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Involvement of the glycine-rich RNA
Involvement of the glycine-rich RNA

... The plant glycine-rich RNA-binding proteins (GRP) are a major class of proteins known to be implicated in plant response to abiotic and biotic stress. Recent studies regarding this type of proteins focused mostly on two of them, namely GRP2 and GRP7, which are mainly involved in osmotic and oxidativ ...
No Slide Title
No Slide Title

... • Translation of trp leader is needed for regulation – Mutation of AUG prevents transcription past the attenuator – Without translation, the 1:2 and 3:4 stem-loops form, and thus causing termination ...
A New Subfamily of Major Intrinsic Proteins in
A New Subfamily of Major Intrinsic Proteins in

... acid residues as ball-and-stick models (Fu et al. 2000). Oxygen, nitrogen, and carbon atoms are depicted in dark, intermediate, and light gray, respectively (in the on-line version, oxygen and nitrogen atoms are visualized in red and blue, respectively). The top of the structure is facing periplasmi ...
Methods S1.
Methods S1.

... accession number NP_015003.1), Rpt6 (amino acids 1-406, RefSeq accession number NP_011467.1), and Rpt4 (amino acids 1-438, RefSeq accession number NP_014902.1). Each gene was cloned into p425-LOC between BamHI and XhoI. For p425-LOC (stop codon) without a fusion protein, we added a stop codon TGA at ...
Lecture 35
Lecture 35

... be a major contributor to aging and degenerative diseases. An increase in mtDNA deletions and point mutations are detected during an individuals lifetime. •Different mtDNA haplotypes are linked to differences in longevity. ...
Biogenesis of hepatitis C virus envelope glycoproteins
Biogenesis of hepatitis C virus envelope glycoproteins

... signal(s) present in this complex are responsible for this subcellular localization. The presence of a retention signal was first demonstrated for E2 by Cocquerel et al. (1998). Indeed, E2 expressed in the absence of E1 can fold properly and is retained in the ER, as shown by the lack of complex gly ...
Protein 3D-structure analysis
Protein 3D-structure analysis

... http://www.rcsb.org/pdb/explore/explore.do?structureId=1THC Similar structure: 2H6U What is the function of transthyretin, respectively of other proteins with similar structure? Have a look at the corresponding UniProt entries! How are they classified at CATH Use text search http://www.cathdb.info/c ...
Biology of Non-coding RNAs
Biology of Non-coding RNAs

... Course description The historical central dogma of molecular biology, stating that “DNA makes RNA makes protein”, has been the cornerstone for studies of cellular and molecular regulation and function. Scientific breakthroughs during the last decade challenge this simplistic view and reveal addition ...
Protein Quality Control along the Route to the Plant Vacuole
Protein Quality Control along the Route to the Plant Vacuole

... process, slower than fragmentation of trimeric phaseolin, which requires transport to the vacuole. This suggests that A363 is not competent for rapid transport to the vacuole. To determine whether vesicular transport along the secretory pathway is necessary for the degradation of assemblydefective p ...
Basic Local Alignment Search Tool (BLAST) IMBB 19, May 2015
Basic Local Alignment Search Tool (BLAST) IMBB 19, May 2015

... ü  StaCsCcal  measures  like  E-­‐value.  P-­‐Value    and  bit  score   ü  Percentage  idenCty  (%  of  idenCcal  residues  between  sequences)   ü  The  length  of  sequence  stretch  that  is  similar   2.  Homology;  homologs  diverse  f ...
bio_ch08
bio_ch08

... – The now empty tRNA molecule exits the ribosome. – A complementary tRNA molecule binds to the next exposed codon. – Once the stop codon is reached, the ribosome releases the protein and disassembles. ...
Molecular mechanisms of Salmonella invasion
Molecular mechanisms of Salmonella invasion

... shown that it plays an essential role in bacterial uptake [53]. Like other members of the PulD family (e.g. pIV protein of filamentous phages), InvG may be a multimeric protein that forms an outer membrane channel, which may serve as a pore for the passage of secreted proteins [57, 74]. PrgH and Prg ...
Capturing protein interactions in the secretory pathway of living cells
Capturing protein interactions in the secretory pathway of living cells

... composed of characteristic membrane compartments, including the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment (ERGIC), and the Golgi apparatus. Approximately one-third of all cellular proteins are translocated into the lumen of the ER, where modification, folding, and oligomeriza ...
Gel-based proteomics • Electrophoresis • One dimensional
Gel-based proteomics • Electrophoresis • One dimensional

... Proteomics Course ...
Aalborg Universitet Characterization of Lipoxygenases from Potato Tuber (cv. kuras)
Aalborg Universitet Characterization of Lipoxygenases from Potato Tuber (cv. kuras)

... The three Lox isoforms from leaf plus leaf and root are longer at their N-termini, corresponding to chloroplast targeting signals. Tuber StLoxs are found in vacuoles, but the transport mechanism is unknown due to no known targeting signal. Tuber Loxs are more closely related to the pathogen-induced ...
Peptides and proteins Chapter 36:
Peptides and proteins Chapter 36:

... ferritin for iron transport, lipoprotein for lipids, including cholesterol); • Difficult to categorize proteins with highly specific functions: receptors such as protein G, genetic regulators such as peroxisome proliferator-activated receptor (PPAR), antibodies, coagulants, histones. Proteins with ...
Pdf
Pdf

... the 20 amino acids could be represented by a 5-bit binary number ranging from 00001 to 11111. To reflect a physically relevant property, such as hydrophobicity for example, the amino acids would be assigned a 5-bit number depending on where the residue sits in the hydrophobic scale.33Isoleucine bein ...
Dual targeting of aminoacyl-tRNA synthetases to the mitochondrion
Dual targeting of aminoacyl-tRNA synthetases to the mitochondrion

... Accepted 18 September 2012 Journal of Cell Science 125, 6176–6184 ß 2012. Published by The Company of Biologists Ltd doi: 10.1242/jcs.116533 ...
Repositório da Universidade de Lisboa
Repositório da Universidade de Lisboa

... interface, CentrioleDB, has the final objective of cataloguing the different morphologies that centriolar structures can have. It was implemented using a relational database and the Django web framework. At this moment it is functioning at http://www.igc.pt/centrioledb and available to a restricted ...
Amino Acids  - جامعة الكوفة
Amino Acids - جامعة الكوفة

... α-carboxyl and one from the α-amino group), the pI is the average of pK1 and pK2 (pI = [2.34 + 9.6]/2 = 5.97, see Figure 8). The pI is thus midway between pK1 (2.34) and pK2 (9.6). It corresponds to the pH at which Form 2 (with a net charge of zero) predominates, and at which there are also equal am ...
3. Orm proteins
3. Orm proteins

... •Without Orm mediated brake on SPT there is toxic accumulation of sphingolipids. •Normal intermidiate phosphorylation will give chance to a rapid responce. ...
669 Salmonella typhimurium - Journal of General Virology
669 Salmonella typhimurium - Journal of General Virology

... Immediately after binding, the tail proteins begin to cleave the O antigen. As the rhamnosylgalactose linkages are cleaved, the proteins apparently migrate down the chain. This is based on the fact that when unattached tail protein is bound to ceils, it is not found free in the medium until some tim ...
sites of protein synthesis in nucleoli of root meristematic cells of
sites of protein synthesis in nucleoli of root meristematic cells of

... The present observations revealed that, as early as 5 min after immersion of primary roots of A. cepa in a solution of [3H]arginine, a radioautographic reaction was obtained over the cytoplasm and nucleus of meristematic cells. This indicated that the radioactive arginine must have reached even the ...
Neisseria conserved hypothetical protein DMP12
Neisseria conserved hypothetical protein DMP12

... non-pathogenic N. lactamica. The gene of this protein is located in an operon located on the 30 -end of the Neisseria maf-3 (N. meningitidis adhesion) gene. Microarray analysis showed the genes in this operon being significantly downregulated on Neisseria attachment to the epithelial cells, suggestin ...
video slide - Wayne State University
video slide - Wayne State University

... Now, here is one of the central problems of biology. Much of what is going on in a cell, as we have seen, is carried out by proteins. There are all kinds of proteins, depending on the sequence of their 20 amino acids: ...
< 1 ... 26 27 28 29 30 31 32 33 34 ... 202 >

Intrinsically disordered proteins



An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure. IDPs cover a spectrum of states from fully unstructured to partially structured and include random coils, (pre-)molten globules, and large multi-domain proteins connected by flexible linkers. They constitute one of the main types of protein (alongside globular, fibrous and membrane proteins).The discovery of IDPs has challenged the traditional protein structure paradigm, that protein function depends on a fixed three-dimensional structure. This dogma has been challenged over the last decades by increasing evidence from various branches of structural biology, suggesting that protein dynamics may be highly relevant for such systems. Despite their lack of stable structure, IDPs are a very large and functionally important class of proteins. In some cases, IDPs can adopt a fixed three-dimensional structure after binding to other macromolecules.
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