Involvement of Tumor Necrosis Factor Alpha in Hippocampal
... performance of affected mice in behavioral tasks related to spatial memory. Moreover, lack of TNFα increased the expression of nerve growth factor (NGF), but not brain-derived neurotrophic factor (BDNF), following performance of the learning task. Our results suggest that TNFα actively influences hi ...
... performance of affected mice in behavioral tasks related to spatial memory. Moreover, lack of TNFα increased the expression of nerve growth factor (NGF), but not brain-derived neurotrophic factor (BDNF), following performance of the learning task. Our results suggest that TNFα actively influences hi ...
Tracking the Emergence of Conceptual Knowledge during Human
... Eichenbaum et al., 2007) and for the reward value of individual stimuli and actions, the latter captured successfully by reinforcement learning (RL) algorithms (e.g., Montague et al., 2006; Rangel et al., 2008). While a collection of isolated memories or reward associations may allow simple inferenc ...
... Eichenbaum et al., 2007) and for the reward value of individual stimuli and actions, the latter captured successfully by reinforcement learning (RL) algorithms (e.g., Montague et al., 2006; Rangel et al., 2008). While a collection of isolated memories or reward associations may allow simple inferenc ...
The Cholinergic Hypothesis of Age and Alzheimer`s Disease
... and Roberts, 1988) as well as centrally acting nicotinic-cholinergic antagonists such as mecamylamine (Levin, 1992). Both muscarinic antagonists (Terry et al., 1993a; Vitiello et al., 1997) and nicotinic antagonists (Elrod and Buccafusco, 1991; Newhouse et al., 1994) have also been shown to impair m ...
... and Roberts, 1988) as well as centrally acting nicotinic-cholinergic antagonists such as mecamylamine (Levin, 1992). Both muscarinic antagonists (Terry et al., 1993a; Vitiello et al., 1997) and nicotinic antagonists (Elrod and Buccafusco, 1991; Newhouse et al., 1994) have also been shown to impair m ...
Poly(A) Binding Protein Nuclear 1 regulates the
... bioRxiv preprint first posted online Mar. 27, 2017; doi: http://dx.doi.org/10.1101/121194. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license. ...
... bioRxiv preprint first posted online Mar. 27, 2017; doi: http://dx.doi.org/10.1101/121194. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license. ...
09_Berman - Structural Biology Knowledgebase
... The PSI Structural Genomics Knowledgebase (PSI SG KB) will turn the products of the PSI effort into major advances in knowledge that can be used to understand living systems and human disease The PSI SG KB will be a key resource for the advancement of biology, biochemistry, functional genomics, ...
... The PSI Structural Genomics Knowledgebase (PSI SG KB) will turn the products of the PSI effort into major advances in knowledge that can be used to understand living systems and human disease The PSI SG KB will be a key resource for the advancement of biology, biochemistry, functional genomics, ...
Neuron Production, Neuron Number, and Structure Size Are
... the total number of neurons in the hippocampus did not. These results were interpreted as evidence for neuronal replacement. Because more neurons were incorporated into the HF in the fall, but the total number of HF neurons did not increase, other neurons must have been lost in order for neuron numb ...
... the total number of neurons in the hippocampus did not. These results were interpreted as evidence for neuronal replacement. Because more neurons were incorporated into the HF in the fall, but the total number of HF neurons did not increase, other neurons must have been lost in order for neuron numb ...
Pre-synaptic Terminal Dynamics in the Hippocampus
... There are several types of structural changes associated to various forms of activity-dependent alterations in both vertebrates and invertebrates. Early examples come from studies of sensory deprivation during critical periods of postnatal development. In kittens, using monocular deprivation Hubel a ...
... There are several types of structural changes associated to various forms of activity-dependent alterations in both vertebrates and invertebrates. Early examples come from studies of sensory deprivation during critical periods of postnatal development. In kittens, using monocular deprivation Hubel a ...
Dendritic RNA Transport: Dynamic Spatio-Temporal Control of Neuronal Gene Expression
... response to neuronal stimulation, an idea that currently has enormous support and has led to breakthroughs in visualizing specific transcript motility in living cells. Structure and Composition of Dendritic ...
... response to neuronal stimulation, an idea that currently has enormous support and has led to breakthroughs in visualizing specific transcript motility in living cells. Structure and Composition of Dendritic ...
Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in
... hippocampal cultures derived from these 5xFAD animals and their wild type littermates showed similar cell density and cell survival after 12 days in vitro (DIV) (Supplementary Figure 1 in Supplementary Material available online at http://dx.doi.org/10.1155/2016/4145708). These cultures were transfec ...
... hippocampal cultures derived from these 5xFAD animals and their wild type littermates showed similar cell density and cell survival after 12 days in vitro (DIV) (Supplementary Figure 1 in Supplementary Material available online at http://dx.doi.org/10.1155/2016/4145708). These cultures were transfec ...
14. Development and Plasticity
... all presynaptic spike trains) in simulation of an IF-neuron with 1000 input channels. The spike trains that lead to the results shown by stars were generated with each weight value fixed to value 0.015. The cross-correlations are consistent with zero when considered within the variance indicated by ...
... all presynaptic spike trains) in simulation of an IF-neuron with 1000 input channels. The spike trains that lead to the results shown by stars were generated with each weight value fixed to value 0.015. The cross-correlations are consistent with zero when considered within the variance indicated by ...
14. Development and Plasticity
... all presynaptic spike trains) in simulation of an IF-neuron with 1000 input channels. The spike trains that lead to the results shown by stars were generated with each weight value fixed to value 0.015. The cross-correlations are consistent with zero when considered within the variance indicated by ...
... all presynaptic spike trains) in simulation of an IF-neuron with 1000 input channels. The spike trains that lead to the results shown by stars were generated with each weight value fixed to value 0.015. The cross-correlations are consistent with zero when considered within the variance indicated by ...
Synaptic plasticity: taming the beast
... ron is effectively summed into a relatively constant input current. In response to such input, a neuron will fire in much the same way as it would in response to the injection of the equivalent constant current through an electrode, by firing rapidly and regularly. In such a situation, the neuron ac ...
... ron is effectively summed into a relatively constant input current. In response to such input, a neuron will fire in much the same way as it would in response to the injection of the equivalent constant current through an electrode, by firing rapidly and regularly. In such a situation, the neuron ac ...
Nancy A. O`Rourke Nicholas C. Weiler Kristina D
... identified 60 highly enriched proteins, some of which were not seen in heterogenous synapse purifications and may be specific to this synapse type 12. Future studies such as this will greatly contribute to a better understanding of synaptic diversity. Multiple lines of evidence from genomic, immunoh ...
... identified 60 highly enriched proteins, some of which were not seen in heterogenous synapse purifications and may be specific to this synapse type 12. Future studies such as this will greatly contribute to a better understanding of synaptic diversity. Multiple lines of evidence from genomic, immunoh ...
A Novel Mechanism and Treatment Target for Presynaptic
... blind-drunk mouse, PPI abnormalities in adulthood are further enhanced if the mice are exposed to prenatal stress (Oliver and Davies, 2009). Treatment of blind-drunk mice with clozapine restored PPI to near normal levels; haloperidol was also moderately effective (Oliver and Davies, 2009). Interesti ...
... blind-drunk mouse, PPI abnormalities in adulthood are further enhanced if the mice are exposed to prenatal stress (Oliver and Davies, 2009). Treatment of blind-drunk mice with clozapine restored PPI to near normal levels; haloperidol was also moderately effective (Oliver and Davies, 2009). Interesti ...
Regulation of thalamocortical axon branching by BDNF and synaptic vesicle cycling
... clathrin-dependent endocytosis might be important for axon development. The aim of this work is to determine if BDNF affects axon branching in the thalamocortical projection and to investigate whether synaptic vesicle cycling might influence this component of development. We demonstrate that exogenou ...
... clathrin-dependent endocytosis might be important for axon development. The aim of this work is to determine if BDNF affects axon branching in the thalamocortical projection and to investigate whether synaptic vesicle cycling might influence this component of development. We demonstrate that exogenou ...
MUSHROOM BODY MEMOIR: FROM MAPS TO MODELS
... How are odour qualities represented in the mushroom bodies? This is an open question. For our discussion of olfactory memory, I will simplify the problem (BOX 2). Let us assume that the glomeruli in the antennal lobe are all-or-none detectors of POQs, and that each odour is defined for an animal by ...
... How are odour qualities represented in the mushroom bodies? This is an open question. For our discussion of olfactory memory, I will simplify the problem (BOX 2). Let us assume that the glomeruli in the antennal lobe are all-or-none detectors of POQs, and that each odour is defined for an animal by ...
If so, is trkB mRNA in SNB motor neurons
... Fluorescent ICC using antibodies to detect fluorogold, VGLUT1, and trkB in a Sham GDX rat. Immunorectivity for trkB was observed in SNB motoneurons. Many terminals contacting SNB motoneurons contained VGLUT1 and trkB. Red arrowheads: trkB immunoreactivity in SNB soma. White arrowheads: VGLUT1-positi ...
... Fluorescent ICC using antibodies to detect fluorogold, VGLUT1, and trkB in a Sham GDX rat. Immunorectivity for trkB was observed in SNB motoneurons. Many terminals contacting SNB motoneurons contained VGLUT1 and trkB. Red arrowheads: trkB immunoreactivity in SNB soma. White arrowheads: VGLUT1-positi ...
Role of Slitrk Family Members in
... 3.7.2. Slitrks and their CNS functions 3.7.2.1. Early experiments with cell lines and primary neurons ..................... 60 3.7.2.2. Interaction between Slitrk1 and the 14-3-3 proteins ......................... 60 3.7.2.3. Characterization of Slitrks knockout mice ................................ ...
... 3.7.2. Slitrks and their CNS functions 3.7.2.1. Early experiments with cell lines and primary neurons ..................... 60 3.7.2.2. Interaction between Slitrk1 and the 14-3-3 proteins ......................... 60 3.7.2.3. Characterization of Slitrks knockout mice ................................ ...
Neuronal RNA Localization and the Cytoskeleton
... For example, tubulin appears to be restricted to the cell body, according to in situ hybridization analysis of rat brain and cultured hippocampal neurons (Garner et al. 1988; Kleiman et al. 1994). The localization of mRNAs into axons has also been demonstrated, although not all axons may utilize thi ...
... For example, tubulin appears to be restricted to the cell body, according to in situ hybridization analysis of rat brain and cultured hippocampal neurons (Garner et al. 1988; Kleiman et al. 1994). The localization of mRNAs into axons has also been demonstrated, although not all axons may utilize thi ...
Expression of ml-m4 Muscarinic Acetylcholine Receptor Proteins in
... Nilsson et al., 1992; Callahan et al., 1993). Also, degeneration of basal forebrain cholinergic systems may contribute to memory loss and other cognitive deficits in Alzheimer’s disease (Coyle et al., 1983). Indeed, the potential for cholinergic replacement therapies in dementia (McKinney and Coyle, ...
... Nilsson et al., 1992; Callahan et al., 1993). Also, degeneration of basal forebrain cholinergic systems may contribute to memory loss and other cognitive deficits in Alzheimer’s disease (Coyle et al., 1983). Indeed, the potential for cholinergic replacement therapies in dementia (McKinney and Coyle, ...
MMNeuropharm2011
... NMDAR activation and subsequently prevents the induction of activity-dependent LTP, suggesting a shared expression mechanism of the two types of plasticity (Ungless et al., 2001). Therefore in vivo cocaine exposure elicits long-lasting synaptic adaptations at excitatory synapses on VTA DA neurons. F ...
... NMDAR activation and subsequently prevents the induction of activity-dependent LTP, suggesting a shared expression mechanism of the two types of plasticity (Ungless et al., 2001). Therefore in vivo cocaine exposure elicits long-lasting synaptic adaptations at excitatory synapses on VTA DA neurons. F ...
Insights into Rapid Modulation of Neuroplasticity by Brain Estrogens
... interchange between these terms. We use the term cognition, or cognitive function, to refer to processes such as attention, learning, and memory that require frontal brain areas including the cortex and hippocampus. Owing to the burgeoning interest in understanding the effect of rapid estrogenic sig ...
... interchange between these terms. We use the term cognition, or cognitive function, to refer to processes such as attention, learning, and memory that require frontal brain areas including the cortex and hippocampus. Owing to the burgeoning interest in understanding the effect of rapid estrogenic sig ...
Cell Type-Specific, Presynaptic LTP of Inhibitory Synapses on Fast
... blockade of AMPA and NMDA receptors elicited synaptic potentials with a relatively slow decay (Fig. 1 A). The onset latency of these synaptic potentials was 3.1 ms. The mean onset latency for the 14 FS-GABA neurons was 2.7 ⫾ 0.1 (SEM) ms. Such a short latency and a very small fluctuation of the late ...
... blockade of AMPA and NMDA receptors elicited synaptic potentials with a relatively slow decay (Fig. 1 A). The onset latency of these synaptic potentials was 3.1 ms. The mean onset latency for the 14 FS-GABA neurons was 2.7 ⫾ 0.1 (SEM) ms. Such a short latency and a very small fluctuation of the late ...
166 - UCSF Physiology - University of California, San Francisco
... locations between neuronal axons and dendrites. On the presynaptic side, it depends on the proper assembly of different synaptic vesicle pools at the active zone (Rosenmund and Stevens, 1996; Schneggenburger et al., 1999; Wu and Borst, 1999; Schikorski and Stevens, 2001; Mozhayeva et al., 2002; Tasc ...
... locations between neuronal axons and dendrites. On the presynaptic side, it depends on the proper assembly of different synaptic vesicle pools at the active zone (Rosenmund and Stevens, 1996; Schneggenburger et al., 1999; Wu and Borst, 1999; Schikorski and Stevens, 2001; Mozhayeva et al., 2002; Tasc ...