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... Growth and culture of C. elegans. C. elegans was grown at 20°C on solid medium as described by Sulston and Hodgkin (1988). All mapping, complementation, and deficiency testing were performed by standard genetic methods (Herman and Horvitz, 1980). Aldicarb, 2-methyl-2[methylthio]proprionaldehyde O-[m ...
... Growth and culture of C. elegans. C. elegans was grown at 20°C on solid medium as described by Sulston and Hodgkin (1988). All mapping, complementation, and deficiency testing were performed by standard genetic methods (Herman and Horvitz, 1980). Aldicarb, 2-methyl-2[methylthio]proprionaldehyde O-[m ...
Clustering of mandibular organ-inhibiting hormone and moult
... directly or following sub-cloning into Bluescript vector) by using M13 forward and reverse primers, together with gene-specific primers. In addition, the sequence of continuous regions of 8.5 kb from a representative group 1 clone (l1) and 4.3 kb from a representative group 4 clone (l12) were determ ...
... directly or following sub-cloning into Bluescript vector) by using M13 forward and reverse primers, together with gene-specific primers. In addition, the sequence of continuous regions of 8.5 kb from a representative group 1 clone (l1) and 4.3 kb from a representative group 4 clone (l12) were determ ...
the lkb1 tumor suppressor - E
... Gatekeepers and Caretakers Tumor suppressors can be further divided into gatekeepers and caretakers based on gene function (Kinzler and Vogelstein, 1997). Gatekeepers prevent neoplasia directly by controlling cell growth, either by regulating proliferation or by promoting cell death. Although multip ...
... Gatekeepers and Caretakers Tumor suppressors can be further divided into gatekeepers and caretakers based on gene function (Kinzler and Vogelstein, 1997). Gatekeepers prevent neoplasia directly by controlling cell growth, either by regulating proliferation or by promoting cell death. Although multip ...
Prediction and investigation of novel proteins in DNA double
... chromosomal rearrangement and genomic instability promoting tumorigenesis or cell death. DSBs are primarily repaired by two independent and highly conserved pathways: homologous recombination (HR) and non-homologous end joining (NHEJ). HR requires a homologous sequence to repair DNA breaks, whereas ...
... chromosomal rearrangement and genomic instability promoting tumorigenesis or cell death. DSBs are primarily repaired by two independent and highly conserved pathways: homologous recombination (HR) and non-homologous end joining (NHEJ). HR requires a homologous sequence to repair DNA breaks, whereas ...
First report of a tetracycline-inducible gene
... is critical for studying gene function. In fact, the control of gene expression has a wide range of applications such as production of conditional knockout mutants (Kamionka et al., 2005), conditional expression of toxin genes (Carroll et al., 2007), plasmid loss through inducible counterselection ( ...
... is critical for studying gene function. In fact, the control of gene expression has a wide range of applications such as production of conditional knockout mutants (Kamionka et al., 2005), conditional expression of toxin genes (Carroll et al., 2007), plasmid loss through inducible counterselection ( ...
Involvement of Pax6 and Otx2 in the forebrain
... In this study, we describe the involvement of the homeodomain containing transcription factors Otx2 and Pax6 in ANF gene regulation. Otx2 is known for its specific function as a transcriptional regulator during forebrain and midbrain development in vertebrates (Boncinelli and Morgan, 2001). In all e ...
... In this study, we describe the involvement of the homeodomain containing transcription factors Otx2 and Pax6 in ANF gene regulation. Otx2 is known for its specific function as a transcriptional regulator during forebrain and midbrain development in vertebrates (Boncinelli and Morgan, 2001). In all e ...
Unit 3 Solutions - Manning`s Science
... thymine, and the percent composition of cytosine is the same as guanine). Chargaff ’s rule helped Watson and Crick infer that adenine paired with thymine, and cytosine paired with guanine. c. Franklin determined that DNA had a helical structure, with nitrogenous bases located on the inside of the ...
... thymine, and the percent composition of cytosine is the same as guanine). Chargaff ’s rule helped Watson and Crick infer that adenine paired with thymine, and cytosine paired with guanine. c. Franklin determined that DNA had a helical structure, with nitrogenous bases located on the inside of the ...
Phenotypic overlap in the contribution of individual genes to CNV
... Numerous disease syndromes are associated with regions of copy number variation (CNV) in the human genome and, in most cases, the pathogenicity of the CNV is thought to be related to altered dosage of the genes contained within the affected segment. However, establishing the contribution of individu ...
... Numerous disease syndromes are associated with regions of copy number variation (CNV) in the human genome and, in most cases, the pathogenicity of the CNV is thought to be related to altered dosage of the genes contained within the affected segment. However, establishing the contribution of individu ...
Confrontation of scabrous expressing and non
... Neural development in the eye imaginal disc is thought to be similar to peripheral neurogenesis in other imaginal discs, and mutations in most of the neurogenic genes also result in neural hypertrophy in the eye (Dietrich and Campos-Ortega, 1984). Proneural genes and the extent of neurogenic regions ...
... Neural development in the eye imaginal disc is thought to be similar to peripheral neurogenesis in other imaginal discs, and mutations in most of the neurogenic genes also result in neural hypertrophy in the eye (Dietrich and Campos-Ortega, 1984). Proneural genes and the extent of neurogenic regions ...
The Drosophila small conductance calcium
... personal friendship. The skill set that I have learned in his laboratory is broad and varied, reflecting his style or research. Mostly I am grateful for his patience during the difficult, trying thesis process. I hope to repay his commitment to my education by making significant contributions to the ...
... personal friendship. The skill set that I have learned in his laboratory is broad and varied, reflecting his style or research. Mostly I am grateful for his patience during the difficult, trying thesis process. I hope to repay his commitment to my education by making significant contributions to the ...
The fibrodysplasia ossificans progressiva R206H
... R206H mutation, we examined the interaction of this receptor with the inhibitory protein FKBP1A/FKBP12, which binds to the GS domain of type I receptors and prevents leaky signal transduction in the absence of ligand binding (20–23). COS-7 cells were cotransfected with an FKBP1A expression construct ...
... R206H mutation, we examined the interaction of this receptor with the inhibitory protein FKBP1A/FKBP12, which binds to the GS domain of type I receptors and prevents leaky signal transduction in the absence of ligand binding (20–23). COS-7 cells were cotransfected with an FKBP1A expression construct ...
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... was compared to that of M 5, one of the β-tubulin gene isotypes, using RNase protection analysis (data not shown). The M 5 gene is a component of the cytoskeleton, which is expressed in a ubiquitous manner (Wang et al., 1986). While no significant change was observed in Sd homozygotes at day 10.5, P ...
... was compared to that of M 5, one of the β-tubulin gene isotypes, using RNase protection analysis (data not shown). The M 5 gene is a component of the cytoskeleton, which is expressed in a ubiquitous manner (Wang et al., 1986). While no significant change was observed in Sd homozygotes at day 10.5, P ...
Introduction: - Statistical Science
... The top 20 enriched pathways for both ‘responder’ and ‘nonresponder’ phenotypes using the GSEA with the S2 (functional) database against the Ann Arbor and Boston lung datasets. Two of the enriched pathways at FDR <0.25 are common on the non-responders side (telomerase and insulin 2F). ...
... The top 20 enriched pathways for both ‘responder’ and ‘nonresponder’ phenotypes using the GSEA with the S2 (functional) database against the Ann Arbor and Boston lung datasets. Two of the enriched pathways at FDR <0.25 are common on the non-responders side (telomerase and insulin 2F). ...
x-linked mental retardation
... by breakpoint mapping and cloning in mentally retarded patients with BALANCED REARRANGEMENTS that involve the X chromosome, or by molecular characterization of small X-chromosomal deletions. The study of chromosomal rearrangements has proved to be particularly informative in the identification of ge ...
... by breakpoint mapping and cloning in mentally retarded patients with BALANCED REARRANGEMENTS that involve the X chromosome, or by molecular characterization of small X-chromosomal deletions. The study of chromosomal rearrangements has proved to be particularly informative in the identification of ge ...
Evolution of Mammalian KELL Blood Group Glycoproteins and
... in human and animal populations. KELL amino acid sequences and structures and KEL gene locations were examined using bioinformatic data from several mammalian genome projects. Mammalian KELL sequences shared 55-99% identity, as compared with 21-31% sequence identities with other M13-like family memb ...
... in human and animal populations. KELL amino acid sequences and structures and KEL gene locations were examined using bioinformatic data from several mammalian genome projects. Mammalian KELL sequences shared 55-99% identity, as compared with 21-31% sequence identities with other M13-like family memb ...
Genetics of Primary ciliary dyskinesia - HAL
... eukaryotic cells 4. These organelles, which are structurally related to the flagella of spermatozoa, can be classified according to the arrangement of their microtubule cytoskeleton core, called axoneme. The axoneme consists either of nine doublets only («9+0» pattern) or of nine outer-doublet micro ...
... eukaryotic cells 4. These organelles, which are structurally related to the flagella of spermatozoa, can be classified according to the arrangement of their microtubule cytoskeleton core, called axoneme. The axoneme consists either of nine doublets only («9+0» pattern) or of nine outer-doublet micro ...
Conservation of Brachyury (T) genes in amphioxus and vertebrates
... The roles of Brachyury in mesoderm and notochord formation, therefore, might not be common to all vertebrates. Alternatively, since neither mesoderm nor notochord are unique to the vertebrates, the conserved roles deduced for Brachyury could have an earlier origin. To resolve these ambiguities, the ...
... The roles of Brachyury in mesoderm and notochord formation, therefore, might not be common to all vertebrates. Alternatively, since neither mesoderm nor notochord are unique to the vertebrates, the conserved roles deduced for Brachyury could have an earlier origin. To resolve these ambiguities, the ...
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... Regulation of expression of the var gene family has many similarities to the systems described above. var genes are likewise expressed in a mutually exclusive manner and encode cell surface receptors. In addition, epigenetic alterations in chromatin structure appear to be important for maintaining ‘ ...
... Regulation of expression of the var gene family has many similarities to the systems described above. var genes are likewise expressed in a mutually exclusive manner and encode cell surface receptors. In addition, epigenetic alterations in chromatin structure appear to be important for maintaining ‘ ...
Endoplasmic Reticulum Protein Quality Control Failure in Myelin
... export, lipid metabolism and ERAD genes (Figure 1; AcostaAlvear et al., 2007; Yamamoto et al., 2007; Shoulders et al., 2013). To orchestrate this program, two transcription factors are recruited. One is spliced X-box binding protein-1 (XBP1s), which is generated via the IRE1-mediated unconventional ...
... export, lipid metabolism and ERAD genes (Figure 1; AcostaAlvear et al., 2007; Yamamoto et al., 2007; Shoulders et al., 2013). To orchestrate this program, two transcription factors are recruited. One is spliced X-box binding protein-1 (XBP1s), which is generated via the IRE1-mediated unconventional ...
No Slide Title
... • Loss of RNAi reveals centromeric transcripts. • dsRNA from centromere targets transcriptional silencing. ...
... • Loss of RNAi reveals centromeric transcripts. • dsRNA from centromere targets transcriptional silencing. ...
Multiple Avirulence Loci and Allele-Specific Effector
... variation in the level of virulence in natural isolates, as described by Brunner et al. (2010), when they calculated the haustorium index of natural isolates during transient expression assays of several Pm3 alleles. Further investigation of interallele interactions revealed that the resistance medi ...
... variation in the level of virulence in natural isolates, as described by Brunner et al. (2010), when they calculated the haustorium index of natural isolates during transient expression assays of several Pm3 alleles. Further investigation of interallele interactions revealed that the resistance medi ...
Gene regulation in three dimensions
... Last, but not least I would like to thank Julie my fiancé who has supported me and been there for me when I needed it the most. K.T.W ...
... Last, but not least I would like to thank Julie my fiancé who has supported me and been there for me when I needed it the most. K.T.W ...
Complex regulation of sister kinetochore orientation in meiosis-I
... manner, probably because both the sister chromatids cosegregate to the same spore due to mono-orientation of the sister kinetochores (Rabitsch et al. 2001). Since diploid budding yeast has sixteen pairs of chromosomes, this resulted in all the spores lacking copies of one or more chromosomes, thereb ...
... manner, probably because both the sister chromatids cosegregate to the same spore due to mono-orientation of the sister kinetochores (Rabitsch et al. 2001). Since diploid budding yeast has sixteen pairs of chromosomes, this resulted in all the spores lacking copies of one or more chromosomes, thereb ...
PDF File - Friends Science Publishers
... populations revealed that the bh genes were hemizygouseffective and dosage-independent. The F1 monosomic analysis showed that the bh genes of Yupi Branching were recessive (Peng et al., 1998b). Disomics. The plants with disomic genetic constitution are also important for the evolutionary perspective ...
... populations revealed that the bh genes were hemizygouseffective and dosage-independent. The F1 monosomic analysis showed that the bh genes of Yupi Branching were recessive (Peng et al., 1998b). Disomics. The plants with disomic genetic constitution are also important for the evolutionary perspective ...