alzheimer-like changes of protein kinase b and glycogen synthase
... Various experimental models of Alzheimer’s disease have been introduced today, and actually no single model has been found to be truly representative of the sporadic type of Alzheimer's disease, unrelated to the genetic manipulations or inheritance. Therefore, considering the fact that Alzheimer’s d ...
... Various experimental models of Alzheimer’s disease have been introduced today, and actually no single model has been found to be truly representative of the sporadic type of Alzheimer's disease, unrelated to the genetic manipulations or inheritance. Therefore, considering the fact that Alzheimer’s d ...
1 Behavioral Dynamics of Episodic Memory
... but I can also recollect portions of episodes from the more distant past, with actions, point of view, and segments of trajectories. I can mentally relive many segments of my past life. This book will focus on the brain mechanisms of episodic memory. On the behavioral level, I will focus on the capa ...
... but I can also recollect portions of episodes from the more distant past, with actions, point of view, and segments of trajectories. I can mentally relive many segments of my past life. This book will focus on the brain mechanisms of episodic memory. On the behavioral level, I will focus on the capa ...
Memory Consolidation and REM Sleep
... and memory. Rats subjected to learning tasks demonstrated increased REM sleep after these tests. This reflects that learning induces REM sleep. In addition, it was found that rats subjected to learning fell into REM sleep faster if they had experienced more trials of the learning activity. A possibl ...
... and memory. Rats subjected to learning tasks demonstrated increased REM sleep after these tests. This reflects that learning induces REM sleep. In addition, it was found that rats subjected to learning fell into REM sleep faster if they had experienced more trials of the learning activity. A possibl ...
The Status of Semantic and Episodic Memory in Amnesia
... words). H.M. had been tested on these subtests 20 times between 1953 (preoperatively) and 2000. When his performance across these test sessions was analyzed, there was no main effect of time, suggesting that H.M.’s semantic knowledge had remained consistent over time, and was not negatively affected ...
... words). H.M. had been tested on these subtests 20 times between 1953 (preoperatively) and 2000. When his performance across these test sessions was analyzed, there was no main effect of time, suggesting that H.M.’s semantic knowledge had remained consistent over time, and was not negatively affected ...
Protein-Engineered Biocatalysts in Industry
... A number of methods are known for specifically substituting individual amino acids in a protein Requires a lot of structural information to be useful, often a crystal structure and computational modeling ...
... A number of methods are known for specifically substituting individual amino acids in a protein Requires a lot of structural information to be useful, often a crystal structure and computational modeling ...
Molecular heterogeneity of central synapses: afferent and target
... requires retrograde signaling. Distribution of some proteins is regulated by cellular domain (Fig. 1f). Some aspects of synaptic composition are determined by synapse location on the cell, and this in turn can be determined intrinsic features of the neuron. Thus certain domains of axons or dendrites ...
... requires retrograde signaling. Distribution of some proteins is regulated by cellular domain (Fig. 1f). Some aspects of synaptic composition are determined by synapse location on the cell, and this in turn can be determined intrinsic features of the neuron. Thus certain domains of axons or dendrites ...
The Influence of Odor and Emotion on Memory
... emotional event is encoded also appear to be active during retrieval of that emotional memory (Maratos et al., 2001). Another way that emotion and memory appear to be connected can be seen by the effect one’s emotional mood can have on the emotionality of the memory recalled. For example, if one beg ...
... emotional event is encoded also appear to be active during retrieval of that emotional memory (Maratos et al., 2001). Another way that emotion and memory appear to be connected can be seen by the effect one’s emotional mood can have on the emotionality of the memory recalled. For example, if one beg ...
in search of memory traces
... But even for a simple behavioral phenomenon like habituation, the neural substrate can prove to be complex, particularly for long-lasting habituation, e.g., between sessions as opposed to within session response decrements. In the Aplysia cellular monosynaptic system, Ezzeddine & Glanzman (2003) hav ...
... But even for a simple behavioral phenomenon like habituation, the neural substrate can prove to be complex, particularly for long-lasting habituation, e.g., between sessions as opposed to within session response decrements. In the Aplysia cellular monosynaptic system, Ezzeddine & Glanzman (2003) hav ...
Synaptic and extrasynaptic traces of long-term memory
... 30,000 excitatory synapses (Megías et al., 2001); in the mouse cerebral cortex, the corresponding number is 8000 (Braitenberg and Schüz, 1998). The continual shower of spikes arriving to all these synapses differs in an essential way from the input streams to gates in a digital computer, which are ...
... 30,000 excitatory synapses (Megías et al., 2001); in the mouse cerebral cortex, the corresponding number is 8000 (Braitenberg and Schüz, 1998). The continual shower of spikes arriving to all these synapses differs in an essential way from the input streams to gates in a digital computer, which are ...
Ribosomes of Mouse Liver following
... Ribosomes. DMNA is activated by a microsomal enzyme system (19), and it might therefore be suspected that CANCER RESEARCH ...
... Ribosomes. DMNA is activated by a microsomal enzyme system (19), and it might therefore be suspected that CANCER RESEARCH ...
The Spatiotemporal Dynamics of Autobiographical
... amygdala were modulated during retrieval by ratings of emotional intensity. However, in this study, the amygdala effects were subthreshold when considering autobiographical memories that occurred only once (as opposed to repeated events). The question of when, during the process of retrieving and ma ...
... amygdala were modulated during retrieval by ratings of emotional intensity. However, in this study, the amygdala effects were subthreshold when considering autobiographical memories that occurred only once (as opposed to repeated events). The question of when, during the process of retrieving and ma ...
Arabidopsis thaliana, a plant model organism for
... environmental stress (Buschmann and Lloyd, 2008). The conservation of actin-interacting proteins between plants and neurons has been discussed, including the possibility that they form ‘plant synapses’ between cells (Baluška et al., 2005). Here the similarities between the plant microtubule cytoske ...
... environmental stress (Buschmann and Lloyd, 2008). The conservation of actin-interacting proteins between plants and neurons has been discussed, including the possibility that they form ‘plant synapses’ between cells (Baluška et al., 2005). Here the similarities between the plant microtubule cytoske ...
A first-principle for the nervous system
... During associative learning of two stimuli, the inputs are expected to converge at certain locations to induce a specific change such that at a later time, the presence of one stimulus can reactivate this change for inducing the internal sensation of memory of the second stimulus (Fig.1a). The next ...
... During associative learning of two stimuli, the inputs are expected to converge at certain locations to induce a specific change such that at a later time, the presence of one stimulus can reactivate this change for inducing the internal sensation of memory of the second stimulus (Fig.1a). The next ...
FOREFRONT REVIEW WHAT IS THE MAMMALIAN DENTATE GYRUS GOOD FOR?
... addition, it contains axons that originate in a limited number of sources, the main ones being the perforant path axons arising from the entorhinal cortex and the intrinsic associational and commissural systems which originate in the ipsilateral and contralateral hilar mossy cells, respectively. Add ...
... addition, it contains axons that originate in a limited number of sources, the main ones being the perforant path axons arising from the entorhinal cortex and the intrinsic associational and commissural systems which originate in the ipsilateral and contralateral hilar mossy cells, respectively. Add ...
Hippocampus duality: memory and novelty detection are subserved
... brain region is apparently responsible both for detecting out-of-context stimuli and also for matching stimuli in the environment to stored representations. Each of these aspects of cognition is associated with frequently used experimental paradigms and robust electrophysiological signatures, but th ...
... brain region is apparently responsible both for detecting out-of-context stimuli and also for matching stimuli in the environment to stored representations. Each of these aspects of cognition is associated with frequently used experimental paradigms and robust electrophysiological signatures, but th ...
Eichenbaum et al., 2012a, #15 - Fortin Lab @ UCI
... successful learning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Conclusions . . . . . . . . . . . . . ...
... successful learning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Conclusions . . . . . . . . . . . . . ...
A Neuropsychological Model of Memory and Consciousness
... the target at a rate significantly above chance level, though on explicit tests no savings was noted (see also De Haan, Young, & Newcombe, 1987). Together, these studies suggest that if an input module is relatively intact, it can store new information as a perceptual record, but its shallow output ...
... the target at a rate significantly above chance level, though on explicit tests no savings was noted (see also De Haan, Young, & Newcombe, 1987). Together, these studies suggest that if an input module is relatively intact, it can store new information as a perceptual record, but its shallow output ...
What do you notice? - Neural Crossroads Laboratory
... Multiple mechanisms for theta generation: CA1 pyramidal neurons have a resonance frequency at theta when slightly depolarized or hyperpolarized: due to hyperpolarization-activated non-specific cation HCN channels ...
... Multiple mechanisms for theta generation: CA1 pyramidal neurons have a resonance frequency at theta when slightly depolarized or hyperpolarized: due to hyperpolarization-activated non-specific cation HCN channels ...
Review Article Long-Term Memory Search across the
... the calcium-dependent kinase CAMKII and are able to spread laterally tens of microns away from the original LTP site [67–69]. Importantly, LTP may be induced by diffusing enzymes even in certain silent spines [66]. The entire dendritic branch is then able to memorize the stimulus direction for short ...
... the calcium-dependent kinase CAMKII and are able to spread laterally tens of microns away from the original LTP site [67–69]. Importantly, LTP may be induced by diffusing enzymes even in certain silent spines [66]. The entire dendritic branch is then able to memorize the stimulus direction for short ...
brain derived neurotrophic factor transport and physiological
... prodomain and mature neurotrophins, and are sorted to constitutive or regulated secretory pathway and released. Brain-derived neurotrophic factor (BDNF) plays a pivotal role in the brain development and in the pathogenesis of neurological diseases. In Huntington’s disease, the defective transport of ...
... prodomain and mature neurotrophins, and are sorted to constitutive or regulated secretory pathway and released. Brain-derived neurotrophic factor (BDNF) plays a pivotal role in the brain development and in the pathogenesis of neurological diseases. In Huntington’s disease, the defective transport of ...
pdf
... elements onto a conjunctive representation1,2. This convergence of information is crucial not only for simple associations between stimulus features, but just as much for the binding of relationships between places, people, objects and events into complex episodic memories. But how does the brain im ...
... elements onto a conjunctive representation1,2. This convergence of information is crucial not only for simple associations between stimulus features, but just as much for the binding of relationships between places, people, objects and events into complex episodic memories. But how does the brain im ...
Cell Assembly Sequences Arising from Spike
... model was driven by temporally and spatially unstructured noise I(t); different instances of Figure 1. Time prediction from sequential neural activity in a memory task. A, Average raster over 18 s for a population of noise was thus the only difference between trisimultaneously recorded neurons durin ...
... model was driven by temporally and spatially unstructured noise I(t); different instances of Figure 1. Time prediction from sequential neural activity in a memory task. A, Average raster over 18 s for a population of noise was thus the only difference between trisimultaneously recorded neurons durin ...
Stressed Memories - Journal of Neuroscience
... language. The stressful movie clips contained scenes with aggressive behavior and violence against men and women. Occasionally, people in the video could be heard shouting and crying out in anger, pain, or distress. Previous studies have confirmed the effectiveness of these movie clips in inducing s ...
... language. The stressful movie clips contained scenes with aggressive behavior and violence against men and women. Occasionally, people in the video could be heard shouting and crying out in anger, pain, or distress. Previous studies have confirmed the effectiveness of these movie clips in inducing s ...
The common northern periwinkle, Littorina littorea
... (Greenway and Storey, 2001). However, L. littorea muscle PK showed similar sensitivity to anoxia in both seasons (Greenway and Storey, 200). Seasonal changes in isoform and in anoxia effects on enzymes may aid prolonged periods of cold-induced inactivity with closed valves or opercula and self-impos ...
... (Greenway and Storey, 2001). However, L. littorea muscle PK showed similar sensitivity to anoxia in both seasons (Greenway and Storey, 200). Seasonal changes in isoform and in anoxia effects on enzymes may aid prolonged periods of cold-induced inactivity with closed valves or opercula and self-impos ...
NOBA Memory (Encoding, Storage, Retrieval)
... Whenever forgetting or misremembering occurs, we can ask, at which stage in the learning/ memory process was there a failure?—though it is often difficult to answer this question with precision. One reason for this inaccuracy is that the three stages are not as discrete as our description implies. R ...
... Whenever forgetting or misremembering occurs, we can ask, at which stage in the learning/ memory process was there a failure?—though it is often difficult to answer this question with precision. One reason for this inaccuracy is that the three stages are not as discrete as our description implies. R ...