enzymes - UniMAP Portal
... • As early as the late 1700s and early 1800s, the digestion of meat by stomach secretions and the conversion of starch to sugars by plant extracts and saliva were known. • However, the mechanism by which this occurred had not been identified. • In the 19th century, when studying the fermentation of ...
... • As early as the late 1700s and early 1800s, the digestion of meat by stomach secretions and the conversion of starch to sugars by plant extracts and saliva were known. • However, the mechanism by which this occurred had not been identified. • In the 19th century, when studying the fermentation of ...
The trans-Golgi network GRIP-domain proteins form α
... are predicted to adopt a rod-like or extended fibrous structure. Members of the family of coiled-coil proteins specifically located on the Golgi (termed golgins), such as p115 and GM130, have been shown to be important as tethering molecules and in the biogenesis of membranes of the Golgi stack [1–5 ...
... are predicted to adopt a rod-like or extended fibrous structure. Members of the family of coiled-coil proteins specifically located on the Golgi (termed golgins), such as p115 and GM130, have been shown to be important as tethering molecules and in the biogenesis of membranes of the Golgi stack [1–5 ...
A domain-specific usherin/collagen IV interaction may be required
... 100 amino acids, are shared with at least 45 different families of molecules ranging from cytokine receptors to cell surface binding proteins. Different type III domains may be almost completely dissimilar at the amino acid level and as much as 90% structurally similar (Sharma et al., 1999). Like th ...
... 100 amino acids, are shared with at least 45 different families of molecules ranging from cytokine receptors to cell surface binding proteins. Different type III domains may be almost completely dissimilar at the amino acid level and as much as 90% structurally similar (Sharma et al., 1999). Like th ...
How Translocons Select Transmembrane Helices
... Membrane protein assembly. (a) The machinery of membrane protein assembly. (Step 1) A ribosome translating the mRNA of a protein targeted for secretion across or insertion into membranes and a signal of a recognition particle (SRP), which is a GTPase. The structures of ribosomes are reviewed in Refe ...
... Membrane protein assembly. (a) The machinery of membrane protein assembly. (Step 1) A ribosome translating the mRNA of a protein targeted for secretion across or insertion into membranes and a signal of a recognition particle (SRP), which is a GTPase. The structures of ribosomes are reviewed in Refe ...
On The Determination of Enzyme Structure, Function, and
... structures, and it also contains a heme molecule as a cofactor (thicker lines in the middle). Right: magnification of a small portion of the polypeptide chain indicating two amino acids (phenylalanine and aspartic acid) linked by a peptide bond (*). The main chain is running horizontally from left t ...
... structures, and it also contains a heme molecule as a cofactor (thicker lines in the middle). Right: magnification of a small portion of the polypeptide chain indicating two amino acids (phenylalanine and aspartic acid) linked by a peptide bond (*). The main chain is running horizontally from left t ...
localization of products of atp hydrolysis in mammalian smooth
... organelle in excitation-contraction coupling. A similar role would be suggested for agranular endoplasmic reticulum in smooth muscle by the demonstration of ATPase activity at this site, although this function may be unlikely in view of the sparsity of the organelle and its longitudinal disposition ...
... organelle in excitation-contraction coupling. A similar role would be suggested for agranular endoplasmic reticulum in smooth muscle by the demonstration of ATPase activity at this site, although this function may be unlikely in view of the sparsity of the organelle and its longitudinal disposition ...
Muscle Pathology
... *Extends from Z-band to Z-band. A band includes overlap of actin and myosin. Note arrangement of thick and thin filaments. ...
... *Extends from Z-band to Z-band. A band includes overlap of actin and myosin. Note arrangement of thick and thin filaments. ...
localization of products of atp hydrolysis in
... organelle in excitation-contraction coupling. A similar role would be suggested for agranular endoplasmic reticulum in smooth muscle by the demonstration of ATPase activity at this site, although this function may be unlikely in view of the sparsity of the organelle and its longitudinal disposition ...
... organelle in excitation-contraction coupling. A similar role would be suggested for agranular endoplasmic reticulum in smooth muscle by the demonstration of ATPase activity at this site, although this function may be unlikely in view of the sparsity of the organelle and its longitudinal disposition ...
Clathrinmediated transport: assembly required
... clathrin chains (reviewed in Brodsky, 2001). The heavy-chain proximal domain has a superhelical structure composed of clathrin heavychain repeats of ten short α-helices and contains binding sites for clathrin light chains (Ybe et al, 1999). It has been proposed that light chains might prevent the sp ...
... clathrin chains (reviewed in Brodsky, 2001). The heavy-chain proximal domain has a superhelical structure composed of clathrin heavychain repeats of ten short α-helices and contains binding sites for clathrin light chains (Ybe et al, 1999). It has been proposed that light chains might prevent the sp ...
Vacuoles - Plant Physiology
... that sugar uptake is a secondary consequence of the activity of The fact that the curve for uptake of L-glucose by vacuoles this pump (19). We have in fact observed K-stimulated ATPase differed so strikingly from that for uptake of MeG (Fig. 1) is a activity in the vacuoles. This ATPase activity inc ...
... that sugar uptake is a secondary consequence of the activity of The fact that the curve for uptake of L-glucose by vacuoles this pump (19). We have in fact observed K-stimulated ATPase differed so strikingly from that for uptake of MeG (Fig. 1) is a activity in the vacuoles. This ATPase activity inc ...
Structure of the Transmembrane Cysteine Residues in
... These two proteins have extremely different structures, yet share some common features that provide insights into questions of mechanism. One of the most striking similarities is the role of polar and hydrophobic residues in modulating ion conductance. In gramicidin, a 15-residue antibiotic peptide ...
... These two proteins have extremely different structures, yet share some common features that provide insights into questions of mechanism. One of the most striking similarities is the role of polar and hydrophobic residues in modulating ion conductance. In gramicidin, a 15-residue antibiotic peptide ...
Substrate orientation and the origin of catalytic power in xanthine
... the reaction (in this case, through to formation of the LMoIVO(SH)(OR) intermediate) decreased by two orders of magnitude from 1.97 × 106 M-1s-1 to 1.34 × 104 M-1s-1. At face value, the effect on kred and Kd is such that the interaction between Glu 232 and substrate provides some 3 kcal/mol of free ...
... the reaction (in this case, through to formation of the LMoIVO(SH)(OR) intermediate) decreased by two orders of magnitude from 1.97 × 106 M-1s-1 to 1.34 × 104 M-1s-1. At face value, the effect on kred and Kd is such that the interaction between Glu 232 and substrate provides some 3 kcal/mol of free ...
SED4 Encodes a Yeast Endoplasmic Reticulum
... from the E R (Novick et al., 1980; Nakano and Muramatsu, 1989; Kaiser and Schekman, 1990; Hicke et al., 1992; Salama et al., 1993). Five of these proteins (Secl3p, Sec31p, Sec23p, Sec24p, and Sarlp) when added in soluble form to ER membranes will drive vesicle budding (Salama et al., 1993; Barlowe e ...
... from the E R (Novick et al., 1980; Nakano and Muramatsu, 1989; Kaiser and Schekman, 1990; Hicke et al., 1992; Salama et al., 1993). Five of these proteins (Secl3p, Sec31p, Sec23p, Sec24p, and Sarlp) when added in soluble form to ER membranes will drive vesicle budding (Salama et al., 1993; Barlowe e ...
An Introduction to Ligand-Gated Ion Channels and Summary of
... EM structure, but it does provide a general picture of the overall topology and secondary structures of a full-length protein. In 2007, a crystal structure of the extracellular domain of the nAChR α1 solved at 1.94 Å resolution was published (15). The glycosylation patterns are well resolved at this ...
... EM structure, but it does provide a general picture of the overall topology and secondary structures of a full-length protein. In 2007, a crystal structure of the extracellular domain of the nAChR α1 solved at 1.94 Å resolution was published (15). The glycosylation patterns are well resolved at this ...
Defining the tree of life: Archaea`s place in the evolutionary
... because the rates of evolution are not equal among the three domains (Iwabe 1989). As such the conservation of cellular and metabolic traits is less than that of the fundamental systems of genomic replication, transcription and translation (Olsen 1997). Comparing the evolutionary relationship betwe ...
... because the rates of evolution are not equal among the three domains (Iwabe 1989). As such the conservation of cellular and metabolic traits is less than that of the fundamental systems of genomic replication, transcription and translation (Olsen 1997). Comparing the evolutionary relationship betwe ...
REVIEWS
... transporters have also been implicated in antibiotic resistance, drug resistance in fungi and parasitic protozoa, and herbicide resistance in plants6. Intriguingly, the bacterial transporter LmrA, when expressed in mammalian cells, confers multidrug resistance indistinguishable from that of mammalia ...
... transporters have also been implicated in antibiotic resistance, drug resistance in fungi and parasitic protozoa, and herbicide resistance in plants6. Intriguingly, the bacterial transporter LmrA, when expressed in mammalian cells, confers multidrug resistance indistinguishable from that of mammalia ...
introduction figures
... NAD+ molecule. The data were taken from Sims et al., 1982. All the compounds were tested at a concentration of 2 mM. The inhibition is expressed as percent of the PARP activity of untreated control cells. ...
... NAD+ molecule. The data were taken from Sims et al., 1982. All the compounds were tested at a concentration of 2 mM. The inhibition is expressed as percent of the PARP activity of untreated control cells. ...
Protein-Protein Inte..
... data structures used to implement MSC. In order to use MSC you need to have a training data set. This data set needs to include several protein interactions and the protein structure of every protein involved in an interaction, in other words the domains contained in the protein involved in an inter ...
... data structures used to implement MSC. In order to use MSC you need to have a training data set. This data set needs to include several protein interactions and the protein structure of every protein involved in an interaction, in other words the domains contained in the protein involved in an inter ...
sv-lncs - Department of Computer Science and Engineering
... InterDom is a database containing domain interactions. These interactions are derived using four different methods. Looking at protein interactions is one of the methods. They assign a domain interaction the probability (1/mn) where m is the number of domains in the first interacting protein and n i ...
... InterDom is a database containing domain interactions. These interactions are derived using four different methods. Looking at protein interactions is one of the methods. They assign a domain interaction the probability (1/mn) where m is the number of domains in the first interacting protein and n i ...
PDF - International Journal of Biological Sciences
... reduced transpiration rate in pine can stimulate population growth of B. xylophilus [8]. In addition to abiotic factors, such as temperature and water stress, biotic factors also play a prominent role in the infection and distribution of this plant pathogenic nematode. A better understanding of thes ...
... reduced transpiration rate in pine can stimulate population growth of B. xylophilus [8]. In addition to abiotic factors, such as temperature and water stress, biotic factors also play a prominent role in the infection and distribution of this plant pathogenic nematode. A better understanding of thes ...
Discovery of Enzymes
... does not fit exactly in the active site. This induces a change in the enzymes conformation (shape) to make a closer fit. In reactions that involve breaking bonds, the inexact fit puts stress on certain bonds of the substrate. This lowers the amount of energy needed to break them. ...
... does not fit exactly in the active site. This induces a change in the enzymes conformation (shape) to make a closer fit. In reactions that involve breaking bonds, the inexact fit puts stress on certain bonds of the substrate. This lowers the amount of energy needed to break them. ...
Biochem-EnzymesL
... does not fit exactly in the active site. This induces a change in the enzymes conformation (shape) to make a closer fit. In reactions that involve breaking bonds, the inexact fit puts stress on certain bonds of the substrate. This lowers the amount of energy needed to break them. ...
... does not fit exactly in the active site. This induces a change in the enzymes conformation (shape) to make a closer fit. In reactions that involve breaking bonds, the inexact fit puts stress on certain bonds of the substrate. This lowers the amount of energy needed to break them. ...
chemistry bulletin 2005
... pointed to ribosome function and to DNA replication. The obg gene was selected from a random genomic multicopy library for supressors of an E. coli mutant in rrmJ, encoding a 23S rRNA methyltransferase (Tan et al. 2002). Most recently, a transposon insertion mutant in the 3’ end of obg was isolated ...
... pointed to ribosome function and to DNA replication. The obg gene was selected from a random genomic multicopy library for supressors of an E. coli mutant in rrmJ, encoding a 23S rRNA methyltransferase (Tan et al. 2002). Most recently, a transposon insertion mutant in the 3’ end of obg was isolated ...
P-type ATPase
The P-type ATPases, also known as E1-E2 ATPases, are a large group of evolutionarily related ion and lipid pumps that are found in bacteria, archaea, and eukaryotes. They are α-helical bundle primary transporters referred to as P-type ATPases because they catalyze auto- (or self-) phosphorylation of a key conserved aspartate residue within the pump. In addition, they all appear to interconvert between at least two different conformations, denoted by E1 and E2.Most members of this transporter family are specific for the pumping of a large array of cations, however one subfamily is involved in flipping phospholipids to maintain the asymmetric nature of the biomembrane.Prominent examples of P-type ATPases are the sodium-potassium pump (Na+,K+-ATPase), the plasma membrane proton pump (H+-ATPase), the proton-potassium pump (H+,K+-ATPase), and the calcium pump (Ca2+-ATPase).