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Atypical Antipsychotic Drugs: Clozapine, olanzapine
Atypical Antipsychotic Drugs: Clozapine, olanzapine

... hydroxyrisperidone in vivo in most patients, except for about 10% of patients who are poor metabolizers. These drugs have complex pharmacology but they share a greater ability to alter 5-HT 2A -receptor activity than to interfere with D 2 -receptor action. In most cases, they act as partial agonist ...
Pharmacology 2a – Mechanisms of Drug action
Pharmacology 2a – Mechanisms of Drug action

... o Conformation change of the receptor such that the receptor doesn’t bring about response any more. o E.g. Acetylcholine receptors at neuromuscular junction ...
Drugs of Abuse: Psychedelic Agents
Drugs of Abuse: Psychedelic Agents

... may also have an inhibitory effect on certain areas such as the visual cortex.  Necessary for mechanism of the action of hallucinogens  Inhibition of the firing of neurons in the visual cortex, which are normally involved in the perception of the objects, is thought to be the cause of the visual h ...
PROPALIN syrup
PROPALIN syrup

... bitches. Contrai-ndications: The use of Propalin is not appropriate for the treatment of behavioural causes of inappropriate urination. Do not administer to patients treated with non-selective monoamine oxidase inhibitors. In the course of field clinical trials loose stools liquid diarrhoea decrease ...
1. b-adrenergic Blockers
1. b-adrenergic Blockers

... 3) Direct vasodilators (calcium channel Blockers, Hydralazine; Minoxidil) 4) Drugs that block production or action of angiotensin I Why it is so fortunate that these drugs have different mechanisms and site of action? ...
Initial Drug Choices
Initial Drug Choices

... Short-acting CCB (niphedipine) should not be used because they increase CV risk. Only long-acting CCB or slow-release niphedipine formulation should be used. ...
Pharmacology 1 for pharmacy students
Pharmacology 1 for pharmacy students

... purely basic sciences and clinical sciences to promote a safe and effective drug use optimizing benefits and minimizing risks. Rational drug use embraces not only rational drug prescribing by the clinical practitioner but also rational drug dispensing by the pharmacist and rational drug consumption ...
Clinical Pharmacy Specialists Scope of Practice
Clinical Pharmacy Specialists Scope of Practice

... HYPERTENSION MANAGEMENT PROTOCOL (clinic and or pharmacy name here) EFFECTIVE DATE: (date) APPROVED BY: (list prescribers here SUPERSEDES: (if applicable) REVIEW DATE: (recommended yearly) PATIENT POPULATION: Patients referred by a provider with the diagnosis of hypertension who have not reached blo ...
Alfuzosin用於治療女性case之討論
Alfuzosin用於治療女性case之討論

... • Like tamsulosin, alfuzosin is more selective for α-1 adrenergic receptors in the lower urinary tract than other drugs in its class. Although alfuzosin is less selective than tamsulosin, both drugs have a less pronounced effect on blood pressure than the other α-blockers and neither is labeled to t ...
HYPERTENSIN PHL315
HYPERTENSIN PHL315

... Advantages of ACE inhibitors over other therapies: • There is no reflex sympathetic (NO tachycardia or edema) • Less adverse effects on lipid profile and glucose than diuretics and β blockers • The most beneficial effect is its inhibition of cardiovascular remodeling due to effect of Ang II on heart ...
Adrenergic drugs
Adrenergic drugs

... 2. Diazoxide and sodium nitroprusside are classified as vasodilators and result in peripheral vasodilation, resulting in a reduction in systemic vascular resistance and reduced blood pressure. 3. Prazosin (Minipress) is a peripherally acting alpha1-blocker. 4. Propranolol works to decrease blood pre ...
Drugs on the brain
Drugs on the brain

... Drug effects and side effects result from interaction with individual receptors ...
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... adrenaline (肾上腺素) and noradrenaline (去甲肾上腺素). Widely distributed, being responsible for control of the stimulation and relaxation of muscle, including the heart. Mediate the control of cardiac function by the sympathetic nervous system; the parasympathetic nervous system control is mediated by musca ...
beta blocker in combination with Other Antihypertensives
beta blocker in combination with Other Antihypertensives

... used over monotherapy must be proven. The two drugs in combination must be established to lower blood pressure by a greater amount than each alone. Lower doses in combination must be as effective as usual higher monotherapy doses but with fewer side effects. ...
Medical Pressure
Medical Pressure

... o Sodium thiosulphate increases metabolism of cyanide to thiocyanate o hydroxocobolamine combines with cyanide to form cyanocobolamine (non toxic) ❏ Thiocyanate accumulation cause thiocyanate toxicity ( in renal disease ) manifested as weakness, psychoses, muscle spasms and convulsions ...
4 Common eye medications
4 Common eye medications

... • Decrease ptosis—useful in mild ptosis secondary to Homer's syndrome; the drug stimulates Miiller's muscle of the lid and results in a decrease in ptosis Side effects Systemic • Hypertension • Myocardial infarction Fifteen cases of acute myocardial infarction were documented (Fraunfelder, 1978) aft ...
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No Slide Title

... increased decreased blood blood flow flow ...
Antihypertensive agents
Antihypertensive agents

... Principles of treatment of arterial hypertension 1. Treatment should be started as soon as possible and should be hold till the end of life. Canceling antihypertensive drugs administration causes relapse of AH. 2. All the individuals with increased arterial pressure should obtain drugless treatment ...
5-Mechanism of drug action2015-10-14 05:152.0 MB
5-Mechanism of drug action2015-10-14 05:152.0 MB

... Mechanisms of Drug Action ...
Medicinal Chemistry (MDCH) 5220
Medicinal Chemistry (MDCH) 5220

... substituted benzoic acid. Ortho-nitro substituted benzoic acid is very acidic. What are the influences that lead to the increased acidity? (11) What are bioisosteres? Know the common bioisosteric substitutions possible for various groups (i.e. ring equivalents, tetravalent substitutions, …) ...
Seventh Report of the Joint National Committee on Prevention
Seventh Report of the Joint National Committee on Prevention

... AASK, African American Study of Kidney Disease and Hypertension; ACC/AHA, American College of Cardiology/American Heart Association; ACEI, angiotensin converting enzyme inhibitor; AIRE, Acute Infarction Ramipril Efficacy; Aldo ANT, aldosterone antagonist; ALLHAT, Antihypertensive and Lipid-Lowering ...
Read more. - Griffin Discoveries
Read more. - Griffin Discoveries

...  The unique drug development platform consists of medicinal chemistry and molecular pharmacology tools that allow histamine receptors to be studied at an unprecedented level of details. No other company has these capabilities.  30% of all marketed drugs target GPCRs while histamine receptor drugs ...
Medications to Treat Hypertension
Medications to Treat Hypertension

... symptoms, high blood pressure contributed to the death of more than 52,600 people in 2003 (American Heart Association, 2005). The death rate for African Americans, both men and women, is significantly higher than for Caucasians. Hypertension also remains the number-one risk factor for stroke, a lead ...
antihypertensive drugs
antihypertensive drugs

...  E. Losartan is suitable for administration to patients with heart failure, whereas captopril and related drugs should be avoided ...
Antihypertensive Drugs (CVS)
Antihypertensive Drugs (CVS)

...  MOA: Converted to alpha methyl noradrenaline which acts on alpha-2 receptors in brain and causes inhibition of adrenergic discharge in medulla – fall in PVR and fall in BP  Various adverse effects – cognitive impairement, postural hypotension, positive coomb`s test etc. –  Only used in Hypertens ...
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Discovery and development of beta-blockers

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