Download Pharmacology 1 for pharmacy students

Course Name:
Course Number:
Credit Hours:
Pharmacology and Therapeutics -I
700235
3 Hrs. ( 2 Lect. + 1 Pract. )
Introduction
Pharmacology is a specialty, which has grown in importance with the increase in both
the number and the complexity of drugs. The subject should bridge the gap between
purely basic sciences and clinical sciences to promote a safe and effective drug use
optimizing benefits and minimizing risks.
Rational drug use embraces not only rational drug prescribing by the clinical practitioner
but also rational drug dispensing by the pharmacist and rational drug consumption by
the patient.
The pharmacist can play an important role in achieving rational drug use and educating
the patients about the various aspects of how to handle drugs. With such views in mind,
the present course is designed as a clinically oriented subject rather than a purely basic
one. Therefore, therapeutic applications of drugs and their adverse effects are
emphasized throughout the course. In addition the importance of monitoring plasma
concentrations of many drugs and the beneficial outcomes of conducting drug utilization
studies to serve as a feedback to medical practitioners are also stressed through seminars
and tutorials.
Moreover, a separate course is taught covering the mechanisms of action, therapeutic
indications and adverse effects of anti-microbial agents, and drug treatment of cancer
and general principles of toxicology.
It is hoped that these courses will provide a clear understanding not only of how but also
of when to use drugs.
Theory lectures
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Pharmacokinetics
4
General principles controlling passage of drugs through biological membranes.
Drug absorption, distribution, metabolism and excretion.
Pharmacodynamics
4
Types and mechanisms of actions of drugs (including receptors, ion channels,
enzymes and the signaling mechanism)
Mechanisms of drug antagonism.
Dose response curves and factors modifying dose
Tachyphylaxis. Tolerance and potentiation
Drugs acting on the autonomic nervous system
Introduction
Parasympathomimetics
Parasympatholytics
Neuromuscular blockers
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Sympathomimetics
3
Sympathetic antagonist (receptors antagonists, neuron blockers & centrally
acting)
3
Drugs acting on autonomic ganglia
1
Drugs acting on the respiratory system
3
Pharmacotherapy of bronchial asthma, central and peripheral antitussives and
expectorants
Autacoids & local hormones
Histamine and antagonists
5-Hydroxytryptamine & antagonists
Renin-angiotensin system & antagonists
Prostaglandin’s & antagonists
Prescription writing
Rational drug use
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Lab & tutorials
Introduction to experimental pharmacology
Effect of method of administration on the response of the drug
(experimental)
Introduction to isolated tissue experiments (computer simulation).
Tutorials on pharmacokinetics and pharmacodynamics + Test1
Effect of agonist on guinea pig ileum (computer simulation)
Effect of agonist on guinea pig ileum (experimental)
Effect of antagonist on guinea pig ileum (computer simulation)
Effect of antagonist on guinea pig ileum (experimental)
Tutorial on autonomic nerves system (computer simulation) + Test2
Effect of agonist on guinea pig ileum (experimental)
Effect of agonist on rabbit jejunum (computer simulation)
Effect of antagonist on rabbit jejunum (computer simulation)
The effect of drugs on frog gastrocnemius muscle preparation
(computer simulation)
Tutorial on local hormones & neuromuscular blockers + Test3
Main Text Book:
Pharmacology 2nd ed., H.P.Rang & M.M.Dale, Churchill
Livingston Publisher, 1994 (we prefer the latest edition)
Additional Reference:
1. Basic and Clinical Pharmacology Ed. B. Katzung
2. Modern Pharmacology, Craig & Stizel
3. The Pharmacological Basis of Therapeutics, Goodman & Gilman