Chapter 11
... • Ultimately, a signal transduction pathway leads to regulation of one or more cellular activities • The response may occur in the cytoplasm or may involve action in the nucleus • Many pathways regulate the activity of enzymes ...
... • Ultimately, a signal transduction pathway leads to regulation of one or more cellular activities • The response may occur in the cytoplasm or may involve action in the nucleus • Many pathways regulate the activity of enzymes ...
Gene Section ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1)
... middle part (519-615 amino acids) of the ADAMTS1 gene product shows about 40% homology with thrombospondin-1 and thrombospondin-2 (Kuno et al., 1997b). The TSP type I motifs present in the C-terminal half of ADAMTS1 are functional for binding to heparin. Moreover, analyses of deletion mutants have r ...
... middle part (519-615 amino acids) of the ADAMTS1 gene product shows about 40% homology with thrombospondin-1 and thrombospondin-2 (Kuno et al., 1997b). The TSP type I motifs present in the C-terminal half of ADAMTS1 are functional for binding to heparin. Moreover, analyses of deletion mutants have r ...
Amino Acid Sequence and Domain Structure of Entactin. Homology
... The open reading frame encodes a 1,245-amino acid polypeptide with an unglycosylated 34, of 136,500; this is close to the Mr of 143,000 estimated for the in vitro translation product of entactin mRNA (15). The NH2 terminus of mature entactin was determined to be LNXQELFPFGPG by Edman degradation, an ...
... The open reading frame encodes a 1,245-amino acid polypeptide with an unglycosylated 34, of 136,500; this is close to the Mr of 143,000 estimated for the in vitro translation product of entactin mRNA (15). The NH2 terminus of mature entactin was determined to be LNXQELFPFGPG by Edman degradation, an ...
Slide 1
... FIGURE 8.6 (A) Model of one of the subunits of the ionotropic glutamate receptor. Ionotropic glutamate receptors have four membrane-associated segments; however, unlike nAChR, only three of them completely traverse the lipid bilayer. TM2 forms a loop and exits back into the cytoplasm. This leaves t ...
... FIGURE 8.6 (A) Model of one of the subunits of the ionotropic glutamate receptor. Ionotropic glutamate receptors have four membrane-associated segments; however, unlike nAChR, only three of them completely traverse the lipid bilayer. TM2 forms a loop and exits back into the cytoplasm. This leaves t ...
SIGNAL TRANSDUCTION PATHWAYS Student Version Outline
... Change in ion concentration can directly affect cellular activity. ...
... Change in ion concentration can directly affect cellular activity. ...
SIGNAL TRANSDUCTION PATHWAYS Outline
... Change in ion concentration can directly affect cellular activity. ...
... Change in ion concentration can directly affect cellular activity. ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.