Fanconi anemia and RAD50 deficiency: genetic and functional
... FA cell lines that could not be assigned to one of the known groups were further classified as defective or proficient in FANCD2 monoubiquitination, a central process in the FA caretaker pathway. This allowed to classify these patient cell lines as upstream or downstream partners within the FA caret ...
... FA cell lines that could not be assigned to one of the known groups were further classified as defective or proficient in FANCD2 monoubiquitination, a central process in the FA caretaker pathway. This allowed to classify these patient cell lines as upstream or downstream partners within the FA caret ...
Full Text - The International Journal of Developmental Biology
... ABSTRACT Higher plants have evolved to be one of the predominant life forms on this planet. A great deal of this evolutionary success relies in a very short gametophytic phase which underlies the sexual reproduction cycle. Sexual plant reproduction takes place in special organs of the flower. In mos ...
... ABSTRACT Higher plants have evolved to be one of the predominant life forms on this planet. A great deal of this evolutionary success relies in a very short gametophytic phase which underlies the sexual reproduction cycle. Sexual plant reproduction takes place in special organs of the flower. In mos ...
Environmental Microbiology
... mechanism of phase variation (van der Woude et al., 1996; Henderson et al., 1999). Methylation of GATC sites in the genome is dependent on deoxyadenosine methylase (dam), which binds to the GATC site and methylates adenosine at the N6 position (Palmer and Marinus, 1994). Normally, methylation provid ...
... mechanism of phase variation (van der Woude et al., 1996; Henderson et al., 1999). Methylation of GATC sites in the genome is dependent on deoxyadenosine methylase (dam), which binds to the GATC site and methylates adenosine at the N6 position (Palmer and Marinus, 1994). Normally, methylation provid ...
BAM Receptors Regulate Stem Cell Specification and Organ
... extracellular domain (Ogawa et al. 2008). Taken together these data suggest a model in which CLV1 and CLV2 form a receptor complex that is capable of activating specific signal transduction pathways upon perception of the CLE peptide derived from CLV3. CLV1, CLV2, and CLV3 function in a common genet ...
... extracellular domain (Ogawa et al. 2008). Taken together these data suggest a model in which CLV1 and CLV2 form a receptor complex that is capable of activating specific signal transduction pathways upon perception of the CLE peptide derived from CLV3. CLV1, CLV2, and CLV3 function in a common genet ...
Fulltext PDF - Indian Academy of Sciences
... zeste 12, a Polycomb group (PcG) gene of enormous importance in the development of the fruit fly Drosophila melanogaster. In Drosophila, PcG proteins generally act by remodelling chromatin structure and mediating the silencing of homeotic genes. VRN2 does not appear to be required for the vernalizat ...
... zeste 12, a Polycomb group (PcG) gene of enormous importance in the development of the fruit fly Drosophila melanogaster. In Drosophila, PcG proteins generally act by remodelling chromatin structure and mediating the silencing of homeotic genes. VRN2 does not appear to be required for the vernalizat ...
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... exists post-zygotically (28). The supportive evidence is that full mutation carriers are found to be somatic mosaicisms of CGG repeats (28,29). However, the length of CGG repeats on a particular allele in a differentiated cell derived from these carriers is generally mitotically stable although rece ...
... exists post-zygotically (28). The supportive evidence is that full mutation carriers are found to be somatic mosaicisms of CGG repeats (28,29). However, the length of CGG repeats on a particular allele in a differentiated cell derived from these carriers is generally mitotically stable although rece ...
Mice 2 NZW)F Genetic Complementation in Female (BXSB ×
... possibly two on chromosome 4, and a single locus each on chromosomes 3, 7, 8, 10, 13, 14, and 17) (10 –12). Although some of the overlapping loci from different strains may represent the same gene, it is evident from this and other studies of gene knockout animals (reviewed in Ref. 1) that a substan ...
... possibly two on chromosome 4, and a single locus each on chromosomes 3, 7, 8, 10, 13, 14, and 17) (10 –12). Although some of the overlapping loci from different strains may represent the same gene, it is evident from this and other studies of gene knockout animals (reviewed in Ref. 1) that a substan ...
MA112 Expresso® Rhamnose SUMO Cloning and
... is designed for expression in E. coli, fusion clones constructed using this system can also be transferred into eukaryotic expression vectors for expression of SUMO-tagged proteins in mammalian or insect cells. The rhaP BAD promoter is a versatile tool for protein expression. In the absence of rhamn ...
... is designed for expression in E. coli, fusion clones constructed using this system can also be transferred into eukaryotic expression vectors for expression of SUMO-tagged proteins in mammalian or insect cells. The rhaP BAD promoter is a versatile tool for protein expression. In the absence of rhamn ...
Bacteroides mobilizable and conjugative genetic elements
... rteA and rteB have been shown to be in the same operon as tetQ, production of these proteins is presumably due to translational coupling one ribosomes begin to translate the operon mRNA. RteA and RteB have no role in tetracycline regulation of operon expression. This was somewhat surprising because ...
... rteA and rteB have been shown to be in the same operon as tetQ, production of these proteins is presumably due to translational coupling one ribosomes begin to translate the operon mRNA. RteA and RteB have no role in tetracycline regulation of operon expression. This was somewhat surprising because ...
22q12 and 22q13 duplications
... shows gains and losses of tiny amounts of DNA throughout the chromosomes. Microarrays can also show whether particular genes are duplicated or not. The break points in chromosome 22 vary from person to person, so each person will have a different number of genes duplicated. The smallest duplications ...
... shows gains and losses of tiny amounts of DNA throughout the chromosomes. Microarrays can also show whether particular genes are duplicated or not. The break points in chromosome 22 vary from person to person, so each person will have a different number of genes duplicated. The smallest duplications ...
Mechanisms of translational regulation in bacteria
... fluctuations in the frequency of neutral genetic traits become important in small populations. Since such changes are random they are referred to as genetic drift (44, 113). The interplay between mutations, causing genetic variations, selection and genetic drift, either leading to the increase or de ...
... fluctuations in the frequency of neutral genetic traits become important in small populations. Since such changes are random they are referred to as genetic drift (44, 113). The interplay between mutations, causing genetic variations, selection and genetic drift, either leading to the increase or de ...
uncorrected page proofs
... ‘naked lady’ is due to the fact that after the leaves of the plant appear in spring they die off, and the flowers appear in autumn on their own (see figure 14.2). This simple but beautiful plant is poisonous. Deaths have occurred, often after a person has mistaken the plant for wild garlic and eaten ...
... ‘naked lady’ is due to the fact that after the leaves of the plant appear in spring they die off, and the flowers appear in autumn on their own (see figure 14.2). This simple but beautiful plant is poisonous. Deaths have occurred, often after a person has mistaken the plant for wild garlic and eaten ...
Genetic Control of Seed Shattering in Rice by the
... Whitelaw, 2001). Understanding how the process of abscission is regulated in model crops would benefit agriculture. Previous studies of rice (Oryza sativa) have identified a few of the factors involved in seed shattering. SH4 is a member of the trihelix family of transcription factors and promotes h ...
... Whitelaw, 2001). Understanding how the process of abscission is regulated in model crops would benefit agriculture. Previous studies of rice (Oryza sativa) have identified a few of the factors involved in seed shattering. SH4 is a member of the trihelix family of transcription factors and promotes h ...
www.studyguide.pk UNIVERSITY OF CAMBRIDGE INTERNATIONAL EXAMINATIONS General Certificate of Education Advanced Level 9700/04
... (b) Herceptin is a monoclonal antibody used in the treatment of some breast cancers. It binds strongly to molecules of a receptor protein, HER2, that is produced in abnormally large quantities in the plasma (cell surface) membranes of about 30% of human breast cancers. Investigations have been made ...
... (b) Herceptin is a monoclonal antibody used in the treatment of some breast cancers. It binds strongly to molecules of a receptor protein, HER2, that is produced in abnormally large quantities in the plasma (cell surface) membranes of about 30% of human breast cancers. Investigations have been made ...
genetics - Liceocopernico.it
... Some exposure to college-level or university-level biology is desirable before embarking on the study of genetics. In this volume, however, basic biological principles (such as cell structures and functions) are reviewed to provide a common base of essential background information. The quantitative ...
... Some exposure to college-level or university-level biology is desirable before embarking on the study of genetics. In this volume, however, basic biological principles (such as cell structures and functions) are reviewed to provide a common base of essential background information. The quantitative ...
Idic(15)
... infancy. Concerns usually only arise after they miss their developmental milestones and even then other conditions may be considered first. This means that families have tended to receive a diagnosis quite late, in many children not until they were three or four years old and in some cases even late ...
... infancy. Concerns usually only arise after they miss their developmental milestones and even then other conditions may be considered first. This means that families have tended to receive a diagnosis quite late, in many children not until they were three or four years old and in some cases even late ...
Root Hairs as a Model System for Studying Plant
... strand and is acropetal in the sub-cortical region. This suggests organelles and vesicles move towards the tip in the transvacuolar strand and away from the tip in the subcortical region (Tominaga et al., 2000). Consistent with this view is the observation that actin ®laments have their barbed ( fas ...
... strand and is acropetal in the sub-cortical region. This suggests organelles and vesicles move towards the tip in the transvacuolar strand and away from the tip in the subcortical region (Tominaga et al., 2000). Consistent with this view is the observation that actin ®laments have their barbed ( fas ...
A mutation in the Arabidopsis mTERFrelated plastid protein
... factor mTERF. As a consequence of this mutation, plastid-specific rRNA levels decrease and protein synthesis in plastids of soldat10 is attenuated. This disruption of chloroplast homeostasis in soldat10 seedlings affects communication between chloroplasts and the nucleus and leads to changes in the ...
... factor mTERF. As a consequence of this mutation, plastid-specific rRNA levels decrease and protein synthesis in plastids of soldat10 is attenuated. This disruption of chloroplast homeostasis in soldat10 seedlings affects communication between chloroplasts and the nucleus and leads to changes in the ...
Identification of Functional Domains in the Cohesin Loader Subunit
... with Scc2 shows that the N-terminal region of Scc2 is important for Scc4 interaction (Chao et al. 2015; Hinshaw et al. 2015). Multiple contacts between the proteins were reported recently (Chao et al. 2015; Hinshaw et al. 2015). However, these latter studies did not identify key regions in Scc4 that ...
... with Scc2 shows that the N-terminal region of Scc2 is important for Scc4 interaction (Chao et al. 2015; Hinshaw et al. 2015). Multiple contacts between the proteins were reported recently (Chao et al. 2015; Hinshaw et al. 2015). However, these latter studies did not identify key regions in Scc4 that ...
Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting Open Access
... reduction, occurred after the split of the therian mammals into the marsupials and eutherians. Conclusions: Our results confirm the idea that acquisition of genomic imprinting in the KCNQ1 domain occurred specifically in the eutherian lineage after the divergence of marsupials, even though imprintin ...
... reduction, occurred after the split of the therian mammals into the marsupials and eutherians. Conclusions: Our results confirm the idea that acquisition of genomic imprinting in the KCNQ1 domain occurred specifically in the eutherian lineage after the divergence of marsupials, even though imprintin ...
The Wnt code: cnidarians signal the way
... libraries) RNAi, morpholinos, transient and stable transfection are available or under optimization procedure. The introduction of transgenic approaches to the field of cnidarian biology was a major breakthrough. Wittlieb et al. (2006) succeeded in producing the first stable transgenic Hydra by using ...
... libraries) RNAi, morpholinos, transient and stable transfection are available or under optimization procedure. The introduction of transgenic approaches to the field of cnidarian biology was a major breakthrough. Wittlieb et al. (2006) succeeded in producing the first stable transgenic Hydra by using ...
An Introduction to RNA Interference (RNAi)
... with its RNA target usually leads to direct translational inhibition rather than specific site-directed cleavage of the mRNA. Regardless of translational inhibition or cleavage, both microRNAs and siRNAs are able to regulate protein production at the RNA level in a very specific sequence-based manne ...
... with its RNA target usually leads to direct translational inhibition rather than specific site-directed cleavage of the mRNA. Regardless of translational inhibition or cleavage, both microRNAs and siRNAs are able to regulate protein production at the RNA level in a very specific sequence-based manne ...
Different strategies of osmoadaptation in the closely
... metabolism, and so is used in food conservation by pickling. One strategy to thrive in such environments involves the production of so-called osmolytes to maintain osmotic equilibrium across the cytoplasmic membrane. Osmolytes are organic compounds of low molecular mass that have no influence on cel ...
... metabolism, and so is used in food conservation by pickling. One strategy to thrive in such environments involves the production of so-called osmolytes to maintain osmotic equilibrium across the cytoplasmic membrane. Osmolytes are organic compounds of low molecular mass that have no influence on cel ...
encore, a gene required for the regulation of germ line mitosis and
... chamber, and instead, resides in a central location and is flanked by nurse cells on either side (Gonzalez-Reyes and St Johnston, 1994; Lohs-Schardin, 1982). Few good candidates exist for genes directly involved in controlling stem cell or cystocyte divisions. Female sterile mutations in the ovarian ...
... chamber, and instead, resides in a central location and is flanked by nurse cells on either side (Gonzalez-Reyes and St Johnston, 1994; Lohs-Schardin, 1982). Few good candidates exist for genes directly involved in controlling stem cell or cystocyte divisions. Female sterile mutations in the ovarian ...