Clean, Burn and Shape
... The Shape Nutritional Shake is vegetarian, has very few net carbs and is therefore friendly to blood sugar levels, includes all essential ...
... The Shape Nutritional Shake is vegetarian, has very few net carbs and is therefore friendly to blood sugar levels, includes all essential ...
cytoplasm nucleus and the A specific subset of
... domain is required for shuttling. This domain, however, is not sufficient to promote shuttling of an unrelated protein reporter, suggesting that stable RNA binding mediated by the RNA-recognition motifs may be required for shuttling. Consistent with such a requirement, a double point-mutation in RRM ...
... domain is required for shuttling. This domain, however, is not sufficient to promote shuttling of an unrelated protein reporter, suggesting that stable RNA binding mediated by the RNA-recognition motifs may be required for shuttling. Consistent with such a requirement, a double point-mutation in RRM ...
Stabilization by GroEL, a Molecular Chaperone, and a Periplasmic
... The terminal reductase of such respiration, DMSO reductase (DMSOR), is a soluble periplasmic protein consisting of a single polypeptide and containing one molecule of a molybdenum (Mo) cofactor per molecule (Satoh et al. 1987). DMSOR is synthesized as a precursor, with a molecular mass of 89,206 Da. ...
... The terminal reductase of such respiration, DMSO reductase (DMSOR), is a soluble periplasmic protein consisting of a single polypeptide and containing one molecule of a molybdenum (Mo) cofactor per molecule (Satoh et al. 1987). DMSOR is synthesized as a precursor, with a molecular mass of 89,206 Da. ...
ppt
... Diverse in function, similar in structure – Generally categorized by presence of SNARE domain 60-70 amino acid stretch Heptad repeats Propensity to form coiled-coils ...
... Diverse in function, similar in structure – Generally categorized by presence of SNARE domain 60-70 amino acid stretch Heptad repeats Propensity to form coiled-coils ...
Bioinformatic Software in Web
... Identifying the origin of body fluid samples or the origin of a tissue biopsy. Analyzing protein phenotypes and protein post-translational modifications in fluid, cells, or tissues. Examining the clonality of immunoglobulins and detecting clones which are not seen with conventional techniques. Monit ...
... Identifying the origin of body fluid samples or the origin of a tissue biopsy. Analyzing protein phenotypes and protein post-translational modifications in fluid, cells, or tissues. Examining the clonality of immunoglobulins and detecting clones which are not seen with conventional techniques. Monit ...
bioinformatics - Noble Research Lab
... has been discovered (von Mering et al., 2002). In view of the very small overlap between interactions discovered by various high-throughput studies, some of them using the same method, the actual number of interactions is likely to be much higher. Computational methods are therefore required for dis ...
... has been discovered (von Mering et al., 2002). In view of the very small overlap between interactions discovered by various high-throughput studies, some of them using the same method, the actual number of interactions is likely to be much higher. Computational methods are therefore required for dis ...
Claudins, dietary milk proteins, and intestinal barrier regulation
... 63 amino acids, and contributes to isoform-dependent paracellular selectivity.3 The C-terminus PDZ-binding motif facilitates direct interaction between claudins and scaffolding proteins. Not all claudins contain a PDZbinding domain, claudin-12 being an example.8 The N-terminus consists of seven amino ...
... 63 amino acids, and contributes to isoform-dependent paracellular selectivity.3 The C-terminus PDZ-binding motif facilitates direct interaction between claudins and scaffolding proteins. Not all claudins contain a PDZbinding domain, claudin-12 being an example.8 The N-terminus consists of seven amino ...
Uniikki kuitu
... It consists of biologically significant sites, patterns and profiles that help to reliably identify to which known protein family (if any) a new sequence belongs. ...
... It consists of biologically significant sites, patterns and profiles that help to reliably identify to which known protein family (if any) a new sequence belongs. ...
Insights into the mechanistic details of protein synthesis
... blocked. Credit: Reproduced, with permission, from Ref. a mutation that changed this naturally occurring 1 © 2014 M. Naganuma et al. guanine–uracil pairing to adenine–uracil had subtle but important consequences. The nucleobases in each pairing bind with different geometries, and the mutation introd ...
... blocked. Credit: Reproduced, with permission, from Ref. a mutation that changed this naturally occurring 1 © 2014 M. Naganuma et al. guanine–uracil pairing to adenine–uracil had subtle but important consequences. The nucleobases in each pairing bind with different geometries, and the mutation introd ...
Structural basis of ubiquitylation Andrew P VanDemark and
... Some APC substrates are targeted by their interaction with the Cdc20 protein, a processes that is inhibited by the binding of the checkpoint protein Mad2 to Cdc20. Recent structure determinations have revealed a dramatic conformational change in Mad2 upon binding to a peptide derived from the bindin ...
... Some APC substrates are targeted by their interaction with the Cdc20 protein, a processes that is inhibited by the binding of the checkpoint protein Mad2 to Cdc20. Recent structure determinations have revealed a dramatic conformational change in Mad2 upon binding to a peptide derived from the bindin ...
Dynamin and the Actin Cytoskeleton Cooperatively Regulate
... Syndapin/PACSIN is an endocytic and actin regulatory protein that binds dynamin, synaptojanin, and N-WASP via a C-terminal SH3 domain (Modregger et al., 2000; Qualmann et al., 1999). In addition to this domain, syndapin comprises an N-terminal FCH (Fes/CIP4 homology) domain, followed by a coiled-coi ...
... Syndapin/PACSIN is an endocytic and actin regulatory protein that binds dynamin, synaptojanin, and N-WASP via a C-terminal SH3 domain (Modregger et al., 2000; Qualmann et al., 1999). In addition to this domain, syndapin comprises an N-terminal FCH (Fes/CIP4 homology) domain, followed by a coiled-coi ...
(1) Kinetic Studies -the type of information available from kinetic
... via the formation and decay of one or more E-S complexes but cannot give any indication of the sequence of such complexes. Thus, need additional information from product inhibition, substrate binding in order to distinguish between mechanisms in which a ternary complex is formed in an ordered or a r ...
... via the formation and decay of one or more E-S complexes but cannot give any indication of the sequence of such complexes. Thus, need additional information from product inhibition, substrate binding in order to distinguish between mechanisms in which a ternary complex is formed in an ordered or a r ...
Reitmaier, Rick: Review of Immunoinformatic Approaches to In-silico B-Cell Epitope Prediction
... These regions are also known as complementary determining regions (CDRs) and this term is useful when discussing the general mechanism of binding to antigen or the means by which these regions are created by the host cells. The CDRs of antibodies, as noted earlier, are derived from the combination o ...
... These regions are also known as complementary determining regions (CDRs) and this term is useful when discussing the general mechanism of binding to antigen or the means by which these regions are created by the host cells. The CDRs of antibodies, as noted earlier, are derived from the combination o ...
Computational Tools For Protein Modeling
... classification, phylogenetic reconstruction, etc. The conserved regions (motifs) in multiple sequence alignment often have biological significance in terms of structure and function. A correlated mutation between two residue positions can be used to predict a probable physical contact in structure [ ...
... classification, phylogenetic reconstruction, etc. The conserved regions (motifs) in multiple sequence alignment often have biological significance in terms of structure and function. A correlated mutation between two residue positions can be used to predict a probable physical contact in structure [ ...
Speculations on the origin of the genetic code
... membrane proteins was largely c~ helical (Wallach and Zahler 1966). This necessitated a modification of the Davson-Danielli model for the cellular membrane. The new model was called the fluid-mosaic model. The lipid bilayer of phospholipids was retained but now there were two types of proteins assoc ...
... membrane proteins was largely c~ helical (Wallach and Zahler 1966). This necessitated a modification of the Davson-Danielli model for the cellular membrane. The new model was called the fluid-mosaic model. The lipid bilayer of phospholipids was retained but now there were two types of proteins assoc ...
Lecture 4-5 Slides
... • Pre-mRNA can be spliced in different ways (alternate RNA splicing), thereby generating several different mRNAs which code for several different proteins [e.g. approx. 30,000 human genes can produce mRNAs coding for more than 100,000 proteins] • Introns quickens the evolution of new and biologicall ...
... • Pre-mRNA can be spliced in different ways (alternate RNA splicing), thereby generating several different mRNAs which code for several different proteins [e.g. approx. 30,000 human genes can produce mRNAs coding for more than 100,000 proteins] • Introns quickens the evolution of new and biologicall ...
Nuclear accumulation of hepatitis B virus preS fragments
... Fig. 1. Functional domains within the large hepatitis B surface protein (LHBs) and the amino acid sequences of preS(1-174) region of HBV (adr subtype). (A) The LHBs consists of the preS and S domains, of which the S protein contains four membrane-spanning regions. Depending on the orientation of the ...
... Fig. 1. Functional domains within the large hepatitis B surface protein (LHBs) and the amino acid sequences of preS(1-174) region of HBV (adr subtype). (A) The LHBs consists of the preS and S domains, of which the S protein contains four membrane-spanning regions. Depending on the orientation of the ...
tethering redox proteins to the outer membrane in Neisseria and
... In a system where redox proteins are free to move in the periplasm, there is effectively free tumbling in the aqueous milieu, although diffusion rates may be slow due to constrained space, since the compartment has a high concentration of biomolecules including the cross-linked cell wall polymer pep ...
... In a system where redox proteins are free to move in the periplasm, there is effectively free tumbling in the aqueous milieu, although diffusion rates may be slow due to constrained space, since the compartment has a high concentration of biomolecules including the cross-linked cell wall polymer pep ...
Protein Engineering in the Development of
... and motifs used in the responsive materials. We also highlight protein domains with unrealized potential for hydrogel materials applications. One of the most widely exploited protein domains is the α-helical coiled-coil or leucine zipper domain. Coiled coils have been extensively studied (23–29) and ...
... and motifs used in the responsive materials. We also highlight protein domains with unrealized potential for hydrogel materials applications. One of the most widely exploited protein domains is the α-helical coiled-coil or leucine zipper domain. Coiled coils have been extensively studied (23–29) and ...
Membrane nanodomains in plants: capturing form, function, and
... et al., 2006). Another stomatal protein, slow anion channel homolog 3 (SLAH3), interacts with calcium dependent protein kinase 22 (CPK21) in guard cell NDs (Demir et al., 2013). ABA binding to the receptor regulatory components of ABA receptor1/PYR1 (pyrobactin resistance 1)-like proteinc9 (RCAR/PY ...
... et al., 2006). Another stomatal protein, slow anion channel homolog 3 (SLAH3), interacts with calcium dependent protein kinase 22 (CPK21) in guard cell NDs (Demir et al., 2013). ABA binding to the receptor regulatory components of ABA receptor1/PYR1 (pyrobactin resistance 1)-like proteinc9 (RCAR/PY ...
Elastin
... They can be stretched to several times their normal length, but recoil to their original shape when the stretching force is relaxed. ...
... They can be stretched to several times their normal length, but recoil to their original shape when the stretching force is relaxed. ...
Solid Tumour Section Ovary: inv(10)(q11q11) in ovarian germ cell tumors
... Ovary: inv(10)(q11q11) in ovarian germ cell tumors Douglas S Richardson, Lois M Mulligan Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Cancer ...
... Ovary: inv(10)(q11q11) in ovarian germ cell tumors Douglas S Richardson, Lois M Mulligan Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Cancer ...
Supplementary Information (doc 42K)
... Table S3: Genes of particular interest. Selected representative genes encoding relevant ...
... Table S3: Genes of particular interest. Selected representative genes encoding relevant ...
Poster
... amino-terminal GATA-1 zinc finger domain was inserted into a yeast two-hybrid bait vector resulting in a plasmid encoding the GATA-1 zinc finger domain inframe with the GAL4 DNA binding domain. This plasmid was transformed into yeast along with the prey cDNA library generated from a mouse blood cell ...
... amino-terminal GATA-1 zinc finger domain was inserted into a yeast two-hybrid bait vector resulting in a plasmid encoding the GATA-1 zinc finger domain inframe with the GAL4 DNA binding domain. This plasmid was transformed into yeast along with the prey cDNA library generated from a mouse blood cell ...
Intrinsically disordered proteins
An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure. IDPs cover a spectrum of states from fully unstructured to partially structured and include random coils, (pre-)molten globules, and large multi-domain proteins connected by flexible linkers. They constitute one of the main types of protein (alongside globular, fibrous and membrane proteins).The discovery of IDPs has challenged the traditional protein structure paradigm, that protein function depends on a fixed three-dimensional structure. This dogma has been challenged over the last decades by increasing evidence from various branches of structural biology, suggesting that protein dynamics may be highly relevant for such systems. Despite their lack of stable structure, IDPs are a very large and functionally important class of proteins. In some cases, IDPs can adopt a fixed three-dimensional structure after binding to other macromolecules.