The mammalian oxysterol-binding protein
... the yeast S. cerevisiae ORP Osh4p [16]. We have previously characterized human ORP2, and demonstrated functional effects of ORP2 overexpression on cholesterol, phospholipid and neutral lipid metabolism [11,12,27]. We therefore chose to model the structure of ORP2 using the yeast Osh4p structure as a ...
... the yeast S. cerevisiae ORP Osh4p [16]. We have previously characterized human ORP2, and demonstrated functional effects of ORP2 overexpression on cholesterol, phospholipid and neutral lipid metabolism [11,12,27]. We therefore chose to model the structure of ORP2 using the yeast Osh4p structure as a ...
Translocation of effector proteins from the oomycete Phytophthora
... translocates effector proteins into host plant cells during infection. Whereas bacteria possess the well characterized type III secretion system, the mechanism used by eukaryotic plant pathogens for delivering effector proteins into the host cell remains unclear. In oomycetes this process depends on ...
... translocates effector proteins into host plant cells during infection. Whereas bacteria possess the well characterized type III secretion system, the mechanism used by eukaryotic plant pathogens for delivering effector proteins into the host cell remains unclear. In oomycetes this process depends on ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008.
... Insulin is a peptide hormone, produced by beta cells of the pancreas, and is central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, skeletal muscles, and fat tissue to absorb glucose from the blood. In the liver and skeletal muscles, glucose is stored a ...
... Insulin is a peptide hormone, produced by beta cells of the pancreas, and is central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, skeletal muscles, and fat tissue to absorb glucose from the blood. In the liver and skeletal muscles, glucose is stored a ...
Appendix
... The thermodynamics of PEG-salt systems have been studied quite extensively (Willauer et al., 2002). These systems tend to phase separate due to the strong "negative" interactions between the salts and the polyethylene glycol, with the salt concentration in the PEG phase as much as seven times smalle ...
... The thermodynamics of PEG-salt systems have been studied quite extensively (Willauer et al., 2002). These systems tend to phase separate due to the strong "negative" interactions between the salts and the polyethylene glycol, with the salt concentration in the PEG phase as much as seven times smalle ...
example of an abstract for the germn biannual meeting
... leukocyte trafficking and extravasation. Intercellular adhesion molecule-1 (ICAM-1) , a cell surface ligand for LFA-1 is a member of the immunoglobulin protein super-family. The interaction of LFA-1 and ICAM-1 is critical to many immunological reactions, including T lymphocyte antigen-specific respo ...
... leukocyte trafficking and extravasation. Intercellular adhesion molecule-1 (ICAM-1) , a cell surface ligand for LFA-1 is a member of the immunoglobulin protein super-family. The interaction of LFA-1 and ICAM-1 is critical to many immunological reactions, including T lymphocyte antigen-specific respo ...
lecture 7
... - prefoldin can stabilize an unfolded protein for subsequent folding by chaperonin (explanation in class) - range of proteins archaeal prefoldin stabilizes is considerable: 14-62 kDa Archaeal prefoldin (with 2 different subunits) may play a general role in protein folding whereas the eukaryotic ch ...
... - prefoldin can stabilize an unfolded protein for subsequent folding by chaperonin (explanation in class) - range of proteins archaeal prefoldin stabilizes is considerable: 14-62 kDa Archaeal prefoldin (with 2 different subunits) may play a general role in protein folding whereas the eukaryotic ch ...
PREVIEW_on_Ng_etal_STRUCTURE-MK
... consensus sequence, HEXXHXXGXXH, with the three histidines liganding the catalytic metal ion, the glutamate acting as a general base/acid during catalysis, and the glycine accounting for a characteristic sharp change in the direction of the polypeptide after the active-site helix to reach the third ...
... consensus sequence, HEXXHXXGXXH, with the three histidines liganding the catalytic metal ion, the glutamate acting as a general base/acid during catalysis, and the glycine accounting for a characteristic sharp change in the direction of the polypeptide after the active-site helix to reach the third ...
Protein
... G Protein Signal Cascade A hormone (e.g., epinephrine or glucagon) that activates formation of cAMP or IP3, binds at the cell surface to a receptor with 7 transmembrane αhelices. Rhodopsin was the first member of the family of 7-helix receptors to have its structure determined by X-ray crystallogra ...
... G Protein Signal Cascade A hormone (e.g., epinephrine or glucagon) that activates formation of cAMP or IP3, binds at the cell surface to a receptor with 7 transmembrane αhelices. Rhodopsin was the first member of the family of 7-helix receptors to have its structure determined by X-ray crystallogra ...
Gene Section DENR (density-regulated protein) Atlas of Genetics and Cytogenetics
... the translation initiation complex fraction in both human embryonic kidney cell cultures and lymphoid cell lines. This complex was shown to interact with the cap complex and to alter the mRNA translational profile of a subset of cancer-related mRNAs. This supports a model where MCT-1 exerts it ongog ...
... the translation initiation complex fraction in both human embryonic kidney cell cultures and lymphoid cell lines. This complex was shown to interact with the cap complex and to alter the mRNA translational profile of a subset of cancer-related mRNAs. This supports a model where MCT-1 exerts it ongog ...
Supplementary Material Recovery of the first full
... aligned to proteins encoded by all annotated coding sequences (CDS) of 43 fully sequenced poxvirus genomes deposited in the RefSeq database as of 27/02/2017. Alignments were carried out using the blastp tool from the NCBI blast+ package (v2.6.0) using default stringency parameters and retaining all ...
... aligned to proteins encoded by all annotated coding sequences (CDS) of 43 fully sequenced poxvirus genomes deposited in the RefSeq database as of 27/02/2017. Alignments were carried out using the blastp tool from the NCBI blast+ package (v2.6.0) using default stringency parameters and retaining all ...
Lecture 11, chemical genetics - Cal State LA
... Protein Microarrays: Example Kuruvilla et al. wanted to find a small molecule inhibitor of a known protein, Ure2p (5) Made of series of derivatives of uretupamine, found 1 w/ improved inhibitory activity (uretupamine B) (6) Used microarrays to probe the effects of inhibiting Ure2p on overall gene e ...
... Protein Microarrays: Example Kuruvilla et al. wanted to find a small molecule inhibitor of a known protein, Ure2p (5) Made of series of derivatives of uretupamine, found 1 w/ improved inhibitory activity (uretupamine B) (6) Used microarrays to probe the effects of inhibiting Ure2p on overall gene e ...
Gene Section HSPA5 (heat shock 70kDa protein 5 (glucose regulated protein, 78kDa)) -
... with low affinity for substrate (poly)peptides and an ADP-form with high substrate affinity and is regulated by Hsp40-type co-chaperones and nucleotide exchange factors. Molecular chaperones of the Hsp70 type family reversibly bind to substrate polypeptides via the substrate binding domain (SBD). Ty ...
... with low affinity for substrate (poly)peptides and an ADP-form with high substrate affinity and is regulated by Hsp40-type co-chaperones and nucleotide exchange factors. Molecular chaperones of the Hsp70 type family reversibly bind to substrate polypeptides via the substrate binding domain (SBD). Ty ...
Table S4: Domains present in a network region characterized by
... This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 205 to 258 amino acids in length. This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Prot ...
... This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 205 to 258 amino acids in length. This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Prot ...
Building the Tree of Life
... Genetic analysis has revealed that the two main prokaryotic kingdoms are more different from each other, and from eukaryotes, than previously thought. So, biologists established a new taxonomic category—the domain. A domain is a larger, more inclusive category than a kingdom. Under this system, ther ...
... Genetic analysis has revealed that the two main prokaryotic kingdoms are more different from each other, and from eukaryotes, than previously thought. So, biologists established a new taxonomic category—the domain. A domain is a larger, more inclusive category than a kingdom. Under this system, ther ...
A Figure S7. A. Standard curve of actin quantification using silver
... Figure S7. A. Standard curve of actin quantification using silver staining. Actin standards were prepared by serial dilution and separated using SDS gel electrophoresis. Silver staining was carried out and band quantification was accomplished using the BioRad QuantityOne software. Linear regression ...
... Figure S7. A. Standard curve of actin quantification using silver staining. Actin standards were prepared by serial dilution and separated using SDS gel electrophoresis. Silver staining was carried out and band quantification was accomplished using the BioRad QuantityOne software. Linear regression ...
Where are proton-translocating site(s) and quinone
... site(s)?It is generally believed that the energy coupling site(s) in complex I is located between Center N2 (the highest mid redox potential [4Fe-4S] cluster) and electron acceptor quinone. However, the location(s) has not been identified yet. In addition, there is no consensus about the number of c ...
... site(s)?It is generally believed that the energy coupling site(s) in complex I is located between Center N2 (the highest mid redox potential [4Fe-4S] cluster) and electron acceptor quinone. However, the location(s) has not been identified yet. In addition, there is no consensus about the number of c ...
Document
... toxin, and heat-labile enterotoxin. These toxin proteins are ADP- ribosyl transferases that modify target proteins in human cells. For example, cholera toxin ADP- ribosylates G proteins, causing massive fluid secretion from the lining of the small intestine, resulting in lifethreatening diarrhea. P. ...
... toxin, and heat-labile enterotoxin. These toxin proteins are ADP- ribosyl transferases that modify target proteins in human cells. For example, cholera toxin ADP- ribosylates G proteins, causing massive fluid secretion from the lining of the small intestine, resulting in lifethreatening diarrhea. P. ...
Protein domain
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural domains. One domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. Domains vary in length from between about 25 amino acids up to 500 amino acids in length. The shortest domains such as zinc fingers are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be ""swapped"" by genetic engineering between one protein and another to make chimeric proteins.