Why Ca2+ is chosen by nature for diverse regulations?
... • Larger diameter and flexible coordination number • Can bind in to irregularly shaped protein cavities ...
... • Larger diameter and flexible coordination number • Can bind in to irregularly shaped protein cavities ...
Cholesterol Metabolism_MJH
... The human genome encodes 57 members of the cyt P450 superfamily, with tissue-specific expression and intracellular localization highly regulated. Some P450 enzymes are localized in mitochondria. ...
... The human genome encodes 57 members of the cyt P450 superfamily, with tissue-specific expression and intracellular localization highly regulated. Some P450 enzymes are localized in mitochondria. ...
eIF-3 - Universidad Autónoma de San Luis Potosí
... Termination In every gene that has been sequenced, one of the termination codons lies immediately after the codon representing the C-terminal amino acid of the wildtype sequence. The UAG, UAA, and UGA triplet sequences are therefore necessary and sufficient to end protein synthesis, whether occurri ...
... Termination In every gene that has been sequenced, one of the termination codons lies immediately after the codon representing the C-terminal amino acid of the wildtype sequence. The UAG, UAA, and UGA triplet sequences are therefore necessary and sufficient to end protein synthesis, whether occurri ...
HIGH CONDUCTIVE PROTON ELECTROLYTES
... metals MnHm(AO4)p, where М = Cs, Rb, K, Na, Li, NH4; А = S, Se, As, P to be used as a proton membrane in intermediate temperature fuel cells. It has one of the highest value of proton conductivity, 6·10-2 S•cm-1 in superionic phase. The CsH2PO4 low temperature phase (LT) (P21/m) conductivity is less ...
... metals MnHm(AO4)p, where М = Cs, Rb, K, Na, Li, NH4; А = S, Se, As, P to be used as a proton membrane in intermediate temperature fuel cells. It has one of the highest value of proton conductivity, 6·10-2 S•cm-1 in superionic phase. The CsH2PO4 low temperature phase (LT) (P21/m) conductivity is less ...
Crystal structure of plant photosystem I
... are positioned in strategic locations in the cleft between LHCI and the core. This structure provides a framework for exploration not only of energy and electron transfer but also of the evolutionary forces that shaped the photosynthetic apparatus of terrestrial plants after the divergence of chloro ...
... are positioned in strategic locations in the cleft between LHCI and the core. This structure provides a framework for exploration not only of energy and electron transfer but also of the evolutionary forces that shaped the photosynthetic apparatus of terrestrial plants after the divergence of chloro ...
Polyphosphate-ATP Amplification Technology: Principle and its
... 1. Bioluminescence assay is useful but not sensitive enough to detect a single bacterial cell Adenosine triphosphate (ATP) plays a central role in all aspects of metabolism, and, therefore, the development of methods to detect very low concentrations of ATP is very important in many areas of pure an ...
... 1. Bioluminescence assay is useful but not sensitive enough to detect a single bacterial cell Adenosine triphosphate (ATP) plays a central role in all aspects of metabolism, and, therefore, the development of methods to detect very low concentrations of ATP is very important in many areas of pure an ...
active site
... metabolic pathways • Some enzymes act as structural components of membranes • In eukaryotic cells, some enzymes reside in specific organelles; for example, enzymes for cellular respiration are located in mitochondria ...
... metabolic pathways • Some enzymes act as structural components of membranes • In eukaryotic cells, some enzymes reside in specific organelles; for example, enzymes for cellular respiration are located in mitochondria ...
Recruiting Coreceptors to the T Cell Receptor Complex
... CD4. Second, it was shown that T cell development and TCR-mediated antigen recognition, although entirely dependent on Lck, can occur in the complete absence of coreceptors (e.g., see Schilham et al., 1993). These results showed that coreceptors are not required to deliver Lck to the engaged TCR and ...
... CD4. Second, it was shown that T cell development and TCR-mediated antigen recognition, although entirely dependent on Lck, can occur in the complete absence of coreceptors (e.g., see Schilham et al., 1993). These results showed that coreceptors are not required to deliver Lck to the engaged TCR and ...
MINI REVIEW Lectin-like proteins in model organisms: implications
... proteins that contain CTLDs. Following identification of protein domains using the Pfam library of protein motifs, structural categories were defined by the arrangement of protein domains around the CTLDs. Thus, groups A1 to A4 contain signal sequences and single CTLDs with no spacer regions (group ...
... proteins that contain CTLDs. Following identification of protein domains using the Pfam library of protein motifs, structural categories were defined by the arrangement of protein domains around the CTLDs. Thus, groups A1 to A4 contain signal sequences and single CTLDs with no spacer regions (group ...
Crystal structure of plant photosystem I
... are positioned in strategic locations in the cleft between LHCI and the core. This structure provides a framework for exploration not only of energy and electron transfer but also of the evolutionary forces that shaped the photosynthetic apparatus of terrestrial plants after the divergence of chloro ...
... are positioned in strategic locations in the cleft between LHCI and the core. This structure provides a framework for exploration not only of energy and electron transfer but also of the evolutionary forces that shaped the photosynthetic apparatus of terrestrial plants after the divergence of chloro ...
Modular evolution of phosphorylation
... indicates its importance in cellular function. The relative abundance of pSer/pThr-binding domains when compared with pTyr-recognition modules reflects the fact that the phosphorylation of serine/threonine sites is more ancient and more prevalent than tyrosine phosphorylation. A particular phosphope ...
... indicates its importance in cellular function. The relative abundance of pSer/pThr-binding domains when compared with pTyr-recognition modules reflects the fact that the phosphorylation of serine/threonine sites is more ancient and more prevalent than tyrosine phosphorylation. A particular phosphope ...
Phosphorylation of Beclin 1 by DAP
... affects the interaction of Beclin 1 with Bcl-2. We first compared in silico the amino acids in Bcl-XL that form the binding pocket of T119 to the corresponding residues in Bcl-2 (Fig. 1). We found that these residues are conserved in Bcl-2, except for the solventexposed A104 in Bcl-XL, which is repl ...
... affects the interaction of Beclin 1 with Bcl-2. We first compared in silico the amino acids in Bcl-XL that form the binding pocket of T119 to the corresponding residues in Bcl-2 (Fig. 1). We found that these residues are conserved in Bcl-2, except for the solventexposed A104 in Bcl-XL, which is repl ...
Zinc, cadmium and lead resistance mechanisms in bacteria
... term “P-type” refers to the formation of a phosphoenzyme intermediate in the reaction cycle. The energy released by the removal of the !-phosphate from ATP is coupled to the translocation of an ion across biological membranes. Substrates are inorganic cations such as H+, Na+, K+, Mg2+, Ca2+, Cu+, Ag ...
... term “P-type” refers to the formation of a phosphoenzyme intermediate in the reaction cycle. The energy released by the removal of the !-phosphate from ATP is coupled to the translocation of an ion across biological membranes. Substrates are inorganic cations such as H+, Na+, K+, Mg2+, Ca2+, Cu+, Ag ...
Function of Conserved Tryptophans in the Aspergillus niger
... residues of G1 are important for fully functional starch binding. Large deletions of SBD residues result in alteration of the folding and stability properties of the protein and eliminate ligand binding. Recently, the solution structure of the G1 SBD has been solved by nuclear magnetic resonance (NM ...
... residues of G1 are important for fully functional starch binding. Large deletions of SBD residues result in alteration of the folding and stability properties of the protein and eliminate ligand binding. Recently, the solution structure of the G1 SBD has been solved by nuclear magnetic resonance (NM ...
Rhodopsin
... Light activates Rhodopsin which activates Transducin by exchanging its GDP for GTP When active, Transducin’s alpha subunit dissociates from the other two subunits The active Transducin then activates a membrane bound protein called phosphodiesterase Phosphodiesterase hydrolyzes cGMP The hydrolyzes o ...
... Light activates Rhodopsin which activates Transducin by exchanging its GDP for GTP When active, Transducin’s alpha subunit dissociates from the other two subunits The active Transducin then activates a membrane bound protein called phosphodiesterase Phosphodiesterase hydrolyzes cGMP The hydrolyzes o ...
on the enzyme
... above that the enzyme did not change shape or split. This means it can now fit with another substrate or set of substrates and repeat its role in speeding up the ...
... above that the enzyme did not change shape or split. This means it can now fit with another substrate or set of substrates and repeat its role in speeding up the ...
Like-acetylglucosaminyltransferase (LARGE)
... possess laminin globular (LG) domains (3, 4). The transmembrane subunit, β-dystroglycan, anchors α-dystroglycan to the plasma membrane and binds dystrophin within the cell. α-Dystroglycan is composed of three domains: an N-terminal domain (DGN), a mucin-like domain, and a C-terminal domain (Fig. 1A) ...
... possess laminin globular (LG) domains (3, 4). The transmembrane subunit, β-dystroglycan, anchors α-dystroglycan to the plasma membrane and binds dystrophin within the cell. α-Dystroglycan is composed of three domains: an N-terminal domain (DGN), a mucin-like domain, and a C-terminal domain (Fig. 1A) ...
The Cell Membrane - Libreria Universo
... hydrophobic and hydrophilic regions. The hydrophilic (polar) region is their globular head; the hydrophobic (nonpolar) regions are their fatty acid tails. The membrane lipids are organized into a continuous bilayer (as seen in Fig. 2.2A) in which the hydrophobic regions of the phospholipids are shie ...
... hydrophobic and hydrophilic regions. The hydrophilic (polar) region is their globular head; the hydrophobic (nonpolar) regions are their fatty acid tails. The membrane lipids are organized into a continuous bilayer (as seen in Fig. 2.2A) in which the hydrophobic regions of the phospholipids are shie ...
Chapter 1: Biological Introduction: RING domain proteins
... enzymes are involved in the ubiquitination pathway. Firstly, an E1 or ubiquitin activating enzyme forms a thiol ester with the carboxyl terminal group of the small protein ubiquitin at position Gly76. The ubiquitin is then transferred to the ubiquitin conjugating enzyme (E2). Finally, ubiquitin liga ...
... enzymes are involved in the ubiquitination pathway. Firstly, an E1 or ubiquitin activating enzyme forms a thiol ester with the carboxyl terminal group of the small protein ubiquitin at position Gly76. The ubiquitin is then transferred to the ubiquitin conjugating enzyme (E2). Finally, ubiquitin liga ...
Luminescent Calcium Instructions
... in research applications or for detect bacterial contamination detection (used to measure 10-15 molar quantity of ATP). It also has been used for detecting certain amphipathic and hydrophobic substances, including anesthetics and hormones, as these compete with luciferin for the hydrophobic site on ...
... in research applications or for detect bacterial contamination detection (used to measure 10-15 molar quantity of ATP). It also has been used for detecting certain amphipathic and hydrophobic substances, including anesthetics and hormones, as these compete with luciferin for the hydrophobic site on ...
27_InstGuide_AR
... 4. Describe how prokaryotes carry out cellular respiration when they lack compartmentalized organelles such as mitochondria. 5. List the three domains of life. 6. Describe the structure, composition, and functions of prokaryotic cell walls. 7. Distinguish the structure and staining properties of gra ...
... 4. Describe how prokaryotes carry out cellular respiration when they lack compartmentalized organelles such as mitochondria. 5. List the three domains of life. 6. Describe the structure, composition, and functions of prokaryotic cell walls. 7. Distinguish the structure and staining properties of gra ...
uos--smith_20060314
... different formats; but much of their information content is not formal in nature, or is not yet formalized. Upper ontologies can help bring advances where one needs to work with pluralities of very large domain ontologies, some with several million terms http://ontologist.com ...
... different formats; but much of their information content is not formal in nature, or is not yet formalized. Upper ontologies can help bring advances where one needs to work with pluralities of very large domain ontologies, some with several million terms http://ontologist.com ...
Dynamin and the Actin Cytoskeleton Cooperatively Regulate
... acid sequence with the BAR domain and predicted, as in the case of the BAR domain, three distinct helices (Figure 1A). Thus, the FCH domain, although defined as a separate domain in databases, may be part of a larger, BAR domain-related module that includes the CC region. Based on these consideratio ...
... acid sequence with the BAR domain and predicted, as in the case of the BAR domain, three distinct helices (Figure 1A). Thus, the FCH domain, although defined as a separate domain in databases, may be part of a larger, BAR domain-related module that includes the CC region. Based on these consideratio ...
Materials - HAL
... and Psp5II restriction sites were introduced in SacII-NotI sites of pHM6 vector. The cDNA encoding the N-terminal part of PTPL1 was cloned by PCR using pSV7d-PTPL1 (gift of Prof. C.H. Heldin) as a template in SacII-Bsu15I sites of modified pHM6 vector. SacII site was introduced by PCR in frame with ...
... and Psp5II restriction sites were introduced in SacII-NotI sites of pHM6 vector. The cDNA encoding the N-terminal part of PTPL1 was cloned by PCR using pSV7d-PTPL1 (gift of Prof. C.H. Heldin) as a template in SacII-Bsu15I sites of modified pHM6 vector. SacII site was introduced by PCR in frame with ...
Satisfying the Immense Energy Demands of the Body, and the
... pumped from the matrix into the inter-membrane space and stores the excess energy within the proton gradient rather than ATP (Elston et al., 1998). Inheritance and Molecular Genetics of ATP6 Only the ATP6 and ATP8 subunits of ATP synthase are encoded in the 16,569 base-pair circular mitochondrial ge ...
... pumped from the matrix into the inter-membrane space and stores the excess energy within the proton gradient rather than ATP (Elston et al., 1998). Inheritance and Molecular Genetics of ATP6 Only the ATP6 and ATP8 subunits of ATP synthase are encoded in the 16,569 base-pair circular mitochondrial ge ...
P-type ATPase
The P-type ATPases, also known as E1-E2 ATPases, are a large group of evolutionarily related ion and lipid pumps that are found in bacteria, archaea, and eukaryotes. They are α-helical bundle primary transporters referred to as P-type ATPases because they catalyze auto- (or self-) phosphorylation of a key conserved aspartate residue within the pump. In addition, they all appear to interconvert between at least two different conformations, denoted by E1 and E2.Most members of this transporter family are specific for the pumping of a large array of cations, however one subfamily is involved in flipping phospholipids to maintain the asymmetric nature of the biomembrane.Prominent examples of P-type ATPases are the sodium-potassium pump (Na+,K+-ATPase), the plasma membrane proton pump (H+-ATPase), the proton-potassium pump (H+,K+-ATPase), and the calcium pump (Ca2+-ATPase).