PDF + SI - Journal of Cell Science
... Intracellular trafficking and protein sorting are mediated by various protein complexes, with the retromer complex being primarily involved in retrograde traffic from the endosome or lysosome to the Golgi complex. Here, comparative genomics, cell biology and phylogenetics were used to probe the earl ...
... Intracellular trafficking and protein sorting are mediated by various protein complexes, with the retromer complex being primarily involved in retrograde traffic from the endosome or lysosome to the Golgi complex. Here, comparative genomics, cell biology and phylogenetics were used to probe the earl ...
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6-ch05-proteins -Lec 6 [Compatibility Mode]
... Antagonist binds reversibly to the binding site Intermolecular bonds involved in binding Different induced fit means receptor is not activated No reaction takes place on antagonist Level of antagonism depends on strength of antagonist binding and concentration Messenger is blocked from the binding s ...
... Antagonist binds reversibly to the binding site Intermolecular bonds involved in binding Different induced fit means receptor is not activated No reaction takes place on antagonist Level of antagonism depends on strength of antagonist binding and concentration Messenger is blocked from the binding s ...
No Slide Title
... Antagonist binds reversibly to the binding site Intermolecular bonds involved in binding Different induced fit means receptor is not activated No reaction takes place on antagonist Level of antagonism depends on strength of antagonist binding and concentration Messenger is blocked from the binding s ...
... Antagonist binds reversibly to the binding site Intermolecular bonds involved in binding Different induced fit means receptor is not activated No reaction takes place on antagonist Level of antagonism depends on strength of antagonist binding and concentration Messenger is blocked from the binding s ...
Gene Section EP300 (E1A binding protein p300) Atlas of Genetics and Cytogenetics
... Widely expressed ; also expressed in the whole embryo; possesses from N term to C term: a nuclear localization signal, a poly-serine, a bromodomain, a poly-glu, a binding region for E1A adenovirus, and a poly-gln. ...
... Widely expressed ; also expressed in the whole embryo; possesses from N term to C term: a nuclear localization signal, a poly-serine, a bromodomain, a poly-glu, a binding region for E1A adenovirus, and a poly-gln. ...
Stress signaling from the lumen of the endoplasmic reticulum
... is also the site for the synthesis of lipids and sterols. In S. cerevisiae, the UPR is also activated in response to lipid deprivation. Therefore, the UPR also coordinates the synthesis of lipids and new membrane structures as the demand arises. On sterol deprivation in the ER membrane, a signal is ...
... is also the site for the synthesis of lipids and sterols. In S. cerevisiae, the UPR is also activated in response to lipid deprivation. Therefore, the UPR also coordinates the synthesis of lipids and new membrane structures as the demand arises. On sterol deprivation in the ER membrane, a signal is ...
to the complete text
... reconstituted from chemically defined liposomes. Using this reductionist system, it was shown that all that is needed to form a COPI-coated vesicle are the cytosolic proteins ARF and coatomer and the cytoplasmic domains of coat/cargo receptors (p24 family) emanating from the bilayer surface [41••]. ...
... reconstituted from chemically defined liposomes. Using this reductionist system, it was shown that all that is needed to form a COPI-coated vesicle are the cytosolic proteins ARF and coatomer and the cytoplasmic domains of coat/cargo receptors (p24 family) emanating from the bilayer surface [41••]. ...
the unfolded protein response in yeast and mammals Chris
... An as-yet undiscovered mammalian Ire1 substrate mRNA may encode a transcription factor analogous to Hac1p in yeast, but it is also conceivable that Hac1p’s position in the pathway as proximal activator of transcription is filled by another protein whose activation is not regulated by splicing. Mamma ...
... An as-yet undiscovered mammalian Ire1 substrate mRNA may encode a transcription factor analogous to Hac1p in yeast, but it is also conceivable that Hac1p’s position in the pathway as proximal activator of transcription is filled by another protein whose activation is not regulated by splicing. Mamma ...
a review of the BLAST meeting, ï - Bacterial Locomotion and Signal
... ‘keel-like’ density (turquoise) beneath two adjacent receptor trimers (Fig. 2C, left). This density was confirmed to be P1 and P2, as a mutant that lacks these two domains was missing this density (Fig. 2C, right). When locked in the active state, this density is less prominent, suggesting signallin ...
... ‘keel-like’ density (turquoise) beneath two adjacent receptor trimers (Fig. 2C, left). This density was confirmed to be P1 and P2, as a mutant that lacks these two domains was missing this density (Fig. 2C, right). When locked in the active state, this density is less prominent, suggesting signallin ...
Direct interaction of two polarity complexes implicated in epithelial
... contrast, the Crb–PALS1–PATJ complex seems to be more specific for epithelia, at least in D. melanogaster, suggesting it functions as a specific adaptor assisting in the localization of the Par3–Par6–aPKC complex in this cell type2,3. However, it remains unclear whether all these proteins are simult ...
... contrast, the Crb–PALS1–PATJ complex seems to be more specific for epithelia, at least in D. melanogaster, suggesting it functions as a specific adaptor assisting in the localization of the Par3–Par6–aPKC complex in this cell type2,3. However, it remains unclear whether all these proteins are simult ...
y. Cell Set. Suppl. ¡1, 1-11 (1989) Printed in
... III). Lanes: 1, 20% of the ADH III precursor added to each import assay; 2 -5 , import of ADH III precursor by four identical samples of control mitochondria; 6-9, import of ADH III precursor by mitochondria that had been preincubated with 12S, 250, 375 and 500 ng, respectively, of chimeric precurso ...
... III). Lanes: 1, 20% of the ADH III precursor added to each import assay; 2 -5 , import of ADH III precursor by four identical samples of control mitochondria; 6-9, import of ADH III precursor by mitochondria that had been preincubated with 12S, 250, 375 and 500 ng, respectively, of chimeric precurso ...
The Plant Journal
... by Kang et al. (2001) suggested that ADL1 is associated with the cell plate. ADL2 was localized to the plastids (Kang et al., 1998). ADL6 was shown to associate with the Golgi apparatus (Jin et al., 2001). The cellular compartment to which ADL3 associates is currently unknown. Apart from difference ...
... by Kang et al. (2001) suggested that ADL1 is associated with the cell plate. ADL2 was localized to the plastids (Kang et al., 1998). ADL6 was shown to associate with the Golgi apparatus (Jin et al., 2001). The cellular compartment to which ADL3 associates is currently unknown. Apart from difference ...
Complement - microbiology and immunology on-line
... proteins (nomenclature) Activated component are usually over-lined: e.g. C1qrs When enzymatically cleaved, the larger moiety, binds to the activation complex or membrane and the smaller peptide is released in the ...
... proteins (nomenclature) Activated component are usually over-lined: e.g. C1qrs When enzymatically cleaved, the larger moiety, binds to the activation complex or membrane and the smaller peptide is released in the ...
A Distinct and Parallel Pathway for the Nuclear Import of an mRNA
... Nup1p (Fig. 4 a). Kap95p gave a stronger signal with all the nucleoporins tested, including Nup2p (Fig. 4 a). The ladder of bands detected with the nucleoporins Nup1p and Nup2p suggests that these proteins have undergone some proteolytic degradation and the Kap95p is able to recognize the proteolyti ...
... Nup1p (Fig. 4 a). Kap95p gave a stronger signal with all the nucleoporins tested, including Nup2p (Fig. 4 a). The ladder of bands detected with the nucleoporins Nup1p and Nup2p suggests that these proteins have undergone some proteolytic degradation and the Kap95p is able to recognize the proteolyti ...
Autophagy_Marc
... cellular components through the actions of lysosomes . The breakdown of cellular components promotes cellular survival during starvation by maintaining cellular energy levels. Autophagy allows the degradation and recycling of cellular components. During this process, targeted cytoplasmic constituent ...
... cellular components through the actions of lysosomes . The breakdown of cellular components promotes cellular survival during starvation by maintaining cellular energy levels. Autophagy allows the degradation and recycling of cellular components. During this process, targeted cytoplasmic constituent ...
Leishmania Flagellum
... Eukaryotic flagella present a remarkable evolutionary conservation of their structure and constituents [1]. They have been mostly studied in Chlamydomonas reinhardtii [2,3] and Trypanosoma brucei [4,5], two flagellated organisms. Thus, intraflagellar transport was first described in C. reinhardtii b ...
... Eukaryotic flagella present a remarkable evolutionary conservation of their structure and constituents [1]. They have been mostly studied in Chlamydomonas reinhardtii [2,3] and Trypanosoma brucei [4,5], two flagellated organisms. Thus, intraflagellar transport was first described in C. reinhardtii b ...
Fig. - Journal of Cell Science
... fingers (Stogios et al., 2005). No such domains have been described for KCTD proteins, yet the region comprising residues 114–237, which is located directly after its BTB domain, is sufficient for interaction with USP21 (Fig. 3A). The combined results of Y2H and pull-down analyses narrow down the US ...
... fingers (Stogios et al., 2005). No such domains have been described for KCTD proteins, yet the region comprising residues 114–237, which is located directly after its BTB domain, is sufficient for interaction with USP21 (Fig. 3A). The combined results of Y2H and pull-down analyses narrow down the US ...
1 Introduction - diss.fu
... Probably the first initiation factor, which binds to the ribosome, is IF3. It has two identified functions. (1) It acts as an anti-association factor preventing formation of the 70S ribosome from 50S and 30S subunits. (2) It plays an important role in the codon-anticodon discrimination at the P-site ...
... Probably the first initiation factor, which binds to the ribosome, is IF3. It has two identified functions. (1) It acts as an anti-association factor preventing formation of the 70S ribosome from 50S and 30S subunits. (2) It plays an important role in the codon-anticodon discrimination at the P-site ...
Murine Siva-1 and Siva-2, alternate splice forms of the mouse Siva
... receptor cytoplasmic tail appears to be critical for signal transduction. Several novel and important intracellular signaling molecules that associate with the cytoplasmic tails of various TNFR family members have been cloned and characterized. They can broadly be divided into three groups, the ®rst ...
... receptor cytoplasmic tail appears to be critical for signal transduction. Several novel and important intracellular signaling molecules that associate with the cytoplasmic tails of various TNFR family members have been cloned and characterized. They can broadly be divided into three groups, the ®rst ...
Saito et al, 2009 - The EMBO Journal
... complex binds Sar1 by direct interaction of Sec23 with Sar1GTP. This forms the first of two layers of coat proteins on the cytoplasmic surface of the ER (Bi et al, 2002). In this prebudding complex, Sec24 is thought to be key for the binding and concentration of transmembrane (TM) cargoes that conta ...
... complex binds Sar1 by direct interaction of Sec23 with Sar1GTP. This forms the first of two layers of coat proteins on the cytoplasmic surface of the ER (Bi et al, 2002). In this prebudding complex, Sec24 is thought to be key for the binding and concentration of transmembrane (TM) cargoes that conta ...
Mitochondria as signaling organelles R E V I E W Open Access
... Almost 20 years ago, the discovery that mitochondrial release of cytochrome c initiates a cascade that leads to cell death brought about a wholesale change in how cell biologists think of mitochondria. Formerly viewed as sites of biosynthesis and bioenergy production, these double membrane organelle ...
... Almost 20 years ago, the discovery that mitochondrial release of cytochrome c initiates a cascade that leads to cell death brought about a wholesale change in how cell biologists think of mitochondria. Formerly viewed as sites of biosynthesis and bioenergy production, these double membrane organelle ...
C-terminal EH-domain-containing proteins
... that have an EH domain can carry out a variety of crucial cellular functions ranging from regulation of the actin cytoskeleton, signal transduction and transcriptional regulation to control of the endocytic pathway. EH domains bind to proteins that contain the tripeptide asparagineproline-phenylalan ...
... that have an EH domain can carry out a variety of crucial cellular functions ranging from regulation of the actin cytoskeleton, signal transduction and transcriptional regulation to control of the endocytic pathway. EH domains bind to proteins that contain the tripeptide asparagineproline-phenylalan ...
Abstract Importance Structure of Primary Cilia A B Functional Kif3B
... designed a model of Kif3B to investigate the interaction of amino acid residues 96 through 104 of Kif3B with ATP and to visualize the neck region in Kif3B important for dimerization with Kif3A and for microtubule motility. ...
... designed a model of Kif3B to investigate the interaction of amino acid residues 96 through 104 of Kif3B with ATP and to visualize the neck region in Kif3B important for dimerization with Kif3A and for microtubule motility. ...
Review Structural Insights into Biological Roles of Protein
... Microbial pathogenesis Microbial pathogenesis Microbial pathogenesis Inflammation/immune response ...
... Microbial pathogenesis Microbial pathogenesis Microbial pathogenesis Inflammation/immune response ...
The Abundance of Cell Cycle Regulatory Protein Cdc4p Is
... other essential F-box proteins. There is much genetic evidence indicating that the abundance of SCF components must be balanced to allow normal cell growth (23, 25, 27, 30, 39). However, overexpression of genes encoding F-box proteins only has a detrimental effect on cell growth when the cell also c ...
... other essential F-box proteins. There is much genetic evidence indicating that the abundance of SCF components must be balanced to allow normal cell growth (23, 25, 27, 30, 39). However, overexpression of genes encoding F-box proteins only has a detrimental effect on cell growth when the cell also c ...
Apoptosome
The apoptosome is a large quaternary protein structure formed in the process of apoptosis. Its formation is triggered by the release of cytochrome c from the mitochondria in response to an internal (intrinsic) or external (extrinsic) cell death stimulus. Stimuli can vary from DNA damage and viral infection to developmental cues such as those leading to the degradation of a tadpole's tail.In mammalian cells, once cytochrome c is released, it binds to the cytosolic protein Apaf-1 to facilitate the formation of apoptosome. An early biochemical study suggests a two-to-one ratio of cytochrome c to apaf-1 for apoptosome formation. However, recent structural studies suggest the cytochrome c to apaf-1 ratio is one-to-one. It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. The mammalian apoptosome had never been crystallized, but a human APAF-1/cytochrome-c apoptosome has been imaged at lower (2 nm) resolution by cryogenic transmission electron microscopy 10 years ago, revealing a wheel-like particle with 7-fold symmetry. Recently, a medium resolution (9.5 Ångström) structure of human apoptosome was also solved by cryo-electron microscopy, which allows unambiguous inference for positions of all the APAF-1 domains (CARD, NBARC and WD40) and cytochrome c. There is also now a crystal structure of the monomeric, inactive Apaf-1 subunit (PDB 3SFZ). Once formed, the apoptosome can then recruit and activate the inactive pro-caspase-9. Once activated, this initiator caspase can then activate effector caspases and trigger a cascade of events leading to apoptosis.