In Memoriam: Jacques Monod (1910–1976)
... transacetylase (coded by the a gene) and induced at the same time as b-galactosidase and permease, was discovered, thus facilitating later studies on the genetic determinism of induction (Zabin et al. 1962). The physiological function of transacetylase remains unknown to this day. Studies on galacto ...
... transacetylase (coded by the a gene) and induced at the same time as b-galactosidase and permease, was discovered, thus facilitating later studies on the genetic determinism of induction (Zabin et al. 1962). The physiological function of transacetylase remains unknown to this day. Studies on galacto ...
Termination of Stem Cell Maintenance in Arabidopsis Floral
... transgenic WUS copy as soon as the floral meristem represses the endogenous WUS gene. For this and all subsequent misexpression experiments, we used the pOpL two component system, where expression of a synthetic transcriptional activator, LhG4, is driven by a promotor of interest (Moore et al., 1998 ...
... transgenic WUS copy as soon as the floral meristem represses the endogenous WUS gene. For this and all subsequent misexpression experiments, we used the pOpL two component system, where expression of a synthetic transcriptional activator, LhG4, is driven by a promotor of interest (Moore et al., 1998 ...
A novel role for the floral homeotic gene APETALA2
... margins. The valves, which are derived from the ovary walls, are separated along their entire length by the replum. The valve margin, which consists of a separation layer and a lignified layer, forms as a narrow stripe of cells at the valve-replum boundaries. The valve margin identity genes are expr ...
... margins. The valves, which are derived from the ovary walls, are separated along their entire length by the replum. The valve margin, which consists of a separation layer and a lignified layer, forms as a narrow stripe of cells at the valve-replum boundaries. The valve margin identity genes are expr ...
Complex Heterozygosity Screening with Actin Alanine Scan Alleles
... analysis enables the systematic construction of all possible haploid double mutant strains. This has led to an unprecedented view of the genetic interaction landscape of a eukaryotic cell (Costanzo et al. 2010) and the formulation of rules for the interpretation of the biological meaning of genetic ...
... analysis enables the systematic construction of all possible haploid double mutant strains. This has led to an unprecedented view of the genetic interaction landscape of a eukaryotic cell (Costanzo et al. 2010) and the formulation of rules for the interpretation of the biological meaning of genetic ...
The Genetic Principles of Crossbreeding
... comparisons among the breeds involved. Table 1 summarizes results on the percentage of heterosis for various traits based on research from several locations. Heterosis may be a positive or negative value. Also, heterosis may be positive even when one of the parent breeds outperforms the crossbred av ...
... comparisons among the breeds involved. Table 1 summarizes results on the percentage of heterosis for various traits based on research from several locations. Heterosis may be a positive or negative value. Also, heterosis may be positive even when one of the parent breeds outperforms the crossbred av ...
SNP Discovery and Genotyping Workshop (PowerPoint)
... Where do I find SNPs to use in my association studies? (e.g. databases, direct resequencing) 2. SNP Selection: How do I choose SNPs that are informative? (i.e. assessing SNP correlation - linkage disequilibrium) 3. SNP Associations: What analyses can I perform after genotyping these SNPs? (e.g. sing ...
... Where do I find SNPs to use in my association studies? (e.g. databases, direct resequencing) 2. SNP Selection: How do I choose SNPs that are informative? (i.e. assessing SNP correlation - linkage disequilibrium) 3. SNP Associations: What analyses can I perform after genotyping these SNPs? (e.g. sing ...
New variants of the tet(M) gene in Clostridium
... Sequence analysis revealed that except for tet(M)1, which was 100% identical to the tet(M) gene found in Streptococcus agalactiae 2603V/R (GenBank accession no. AE014233), the other alleles did not show complete identity with other tet(M) genes. The phylogenetic tree obtained by nucleotide sequence ...
... Sequence analysis revealed that except for tet(M)1, which was 100% identical to the tet(M) gene found in Streptococcus agalactiae 2603V/R (GenBank accession no. AE014233), the other alleles did not show complete identity with other tet(M) genes. The phylogenetic tree obtained by nucleotide sequence ...
i A Thesis Entitled A Visual Screen for Centriolar Mutants in
... cancer and a type of human developmental diseases called ciliopathies. While the importance of studying this organelle is clear, how it forms and functions is not fully understood. In particular, understanding of the mechanisms of centriole elongation is lacking. Drosophila melanogaster is an excell ...
... cancer and a type of human developmental diseases called ciliopathies. While the importance of studying this organelle is clear, how it forms and functions is not fully understood. In particular, understanding of the mechanisms of centriole elongation is lacking. Drosophila melanogaster is an excell ...
Mosaic: A Position-Effect Variegation Eye
... euchromatin in the rearrangement. The effect is therefore usually cis-acting, since the homologue in which the rearrangement has occurred also carries the variegating allele. Furthermore, the lineage-specific modifications of gene expression are unique to each individual and are not inherited. Two o ...
... euchromatin in the rearrangement. The effect is therefore usually cis-acting, since the homologue in which the rearrangement has occurred also carries the variegating allele. Furthermore, the lineage-specific modifications of gene expression are unique to each individual and are not inherited. Two o ...
Primary amenorrhea
... Menarche and the menstrual cycle in adolescence * The conventional wisdom about menstruation in adolescents requires updating 1. Early onset of puberty = 8-9 yrs 2. Age of menarche median age = 12.5 yrs 95% of adol are menstruating by 14 yrs of age ...
... Menarche and the menstrual cycle in adolescence * The conventional wisdom about menstruation in adolescents requires updating 1. Early onset of puberty = 8-9 yrs 2. Age of menarche median age = 12.5 yrs 95% of adol are menstruating by 14 yrs of age ...
Document
... Mice and humans share virtually the same set of genes Mice are well-established experimental model. Genes easily found in mice genome sequences Test experimentally the function of those genes. ...
... Mice and humans share virtually the same set of genes Mice are well-established experimental model. Genes easily found in mice genome sequences Test experimentally the function of those genes. ...
THE GENETICS AND REPRODUCTIVE ISOLATING MECHANISMS
... and ochsenheimeri Stgr., but in Pieris melete Men. too. Spring napi females which show a more marked gray suffusion along the veins than is usual in this species are also distinguishable by the lack of this streak. The distinction between a slightly marked heterozygous bryonice female and a more str ...
... and ochsenheimeri Stgr., but in Pieris melete Men. too. Spring napi females which show a more marked gray suffusion along the veins than is usual in this species are also distinguishable by the lack of this streak. The distinction between a slightly marked heterozygous bryonice female and a more str ...
The disease characteristics of different strains of scrapie in Sinc
... present paper describes the p r o d u c t i o n of congenic mouse lines which differ only in the vicinity of the Sinc locus. This has been achieved by i n t r o d u c i n g the s7 allele into a V M b a c k g r o u n d , selecting on the basis of the i n c u b a t i o n period of the disease p r o d ...
... present paper describes the p r o d u c t i o n of congenic mouse lines which differ only in the vicinity of the Sinc locus. This has been achieved by i n t r o d u c i n g the s7 allele into a V M b a c k g r o u n d , selecting on the basis of the i n c u b a t i o n period of the disease p r o d ...
one-step and stepwise magnification of a bobbed lethal
... regions (Figure lb). Similar observations have been made for other Y chromosomes stained with Hoechst 33258 or quinacrine (GATTI, PIMPINELLI and SANTINI1976; GATTI and PIMPINELLI1983). Three of the one-step y bb" chromosomes, 10, 35 and 48, appeared as acrocentric chromosomes with a uniformly staini ...
... regions (Figure lb). Similar observations have been made for other Y chromosomes stained with Hoechst 33258 or quinacrine (GATTI, PIMPINELLI and SANTINI1976; GATTI and PIMPINELLI1983). Three of the one-step y bb" chromosomes, 10, 35 and 48, appeared as acrocentric chromosomes with a uniformly staini ...
Provisional PDF
... homologous with genes from other species belonging to the Mycoplasmataceae family. For example, an alignment showed all 134 genes to be 33–93% homologous with their corresponding genes in Candidatus Hepatoplasma crinochetorum. The gene with the highest homology (93%) was rpoB. These results indicate ...
... homologous with genes from other species belonging to the Mycoplasmataceae family. For example, an alignment showed all 134 genes to be 33–93% homologous with their corresponding genes in Candidatus Hepatoplasma crinochetorum. The gene with the highest homology (93%) was rpoB. These results indicate ...
Defining characteristics of Tn5 Transposase non
... While non-specific DNA plays a role in target localization for many recombinases, transcription factors and restriction enzymes, the importance of nonspecific DNA interactions for transposases has not been investigated. Here, we discuss non-specific DNA-Tn5 Transposase (Tnp) interactions and suggest ...
... While non-specific DNA plays a role in target localization for many recombinases, transcription factors and restriction enzymes, the importance of nonspecific DNA interactions for transposases has not been investigated. Here, we discuss non-specific DNA-Tn5 Transposase (Tnp) interactions and suggest ...
Virulence factors of Salmonella enterica serovar Enteritidis
... 61). Once ingested, the bacteria first need to pass the acidic environment of the stomach and thus bacterial resistance against these acidic conditions plays an important role in infection (23). Upon reaching the alimentary tract of the chicken, the bacteria are able to colonize the gut without caus ...
... 61). Once ingested, the bacteria first need to pass the acidic environment of the stomach and thus bacterial resistance against these acidic conditions plays an important role in infection (23). Upon reaching the alimentary tract of the chicken, the bacteria are able to colonize the gut without caus ...
Pain genetics: past, present and future
... industry investment have yielded few basic research-toclinical translational successes, and many have looked to the molecular genetics revolution as a new way forward [2]. In fact, genetic approaches in pain research, as elsewhere, are now fully integrated into the research enterprise. For example, ...
... industry investment have yielded few basic research-toclinical translational successes, and many have looked to the molecular genetics revolution as a new way forward [2]. In fact, genetic approaches in pain research, as elsewhere, are now fully integrated into the research enterprise. For example, ...
Emended description of the order Chlamydiales, proposal of
... The current taxonomic classification of Chlamydia is based on limited phenotypic, morphologic and genetic criteria. This classification does not take into account recent analysis of the ribosomal operon or recently identified obligately intracellular organisms that have a chlamydia-like developmenta ...
... The current taxonomic classification of Chlamydia is based on limited phenotypic, morphologic and genetic criteria. This classification does not take into account recent analysis of the ribosomal operon or recently identified obligately intracellular organisms that have a chlamydia-like developmenta ...
Human mitochondrial transfer RNAs: Role of pathogenic
... MtDNA alterations can be divided into three classes: pathogenic, adaptive (advantageous in certain environments), and neutral (accumulated by chance). ...
... MtDNA alterations can be divided into three classes: pathogenic, adaptive (advantageous in certain environments), and neutral (accumulated by chance). ...
Studies on the Mechanisms of Homolog Pairing and Sister
... meiosis I and sister chromatids during meiosis II is essential for the survival of the offspring. Aberrant chromosome segregation at any stage of meiosis can lead to aneuploidy. Meiotic chromosome segregation without crossing over or chiasmata is a widespread but poorly understand chromosome segrega ...
... meiosis I and sister chromatids during meiosis II is essential for the survival of the offspring. Aberrant chromosome segregation at any stage of meiosis can lead to aneuploidy. Meiotic chromosome segregation without crossing over or chiasmata is a widespread but poorly understand chromosome segrega ...
The step-by-step evolution of vertebrate blood coagulation
... recently evolved features are apparent. Reasonable scenarios can be presented that show a step-by-step development of the process. Whole genome duplications may have played a role in expanding the inventory of similar proteins. ...
... recently evolved features are apparent. Reasonable scenarios can be presented that show a step-by-step development of the process. Whole genome duplications may have played a role in expanding the inventory of similar proteins. ...
p53 in Hematologic Malignancies
... CTCL, cutaneous T-cell leukemia; HCL, hairy cell leukemia. * Sixty percent to 80% of cases of mixed cellularity and nodular sclerosing type HD have RS cells that are p53 positive by immunohistochemistry. ...
... CTCL, cutaneous T-cell leukemia; HCL, hairy cell leukemia. * Sixty percent to 80% of cases of mixed cellularity and nodular sclerosing type HD have RS cells that are p53 positive by immunohistochemistry. ...
Breeding Policy - Selkirk Rex Cat Club
... founding Selkirks brought in to the country. Over the following two years a further sixteen cats followed ...
... founding Selkirks brought in to the country. Over the following two years a further sixteen cats followed ...
Biology A Chapter 10
... 1. When an area of a chromatid is exchanged with the matching area on a chromatid of its homologous chromosome, _____ occurs. a. crossing over c. hybridization b. mutagenesis d. fertilization 2. Crossing over results in a _____. a. female genotype c. genetic recombination b. male genotype d. phenoty ...
... 1. When an area of a chromatid is exchanged with the matching area on a chromatid of its homologous chromosome, _____ occurs. a. crossing over c. hybridization b. mutagenesis d. fertilization 2. Crossing over results in a _____. a. female genotype c. genetic recombination b. male genotype d. phenoty ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse