Adrenergic Blocking Drugs
... Adverse Effects: b-Blockers Body System Adverse Effects Blood Agranulocytosis, thrombocytopenia Cardiovascular AV block, bradycardia, heart failure, peripheral vascular insufficiency CNS Dizziness, mental depression, lethargy, hallucinations GastrointestinalNausea, dry mouth, vomiting, diarrhea, cra ...
... Adverse Effects: b-Blockers Body System Adverse Effects Blood Agranulocytosis, thrombocytopenia Cardiovascular AV block, bradycardia, heart failure, peripheral vascular insufficiency CNS Dizziness, mental depression, lethargy, hallucinations GastrointestinalNausea, dry mouth, vomiting, diarrhea, cra ...
Drugs used in angina - NHS Education for Scotland
... Simvastatin* and e.g. verapamil, amiodarone Simvastatin* and grapefruit juice Calcium antagonists and digoxin ACE inhibitors and NSAIDs ACE inhibitors and K+ GTN (tablets) and drugs causing dry mouth Nitrates and e.g. sildenafil (Viagra) ...
... Simvastatin* and e.g. verapamil, amiodarone Simvastatin* and grapefruit juice Calcium antagonists and digoxin ACE inhibitors and NSAIDs ACE inhibitors and K+ GTN (tablets) and drugs causing dry mouth Nitrates and e.g. sildenafil (Viagra) ...
药理概论1
... repeated drug administration. Psychologic dependence is manifested by compulsive drugseeking behavior. Physiologic dependence is present when withdrawal of drug produces symptoms and signs. Drug addiction is defined as the compulsive, out-of-control drug use, despite negative consequences. D ...
... repeated drug administration. Psychologic dependence is manifested by compulsive drugseeking behavior. Physiologic dependence is present when withdrawal of drug produces symptoms and signs. Drug addiction is defined as the compulsive, out-of-control drug use, despite negative consequences. D ...
Pharmacology (translated questions from the Dutch master) 2012 1
... 2) Casus: patient with Myasthenia gravis arrives at ER with extreme muscle weakness. Why is Edrofonium better than atropine to show the difference between a Myasthenia gravis crisis (low Ach) and a cholinergic crisis (too much Ach)? 3) Right or wrong? a. Fresh blood sample: vitamin K antagonists do ...
... 2) Casus: patient with Myasthenia gravis arrives at ER with extreme muscle weakness. Why is Edrofonium better than atropine to show the difference between a Myasthenia gravis crisis (low Ach) and a cholinergic crisis (too much Ach)? 3) Right or wrong? a. Fresh blood sample: vitamin K antagonists do ...
Update in Hypertension: The Seventh Joint National Committee
... years. By the end of the study, BP had decreased to a similar extent in both groups (- 26/12 mm Hg). The cardiovascular events or death from any cause was 56.1 per 1000 patient-years in the ACE-inhibitor group and 59.8 per 1000 patient-years in the diuretics group (hazard ratio 0.89, 95% CI 0.79 to ...
... years. By the end of the study, BP had decreased to a similar extent in both groups (- 26/12 mm Hg). The cardiovascular events or death from any cause was 56.1 per 1000 patient-years in the ACE-inhibitor group and 59.8 per 1000 patient-years in the diuretics group (hazard ratio 0.89, 95% CI 0.79 to ...
Drug-Receptor Interactions
... G-protein-linked receptors compose a large class of membrane-bound receptors. The protein structure of these receptors includes a common seven-membered transmembrane domain. In general, receptors linked to G proteins greatly amplify the biologic signal because they activate G proteins, which in turn ...
... G-protein-linked receptors compose a large class of membrane-bound receptors. The protein structure of these receptors includes a common seven-membered transmembrane domain. In general, receptors linked to G proteins greatly amplify the biologic signal because they activate G proteins, which in turn ...
Norepinephrine
... The prototype of the beta-blocker drugs is propranolol, in which the catechol ring system has been modified to a naphthalene ether, and a bulky N-alkyl substituent has been incorporated. Note: Propranolol has naphthalene ( two benzene rings attached to each other ) in its structure . One aromati ...
... The prototype of the beta-blocker drugs is propranolol, in which the catechol ring system has been modified to a naphthalene ether, and a bulky N-alkyl substituent has been incorporated. Note: Propranolol has naphthalene ( two benzene rings attached to each other ) in its structure . One aromati ...
Cardiovascular Drug Agents
... that acts by blocking sodium channels, increasing the effective refractory period. They are used for both atrial and ventricular arrhythmias. All these agents have low therapeutic toxic ratios and may produce severe adverse reactions. Cinchonism is commonly produced by drugs that are cinchona deriva ...
... that acts by blocking sodium channels, increasing the effective refractory period. They are used for both atrial and ventricular arrhythmias. All these agents have low therapeutic toxic ratios and may produce severe adverse reactions. Cinchonism is commonly produced by drugs that are cinchona deriva ...
I. Angina Pectoris
... dihydropyridines except verapamil, diltiazem and bepridil which bind to different receptors in the channel. 2. Cardiovascular Effects The decrease in vascular muscle tone results in primarily arteriolar dilation and a fall in peripheral resistance and afterload. Coronary dilation and an increase in ...
... dihydropyridines except verapamil, diltiazem and bepridil which bind to different receptors in the channel. 2. Cardiovascular Effects The decrease in vascular muscle tone results in primarily arteriolar dilation and a fall in peripheral resistance and afterload. Coronary dilation and an increase in ...
Carol Dwan
... • GABA (gamma-aminobutyric acid) is the most common inhibitory neurotransmitter in the brain. When this molecule binds to it’s receptor it makes the neuron less likely to fire. • Complex molecule with multiple receptor sites ...
... • GABA (gamma-aminobutyric acid) is the most common inhibitory neurotransmitter in the brain. When this molecule binds to it’s receptor it makes the neuron less likely to fire. • Complex molecule with multiple receptor sites ...
Antihypertensive Drugs
... Specific angiotensin receptors have been discovered, grouped and abbreviated as – AT1 and AT2 They are present on the surface of the target cells Most of the physiological actions of angiotensin are mediated via AT1 receptor Transducer mechanisms of AT1 inhibitors: In different tissues show differen ...
... Specific angiotensin receptors have been discovered, grouped and abbreviated as – AT1 and AT2 They are present on the surface of the target cells Most of the physiological actions of angiotensin are mediated via AT1 receptor Transducer mechanisms of AT1 inhibitors: In different tissues show differen ...
Reading Material
... • Women older than 50 years have higher plasma concentrations of amitriptyline than age matched men ...
... • Women older than 50 years have higher plasma concentrations of amitriptyline than age matched men ...
الشريحة 1
... and progesterone receptors, which may lead to gynecomastia and other sexual side effects; these effects are less frequent with eplerenone because of its low affinity for androgen and progesterone receptors. Based on clinical trial results demonstrating reduced mortality, low-dose aldosterone antagon ...
... and progesterone receptors, which may lead to gynecomastia and other sexual side effects; these effects are less frequent with eplerenone because of its low affinity for androgen and progesterone receptors. Based on clinical trial results demonstrating reduced mortality, low-dose aldosterone antagon ...
Drug-receptor interactions
... Receptor and drug: • 1. Receptor largely determine the quantitative relations between dose or concentration of drug and ...
... Receptor and drug: • 1. Receptor largely determine the quantitative relations between dose or concentration of drug and ...
CHAPTER 11 Cardiovascular Drugs Quiz Yourself 1. Beta
... blood to produce a new supply of bile. This lowers the level of cholesterol in the blood. 4. Digitalis drugs exert two therapeutic effects on the heart; they have a positive inotropic effect that causes the heart to contract more forcefully, and they have a negative chronotropic effect that causes t ...
... blood to produce a new supply of bile. This lowers the level of cholesterol in the blood. 4. Digitalis drugs exert two therapeutic effects on the heart; they have a positive inotropic effect that causes the heart to contract more forcefully, and they have a negative chronotropic effect that causes t ...
教案编写基本格式与要求
... A drug, which is able to fit onto a receptor, is said to have affinity for that receptor. Efficacy is the ability of a drug to produce an effect at a receptor. An agonist has both an affinity and efficacy whereas antagonist has affinity but not efficacy or intrinsic activity. When a drug is able to ...
... A drug, which is able to fit onto a receptor, is said to have affinity for that receptor. Efficacy is the ability of a drug to produce an effect at a receptor. An agonist has both an affinity and efficacy whereas antagonist has affinity but not efficacy or intrinsic activity. When a drug is able to ...
Adverse effects of antimuscarinic drugs
... , the adverse effect of ganglion blocked are so severe (both sympathetic and parasympathetic divisions are blocked), so that patients are unable to tolerate long term treatment with them Trimethaphan It is the only Ganglion-blocker still in clinical use It is used IV to treat severe accelerated hype ...
... , the adverse effect of ganglion blocked are so severe (both sympathetic and parasympathetic divisions are blocked), so that patients are unable to tolerate long term treatment with them Trimethaphan It is the only Ganglion-blocker still in clinical use It is used IV to treat severe accelerated hype ...
Therapy of systemic hypertension
... They are well absorbed, but undergo extensive hepatic metabolism (first pass effect). They are preferred in patients with renal failure. They can also cross the BBB and produce CNS effects. e.g. propranolol, ……. 2-Hydrophilic (water-soluble) beta-blockers: They are less well absorbed and slowly elim ...
... They are well absorbed, but undergo extensive hepatic metabolism (first pass effect). They are preferred in patients with renal failure. They can also cross the BBB and produce CNS effects. e.g. propranolol, ……. 2-Hydrophilic (water-soluble) beta-blockers: They are less well absorbed and slowly elim ...
Is there a difference between an angiotensin
... to evaluate the effect of various classes of antihypertensive drugs.7 Twelve randomised clinical trials and 13 randomised comparisons involving 35 707 patients with hypertension were suitable for data analysis, in which an ACE inhibitor was used compared to placebo, and 13 randomised clinical trials ...
... to evaluate the effect of various classes of antihypertensive drugs.7 Twelve randomised clinical trials and 13 randomised comparisons involving 35 707 patients with hypertension were suitable for data analysis, in which an ACE inhibitor was used compared to placebo, and 13 randomised clinical trials ...
Pharmacology Exam for Grade 2008 Pakistan Students
... 22. Which of the followings about antipyretic effect of NSAIDS is not true? A. inhibiting COX in CNS, decreasing production of PGs B. making body temperature alter with the environmental temperature C. no influence on normal temperature D. effective in rheumatic fever E. can not be used in artificia ...
... 22. Which of the followings about antipyretic effect of NSAIDS is not true? A. inhibiting COX in CNS, decreasing production of PGs B. making body temperature alter with the environmental temperature C. no influence on normal temperature D. effective in rheumatic fever E. can not be used in artificia ...
Summary overview: Gi and Gs G-protein coupled receptors - Di-Et-Tri
... Different effectors & their receptors induce Giα to exchange GDP for GTP than those that activate Gsα. In some cells, the complex of Gβγ that is released when Ga binds GTP is itself an effector that binds to and activates other proteins. Example: Cannaboid receptor • Important endogenous regulation ...
... Different effectors & their receptors induce Giα to exchange GDP for GTP than those that activate Gsα. In some cells, the complex of Gβγ that is released when Ga binds GTP is itself an effector that binds to and activates other proteins. Example: Cannaboid receptor • Important endogenous regulation ...
Slide 1
... Kidney : Ionized drugs > non ionized drugs Alkalinization ( Phenobarbital ) Bicarbonate Acidification ( Amphetamine ) Vitamin C G.I.Tract : Morphine Lungs : Anesthetics Saliva : Dermatitis ( some intravenous drugs ) Mammilary glands : pH= 6.5 Morphine ...
... Kidney : Ionized drugs > non ionized drugs Alkalinization ( Phenobarbital ) Bicarbonate Acidification ( Amphetamine ) Vitamin C G.I.Tract : Morphine Lungs : Anesthetics Saliva : Dermatitis ( some intravenous drugs ) Mammilary glands : pH= 6.5 Morphine ...
Slide 1
... Kidney : Ionized drugs > non ionized drugs Alkalinization ( Phenobarbital ) Bicarbonate Acidification ( Amphetamine ) Vitamin C G.I.Tract : Morphine Lungs : Anesthetics Saliva : Dermatitis ( some intravenous drugs ) Mammilary glands : pH= 6.5 Morphine ...
... Kidney : Ionized drugs > non ionized drugs Alkalinization ( Phenobarbital ) Bicarbonate Acidification ( Amphetamine ) Vitamin C G.I.Tract : Morphine Lungs : Anesthetics Saliva : Dermatitis ( some intravenous drugs ) Mammilary glands : pH= 6.5 Morphine ...
ppt
... [LR] Rate of reaction proportional to [ ] reactants K1=[L]*[R] K2=[LR] At equilibrium, k1=k2. Substituting, k1/k2=[L]*[R]/[LR]=kD, the equilibrium dissociation constant ...
... [LR] Rate of reaction proportional to [ ] reactants K1=[L]*[R] K2=[LR] At equilibrium, k1=k2. Substituting, k1/k2=[L]*[R]/[LR]=kD, the equilibrium dissociation constant ...
Experimental method and procedure
... Fixing samples: Wash your hands and dip some nutrient fluid on your finger tips; Fetch a piece of intestinal samples and tie a thread at each end; Fix the sample, bung the Magnus tube with rubber stopper, pour enough nutrient fluid into the Magnus tube and adjust the length of the thread to make the ...
... Fixing samples: Wash your hands and dip some nutrient fluid on your finger tips; Fetch a piece of intestinal samples and tie a thread at each end; Fix the sample, bung the Magnus tube with rubber stopper, pour enough nutrient fluid into the Magnus tube and adjust the length of the thread to make the ...