Phosphorylation and concomitant structural changes in human 2
... (hPrxII) [5,6], we investigated the peroxidase and molecular chaperone activities of the various forms of hPrxI as prepared in Section 3.1. We found that WT-hPrxI exhibited not only a H2O2 catabolic peroxidase activity (Fig. 2A) but also a chaperone activity that suppressed thermal aggregation of mo ...
... (hPrxII) [5,6], we investigated the peroxidase and molecular chaperone activities of the various forms of hPrxI as prepared in Section 3.1. We found that WT-hPrxI exhibited not only a H2O2 catabolic peroxidase activity (Fig. 2A) but also a chaperone activity that suppressed thermal aggregation of mo ...
Amino Acid Starter Kit©
... neutralize each other. c. Polar sidechains should be on the surface of the protein where they can hydrogen ...
... neutralize each other. c. Polar sidechains should be on the surface of the protein where they can hydrogen ...
Proteins and Amino Acids 14 key
... What might be some of the different properties exhibited by these different R-groups? ...
... What might be some of the different properties exhibited by these different R-groups? ...
Nitroshure-general info
... Nitroshure can be safely mixed into dry mineral vitamin mixes (= 97% dry matter), provided normal industry mixing times are followed (3 minutes or less). Nitroshure will have no storage limitations beyond those of the remainder of the premix in this application. There are no ingredients that need to ...
... Nitroshure can be safely mixed into dry mineral vitamin mixes (= 97% dry matter), provided normal industry mixing times are followed (3 minutes or less). Nitroshure will have no storage limitations beyond those of the remainder of the premix in this application. There are no ingredients that need to ...
The Ubiquitin Proteosome pathway
... Ubiquitylation plays a fundamental role of protein degradation at cellular level. (Levels of proteins in nucleus, cytoplasm, ER lumen and transmembrane protein are kept in check by ubiquitin proteosome pathway.) Ubiquitylation is highly complex, temporally controlled and tightly regulated proces ...
... Ubiquitylation plays a fundamental role of protein degradation at cellular level. (Levels of proteins in nucleus, cytoplasm, ER lumen and transmembrane protein are kept in check by ubiquitin proteosome pathway.) Ubiquitylation is highly complex, temporally controlled and tightly regulated proces ...
Histidine protonation and the activation of viral fusion proteins
... protein specifically play a critical role in fusion activation is that low pH also plays a role in the cleavage of the envelope protein precursor [7]. However, the structure of the uncleaved precursor and therefore its histidine environments are not ...
... protein specifically play a critical role in fusion activation is that low pH also plays a role in the cleavage of the envelope protein precursor [7]. However, the structure of the uncleaved precursor and therefore its histidine environments are not ...
Gene Section PTK7 (PTK7 protein tyrosine kinase 7)
... extracellular domain exposed at the cell surface. It is described that PTK7 is processed by MT1-MPP, a metalloproteinase, that releases a soluble form of PTK7. From in vivo and in vitro studies, it appears that a fine-tuned balance between full length PTK7 and soluble PTK7 is required for normal emb ...
... extracellular domain exposed at the cell surface. It is described that PTK7 is processed by MT1-MPP, a metalloproteinase, that releases a soluble form of PTK7. From in vivo and in vitro studies, it appears that a fine-tuned balance between full length PTK7 and soluble PTK7 is required for normal emb ...
DOC - National Center for Macromolecular Imaging
... disease states. Complete genome sequences have revealed 10,000s of genes in a variety of different organisms. The daunting task of understanding the functions and regulation of these genes can be simplified by associating each of these genes with one of 200-300 core biological processes. Since most ...
... disease states. Complete genome sequences have revealed 10,000s of genes in a variety of different organisms. The daunting task of understanding the functions and regulation of these genes can be simplified by associating each of these genes with one of 200-300 core biological processes. Since most ...
Assignments 3 Problem 1 Below is the protein melting data for a pair
... you rationalize the result? Two hints: i) remember that ΔG is defined by two states of the protein. Which of the two states may be responsible for the effect of the mutant. ii) Remember what you learned about the molecular nature of the hydrophobic effect? ...
... you rationalize the result? Two hints: i) remember that ΔG is defined by two states of the protein. Which of the two states may be responsible for the effect of the mutant. ii) Remember what you learned about the molecular nature of the hydrophobic effect? ...
Polar location and functional domains of the Agrobacterium
... DNA transfer to plants. VirD4 presumably functions as a coupling factor that facilitates communication between a substrate and the transport pore. To serve as a coupling protein, VirD4 may be required to localize near the transport apparatus. In a previous study, we observed that several constituent ...
... DNA transfer to plants. VirD4 presumably functions as a coupling factor that facilitates communication between a substrate and the transport pore. To serve as a coupling protein, VirD4 may be required to localize near the transport apparatus. In a previous study, we observed that several constituent ...
ribosomes - Mircea Leabu
... Assisted folding – chaperones Heat shock proteins family (discovered by Italian researcher Ferruccio Ritossa, in 1962) Classification according the molecular weight - small HSP (sHSP) - HSP40 - HSP60 - HSP70 - HSP90 - HSP100 Various mechanisms of action ...
... Assisted folding – chaperones Heat shock proteins family (discovered by Italian researcher Ferruccio Ritossa, in 1962) Classification according the molecular weight - small HSP (sHSP) - HSP40 - HSP60 - HSP70 - HSP90 - HSP100 Various mechanisms of action ...
as PDF
... Extracellular Regulation of TGF-β Signaling The TGF-β family of signaling proteins is widely represented throughout the animal kingdom and consists of more than 40 known members including TGF-β isoforms, bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), activins and inhibins ...
... Extracellular Regulation of TGF-β Signaling The TGF-β family of signaling proteins is widely represented throughout the animal kingdom and consists of more than 40 known members including TGF-β isoforms, bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), activins and inhibins ...
Phase behaviour and transitions of peptides and proteins
... My research is focused on the application of theoretical computational tools developed in soft condensed matter physics to investigate the phase behaviour and transitions of complex systems of biomolecules. From a purely statistical mechanical point of view an ensemble of many peptides and proteins ...
... My research is focused on the application of theoretical computational tools developed in soft condensed matter physics to investigate the phase behaviour and transitions of complex systems of biomolecules. From a purely statistical mechanical point of view an ensemble of many peptides and proteins ...
Supplementary Information (doc 50K)
... peptides at m/z 4282 and m/z 4298 have the same sequence. As these two peptides have a mass difference of ca.16 Da, the peptide at m/z 4298 may represent an oxidized form of the peptide at m/z 4282. The attempts to obtain the identities of two other peptides, i.e. m/z 2791 and m/z 3956 by MS analysi ...
... peptides at m/z 4282 and m/z 4298 have the same sequence. As these two peptides have a mass difference of ca.16 Da, the peptide at m/z 4298 may represent an oxidized form of the peptide at m/z 4282. The attempts to obtain the identities of two other peptides, i.e. m/z 2791 and m/z 3956 by MS analysi ...
Reticulons (RTNs) are endomembrane bound proteins with a
... Reticulons (RTNs) gained increasing attention in the recent years due to their involvement and crucial role especially in neurodegenerative diseases. RTNs are endomembrane bound proteins with a uniquely conserved C-terminal Reticulon homology domain (RHD), via which they anchor themselves to membran ...
... Reticulons (RTNs) gained increasing attention in the recent years due to their involvement and crucial role especially in neurodegenerative diseases. RTNs are endomembrane bound proteins with a uniquely conserved C-terminal Reticulon homology domain (RHD), via which they anchor themselves to membran ...
Improved topology prediction using the terminal
... they identify hydrophobic TM helices and then combine these predictions with the positive-inside rule in order to determine the topology. The positive-inside rule is used to allow for less hydrophobic TMsegments to be recognized if this results in that more positive residues are found in periplasmic ...
... they identify hydrophobic TM helices and then combine these predictions with the positive-inside rule in order to determine the topology. The positive-inside rule is used to allow for less hydrophobic TMsegments to be recognized if this results in that more positive residues are found in periplasmic ...
Electrophoresis HCC 2013 BMS2 intro
... • Defined as the migration of charged particles through a solution under the influence of an electric field. • Many important biological molecules possess ionisable groups – e.g. amino acids, peptides, proteins, nucleotides, nucleic acids • So, at a given pH they exist in solution as electrically ch ...
... • Defined as the migration of charged particles through a solution under the influence of an electric field. • Many important biological molecules possess ionisable groups – e.g. amino acids, peptides, proteins, nucleotides, nucleic acids • So, at a given pH they exist in solution as electrically ch ...
Subviral-Particle Biogenesis Hepatitis B Virus Small Surface
... derivative was coexpressed from the mRNA encoding the M protein. The N-terminal pre-S2 domain of M is translocated into the ER lumen by signal I in its S domain (15), and during this translocation the N-glycosylation site at asparagine 4 of pre-S2 is modified. Therefore, a double N-glycosylated M ve ...
... derivative was coexpressed from the mRNA encoding the M protein. The N-terminal pre-S2 domain of M is translocated into the ER lumen by signal I in its S domain (15), and during this translocation the N-glycosylation site at asparagine 4 of pre-S2 is modified. Therefore, a double N-glycosylated M ve ...
Poster
... mannose 6-phosphate, which allows for the recognition by the mannose 6-phosphate receptors. The hydrolytic enzymes are responsible for breaking down the metabolic waste within the lysosomes and are therefore essential to be taken into the lysosome. Without the mannose 6phosphate tag, the receptors c ...
... mannose 6-phosphate, which allows for the recognition by the mannose 6-phosphate receptors. The hydrolytic enzymes are responsible for breaking down the metabolic waste within the lysosomes and are therefore essential to be taken into the lysosome. Without the mannose 6phosphate tag, the receptors c ...
Protein domain
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural domains. One domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. Domains vary in length from between about 25 amino acids up to 500 amino acids in length. The shortest domains such as zinc fingers are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be ""swapped"" by genetic engineering between one protein and another to make chimeric proteins.