this PDF file - E-Journal Faculty of Medicine Universitas
... In the homozygous state there is a decrease in enzyme functions up to 60%. Meanwhile, in heterozygotes, the decrease is only about 30%. MTHFR C677T polymorphism gene may alter folate metabolism and low folate intake may result in increased levels of homocysteine. This may lead to a decrease in DNA m ...
... In the homozygous state there is a decrease in enzyme functions up to 60%. Meanwhile, in heterozygotes, the decrease is only about 30%. MTHFR C677T polymorphism gene may alter folate metabolism and low folate intake may result in increased levels of homocysteine. This may lead to a decrease in DNA m ...
Article Mitochondrial DNA turnover occurs during preimplantation
... destabilize mtDNA. The preimplantation period of development in mammals was thought to be relatively immune from environmentally induced changes to mtDNA, since no replication of mtDNA was thought to occur at this stage. This study demonstrates that there is a very short period of mtDNA synthesis im ...
... destabilize mtDNA. The preimplantation period of development in mammals was thought to be relatively immune from environmentally induced changes to mtDNA, since no replication of mtDNA was thought to occur at this stage. This study demonstrates that there is a very short period of mtDNA synthesis im ...
Mendelian and Non-Mendelian Regulation of Gene Expression in
... expression levels of 22,242 genes that were detected in both parents and at least 90% of the IBM RILs. The mean expression levels in the RILs were similar to the mid-parent values for most genes (Figure 1B). Transgressive segregation, defined here as at least 10% of RILs exhibiting expression levels ...
... expression levels of 22,242 genes that were detected in both parents and at least 90% of the IBM RILs. The mean expression levels in the RILs were similar to the mid-parent values for most genes (Figure 1B). Transgressive segregation, defined here as at least 10% of RILs exhibiting expression levels ...
Universal chloroplast integration and expression vectors
... The invention provides universal chloroplast integration and expression vectors which are competent to stably transform and integrate genes of interest into chloroplast genome of multiple species of plants. Transformed plants and their progeny are provided. Monocotyledonous and dicotyledonous plants ...
... The invention provides universal chloroplast integration and expression vectors which are competent to stably transform and integrate genes of interest into chloroplast genome of multiple species of plants. Transformed plants and their progeny are provided. Monocotyledonous and dicotyledonous plants ...
Detailed Algorithm of the DBRF
... moved to the independent group. Then, the overall process is repeated until no new independent group is created. For each group, all sets of minimum numbers of edges that, with essential ...
... moved to the independent group. Then, the overall process is repeated until no new independent group is created. For each group, all sets of minimum numbers of edges that, with essential ...
Yan D et al., 2014 - Drosophila RNAi Screening Center
... both by extrinsic and intrinsic factors. Decapentaplegic (Dpp) and Glass bottom boat (Gbb) produced from niche activate BMP signaling in the GSC to repress the transcription of a key differentiation gene, bag of marbles (bam), thereby maintaining GSC identity (Chen and McKearin, 2003; McKearin and S ...
... both by extrinsic and intrinsic factors. Decapentaplegic (Dpp) and Glass bottom boat (Gbb) produced from niche activate BMP signaling in the GSC to repress the transcription of a key differentiation gene, bag of marbles (bam), thereby maintaining GSC identity (Chen and McKearin, 2003; McKearin and S ...
31 Shareable Fragile X Facts (National Fragile X Foundation)
... Fragile X Awareness month is here! We’ve put together a list of 31 facts that you can share each day of the week on sites like Facebook and Twitter. If you share them, please use the hashtags #FragileXFacts [2] and #KnowFragileX [3]! 1. Fragile X encompasses a group of conditions that can affect fam ...
... Fragile X Awareness month is here! We’ve put together a list of 31 facts that you can share each day of the week on sites like Facebook and Twitter. If you share them, please use the hashtags #FragileXFacts [2] and #KnowFragileX [3]! 1. Fragile X encompasses a group of conditions that can affect fam ...
Journal of Biotechnology Rapid and highly efficient mammalian cell
... ‘all-in-one’ expression vectors containing seven guide RNA expression cassettes and a Cas9 nuclease/nickase expression cassette were delivered into 293T cells with genome cleavage efficiency ranging from 4 to 36% for each individual target (Sakuma et al., 2014). In general, the efficiency of editing m ...
... ‘all-in-one’ expression vectors containing seven guide RNA expression cassettes and a Cas9 nuclease/nickase expression cassette were delivered into 293T cells with genome cleavage efficiency ranging from 4 to 36% for each individual target (Sakuma et al., 2014). In general, the efficiency of editing m ...
Supplementary Data - Word file
... §S2.3. The Random Breakage Model of Genome Evolution As described in the main text, it has long been proposed that genomes evolve according to random breakage model which predicts that distances between breakpoints should follow an exponential distribution of the form f(x) = 1/L e-x/L, where L is t ...
... §S2.3. The Random Breakage Model of Genome Evolution As described in the main text, it has long been proposed that genomes evolve according to random breakage model which predicts that distances between breakpoints should follow an exponential distribution of the form f(x) = 1/L e-x/L, where L is t ...
Determination of the entire sequence of turtle CR1: the first open
... and they have been found in the genomes of many vertebrates. However, they have been only partially characterized, and only a 2-kb region of the 3’ end of chicken CR1 has been sequenced. In the present study, we determined the entire consensus sequence of CR1 elements in the turtle genome, designate ...
... and they have been found in the genomes of many vertebrates. However, they have been only partially characterized, and only a 2-kb region of the 3’ end of chicken CR1 has been sequenced. In the present study, we determined the entire consensus sequence of CR1 elements in the turtle genome, designate ...
GENOTYPE-PHENOTYPE CORRELATION USING
... As our programs can be used to correlate any two binary variables which can be optimized on a phylogenetic tree, it was used to find correlations between avian influenza strains and various traits of the species or organisms affected. In particular, we find correlations between spread of influenza a ...
... As our programs can be used to correlate any two binary variables which can be optimized on a phylogenetic tree, it was used to find correlations between avian influenza strains and various traits of the species or organisms affected. In particular, we find correlations between spread of influenza a ...
blumberg-lab.bio.uci.edu
... The question: “Does BLACK chromatin actively repress transcription or merely forms secondary to a lack of transcription?” ● if repressive, transgenes inserted into BLACK chromatin may exhibit reduced transcription ● if secondary, transgenes should be unaffected ...
... The question: “Does BLACK chromatin actively repress transcription or merely forms secondary to a lack of transcription?” ● if repressive, transgenes inserted into BLACK chromatin may exhibit reduced transcription ● if secondary, transgenes should be unaffected ...
Alfred Henry Sturtevant - National Academy of Sciences
... appeared to be within the gene (point mutations). Efficient methods for the experimental induction and detection of mutations had yet to be worked out, however. Moreover, spontaneous mutants were too rare, for the most part, to permit practical study of specific genes, except in the case of Bar. Thi ...
... appeared to be within the gene (point mutations). Efficient methods for the experimental induction and detection of mutations had yet to be worked out, however. Moreover, spontaneous mutants were too rare, for the most part, to permit practical study of specific genes, except in the case of Bar. Thi ...
Prevalence of BRCA1/2 Gene Mutation Carriage Rate among Local
... carried this mutation. On the other side, both the first degree relatives and patients with benign tumors had the same frequency of this type of BRCA mutation giving a value of 40% (2/5). In this study, BRCA1 exon 20 mutation was the most frequently recorded mutation, it was detected in (15/20) pati ...
... carried this mutation. On the other side, both the first degree relatives and patients with benign tumors had the same frequency of this type of BRCA mutation giving a value of 40% (2/5). In this study, BRCA1 exon 20 mutation was the most frequently recorded mutation, it was detected in (15/20) pati ...
Interactions Between Genes Controlling Pathogenicity in the Flax
... to flax rust caused by Melampsora lini (Ehrenb.) L6v. have been identified. These occur in five series of closely linked or allelic genes, designated K, L, M, N, and P, which contain 1, 13, 7, 3, and 5 genes, respectively (6,11,19,20). In studies of the inheritance of pathogenicity in flax rust, sin ...
... to flax rust caused by Melampsora lini (Ehrenb.) L6v. have been identified. These occur in five series of closely linked or allelic genes, designated K, L, M, N, and P, which contain 1, 13, 7, 3, and 5 genes, respectively (6,11,19,20). In studies of the inheritance of pathogenicity in flax rust, sin ...
About and Key Statistics - American Cancer Society
... A great deal of research has gone into figuring out how certain DNA changes in retinal cells cause them to become cancerous. Scientists understand these changes better for retinoblastoma than for most other cancer types. Although probably still years away, researchers hope that this understanding wi ...
... A great deal of research has gone into figuring out how certain DNA changes in retinal cells cause them to become cancerous. Scientists understand these changes better for retinoblastoma than for most other cancer types. Although probably still years away, researchers hope that this understanding wi ...
You Light Up My Life
... • Mendel concluded that the two “units” for the first trait were to be assorted into gametes independently of the two “units” for the other trait • Members of each pair of homologous ...
... • Mendel concluded that the two “units” for the first trait were to be assorted into gametes independently of the two “units” for the other trait • Members of each pair of homologous ...
Detection of BRCA1/2 Gene Mutation Rate Among Women in Hilla
... Iraq and other communities with these mutations. In one Italian study, Ottini et al.(2000)[20] have found that BRCA1 mutations were detected in only one out of 10 cases from breast cancer families. This is a low proportion compared with other studies which suggested that mutation in BRCA1 and BRCA2 ...
... Iraq and other communities with these mutations. In one Italian study, Ottini et al.(2000)[20] have found that BRCA1 mutations were detected in only one out of 10 cases from breast cancer families. This is a low proportion compared with other studies which suggested that mutation in BRCA1 and BRCA2 ...
Molecular Plant-Microbio Interactions
... negatively on nodulation of Pisum sativum and Vicia hirsuta. Strain RBL5523 is a derivative of R. leguminosarum bv. trifolii RCR5 in which the Sym plasmid is replaced by the R. leguminosarum bv. viciae Sym plasmid pRL1JI (Table 1) and, therefore, should effectively nodulate host plants of the pea cr ...
... negatively on nodulation of Pisum sativum and Vicia hirsuta. Strain RBL5523 is a derivative of R. leguminosarum bv. trifolii RCR5 in which the Sym plasmid is replaced by the R. leguminosarum bv. viciae Sym plasmid pRL1JI (Table 1) and, therefore, should effectively nodulate host plants of the pea cr ...
AP Biology Unit 4: Genetics - Chapter 14
... • Mendel developed a hypothesis to explain the 3:1 inheritance pattern he observed in F2 offspring • Four related concepts make up this model • The first concept is that alternative versions of genes account for variations in inherited characters • For example, the gene for flower color in pea plant ...
... • Mendel developed a hypothesis to explain the 3:1 inheritance pattern he observed in F2 offspring • Four related concepts make up this model • The first concept is that alternative versions of genes account for variations in inherited characters • For example, the gene for flower color in pea plant ...
notes
... fluctuated over time, the history of a sample of alleles taken from the population is entirely equivalent to the history of a sample taken from two demes, with some migration between them. It is therefore a simple manner to construct coalescent simulations in order to investigate the effect of balan ...
... fluctuated over time, the history of a sample of alleles taken from the population is entirely equivalent to the history of a sample taken from two demes, with some migration between them. It is therefore a simple manner to construct coalescent simulations in order to investigate the effect of balan ...
Anther Development
... anther is established, cell and tissue differentiation occur, and microspore mother cells undergo meiosis. At the end of phase 1, the anther contains most of its specialized cells and tissues, and tetrads of microspores are present within the pollen sacs (Figure 1). During phase 2, pollen grains dif ...
... anther is established, cell and tissue differentiation occur, and microspore mother cells undergo meiosis. At the end of phase 1, the anther contains most of its specialized cells and tissues, and tetrads of microspores are present within the pollen sacs (Figure 1). During phase 2, pollen grains dif ...
Chromosomal Abnormalities
... chromosome caused by viruses, chemicals, radiation or other events. Although all cells experience chromosome breakage, in terms of human genetics, only aberrations arising within germ cells are important. Enzymes exist that can repair the breaks, but when multiple breaks occur simultaneously, mistak ...
... chromosome caused by viruses, chemicals, radiation or other events. Although all cells experience chromosome breakage, in terms of human genetics, only aberrations arising within germ cells are important. Enzymes exist that can repair the breaks, but when multiple breaks occur simultaneously, mistak ...
Cluster Analysis for Gene Expression Data
... indicated a relatively small and redundant collection of conditions suffice to separate genes into functional categories, the addition of more and diverse conditions can only enhance those observation [Eisen1998]. Eisen et. al. applied a hierarchical clustering algorithm to two sets of data: gene e ...
... indicated a relatively small and redundant collection of conditions suffice to separate genes into functional categories, the addition of more and diverse conditions can only enhance those observation [Eisen1998]. Eisen et. al. applied a hierarchical clustering algorithm to two sets of data: gene e ...
phage interactions - Experimental Evolution of Communities
... separate bacteria and phage; the supernatant was stored at 4 °C as the whole phage population, while the pelleted bacteria was resuspended and streaked on to KB agar plates and incubated again overnight. Twelve bacterial colonies were then chosen arbitrarily from the incubated plates and used to ini ...
... separate bacteria and phage; the supernatant was stored at 4 °C as the whole phage population, while the pelleted bacteria was resuspended and streaked on to KB agar plates and incubated again overnight. Twelve bacterial colonies were then chosen arbitrarily from the incubated plates and used to ini ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse