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Progesterone-stimulated intracellular calcium increase in human
Progesterone-stimulated intracellular calcium increase in human

... Dipartimento di Fisiopatologia Clinica, Unità di Andrologia, Università di Firenze, viale Pieraccini 6, I-50139 Firenze, Italy 1To ...
The Role of the Bundle Sheath in the Leaf Development of C3 plants
The Role of the Bundle Sheath in the Leaf Development of C3 plants

... Reticulate Arabidopsis leaf mutants are defective in processes governing the development of the inner leaf architecture. These mutants are aberrant in the mesophyll (M) but have an intact vasculature and bundle sheath (BS). While the role of the BS in C 4 plants is well established, knowledge about ...
5 The structure and function of membrane proteins
5 The structure and function of membrane proteins

... to be sequenced, cloned, manipulated and expressed in many different cells. As a result areas of recombinant DNA technology and protein engineering have evolved rapidly to become specialist disciplines in their own right. Almost any protein whose primary sequence is known can be produced in large qu ...
Yeast extract
Yeast extract

... Yeast extract – naturally good Many consumers think that the food industry should be more transparent about the products it makes. As a result, the demand for detailed, easily understood product information and clear labelling of ingredients is rapidly ...
Proteolytic Degradation of Hemoglobin in the Intestine of the Human
Proteolytic Degradation of Hemoglobin in the Intestine of the Human

... cooperative cascades. We investigated the roles played by 3 distinct proteases from adults of the human hookworm Necator americanus. The aspartic protease Na-APR-1 and the cysteine protease Na-CP-3 were expressed in catalytically active form in yeast, and the metalloprotease Na-MEP-1 was expressed i ...
Bacteriophage lambda (l)
Bacteriophage lambda (l)

... Yes ...
Geometrical and Sequence Characteristics of
Geometrical and Sequence Characteristics of

... the three-dimensional path of helix axis; and r2, the square of linear correlation coefficient for the line fit. If the maximum bending angle for the helix is $20°, the helix is classified as kinked. If the maximum bending angle is ,20°, then we look at the other three parameters. If both rmsC and r ...
Cell and Molecular Biology
Cell and Molecular Biology

Lactobacillus plantarum - UEF Electronic Publications
Lactobacillus plantarum - UEF Electronic Publications

... environmental niches due to their large adaptation capacity. They are responsible for the fermentation of many fermented food and feed products because they can transform sugars into organic acids and decrease the pH of the medium. This acidification prevents the growth of pathogenic bacteria, makin ...
IV.1 Structural and Functional Role of
IV.1 Structural and Functional Role of

... form the correct retinal binding pocket, it is intriguing as to why they are still deleterious. We constructed and expressed the synthetic G51L mutant to explore the effect of the size of the amino acid side chain in the packing of the helices and in signal transduction. The correctly folded fractio ...
Strength of the Pnicogen Bond in Complexes Involving Group Va
Strength of the Pnicogen Bond in Complexes Involving Group Va

... As has been investigated at the ωB97X-D/aug-cc-pVTZ level of theory to determine the strength of the pnicogen bond with the help of the local E···E′ stretching force constants ka. The latter are directly related to the amount of charge transferred from an E donor lone pair orbital to an E′ acceptor ...
- Free Documents
- Free Documents

... into proinsulin. Proinsulin is Iurther cleaved yielding active insulin which is composed oI two peptide chains linked togehter through disulIide bonds. Still other proteins oI the enzyme class are synthesized as inactive precursors called zymogens. Zymogens are activated by proteolytic cleavage such ...
catalogue 2012 - olimp
catalogue 2012 - olimp

... Our line of Go4IT! Supplements was designed especially for you and people leading an active life, living in stress, taking on a recreational basis any type of physical activity and valuing their health. The Go4IT! Line includes innovative drinks and functional bars and the first on the market real M ...
Hydrolyzed Source Proteins as Used in Cosmetics
Hydrolyzed Source Proteins as Used in Cosmetics

... of proteins, the amino acids. These protein derivatives are prepared by subjecting animal or vegetable proteins to enzymatic (e.g., papain hydrolysis) or other chemical hydrolyses (e.g., acid or steam hydrolysis). The resulting polypeptide-, oligopepetide-, and peptide-containing products are used a ...
RuBisCO in Non-Photosynthetic Alga Euglena longa: Divergent
RuBisCO in Non-Photosynthetic Alga Euglena longa: Divergent

... II RuBisCO). In these lineages, the Rbc gene was acquired from a bacterium by horizontal gene transfer [3]. In all other cases, the large subunit, possessing the catalytic activity of the holoenzyme, is always encoded in the plastid genome by the rbcL gene and synthesized on the plastid ribosomes in ...
Nonruminant Nutrition: Amino Acids (Abstracts M204–M237)
Nonruminant Nutrition: Amino Acids (Abstracts M204–M237)

MD1-103 Protein Stability Combo Kit
MD1-103 Protein Stability Combo Kit

... 5. Dispense 2 µl of protein sample into each well. It is strongly advised to use a repeater pipette. 6. Freshly prepare a SYPRO Orange solution at 62X by diluting 3 µl of 5000X stock in 237 µl of water (Invitrogen, S6651, 5000X). 240 µl is sufficient to test 96 conditions. 7. Dispense 2 µl of dilute ...
A family of diatom-like silicon transporters in the siliceous loricate
A family of diatom-like silicon transporters in the siliceous loricate

... two pairs of GXQ-containing motifs have been noted previously, the first in TMDs 2 and 3, the second located in TMDs 7 and 8, but symmetrically orientated with respect to the membrane polarity [13]. In our alignment, the C-terminal motifs of the pair contained GRQ, apart from one CRQ motif (Shionodi ...
Basic Local Alignment Search Tool
Basic Local Alignment Search Tool

... condence that the match is real = 4e-45 (4 x 10−45 ), 4e-16 (4 x 10−16 ), or 1e-05 (1 x 10−05 ) 1e-05 (1 x 10−5 ) indicates that there is 1 in 100,000 possiblity that the match is due to chance Note that 0.0 is identity The nearer the value is to unity (1), the greater the chance that the match is ...
Biomolecules
Biomolecules

... • **Polysaccharides have storage and structural roles; the structure and function of a polysaccharide are determined by its sugar monomers and the positions of glycosidic ...
OptCDR: a general computational method for the design
OptCDR: a general computational method for the design

... majority of antibody-binding interactions. Humanization (Almagro and Fransson, 2008) is a common experimental technique where the CDRs from a non-human antibody are attached to the framework of a human antibody, thereby retaining the binding properties of the non-human antibody while decreasing or e ...
PROTEIN SUBCELLULAR LOCALIZATION
PROTEIN SUBCELLULAR LOCALIZATION

... 1/3 of the errors made when using BLAST alone. For 12771 animal proteins a combined accuracy of 95.6% is obtained, eliminating 1/4 of BLAST alone errors, and for 2333 plant proteins the accuracy can be improved to 86% from 84%. ...
From Amino Acid to Glucosinolate Biosynthesis: Protein Sequence
From Amino Acid to Glucosinolate Biosynthesis: Protein Sequence

... precursor amino acids, including Met, Phe, and others, often undergo side chain elongation in a series of reactions that resemble the late steps in Leu biosynthesis (Figure 1) (Kroymann et al., 2001; Textor et al., 2004, 2007; Benderoth et al., 2006; Halkier and Gershenzon, 2006; de Kraker et al., 2 ...
Document
Document

... •List and discuss four forces that stabilize globular protein structure. •List important structural similarities and differences between myoglobin and hemoglobin. •Describe the mutation present in hemoglobin giving rise to sickle cell disease. ...
Sensitivity of plant mitochondrial terminal oxidases to the lipid
Sensitivity of plant mitochondrial terminal oxidases to the lipid

... peroxide), O2 − (superoxide) and the OH•− (hydroxyl radical). In plants, ROS have a dual action whereby high levels exacerbate cellular damage (to proteins, DNA and lipids), yet low concentrations can act as signalling molecules to activate defence responses [1,2]. The polyunsaturated fatty acids of ...
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Protein–protein interaction



Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.
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