Anti-platelet agents
... • Aspirin produces the irreversible inhibition of the enzyme cyclooxygenase and therefore causes irreversible inhibition of platelets for the rest of their lifespan (7 days) ...
... • Aspirin produces the irreversible inhibition of the enzyme cyclooxygenase and therefore causes irreversible inhibition of platelets for the rest of their lifespan (7 days) ...
Print - Circulation Research
... end of occlusion and in the early recovery period, but this trend did not achieve statistical significance. Segment length (normalized to control) rose to 1.06+0.08 at end-diastole and 1.25 ±0.11 at end-systole, resulting in a decline of segment shortening to 5±+2% (0.25+±0.11 normalized to control) ...
... end of occlusion and in the early recovery period, but this trend did not achieve statistical significance. Segment length (normalized to control) rose to 1.06+0.08 at end-diastole and 1.25 ±0.11 at end-systole, resulting in a decline of segment shortening to 5±+2% (0.25+±0.11 normalized to control) ...
Prognostic Value of Angiographic Indices of Coronary Artery
... The univariate results of the Cox proportional hazard model and life table analyses for the left ventricular score and the eight arteriographic indices are shown in Table I. The chi-square statistic and the log-rank statistic test the statistical significance of the indices for predicting survival. ...
... The univariate results of the Cox proportional hazard model and life table analyses for the left ventricular score and the eight arteriographic indices are shown in Table I. The chi-square statistic and the log-rank statistic test the statistical significance of the indices for predicting survival. ...
AHA Conference Proceedings
... during balloon dilation and/or stenting, resulting from “active” disruption of the atherosclerotic plaque (type II embolization). The incidence of type I or type II atheroembolization during diagnostic or interventional procedures is not known. The diagnosis is suspected when subacute renal failure ...
... during balloon dilation and/or stenting, resulting from “active” disruption of the atherosclerotic plaque (type II embolization). The incidence of type I or type II atheroembolization during diagnostic or interventional procedures is not known. The diagnosis is suspected when subacute renal failure ...
Diapositive 1 - Moodle Lille 2
... • ENHANCE raises deep doubts about the use of CIMT and general surrogate markers in clinical trial • This study harms the commercial lifetime of VYTORIN ...
... • ENHANCE raises deep doubts about the use of CIMT and general surrogate markers in clinical trial • This study harms the commercial lifetime of VYTORIN ...
Drug utilisation sub-committee (DUSC)
... Together Figure 5 and 7 show that although ticagrelor has taken a small proportion of the market of clopidogrel and clopidogrel with aspirin, it is now the most commonly used medicine for acute coronary syndrome. Table 2: Prescriptions of medicines for acute coronary syndrome since December 2011 ...
... Together Figure 5 and 7 show that although ticagrelor has taken a small proportion of the market of clopidogrel and clopidogrel with aspirin, it is now the most commonly used medicine for acute coronary syndrome. Table 2: Prescriptions of medicines for acute coronary syndrome since December 2011 ...
2002-2004
... for isolated coronary artery bypass surgery (CABG), valve surgery, and the two procedures done in combination. Isolated CABG represents the majority of adult cardiac surgeries performed, and we have reported risk-adjusted outcomes for that procedure for over 10 years. However, many additional patien ...
... for isolated coronary artery bypass surgery (CABG), valve surgery, and the two procedures done in combination. Isolated CABG represents the majority of adult cardiac surgeries performed, and we have reported risk-adjusted outcomes for that procedure for over 10 years. However, many additional patien ...
Automated Analysis of the 12-lead ECG in the Emergency
... (GE Medical Systems, Milwaukee, WI) at the JHH ED in the time period from January 16, 2012 to June 22, 2012. Each 12-lead ECG was reviewed and clinically evaluated by 2 investigators (D.G. and L.G.T.), blinded to all other clinical data. For each ECG, investigators evaluated cardiac rhythm and deter ...
... (GE Medical Systems, Milwaukee, WI) at the JHH ED in the time period from January 16, 2012 to June 22, 2012. Each 12-lead ECG was reviewed and clinically evaluated by 2 investigators (D.G. and L.G.T.), blinded to all other clinical data. For each ECG, investigators evaluated cardiac rhythm and deter ...
An open-label, randomized, controlled, multicenter study exploring
... Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia of clinical significance, 1 with a prevalence ranging from less than 1% among people younger than 60 years to approximately 10% among those older than 80 years. 2 More than 6 million patients in Europe and approximately 2.3 mil ...
... Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia of clinical significance, 1 with a prevalence ranging from less than 1% among people younger than 60 years to approximately 10% among those older than 80 years. 2 More than 6 million patients in Europe and approximately 2.3 mil ...
CARDOXIN doctor leaflet
... Comparable reactions to exercise-induced stress may occur. Therefore dipyridamolethallium scanning should be performed with continuous ECG monitoring of the patient. When myocardial imaging is performed with intravenous Cardoxin, parenteral aminophylline should be readily available for relieving adv ...
... Comparable reactions to exercise-induced stress may occur. Therefore dipyridamolethallium scanning should be performed with continuous ECG monitoring of the patient. When myocardial imaging is performed with intravenous Cardoxin, parenteral aminophylline should be readily available for relieving adv ...
SLCO1B1 - PGXL Laboratories
... SLCO1B1 is the gene that makes a liver enzyme called OATP1B1, which helps transport statins medications into the liver more effectively. Roughly 15% of the population possesses the *5 variant, an inherited form of SLOC1B1 which increases risk of statin-induced muscle damage, or myopathy, by 3 to 5 f ...
... SLCO1B1 is the gene that makes a liver enzyme called OATP1B1, which helps transport statins medications into the liver more effectively. Roughly 15% of the population possesses the *5 variant, an inherited form of SLOC1B1 which increases risk of statin-induced muscle damage, or myopathy, by 3 to 5 f ...
A ngiographic Study of Normal Coronary A rteries as First
... Reciprocity exists between the right and left coronary arteries of the human heart. The variations have the greatest implication with regard to the blood supply of the crux and the posterior interventricular sulcus. In 80% - 90% of the cases the right coronary artery reaches and supplies this area s ...
... Reciprocity exists between the right and left coronary arteries of the human heart. The variations have the greatest implication with regard to the blood supply of the crux and the posterior interventricular sulcus. In 80% - 90% of the cases the right coronary artery reaches and supplies this area s ...
Cardiac αVβ3 integrin expression following acute - Heart
... restoration of myocardial integrity.2 In some circumstances, maladaptive persistent processes may encourage remodelling and scarring to extend into the myocardium long after the initial causative injury. This may lead to progressive ventricular dilatation, ventricular dysfunction and heart failure. ...
... restoration of myocardial integrity.2 In some circumstances, maladaptive persistent processes may encourage remodelling and scarring to extend into the myocardium long after the initial causative injury. This may lead to progressive ventricular dilatation, ventricular dysfunction and heart failure. ...
Histopathology of Human Coronary Atherosclerosis by
... '463% cholesterol, whereas noncalcified plaques had '26610% and calcified plaques '19610% cholesterol in the noncalcified regions. The average relative weight of calcium salts was 162% in noncalcified plaques and 41621% in calcified plaques. To make this quantitative chemical information clinically ...
... '463% cholesterol, whereas noncalcified plaques had '26610% and calcified plaques '19610% cholesterol in the noncalcified regions. The average relative weight of calcium salts was 162% in noncalcified plaques and 41621% in calcified plaques. To make this quantitative chemical information clinically ...
Left ventricular ejection fraction after acute coronary occlusion in
... global and regional ejection fraction was used in the analysis. The left ventricular region manifesting the maximum change in regional ejection fraction after acute coronary occlusion was identified for each dog.6 The absolute acute decrease in ejection fraction was divided by the control value, and ...
... global and regional ejection fraction was used in the analysis. The left ventricular region manifesting the maximum change in regional ejection fraction after acute coronary occlusion was identified for each dog.6 The absolute acute decrease in ejection fraction was divided by the control value, and ...
Reflection in the Arterial System and the Risk of Coronary Heart
... men ranging in age from 35 to 78 years between January 1990 and March 1999 in whom cardiac catheterizations were done for the first time. Of these, 831 were excluded from this study because of acute myocardial infarction, the presence of local asynergy shown by left ventriculography, chronic renal f ...
... men ranging in age from 35 to 78 years between January 1990 and March 1999 in whom cardiac catheterizations were done for the first time. Of these, 831 were excluded from this study because of acute myocardial infarction, the presence of local asynergy shown by left ventriculography, chronic renal f ...
MRI in the assessment of ischaemic heart disease
... imaging, the diagnostic accuracy increased further (up to 93%).23 A normal stress CMR has a high negative predictive value in troponin-negative ACS.24 In an NSTEMI study, stress CMR reliably predicted significant coronary stenosis (sensitivity, 96%; specificity, 83%). Moreover, CMR assessment was supe ...
... imaging, the diagnostic accuracy increased further (up to 93%).23 A normal stress CMR has a high negative predictive value in troponin-negative ACS.24 In an NSTEMI study, stress CMR reliably predicted significant coronary stenosis (sensitivity, 96%; specificity, 83%). Moreover, CMR assessment was supe ...
Both in - Society for Heart Attack Prevention and
... In this report, the Screening for Heart Attack Prevention and Education (SHAPE) Task Force presents a new practice guideline for cardiovascular screening in the asymptomatic at-risk population. In summary, the SHAPE Guideline calls for noninvasive screening of all asymptomatic men 45–75 years of age ...
... In this report, the Screening for Heart Attack Prevention and Education (SHAPE) Task Force presents a new practice guideline for cardiovascular screening in the asymptomatic at-risk population. In summary, the SHAPE Guideline calls for noninvasive screening of all asymptomatic men 45–75 years of age ...
Evaluation with Multidetector CT and MR Imaging in a
... EXPERIMENTAL STUDIES: Heterogeneous Microinfarcts Caused by Coronary Microemboli ...
... EXPERIMENTAL STUDIES: Heterogeneous Microinfarcts Caused by Coronary Microemboli ...
Salutary actionof nicorandil, a new antianginal drug, on myocardial
... At the completion of each experiment, India Ink was injected into the LAD to delineate the perfusion area. The heart was removed and stored overnight in 10% formalin. The heart was sectioned into subepicardium, midmyocardium, and subendocardium of the normal (three pieces) and ischemic regions (five ...
... At the completion of each experiment, India Ink was injected into the LAD to delineate the perfusion area. The heart was removed and stored overnight in 10% formalin. The heart was sectioned into subepicardium, midmyocardium, and subendocardium of the normal (three pieces) and ischemic regions (five ...
Fragmented Wide QRS on a 12-Lead ECG
... QRS (wQRS; duration ⱖ120 ms). We postulate that fragmented wQRS (f-wQRS) due to bundle branch block, premature ventricular complexes, or paced rhythms (f-pQRS) signify myocardial scar and higher mortality. Methods and Results—Patients who underwent cardiac evaluation with nuclear stress imaging or c ...
... QRS (wQRS; duration ⱖ120 ms). We postulate that fragmented wQRS (f-wQRS) due to bundle branch block, premature ventricular complexes, or paced rhythms (f-pQRS) signify myocardial scar and higher mortality. Methods and Results—Patients who underwent cardiac evaluation with nuclear stress imaging or c ...
Implementation of reperfusion therapy in acute myocardial infarction
... trials, performed in a highly experienced medical environment, and comparing primary PCI and thrombolysis. These trials demonstrated that the benefit of primary PCI with respect to death, re-infarction, or stroke is optimal within this time window.5,6 However, more recent reports have shown that PCI ...
... trials, performed in a highly experienced medical environment, and comparing primary PCI and thrombolysis. These trials demonstrated that the benefit of primary PCI with respect to death, re-infarction, or stroke is optimal within this time window.5,6 However, more recent reports have shown that PCI ...
C-Reactive Protein and Heart Failure after Myocardial Infarction in
... cardiovascular risk factors and history of heart failure (data not shown). During follow-up, 75 deaths occurred. There was a strong positive association between CRP and 1-year survivals. One-year survivals were 93% (95% CI, 88%-98%) among patients in the first CRP tertile, 84% (95% CI, 77%-91%) in t ...
... cardiovascular risk factors and history of heart failure (data not shown). During follow-up, 75 deaths occurred. There was a strong positive association between CRP and 1-year survivals. One-year survivals were 93% (95% CI, 88%-98%) among patients in the first CRP tertile, 84% (95% CI, 77%-91%) in t ...
Inhibition of Smooth Muscle Cells Proliferation Using Sirolimus
... Statement of Purpose: Drug Eluting Stents (DES) are significantly popular for reducing in-stent restenosis (ISR) as compared to bare metal stents.1 However, their long term efficacy remains a problem, mainly because of late-stent thrombosis and delayed endothelialization.2 The objective of this proj ...
... Statement of Purpose: Drug Eluting Stents (DES) are significantly popular for reducing in-stent restenosis (ISR) as compared to bare metal stents.1 However, their long term efficacy remains a problem, mainly because of late-stent thrombosis and delayed endothelialization.2 The objective of this proj ...
Clinical Guideline
... diagnosis of stable known or suspected ischemic heart disease (IHD). This is the first of 2 guidelines addressing stable IHD; the second guideline addresses the management of patients with stable IHD (1). Internists and other primary care physicians are the target audiences for this guideline. The t ...
... diagnosis of stable known or suspected ischemic heart disease (IHD). This is the first of 2 guidelines addressing stable IHD; the second guideline addresses the management of patients with stable IHD (1). Internists and other primary care physicians are the target audiences for this guideline. The t ...
Drug-eluting stent
A drug-eluting stent (DES) is a peripheral or coronary stent (a scaffold) placed into narrowed, diseased peripheral or coronary arteries that slowly releases a drug to block cell proliferation. This prevents fibrosis that, together with clots (thrombi), could otherwise block the stented artery, a process called restenosis. The stent is usually placed within the peripheral or coronary artery by an interventional cardiologist or interventional radiologist during an angioplasty procedure.Drug-eluting stents in current clinical use were approved by the FDA after clinical trials showed they were statistically superior to bare-metal stents for the treatment of native coronary artery narrowings, having lower rates of major adverse cardiac events (usually defined as a composite clinical endpoint of death + myocardial infarction + repeat intervention because of restenosis). The first drug-eluting stents to be approved in Europe and the U.S. were coated with paclitaxel or an mTOR inhibitor, such as sirolimus.