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Date of download: 5/10/2017
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From: Anatomy and Neurophysiology of the Cough Reflex : ACCP Evidence-Based Clinical Practice Guidelines
Chest. 2006;129(1_suppl):33S-47S. doi:10.1378/chest.129.1_suppl.33S
Figure Legend:
Tachykinin-containing C-fibers innervate the rat tracheal mucosa. Double-labeling immunohistochemistry with antisera for (left top,
A) the nonspecific neuronal marker protein gene product 9.5 and (left bottom, B) substance P (SP) in wholemounts of rat trachea.
Substance P-containing nerve fibers occupy a dense neuronal plexus beneath and within the airway epithelium. The majority of the
nerves in this epithelial plexus in rats are C-fibers. Middle, C: retrograde neuronal tracing with fast blue indicates that the perikarya
of the tracheal afferent nerves are located in the vagal sensory ganglia. Right, D: many of the retrogradely labeled neurons stain for
TRPV1, the capsaicin receptor. Provided by Dr. S.B. Mazzone (unpublished observations).