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Neurons-on-chip: The technology of electrical recording from neuronal networks grown on microelectrode arrays and its applications in neurophysiology, neuropharmacology and neurotoxicology Dieter G. Weiss Institute of Biological Sciences, Cell Biology and Biotechnology University of Rostock Dissociated cells from embryonic mouse brain cultivated on microelectrode arrays form electrically active multi-cellular circuits that develop stable electrical activity which lasts for several months. Simultaneous recordings from 64 channels yield information on the electrical activity patterns of many individual neurons which react sensitively to the addition of receptor drugs, neurotoxins and other neuro-active compounds. When subjecting the pattern changes to a quantitative description and pattern analysis a powerful platform results for the study of neuronal circuit behaviour, pharmacology and toxicology.
