Alternative Splicing
... Why so much intron (1-2% of genome is exons)? Mouse and human differences are almost all splicing Half of the human genome is made up of transposable elements, Alus being the most abundant (1.4 million copies) – They continue to multiply and insert themselves into the genome at the rate of one inser ...
... Why so much intron (1-2% of genome is exons)? Mouse and human differences are almost all splicing Half of the human genome is made up of transposable elements, Alus being the most abundant (1.4 million copies) – They continue to multiply and insert themselves into the genome at the rate of one inser ...
Brain and drugs
... Alcohol x GABA When alcohol is binded on GABA receptor at same time → GABA receptor is held for longer → more inhibitory signals alcohol causes, that GABA binds more frequently → increases the inhibitory effect of GABA , more impulses ...
... Alcohol x GABA When alcohol is binded on GABA receptor at same time → GABA receptor is held for longer → more inhibitory signals alcohol causes, that GABA binds more frequently → increases the inhibitory effect of GABA , more impulses ...
Allosteric Function(s) of Proteins
... academia. Specifically, ideas from molecular dynamics have reshaped receptor theory from the rigid single-active state concepts prevalent historically into a modern view of dynamic protein ensembles of multiple receptor active states. Second, the technology of pharmacological assays has exploded to ...
... academia. Specifically, ideas from molecular dynamics have reshaped receptor theory from the rigid single-active state concepts prevalent historically into a modern view of dynamic protein ensembles of multiple receptor active states. Second, the technology of pharmacological assays has exploded to ...
Thyroid Hormone Receptor: Dimers, Dimers, Dimers
... Nuclear reactors are intracellular receptors as well as transcription factors. They respond through physical interactions with their respective ligands. These ligands are small, hydrophobic signaling molecules such as steroid hormones. Once the ligand is bound, co-activators or co-repressors may be ...
... Nuclear reactors are intracellular receptors as well as transcription factors. They respond through physical interactions with their respective ligands. These ligands are small, hydrophobic signaling molecules such as steroid hormones. Once the ligand is bound, co-activators or co-repressors may be ...
Action of the ciliary neurotrophic factor in mouse brainstem
... glial cells of the area postrema, a circumventricular organ devoid of blood-brain barrier, that allows circulating molecules to gain access to the adjacent brain parenchyma. In 120 min CNTF-treated mice specific nuclear staining for c-Fos was detected not only in cells of the area postrema but also ...
... glial cells of the area postrema, a circumventricular organ devoid of blood-brain barrier, that allows circulating molecules to gain access to the adjacent brain parenchyma. In 120 min CNTF-treated mice specific nuclear staining for c-Fos was detected not only in cells of the area postrema but also ...
Trask Zool 3200: Cell Biology Exam 4—Part II
... nucleus, where it turns on genes involved in cell division. When you purify protein A from cells that have not been treated with hormones, you find that protein B is always complexed with it. To determine the function of protein B, you engineer cells lacking the gene for protein B. You compare norma ...
... nucleus, where it turns on genes involved in cell division. When you purify protein A from cells that have not been treated with hormones, you find that protein B is always complexed with it. To determine the function of protein B, you engineer cells lacking the gene for protein B. You compare norma ...
File - The Portfolio of Juliana Madzia
... The VZ houses the primary (early) progenitors while the SVZ houses more mature intermediate progenitors. LGE progenitors give rise to neurons. ...
... The VZ houses the primary (early) progenitors while the SVZ houses more mature intermediate progenitors. LGE progenitors give rise to neurons. ...
Chapter 11. Review Notes [10-2
... A quick note: Never focus on the wording of things as with Biochem its always A to D (i.e. If A, then also B and C but most important the last effect D), not what does this what does that. Most medical questions will be cause and effect, so knowing how things are accomplished (the cell produces more ...
... A quick note: Never focus on the wording of things as with Biochem its always A to D (i.e. If A, then also B and C but most important the last effect D), not what does this what does that. Most medical questions will be cause and effect, so knowing how things are accomplished (the cell produces more ...
Lecture 17 and 18: Cellular Signaling Reference: Lieberman and
... Alters gene expression o Jak – Stat Receptor Tyrosine associated receptor frequently used by cytokines to regulate proliferation of certain cells involved in the immune response. The receptor has no intrinsic kinase activity but it binds to the tyrosine kinase JAK (janus kinase) Their sign ...
... Alters gene expression o Jak – Stat Receptor Tyrosine associated receptor frequently used by cytokines to regulate proliferation of certain cells involved in the immune response. The receptor has no intrinsic kinase activity but it binds to the tyrosine kinase JAK (janus kinase) Their sign ...
Drug-resistance facilitates tumor-targeting of
... Elevation of the human epidermal growth factor receptor subunit 2 (HER2) characterizes HER2+ tumors. HER2 elevation amplifies tumor growth signaling, facilitating recalcitrance to standard therapies. Whereas HER2 inhibitors, trastuzumab and lapatinib, target HER2+ tumors by blocking HER2 signaling, ...
... Elevation of the human epidermal growth factor receptor subunit 2 (HER2) characterizes HER2+ tumors. HER2 elevation amplifies tumor growth signaling, facilitating recalcitrance to standard therapies. Whereas HER2 inhibitors, trastuzumab and lapatinib, target HER2+ tumors by blocking HER2 signaling, ...
File
... Alpha1A – contraction of smooth muscle – high density in prostate gland; also found on arteries and veins Alpha1B – most abundant type in heart (function??), may be involved with alpha 1A in cardiac growth and structure, may be more abundant on blood vessels as we get older; Alpha1C was discovered a ...
... Alpha1A – contraction of smooth muscle – high density in prostate gland; also found on arteries and veins Alpha1B – most abundant type in heart (function??), may be involved with alpha 1A in cardiac growth and structure, may be more abundant on blood vessels as we get older; Alpha1C was discovered a ...
BPS 502
... phosphotyrosines on a subset of tyrosine-phosphorylated proteins. Exhibit high degree of substrate selectivity. These enzyme ensure that the tyrosine phosphorylations are short-lived and are responsible for regulating the intensity of the signal. There are about 30 known PTPs and occur as both trans ...
... phosphotyrosines on a subset of tyrosine-phosphorylated proteins. Exhibit high degree of substrate selectivity. These enzyme ensure that the tyrosine phosphorylations are short-lived and are responsible for regulating the intensity of the signal. There are about 30 known PTPs and occur as both trans ...
campbell biology in focus
... Rainbow’s clone). Why is CC’s coat pattern different from Rainbow’s given that CC and Rainbow are genetically identical? A. random X chromosome inactivation ...
... Rainbow’s clone). Why is CC’s coat pattern different from Rainbow’s given that CC and Rainbow are genetically identical? A. random X chromosome inactivation ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.