which chelates copper of the nirK denitrifier and prevents the process. DGGE primers targeting nitrite reductase gene sequences have been developed (Throback et al., ...
Multiplex in-vitro Detection using SERS
... beneficial in obtaining further enhancement in the form of surface enhanced resonance Raman scattering (SERRS). This occurs when the analyte contains a chromophore close in energy to the exciting radiation. However, a dye label can also be used to achieve this enhancement if the chromophore is not p ...
... beneficial in obtaining further enhancement in the form of surface enhanced resonance Raman scattering (SERRS). This occurs when the analyte contains a chromophore close in energy to the exciting radiation. However, a dye label can also be used to achieve this enhancement if the chromophore is not p ...
Genetic control of cellularisation
... apparently following a wave-like pattern initiated at the anterior pole (Mansfield and Briarty, 1990b). At the completion of cellularisation, anticlinal walls are established in the entire PEN. The endosperm then comprises approx. 200 nuclei (stage IX) (Scott et al., 1998). At late heart stage, a ne ...
... apparently following a wave-like pattern initiated at the anterior pole (Mansfield and Briarty, 1990b). At the completion of cellularisation, anticlinal walls are established in the entire PEN. The endosperm then comprises approx. 200 nuclei (stage IX) (Scott et al., 1998). At late heart stage, a ne ...
What do we need to know about speciation?
... We generated an initial list of speciation questions by asking each group member to propose five questions. We did this with minimal guidance in order to allow the widest possible interpretation of the problem. We did not aim to ask novel questions: many long-standing issues still need work while ot ...
... We generated an initial list of speciation questions by asking each group member to propose five questions. We did this with minimal guidance in order to allow the widest possible interpretation of the problem. We did not aim to ask novel questions: many long-standing issues still need work while ot ...
Conservation and diversification of gene function during mouthpart
... The mandibles are the chewing mouthparts, articulated to the head by two condyles. From the base of the mandibles extend two lobes: the distal incisor lobe and the inner median molar lobe, which are linked by a flexible area (Fig. 5Ai to iv). The setae on the inner periphery of the incisor lobe delim ...
... The mandibles are the chewing mouthparts, articulated to the head by two condyles. From the base of the mandibles extend two lobes: the distal incisor lobe and the inner median molar lobe, which are linked by a flexible area (Fig. 5Ai to iv). The setae on the inner periphery of the incisor lobe delim ...
Sample pages 2 PDF
... expression of particular sets of markers is associated with biased cell fate choices that ultimately lead to the generation of a number of different cell types. These include, besides melanocytes, all cells of the peripheral nervous system, smooth muscle cells, and cartilage cells. The precursors to ...
... expression of particular sets of markers is associated with biased cell fate choices that ultimately lead to the generation of a number of different cell types. These include, besides melanocytes, all cells of the peripheral nervous system, smooth muscle cells, and cartilage cells. The precursors to ...
Gene methylation in gastric cancer
... tumorigenesis [15], which provides a stable gene silencing mechanism that plays an important role in regulating gene expression and chromatin architecture, in association with histone modifications and other chromatin associated protein. Unlike DNA methylation, histone modifications lead to either tra ...
... tumorigenesis [15], which provides a stable gene silencing mechanism that plays an important role in regulating gene expression and chromatin architecture, in association with histone modifications and other chromatin associated protein. Unlike DNA methylation, histone modifications lead to either tra ...
Reproductive isolation and introgression between sympatric
... the phenotypes measured in QTL studies do not always contribute to reproductive isolation in natural populations. If, for example, local adaptation is often caused by conditionally neutral alleles (Hall et al. 2010; Fournier-Level et al. 2011; Leinonen et al. 2013), these loci may not remain diverge ...
... the phenotypes measured in QTL studies do not always contribute to reproductive isolation in natural populations. If, for example, local adaptation is often caused by conditionally neutral alleles (Hall et al. 2010; Fournier-Level et al. 2011; Leinonen et al. 2013), these loci may not remain diverge ...
Regulation of Ovule Development
... REVOLUTA (REV) (and other related genes), expressed laterally, could be these factors (Figure 2A). However, it is unlikely that these factors contribute directly to identity in this region. A double mutant of the ettin and tsl genes produces structures that could be interpreted as naked placentas: t ...
... REVOLUTA (REV) (and other related genes), expressed laterally, could be these factors (Figure 2A). However, it is unlikely that these factors contribute directly to identity in this region. A double mutant of the ettin and tsl genes produces structures that could be interpreted as naked placentas: t ...
phenotype describes a new mutation affecting
... which have normal levels of endogenous ABA, but are insensitive to the germination suppressive effect of exogenous ABA, and class II which have a reduced level of the growth substance, both in the embryo and in the plant, and are unable to accumulate ABA in response to water deficit (Robichaud and S ...
... which have normal levels of endogenous ABA, but are insensitive to the germination suppressive effect of exogenous ABA, and class II which have a reduced level of the growth substance, both in the embryo and in the plant, and are unable to accumulate ABA in response to water deficit (Robichaud and S ...
Parasexual Genetics in Dictyostelium discoideum
... tions affecting pigmentation are known (Sussman & Sussman, 1963) and are useful for monitoring the stability of diploids. The use of these pigmentation markers to recover rare (IO-~)haploids without preselection on drugs is not practical in D. discoideum, although visual selection of haploid segrega ...
... tions affecting pigmentation are known (Sussman & Sussman, 1963) and are useful for monitoring the stability of diploids. The use of these pigmentation markers to recover rare (IO-~)haploids without preselection on drugs is not practical in D. discoideum, although visual selection of haploid segrega ...
Fitness landscapes of gene regulation in variable - UvA-DARE
... Comparing the history traces of the cultures without IPTG (fig. 6.6a) to the trace of the culture grown at 2 μM IPTG (fig. 6.6e), we observe that the rates of adaptation are markedly different. If both traces are fitted with a simple competition model (assuming a single mutant fixation and a sufficiently ...
... Comparing the history traces of the cultures without IPTG (fig. 6.6a) to the trace of the culture grown at 2 μM IPTG (fig. 6.6e), we observe that the rates of adaptation are markedly different. If both traces are fitted with a simple competition model (assuming a single mutant fixation and a sufficiently ...
000927 - JHBS Revista Cientifica 3ª edicao
... followed by a 7 min final extension at 72°C. As a negative control, a tube containing all reagents but genomic DNA was used in each reaction. Detection of virulence genes The presence of virulence genes involved in the three stages of infection was assessed by PCR under the conditions ...
... followed by a 7 min final extension at 72°C. As a negative control, a tube containing all reagents but genomic DNA was used in each reaction. Detection of virulence genes The presence of virulence genes involved in the three stages of infection was assessed by PCR under the conditions ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse