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Different strategies of osmoadaptation in the closely
Different strategies of osmoadaptation in the closely

... metabolism, and so is used in food conservation by pickling. One strategy to thrive in such environments involves the production of so-called osmolytes to maintain osmotic equilibrium across the cytoplasmic membrane. Osmolytes are organic compounds of low molecular mass that have no influence on cel ...
htp Pseudomonas aeruginosa AMANDA SWANEPOEL
htp Pseudomonas aeruginosa AMANDA SWANEPOEL

... as those with cancer or AIDS and those suffering from cystic fibrosis and burns (Van Delden and Iglewski, 1998; Ramsey and Wozniak, 2005), but it has also been shown to infect plants and insects (Schroth et al., 1992; Rahme et al., 1995). The success of P. aeruginosa in colonizing these diverse envi ...
pdf
pdf

... expression or ectopic expression of a defined gene were the cause of some pathology (e.g. some form of cancer), then reducing its expression could have therapeutic value. Other RNAs possibly involved in catalysis, such as the snRNAs involved in splicing pre-mRNA (discussed in the next section). Even ...
REVIEWS
REVIEWS

... BASIC HELIX–LOOP–HELIX (bHLH) transcription factors, which indicates that Snail proteins might compete with them for the same binding sequences26–28. On binding to the E box, Snail family members are thought to act as transcriptional repressors9,14–16,24,26,27,29,30. The repressor activity depends n ...
Evidence that MEK1 positively promotes
Evidence that MEK1 positively promotes

... over-expressing either RAD51 or RAD54, or by deleting the Rad51 inhibitor HED1 (6–9). Rad51 in vegetative cells can bring about strand invasion with the sister chromatid, but this is inhibited during meiosis unless the activity of Rad51 is experimentally increased. Further information on how the bia ...
11-4 Meiosis - Midland Park School District
11-4 Meiosis - Midland Park School District

... Copyright Pearson Prentice Hall ...
CEP290 alleles in mice disrupt tissue-specific cilia
CEP290 alleles in mice disrupt tissue-specific cilia

... (20,21) and mechanosensor (22). In sensory tissues, cilia are modified to mediate specific functions such as establishment of the sterocilia bundles, which transmit sound wave frequency and intensity in the cochlea, transduction of photons by photoreceptors, and ligand–receptor interactions in the olf ...
14 Chromosomes
14 Chromosomes

... chromosomes or short segments of specific chromosomes. Figure 14.8 shows the fluorescent labelling of the human Y chromosome where a labelled probe specific to a segment of DNA on the Y chromosome has been used to distinguish it from the other human chromosomes. Another representation of human chrom ...
- NRC Research Press
- NRC Research Press

... synteny with the distal one-third end of the long arm of rice chromosome 3. In between those conserved regions, there is a region on the long arm of the Group 5 chromosomes which shows broken synteny. The proximal part of the short arms of the Group 5 chromosomes showed conserved synteny with a segm ...
No Slide Title
No Slide Title

... • Use in screening: PCR based detection of populations with anomalies in cell-cycle regulators e.g. L.O.H. of p16, cyclin over-expression, amplification of a gene • Detection of relapse/minimal residual disease • Use in prognosis: e.g. tumors with high S phase fraction detected by flow cytometry hav ...
REVIEW ARTICLE Gene cassettes
REVIEW ARTICLE Gene cassettes

Classifying Gene Expression Data using an Evolutionary Algorithm
Classifying Gene Expression Data using an Evolutionary Algorithm

... leads to statistical and analytical challenges. One challenge area in the studies of gene expression data is the classification of the expression dataset into correct classes. The dissertation is addressing multiclass classification which has been shown to be more difficult than the binary classific ...
A Feeling for the Organism — Life and Work of Barbara McClintock
A Feeling for the Organism — Life and Work of Barbara McClintock

... write books mostly dictated to him by Anastasia. From Anastasia we can learn of the healthy effects of growing one's own vegetables, something that is becoming a growing trend in Russia by urban families who own small dachas in the country and work them on weekends and vacations. From Barbara McClin ...
The zebrafish as a model for muscular dystrophy and congenital
The zebrafish as a model for muscular dystrophy and congenital

... proteins, with the main structural axis being provided by a series of three proteins that link intracellular F-actin below the sarcolemma to laminin outside the cell. The laminin receptor within the DAPC is dystroglycan, which is formed by the cleavage of a precursor protein into extracellular a and ...
Chapter 5 Gases - Saint Demetrios Astoria School
Chapter 5 Gases - Saint Demetrios Astoria School

... Humans? (cont’d.) • Types of genetic mutations – Single genes that follow Mendelian inheritance patterns govern more than 6,000 genetic abnormalities and disorders – Most human traits are polygenic, or influenced by multiple genes – Traits can be influenced by environmental ...
The role of Pax-1 in axial skeleton development
The role of Pax-1 in axial skeleton development

... embryos, abnormalities can be detected from day 10.5 p.c onwards. The phenotypic analyses also suggest that the notochord still influences vertebral body formation some days after the sclerotomes are formed. Furthermore, the notochord diameter is larger in mutant embryos from day 12 p.c., due to inc ...
PCDH19-related Infantile Epileptic Encephalopathy - HAL
PCDH19-related Infantile Epileptic Encephalopathy - HAL

... protein in humans, its absence likely being compensated for or buffered by other proteins and pathways. In contrast, females with heterozygous PCDH19 mutations present with early intractable seizures and a variable degree of mental retardation. PCDH19 is located in a region submitted to Xinactivati ...
Protocadherin-1: epithelial barrier dysfunction in asthma and eczema Grissel Faura Tellez
Protocadherin-1: epithelial barrier dysfunction in asthma and eczema Grissel Faura Tellez

... (SNPs), we considered the possibility of linkage disequilibrium (LD) between these SNPs. LD is defined as the preferential occurrence of specific combinations of SNPs in the population, due to their co-inheritance as a result of their close physical proximity. In a recent study in a German populatio ...
Homeotic genes controlling flower development in Antirrhinum
Homeotic genes controlling flower development in Antirrhinum

... act in a cell-autonomous manner in the tissue giving rise to gametes. The lineage of cells giving rise to gametes is usually restricted to a particular cell layer in the flower (the LII) so that only events represented in this layer will be transmitted to progeny (Imai, 1934; TilneyBassett, 1986). I ...
Multiple Quantitative Trait Loci Modify Cochlear Hair Cell
Multiple Quantitative Trait Loci Modify Cochlear Hair Cell

... and functionally intact. Inner hair cells primarily function as afferent sensory cells, whereas outer hair cells are electromotile amplifiers of auditory stimuli that can be functionally assessed by distortion product otoacoustic emission (DPOAE) analysis. When C3H-Tmc1Bth/Bth is crossed with either ...
LINKAGE AND MAPPING IN EUKARYOTES
LINKAGE AND MAPPING IN EUKARYOTES

... 8; l  3 autosomes  X  Y), whereas human beings have twenty-four linkage groups (2n  46; l  22 autosomes  X  Y). Prokaryotes and viruses, which usually have a single chromosome, are discussed in chapter 7. Historically, classical mapping techniques, as described in this chapter and the next, g ...
Proviral amplification of the Gypsy endogenous retrovirus of
Proviral amplification of the Gypsy endogenous retrovirus of

... Drosophila is amenable to detailed genetic and molecular analysis to manipulate both the virus and the host genome in an attempt to gain insight into this unique paradigm of ERV–host interaction. Genetic analysis of the permissive/restrictive character identified the X-linked flamenco (flam) gene as ...
A catalogue of imprinted genes and parent-of
A catalogue of imprinted genes and parent-of

... gene, UBE3A, was thought not to be imprinted until allele-specific transcription was detected in the brain. Secondly, several conditions show an imprinted pattern of inheritance, for example familial glomus tumours only occur by paternal inheritance. However, in this situation, linkage to the diseas ...
Sulforaphane
Sulforaphane

... stored as fatty molecules and therefore do not mix well in water. The detoxification process starts by transforming these toxic substances into harmless, water soluble molecules which can be excreted out of the body. Phase I enzymes (P-450’s) convert the toxic elements to fat soluble compounds and P ...
20060710_GOannotCamp_Stanford
20060710_GOannotCamp_Stanford

... o 1 curated 6 months ago, 1 curated a year ago o Issues related to which term to use (ontology developed in interim), also which evidence code to use (new guidelines)  Specificity: Relative granularity of terms utilized across annotations. o How are terms used related to each other? Parent/child? o ...
< 1 ... 22 23 24 25 26 27 28 29 30 ... 808 >

Polycomb Group Proteins and Cancer

The Polycomb-group proteins (PcGs) are a family of proteins that use epigenetic mechanisms to maintain or repress expression of their target genes. They were originally discovered in Drosophila (fruit flies), though they've been shown to be conserved in many species due to their vital roles in embryonic development. These proteins' ability to alter gene expression has made them targets of investigation for research groups seeking to understand disease pathology and oncology.
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