Discussion Questions for first 2 weeks.
... The paper is significant for understanding structure-function of Nuclear Receptors (NR) which recruitment cofactors. Nuclear receptors have typically 4 domains. The central zinc finger DNAbinding domain (DBD) relates to the C-terminal hormone-binding domain (LBD) that engenders part of hormone-depen ...
... The paper is significant for understanding structure-function of Nuclear Receptors (NR) which recruitment cofactors. Nuclear receptors have typically 4 domains. The central zinc finger DNAbinding domain (DBD) relates to the C-terminal hormone-binding domain (LBD) that engenders part of hormone-depen ...
Read Jan 9, Discussion on Jan 11, two papers
... The paper is significant for understanding structure-function of Nuclear Receptors (NR) which recruitment cofactors. Nuclear receptors have typically 4 domains. The central zinc finger DNAbinding domain (DBD) relates to the C-terminal hormone-binding domain (LBD) that engenders part of hormone-depen ...
... The paper is significant for understanding structure-function of Nuclear Receptors (NR) which recruitment cofactors. Nuclear receptors have typically 4 domains. The central zinc finger DNAbinding domain (DBD) relates to the C-terminal hormone-binding domain (LBD) that engenders part of hormone-depen ...
WP4 - Jones
... cells for protein expression • The tobacco cells will be multiplied in liquid culture • Induce protein expression • Assay for CSase and SATase activity • Determine kinetic parameters – Km, Vmax ...
... cells for protein expression • The tobacco cells will be multiplied in liquid culture • Induce protein expression • Assay for CSase and SATase activity • Determine kinetic parameters – Km, Vmax ...
Molecular Cell Biology course 1BL320 Spring
... Receptors & signal pathways 1. One central growth regulatory pathway activated by many different receptor types is the Erk MAP kinase pathway. a) Describe how the signal is propagated from the cell surface to the nucleus through the Erk MAP kinase pathway. Include in your answer the following protei ...
... Receptors & signal pathways 1. One central growth regulatory pathway activated by many different receptor types is the Erk MAP kinase pathway. a) Describe how the signal is propagated from the cell surface to the nucleus through the Erk MAP kinase pathway. Include in your answer the following protei ...
Ligand-Gated Ion Channels
... Functional difference: the flip forms of most subunits desensitize more slowly and to a lesser degree than the flop forms distinction that is easily displayed probed with various agents. • NR1 subunit of the NMDARs has 3 alt spliced exons 8 splice variants variations of the C-term exons differ ...
... Functional difference: the flip forms of most subunits desensitize more slowly and to a lesser degree than the flop forms distinction that is easily displayed probed with various agents. • NR1 subunit of the NMDARs has 3 alt spliced exons 8 splice variants variations of the C-term exons differ ...
GABRA1 (gamma-aminobutyric acid (GABA) A receptor. alpha 1
... Disease: Defects in GABRA1 are a cause of juvenile myoclonic epilepsy (JME) [MIM:606904]. JME is a common epileptic syndrome characterized by afebrile seizures, onset in adolescence (rather than in childhood) and myoclonic jerks. Disease: Defects in GABRA1 are the cause of childhood absence epilepsy ...
... Disease: Defects in GABRA1 are a cause of juvenile myoclonic epilepsy (JME) [MIM:606904]. JME is a common epileptic syndrome characterized by afebrile seizures, onset in adolescence (rather than in childhood) and myoclonic jerks. Disease: Defects in GABRA1 are the cause of childhood absence epilepsy ...
Intracellular accumulations 2014-2015Dr.Ban Jumaa Intracellular
... 1. Atherosclerosis (will be taught in CVS) 2. Xanthomas 3. Cholesterolosis Xanthomas ...
... 1. Atherosclerosis (will be taught in CVS) 2. Xanthomas 3. Cholesterolosis Xanthomas ...
Cellular Communication
... • Lipophilic signal molecules — most fatty acid class – Water insoluble. Must be transported in plasma by carrier proteins. – Carrier proteins also protect hormone from degradation. Half-life longer: 1–2 hours. – Released from carrier protein to diffuse across cell membrane into target cells. Act by ...
... • Lipophilic signal molecules — most fatty acid class – Water insoluble. Must be transported in plasma by carrier proteins. – Carrier proteins also protect hormone from degradation. Half-life longer: 1–2 hours. – Released from carrier protein to diffuse across cell membrane into target cells. Act by ...
Pharmacology
... * Binding ligand to extracellular region of receptor , which activate G_ protein , so that GTP replaced GDP on α_ subunit * β&γ interaet with other ion channel * these effectors change the concentration of 2_ messenger which are responsible for further action in the cell * activation of adenyl cycla ...
... * Binding ligand to extracellular region of receptor , which activate G_ protein , so that GTP replaced GDP on α_ subunit * β&γ interaet with other ion channel * these effectors change the concentration of 2_ messenger which are responsible for further action in the cell * activation of adenyl cycla ...
Negative autoregulation of BCL-6 is bypassed B cell lymphomas Xing Wang*
... ‘‘activated B-like DLBCL’’ with poor survival (18). As expected, only the first subtype expresses high levels of BCL-6. In the second study, BCL-6 expression as a single variable was found to strongly predict survival in DLBCL patients irrespective of any subclassification (19). Clearly, these tanta ...
... ‘‘activated B-like DLBCL’’ with poor survival (18). As expected, only the first subtype expresses high levels of BCL-6. In the second study, BCL-6 expression as a single variable was found to strongly predict survival in DLBCL patients irrespective of any subclassification (19). Clearly, these tanta ...
![Effect of arachidonic acid on specific binding of [3H]naloxone to](http://s1.studyres.com/store/data/022505598_1-085ad7f0231ed6be49b2c9c96115ca73-300x300.png)
Effect of arachidonic acid on specific binding of [3H]naloxone to
... The present results show that AA did not significantly influence the affinity of the agonist and antagonist configuration of opioid receptors towards nalaxone. In both configurations, the maximum number of binding sites was significantly reduced by AA and the antagonist configuration of the opioid r ...
... The present results show that AA did not significantly influence the affinity of the agonist and antagonist configuration of opioid receptors towards nalaxone. In both configurations, the maximum number of binding sites was significantly reduced by AA and the antagonist configuration of the opioid r ...
adrenegics
... 11. Why salbutamol is a catecholamine, however it is selective for beta2-receptors. Why? 12. Why salbutamol is a catecholamine, however it has longer half-life in the body. Why? 13. How you can switch the selectivity of adrenaline analogues toward beta2-receptors? 14. How you can identify the compou ...
... 11. Why salbutamol is a catecholamine, however it is selective for beta2-receptors. Why? 12. Why salbutamol is a catecholamine, however it has longer half-life in the body. Why? 13. How you can switch the selectivity of adrenaline analogues toward beta2-receptors? 14. How you can identify the compou ...
G-Protein-Coupled Receptors
... Cell communication systems based on surface receptors have 3 components: (1) Extracellular signal molecules (2) Surface receptors that receive signals (3) Internal response pathways triggered when receptors bind a signal ...
... Cell communication systems based on surface receptors have 3 components: (1) Extracellular signal molecules (2) Surface receptors that receive signals (3) Internal response pathways triggered when receptors bind a signal ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.