Host Genetic Control of Incubation Periods of Creutzfeldt
... that the Prn-i gene was linked to or congruent with the murine prion protein gene (Prn-p) which encoded the prion protein. These genes from the prion gene complex were located on chromosome 2 (Sparkes et al., 1986). Studies of the nucleotide sequence of the Prn-p gene of inbred mouse strains reveale ...
... that the Prn-i gene was linked to or congruent with the murine prion protein gene (Prn-p) which encoded the prion protein. These genes from the prion gene complex were located on chromosome 2 (Sparkes et al., 1986). Studies of the nucleotide sequence of the Prn-p gene of inbred mouse strains reveale ...
Pax1, Pax9, Vertebral column, Chondrogenesis, Proliferation
... showed defects in gap-junctional communication as evident from a dramatic reduction in dye coupling of imaginal disc cells (Jursnich et al., 1990). To analyze the molecular basis for its mutant phenotypes and to investigate its role in cell proliferation, we have now identified and isolated the dco ...
... showed defects in gap-junctional communication as evident from a dramatic reduction in dye coupling of imaginal disc cells (Jursnich et al., 1990). To analyze the molecular basis for its mutant phenotypes and to investigate its role in cell proliferation, we have now identified and isolated the dco ...
Gene expression analysis
... Why find genes that behave differently in two classes (e.g. normal and tumor)? Better understanding of the genetic circumstances that cause the difference (disease) hopefully leads to better therapy. Detection of marker-genes enables the early recognition of diseases as well as the recognition of su ...
... Why find genes that behave differently in two classes (e.g. normal and tumor)? Better understanding of the genetic circumstances that cause the difference (disease) hopefully leads to better therapy. Detection of marker-genes enables the early recognition of diseases as well as the recognition of su ...
emboj7601705-sup
... somites are formed in regions of intermediate Gsc. We observed very similar expression profiles for notochord and somites - rather than more separate peaks, with notochord being formed at lower Gsc MO doses than somites, as expected from previous histological work of Niehrs et al. (1994). This might ...
... somites are formed in regions of intermediate Gsc. We observed very similar expression profiles for notochord and somites - rather than more separate peaks, with notochord being formed at lower Gsc MO doses than somites, as expected from previous histological work of Niehrs et al. (1994). This might ...
SALSA MLPA probemix P222-A2 LCA mix-2 - MRC
... c.2991+1655AG seem to be an important cause of LCA and may explain up to 21% of LCA cases. (den Hollander et al., Am J Hum Genet, 2006). The P222 probemix contains 2 probes for the CEP290 gene. One probe is specific for the wild type sequence of the c.2991+1655AG mutation and the other probe detec ...
... c.2991+1655AG seem to be an important cause of LCA and may explain up to 21% of LCA cases. (den Hollander et al., Am J Hum Genet, 2006). The P222 probemix contains 2 probes for the CEP290 gene. One probe is specific for the wild type sequence of the c.2991+1655AG mutation and the other probe detec ...
Mapping Polygenes - University of Warwick
... (34, 43, 52, 55, 62). In species where severe inbreeding is tolerated, recombinant inbred populations (derived by inbreeding F2 progeny until they become virtually homozygous lines by selfing or sibbing) have also been used (9, 57). While the latter case has less linkage disequilibrium, due to more ...
... (34, 43, 52, 55, 62). In species where severe inbreeding is tolerated, recombinant inbred populations (derived by inbreeding F2 progeny until they become virtually homozygous lines by selfing or sibbing) have also been used (9, 57). While the latter case has less linkage disequilibrium, due to more ...
Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail
... zygotic genes that are expressed in the ventral region with different lateral limits. These target genes may promote the ventral (mesodermal) cell fate or the lateral (neuroectodermal) cell fate. Snail specifically represses those genes that are not compatible with mesoderm formation. Consistent wit ...
... zygotic genes that are expressed in the ventral region with different lateral limits. These target genes may promote the ventral (mesodermal) cell fate or the lateral (neuroectodermal) cell fate. Snail specifically represses those genes that are not compatible with mesoderm formation. Consistent wit ...
Auxin signals — turning genes on and turning cells around
... PIN protein (red) depends on BFA-sensitive vesicle transport. In BFA-treated cells, PIN accumulates in undefined endosomal membrane structures (light blue) [40,42]. Polar auxin transport depends on an intact actin cytoskeleton, and a high-affinity 1-N-naphthylphthalamic acid (NPA)-binding protein ...
... PIN protein (red) depends on BFA-sensitive vesicle transport. In BFA-treated cells, PIN accumulates in undefined endosomal membrane structures (light blue) [40,42]. Polar auxin transport depends on an intact actin cytoskeleton, and a high-affinity 1-N-naphthylphthalamic acid (NPA)-binding protein ...
Common Quantitative Trait Loci for Alcohol
... SS progenitors of the Ris, we were unable to use the interval mapping method described by Markel et al. (1996) in identifying QTL. Therefore, one-way analysis of variances were carried out with the phenotypic measure as the dependent variable and the RI strains were grouped by allele type. In approx ...
... SS progenitors of the Ris, we were unable to use the interval mapping method described by Markel et al. (1996) in identifying QTL. Therefore, one-way analysis of variances were carried out with the phenotypic measure as the dependent variable and the RI strains were grouped by allele type. In approx ...
Chapter 1: What is PKU?
... is a precursor to neurotransmitters and hormones3. There are different categories of PKU that are determined based on diagnostic Phe level, mutation testing (if performed) and the amount of Phe that an individual can tolerate. ...
... is a precursor to neurotransmitters and hormones3. There are different categories of PKU that are determined based on diagnostic Phe level, mutation testing (if performed) and the amount of Phe that an individual can tolerate. ...
Additional Table 1. Genotype and phenotype of the
... kb, 14,823,878-15,041,954, genomic yes build hg 18). One gene involved (MACROD2 ). No parental studies were performed. The clinical significance of these copy number variants is unclear. ...
... kb, 14,823,878-15,041,954, genomic yes build hg 18). One gene involved (MACROD2 ). No parental studies were performed. The clinical significance of these copy number variants is unclear. ...
C57BL/6 - Envigo
... In vitro, multimerin 1 supports platelet adhesion and it also binds to collagen and enhances von Willebrand factor-dependent platelet adhesion to collagen. Rd8 = retinal degeneration 8; the rd-8 mutation is due to a single base pair mutation in the CRB1 gene. This gene when mutated in humans is link ...
... In vitro, multimerin 1 supports platelet adhesion and it also binds to collagen and enhances von Willebrand factor-dependent platelet adhesion to collagen. Rd8 = retinal degeneration 8; the rd-8 mutation is due to a single base pair mutation in the CRB1 gene. This gene when mutated in humans is link ...
The qSD12 Locus Controls Offspring Tissue-Imposed
... 1994). Wild or weedy species developed these dormancy mechanisms during evolution to enhance their survival under adverse natural or in human-disturbed environments by selection for an optimum time to germinate. In contrast, many crop species have lost part or all dormancy mechanisms due to the sele ...
... 1994). Wild or weedy species developed these dormancy mechanisms during evolution to enhance their survival under adverse natural or in human-disturbed environments by selection for an optimum time to germinate. In contrast, many crop species have lost part or all dormancy mechanisms due to the sele ...
Different susceptibility of two animal species infected with isogenic
... versus animal species susceptibility was investigated by inoculating all the above strains by aerosol into guinea pigs and mice and comparing these to the earlier results. Characterization of PhoT indicated that it plays a role in phosphate uptake at low phosphate concentrations. At least in vitro, ...
... versus animal species susceptibility was investigated by inoculating all the above strains by aerosol into guinea pigs and mice and comparing these to the earlier results. Characterization of PhoT indicated that it plays a role in phosphate uptake at low phosphate concentrations. At least in vitro, ...
1 RUNNING TITLE Diversity and selection of
... at 33%. The majority of the round tomatoes with the LC mutation were S. lycopersicum var cerasiforme lines (Table S1). To evaluate whether fruit shape category and shape gene mutations were correlated to one another, we conducted a Chi-square test. The test corroborated the lack of independence bet ...
... at 33%. The majority of the round tomatoes with the LC mutation were S. lycopersicum var cerasiforme lines (Table S1). To evaluate whether fruit shape category and shape gene mutations were correlated to one another, we conducted a Chi-square test. The test corroborated the lack of independence bet ...
Distalless and dachshund pattern both plesiomorphic
... The leg gap genes serve to regionalize the arthropod leg, conferring proximal (hth and exd), medial (dac), and distal (Dll) identities (Sunkel and Whittle 1987; Cohen and Jürgens 1989; Mardon et al. 1994; González‐Crespo and Morata 1996; Lecuit and Cohen 1997; Rieckhof et al. 1997; Abu‐Shaar and Man ...
... The leg gap genes serve to regionalize the arthropod leg, conferring proximal (hth and exd), medial (dac), and distal (Dll) identities (Sunkel and Whittle 1987; Cohen and Jürgens 1989; Mardon et al. 1994; González‐Crespo and Morata 1996; Lecuit and Cohen 1997; Rieckhof et al. 1997; Abu‐Shaar and Man ...
Horizontal gene transfer from flowering plants to Gnetum
... with homologous regions in Citrullus (watermelon, Cucurbitaceae) whose secondary structure has been predicted (11). This helped to find and align the stem regions of the six domains. A data matrix of seed plant nad1 exon b and c and intron 2 sequences was constructed that included information on the ...
... with homologous regions in Citrullus (watermelon, Cucurbitaceae) whose secondary structure has been predicted (11). This helped to find and align the stem regions of the six domains. A data matrix of seed plant nad1 exon b and c and intron 2 sequences was constructed that included information on the ...
Regulatory Motifs in DNA Sequences
... • Examine frequencies of l-tuples, combinations of 2 symbols, 3 symbols, etc. • “The” is the most frequent 3-tuple in English and “;48” is the most frequent 3tuple in the encrypted text • Make inferences of unknown symbols by examining other frequent l-tuples ...
... • Examine frequencies of l-tuples, combinations of 2 symbols, 3 symbols, etc. • “The” is the most frequent 3-tuple in English and “;48” is the most frequent 3tuple in the encrypted text • Make inferences of unknown symbols by examining other frequent l-tuples ...
Evolutionary dynamics of CRISPR gene drives
... contains (i) multiple CRISPR guide RNAs which target the 3’ end of a gene, and (ii) a recoded copy of the target gene which is functional but resistant to cutting. We concluded that this architecture substantially improves the stability of CRISPR gene drives. Another alternative strategy which we ha ...
... contains (i) multiple CRISPR guide RNAs which target the 3’ end of a gene, and (ii) a recoded copy of the target gene which is functional but resistant to cutting. We concluded that this architecture substantially improves the stability of CRISPR gene drives. Another alternative strategy which we ha ...
CFTR mutation classifications toward genotype
... approaches have enabled the identification of small molecules targeting either the CFTR protein directly or its key processing steps, giving rise to novel promising therapeutic tools. This review presents the current CFTR mutation classifications according to their clinical consequences and to their ...
... approaches have enabled the identification of small molecules targeting either the CFTR protein directly or its key processing steps, giving rise to novel promising therapeutic tools. This review presents the current CFTR mutation classifications according to their clinical consequences and to their ...
Notes for Chaper 4 of the Jones/Pevzer book
... • Nucleotides in motifs encode for a message in the “genetic” language. Symbols in “The Gold Bug” encode for a message in English • In order to solve the problem, we analyze the frequencies of patterns in DNA/Gold Bug message. • Knowledge of established regulatory motifs makes the Motif Finding prob ...
... • Nucleotides in motifs encode for a message in the “genetic” language. Symbols in “The Gold Bug” encode for a message in English • In order to solve the problem, we analyze the frequencies of patterns in DNA/Gold Bug message. • Knowledge of established regulatory motifs makes the Motif Finding prob ...
Quantitative trait loci associated with maximal exercise endurance in
... exercise endurance (HEE) and low exercise endurance (LEE), respectively (26). Ten female Balb/cJ mice were bred with nine male DBA/2J mice to produce BaD2 F1 mice. We chose the Balb/cJ mice as the maternal progenitor strain because earlier studies had suggested that exercise endurance was a maternal ...
... exercise endurance (HEE) and low exercise endurance (LEE), respectively (26). Ten female Balb/cJ mice were bred with nine male DBA/2J mice to produce BaD2 F1 mice. We chose the Balb/cJ mice as the maternal progenitor strain because earlier studies had suggested that exercise endurance was a maternal ...
In Memoriam: Jacques Monod (1910–1976)
... transacetylase (coded by the a gene) and induced at the same time as b-galactosidase and permease, was discovered, thus facilitating later studies on the genetic determinism of induction (Zabin et al. 1962). The physiological function of transacetylase remains unknown to this day. Studies on galacto ...
... transacetylase (coded by the a gene) and induced at the same time as b-galactosidase and permease, was discovered, thus facilitating later studies on the genetic determinism of induction (Zabin et al. 1962). The physiological function of transacetylase remains unknown to this day. Studies on galacto ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse