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Genetically controlled fusion
Genetically controlled fusion

... (1) Noireaux et al. A vesicle bioreactor as a step toward an artificial cell assembly. 2004. Proc Natl Acad Sci U S A 101(51): p. 17669-17674; (2) Caschera et al. Programmed Vesicle Fusion Triggers Gene Expression. 2011. Langmuir. In print; (3) Nomura et al. Microscopic observations reveal that fuso ...
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Vesicular monoamine transporter

The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membrane of synaptic vesicles of presynaptic neurons. It acts to transport monoamine neurotransmitters – such as dopamine, serotonin, norepinephrine, epinephrine, and histamine – into the vesicles, which release the neurotransmitters into synapses as chemical messages to postsynaptic neurons. VMATs utilize a proton gradient generated by V-ATPases in vesicle membranes to power monoamine import.Pharmaceutical drugs that target VMATs have possible applications for many conditions, leading to a plethora of biological research. These applications include drug addiction, psychiatric disorders, Parkinson's disease, and other neurological disorders. Many drugs that target VMAT act as inhibitors and alter the kinetics of the protein. Much research regarding the effects of altered VMATs on biological systems is still ongoing.
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