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Hox, ParaHox, ProtoHox: facts and guesses
Hox, ParaHox, ProtoHox: facts and guesses

... The four-gene model is supported by phylogenetic analyses of the 60 aa homeodomain alone (or the homeodomain plus five flanking aa), of proteins that diverged more than 800 million years ago (Banerjee-Basu and Baxevanis, 2001; Peterson et al, 2004). The bootstrap values for any particular grouping o ...
GO and Annotation
GO and Annotation

The human Y chromosome: a sole survivor Noordam, MJ - UvA-DARE
The human Y chromosome: a sole survivor Noordam, MJ - UvA-DARE

... Inclusion criteria: patient and control definition In association studies, rigorously defined inclusion criteria are essential so that patients and controls are identical with the exception of the phenotype of interest. Therefore, we used patient and control groups that were categorized solely by th ...
Chromosomal Basis of Heredity
Chromosomal Basis of Heredity

... colleagues were able to map the linear positions of genes in Drosophila into four groups, one for each chromosome. ...
Reassignment of the Human CSFl Gene to Chromosome lp13-p21
Reassignment of the Human CSFl Gene to Chromosome lp13-p21

... Submitted April 3,1991; accepted June 20, 1991. Supported in part by Grants No. CA-20180, CA-23099, and CA-21765, from the National Cancer Institute, National Institutes of Health, and by the American Lebanese Syrian Associated Chanties ...
Experimental matings: Df/wt x wt
Experimental matings: Df/wt x wt

...  Among many animals species, females retain sperm within specific regions of their reproductive tract (often chambers called storage organs) for various periods of time between the start of sperm transfer and when sperm leave the reproductive tract (Bloch Qazi et al., 2003). This phenomenon is cal ...
A String-based Model for Simple Gene Assembly
A String-based Model for Simple Gene Assembly

... Given this definition for genes, we may now consider gene assembly as a sorting of signed permutations. We will define the simple operations as transformation rules for signed permutations in such a way that a simple operation is applicable on a gene pattern if and only if the corresponding rule is ...
MayerFrankiPoster
MayerFrankiPoster

... cyanobacterium Synechococcus sp. PCC 7002 to produce isoprene. However, for this ‘photo-isoprene’ to become a marketable option for replacing petroleum products, there are many more modifications to be made. One of these involves the gene cpcB that codes for a protein, called phycocyanin, that captu ...
GhMYB25-like: a key regulator of early cotton fiber development.
GhMYB25-like: a key regulator of early cotton fiber development.

... and that had an expression profile similar to GhMYB25 (Wu et al., 2006). It was designated GhMYB25-like. In this study we examine the role of GhMYB25-like in fiber development using RNAi-mediated gene silencing and a transgenic cotton line containing an extra copy of GhMYB25-like under the control o ...
Overview of splicing relevant databases - Stamm
Overview of splicing relevant databases - Stamm

... sequences, “full-length” complementary DNAs (flcDNA) allow to define the whole exon content of the different gene products. At the beginning of the 90’s, there were the first massive generations of Expressed Sequence Tags (EST). ESTs are unique read from clone extremity from normal or pathological t ...
Characterisation of a Non-canonical Genetic Code in
Characterisation of a Non-canonical Genetic Code in

... canonical CAA and CAG codons, and by TAA and TAG codons. This is only the fifth lineage of eukaryotes known to employ a non-canonical genetic code in the nuclear genome, but already the fourth lineage where this particular variant is found. The recurrent evolution of this variant code in nuclear gen ...
Loss And Gain Of Function Experiments Implicate TMEM18
Loss And Gain Of Function Experiments Implicate TMEM18

... the PVN would have upon energy balance so we followed a cohort of mice for 6 weeks after surgery, recording body weight weekly, measuring food intake in home cage at 2 weeks post-surgery and finally assessing both food intake and energy expenditure at the end of the 6 week period. In terms of absolu ...
Estonian HumanGenesResearchAct.
Estonian HumanGenesResearchAct.

... a Gene Bank, to organise the genetic research necessary therefor, to ensure the voluntary nature of gene donation and the confidentiality of the identity of gene donors, and to protect persons from misuse of genetic data and from discrimination based on interpretation of the structure of their DNA a ...
Alpha and beta subunits of pyruvate dehydrogenase E1
Alpha and beta subunits of pyruvate dehydrogenase E1

... within a clade composed exclusively of eukaryotic mitochondrial PDH genes (with bootstrap support between 70 and 97%), which is itself related to the alpha-proteobacterial PDH clade (bootstrap support between 95 and 100%). This position for the microsporidian sequence is exactly what one would expec ...
Invagination centers within the Drosophila stomatogastric nervous
Invagination centers within the Drosophila stomatogastric nervous

... genes fail to single-out AS-C gene-expressing cells and thereby show an overproduction of neural precursor cells both in the central and the peripheral nervous system (Brand and CamposOrtega, 1988; Goriely et al., 1991). Here we describe the early development of the Drosophila stomatogastric nervous ...
Infinium Multi-Ethnic EUR/EAS/SAS BeadChip
Infinium Multi-Ethnic EUR/EAS/SAS BeadChip

... a. Estimated sample throughput based on use of 1 HiScan System, 1 AutoLoader 2.x, 1 Tecan robot, and a 5-day work week. b. Values are derived from genotyping 708 HapMap reference samples. c. Value expected for typical projects using standard Illumina protocols. Tumor samples and samples prepared ...
Module 1 - Bioinformatics.ca
Module 1 - Bioinformatics.ca

... Why sequence RNA (versus DNA)? • Interpreting mutations that do not have an obvious effect on protein sequence – ‘Regulatory’ mutations that affect what mRNA isoform is expressed and how much • e.g. splice sites, promoters, exonic/intronic splicing motifs, etc. ...
Document
Document

... • Ask meaningful questions of microarray data e.g. – genes involved in the same process, same/different expression patterns? ...
Genetic Inheritance - Spaniel Club Deutschland
Genetic Inheritance - Spaniel Club Deutschland

...  When two genetically CLEAR dogs are mated together, all the resulting offspring will be genetically CLEAR. When two genetically AFFECTED dogs are mated together, all the resulting offspring will be genetically AFFECTED.  When mating a genetic CLEAR to a genetic CARRIER, no AFFECTED dogs will be p ...
The Jumping SHOX Gene—Crossover in the Pseudoautosomal
The Jumping SHOX Gene—Crossover in the Pseudoautosomal

... genes within PAR1 escape X inactivation in women. However, the only gene in this region associated with human disease is the SHOX gene (10). Inheritance of LWD is pseudoautosomal. The SHOX gene in the normal situation is present in two functional copies. In fact, one might consider PAR1 as a very sm ...
Visualizing expression patterns of Shh and Foxf1 genes
Visualizing expression patterns of Shh and Foxf1 genes

... Recently, various tools for obtaining three-dimensional (3D) information on biological tissues have been investigated and improved [17–19]. Optical projection tomography (OPT) is a new, rapid and non-invasive technique for 3D imaging of small biological specimens that allows visualization of the tis ...
Word file
Word file

... Undescended gonads in triple mutant XY embryos. SEM analysis of the genito-urinary system of E18.5 embryos. The left panel shows embryos of XX, and the right panel of XY genotype. Arrows indicate the position of gonads in each panel, narrow arrowheads indicate the uterus, and wide arrowhead the blad ...
Transferrin receptor 2 (TfR2) and HFE mutational analysis in non
Transferrin receptor 2 (TfR2) and HFE mutational analysis in non

... ver, BC, Canada, for genetic testing for HH prior to May 5, 2000. From this database, we selected all patients with a transferrin saturation greater than or equal to 60%, an elevated serum ferritin level, and a negative test result for the C282Y HFE mutation. From the same laboratory, 93 control sam ...
Interactions between SNP Alleles at Multiple Loci Contribute to Skin
Interactions between SNP Alleles at Multiple Loci Contribute to Skin

... regard to skin color. In spite of recent advances in gene identification and functional analysis, much work remains to elucidate the underlying genetic mechanisms regulating normal human skin pigmentation [6]. Our previous study was undertaken to discover the genetic basis of the substantial differe ...
Nutritional Genomics
Nutritional Genomics

...  Evidence that maternal diets can indeed modulate gene expression in the offspring  Functional ramifications of the observed gene expression changes warrant future research  The epigenetic mechanisms underlying fetal programming are not well understood  Critical need to understand the effects of ...
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Gene expression profiling



In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.
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