the peroxisomal endomembrane system and the role of the ER
... large pleomorphic structures reminiscent of the mammalian peroxisomal reticulum (Mullen et al., 2006) and are engaged in ER-destined retrograde vesicular flow (Fig. 1). Evidence for this latter conclusion comes from observations that when the tomato bushy stunt virus (TBSV) replication protein p33 i ...
... large pleomorphic structures reminiscent of the mammalian peroxisomal reticulum (Mullen et al., 2006) and are engaged in ER-destined retrograde vesicular flow (Fig. 1). Evidence for this latter conclusion comes from observations that when the tomato bushy stunt virus (TBSV) replication protein p33 i ...
Evidence that non-caspase proteases are required for
... the capsase inhibitors Ac-Asp-Glu-Val-Asp-aldehyde, Ac-TyrVal-Ala-Asp-aldehyde, or Z-Val-Ala-Asp-fluoromethyl ketone. Both activities were insensitive to protease inhibitors when extracts were incubated with naked linear DNA, indicating the presence of both nuclease and protease activities in the pr ...
... the capsase inhibitors Ac-Asp-Glu-Val-Asp-aldehyde, Ac-TyrVal-Ala-Asp-aldehyde, or Z-Val-Ala-Asp-fluoromethyl ketone. Both activities were insensitive to protease inhibitors when extracts were incubated with naked linear DNA, indicating the presence of both nuclease and protease activities in the pr ...
Bridging the divide between cytokinesis and cell
... reduction of vacuole surface area by half in the late stages of cytokinesis [38]. Nonetheless, the data presented by Dhonukshe et al. [29] do support the notion that endocytic membrane and cargo can become integrated into the cell plate. In this case, one would suspect that the regulatory mechanis ...
... reduction of vacuole surface area by half in the late stages of cytokinesis [38]. Nonetheless, the data presented by Dhonukshe et al. [29] do support the notion that endocytic membrane and cargo can become integrated into the cell plate. In this case, one would suspect that the regulatory mechanis ...
Infectious Hematopoietic Necrosis recombinant viruses induce
... on the recovery of recombinant viruses from vaccinia-infected cells that are transfected ...
... on the recovery of recombinant viruses from vaccinia-infected cells that are transfected ...
DLG5 in Cell Polarity Maintenance and Cancer Development
... downregulation of DLG5 is associated with overexpression of YAP (Yes-associated protein), a protein ...
... downregulation of DLG5 is associated with overexpression of YAP (Yes-associated protein), a protein ...
Bio 226: Cell and Molecular Biology
... Hemicelluloses AKA cross-linking glycans A diverse group of glucans also linked b 1-4, but may have other sugars and components attached to C6 makes digestion more difficult Assembled in Golgi Secreted cf woven ...
... Hemicelluloses AKA cross-linking glycans A diverse group of glucans also linked b 1-4, but may have other sugars and components attached to C6 makes digestion more difficult Assembled in Golgi Secreted cf woven ...
Exploring Bioinorganic Pattern Formation in Diatoms. A Story of
... Much of the biochemical studies of frustule composition have been done in the pennate diatom Cylindrotheca fusiformis (Kröger and Sumper, 1998). This work has led to the discovery of novel peptides known as silaffins that may participate in the basic biomineralization process within the SDV (Kröge ...
... Much of the biochemical studies of frustule composition have been done in the pennate diatom Cylindrotheca fusiformis (Kröger and Sumper, 1998). This work has led to the discovery of novel peptides known as silaffins that may participate in the basic biomineralization process within the SDV (Kröge ...
Mycobacterium tuberculosis evades macrophage defenses by
... Avirulent mycobacteria, including mutant forms of MTb that have lost their ability to cause disease, stimulate the macrophage to undergo apoptosis, which results in a 'cellular corpse' with an impermeable envelope that prevents bacteria from escaping. This process leads to containment and killing of ...
... Avirulent mycobacteria, including mutant forms of MTb that have lost their ability to cause disease, stimulate the macrophage to undergo apoptosis, which results in a 'cellular corpse' with an impermeable envelope that prevents bacteria from escaping. This process leads to containment and killing of ...
machinery pre-mRNA in sensing defects in the spliceosomal Mdm4
... increasing their affinity for the Tudor domain of spinal motor neuron 1 (SMN1) (Friesen et al. 2001a,b, 2002; Meister et al. 2001). SMN1 deficiency results in early lethality (embryonic day 3.5 [E3.5]) in the mouse embryo, similarly to Prmt5 constitutive deletion (Hsieh-Li et al. 2000; Tee et al. 20 ...
... increasing their affinity for the Tudor domain of spinal motor neuron 1 (SMN1) (Friesen et al. 2001a,b, 2002; Meister et al. 2001). SMN1 deficiency results in early lethality (embryonic day 3.5 [E3.5]) in the mouse embryo, similarly to Prmt5 constitutive deletion (Hsieh-Li et al. 2000; Tee et al. 20 ...
Cytoplasmic sequestration of the tumor suppressor p53 by a heat
... With nuclear and cytoplasmic protein fractions successfully separated, mortalin was detected exclusively in the cytoplasmic fractions of all the colorectal carcinoma cell lines while p53 was detected in the cytoplasmic fraction of six of the eight cell lines. Exceptions were the cytoplasmic fraction ...
... With nuclear and cytoplasmic protein fractions successfully separated, mortalin was detected exclusively in the cytoplasmic fractions of all the colorectal carcinoma cell lines while p53 was detected in the cytoplasmic fraction of six of the eight cell lines. Exceptions were the cytoplasmic fraction ...
The hypersensitive response and the induction of cell death in plants
... precisely established using video microscopy during an incompatible interaction between Phytophthora infestans and potato. Only 26 s are necessary for plant cell collapse and death, and death of the fungus follows 20 s later (Freytag et al, 1994). Such rapid responses could make detection of interme ...
... precisely established using video microscopy during an incompatible interaction between Phytophthora infestans and potato. Only 26 s are necessary for plant cell collapse and death, and death of the fungus follows 20 s later (Freytag et al, 1994). Such rapid responses could make detection of interme ...
Neurotrophins: the biological paradox of survival factors
... implication of these findings is that 192-antibody may act as agonist or may mimick ligand binding to the receptor. A more direct role for NGF in neuronal apoptosis was suggested by the observation that injection of NGF in newborn rats which had received a facial nerve transection resulted in a 50% ...
... implication of these findings is that 192-antibody may act as agonist or may mimick ligand binding to the receptor. A more direct role for NGF in neuronal apoptosis was suggested by the observation that injection of NGF in newborn rats which had received a facial nerve transection resulted in a 50% ...
Simian Virus 40 Large T Antigen and p53 Are
... 60,000 proteins from suspension cultures of the simian virus 40-transformed mouse cell line mKSA. Partial protease mapping showed each of the associated proteins to be unique. Automated ...
... 60,000 proteins from suspension cultures of the simian virus 40-transformed mouse cell line mKSA. Partial protease mapping showed each of the associated proteins to be unique. Automated ...
Lysosomes in iron metabolism, ageing and apoptosis
... receive newly produced lysosomal enzymes by fusion with other lysosomes (Brunk and Ericsson 1972a). Lysosomal enzymes are produced in the reticular network, matured in the cis-Golgi apparatus, and transported from the trans-Golgi network (TGN) within tiny vesicles, sometimes called primary lysosomes ...
... receive newly produced lysosomal enzymes by fusion with other lysosomes (Brunk and Ericsson 1972a). Lysosomal enzymes are produced in the reticular network, matured in the cis-Golgi apparatus, and transported from the trans-Golgi network (TGN) within tiny vesicles, sometimes called primary lysosomes ...
PROTEIN DEPHOSPHORYLATION AND THE INTRACELLULAR
... was quickly suggested that PP1 and PP2A might be tumor suppressors in their own right (6). These exciting discoveries occurred a short time after we learned that many oncogenes encode protein kinases, and, more specifically, that the enzyme responsible for triggering entry into mitosis, p34cdc2/CDC2 ...
... was quickly suggested that PP1 and PP2A might be tumor suppressors in their own right (6). These exciting discoveries occurred a short time after we learned that many oncogenes encode protein kinases, and, more specifically, that the enzyme responsible for triggering entry into mitosis, p34cdc2/CDC2 ...
A C-terminus Mitochondrial-localization Region and BH3 Domain of
... stages of apoptosis, the cellular membrane shrinks and develops a rounded appearance (Kerr et al. 1972). At the same time, the chromatin condenses in the now shrinking nucleus, in a process termed pyknosis (Kerr et al. 1972). The cellular membrane then takes on the blebbed appearance characteristic ...
... stages of apoptosis, the cellular membrane shrinks and develops a rounded appearance (Kerr et al. 1972). At the same time, the chromatin condenses in the now shrinking nucleus, in a process termed pyknosis (Kerr et al. 1972). The cellular membrane then takes on the blebbed appearance characteristic ...
Organelle communication - Repositorio Académico
... between the ER and mitochondria. For example, Mfn2 silencing causes a loss of ER–mitochondria interaction sites, alterations in Ca2+ signaling, and both ER and mitochondrial dysfunction. These disturbances lead to the engagement of stress signals such as hydrogen peroxide elevation, JNK activation a ...
... between the ER and mitochondria. For example, Mfn2 silencing causes a loss of ER–mitochondria interaction sites, alterations in Ca2+ signaling, and both ER and mitochondrial dysfunction. These disturbances lead to the engagement of stress signals such as hydrogen peroxide elevation, JNK activation a ...
Consulta: subjectFacets:"Alternative oxidase" Registros
... Alternative oxidase in the branched mitochondrial respiratory network: an overview on structure, function, regulation, and role Provedor de dados: 56 Autores: Sluse,F.E.; Jarmuszkiewicz,W. Plants and some other organisms including protists possess a complex branched respiratory network in their mito ...
... Alternative oxidase in the branched mitochondrial respiratory network: an overview on structure, function, regulation, and role Provedor de dados: 56 Autores: Sluse,F.E.; Jarmuszkiewicz,W. Plants and some other organisms including protists possess a complex branched respiratory network in their mito ...
G1 Phase-Dependent Expression of Bcl
... We investigated levels of Bcl-2 family proteins during the cell cycle progression. Human Jurkat T cells were synchronized at the G1/S boundary by using aphidicolin, an inhibitor of DNA polymerase ␣ (Huberman, 1981), followed by removal of the drug and further incubation of the cells in fresh growth ...
... We investigated levels of Bcl-2 family proteins during the cell cycle progression. Human Jurkat T cells were synchronized at the G1/S boundary by using aphidicolin, an inhibitor of DNA polymerase ␣ (Huberman, 1981), followed by removal of the drug and further incubation of the cells in fresh growth ...
An A/ENTH Domain-Containing Protein Functions
... The Arabidopsis genome encodes 22 proteins with an A/ENTH domain. Phylogenetic analysis revealed that they can be grouped into five to six subfamilies (Supplemental Fig. S1; Holstein and Oliviusson, 2005). To gain insight into the role of these proteins in plant cells, the cellular localization of Ar ...
... The Arabidopsis genome encodes 22 proteins with an A/ENTH domain. Phylogenetic analysis revealed that they can be grouped into five to six subfamilies (Supplemental Fig. S1; Holstein and Oliviusson, 2005). To gain insight into the role of these proteins in plant cells, the cellular localization of Ar ...
Mitochondria as signaling organelles R E V I E W Open Access
... By contrast, mitochondrial ROS (mROS) were proposed to be produced only under pathological conditions to invoke damage [17]. However, in the late 1990s, mROS emerged as signaling molecules that communicate between mitochondria and the rest of the cell under physiological conditions. An early example ...
... By contrast, mitochondrial ROS (mROS) were proposed to be produced only under pathological conditions to invoke damage [17]. However, in the late 1990s, mROS emerged as signaling molecules that communicate between mitochondria and the rest of the cell under physiological conditions. An early example ...
programmed cell death in plant
... that may encode a nucleotide-binding domain (82). Other plant genes involved in resistance include typical signal transduction molecules such as the Pto kinase and the Pti kinase of tomato (61, 97). As alluded to above, resistance to pathogens that is conditioned by a genefor-gene interaction is an ...
... that may encode a nucleotide-binding domain (82). Other plant genes involved in resistance include typical signal transduction molecules such as the Pto kinase and the Pti kinase of tomato (61, 97). As alluded to above, resistance to pathogens that is conditioned by a genefor-gene interaction is an ...
Max and inhibitory c-Myc mutants induce erythroid di
... In373 is unable to bind DNA (Figure 1b, lane 4), whereas tMyc forms a distinct homodimeric complex (Figure 1b, lane 3). In this experimental design, Max (6 ng) was mixed with an excess of tMyc (600 ng) so that tMyc-tMyc homodimers and tMyc-Max heterodimers are readily detected on EMSA (Figure 1b, la ...
... In373 is unable to bind DNA (Figure 1b, lane 4), whereas tMyc forms a distinct homodimeric complex (Figure 1b, lane 3). In this experimental design, Max (6 ng) was mixed with an excess of tMyc (600 ng) so that tMyc-tMyc homodimers and tMyc-Max heterodimers are readily detected on EMSA (Figure 1b, la ...
Apoptosis
Apoptosis (/ˌæpəˈtoʊsɪs/; from Ancient Greek ἀπό apo, ""by, from, of, since, than"" and πτῶσις ptōsis, ""fall"") is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay.In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's lifecycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytic cells are able to engulf and quickly remove before the contents of the cell can spill out onto surrounding cells and cause damage.Between 50 and 70 billion cells die each day due to apoptosis in the average human adult. For an average child between the ages of 8 and 14, approximately 20 billion to 30 billion cells die a day.Research in and around apoptosis has increased substantially since the early 1990s. In addition to its importance as a biological phenomenon, defective apoptotic processes have been implicated in a wide variety of diseases. Excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer.Some factors like Fas receptor, caspases (C-cysteine rich, asp- aspartic acid moiety containing, ase – proteases) etc. promote apoptosis, while members of Bcl-2 inhibit apoptosis.