(1) Giycophorin was incorporated into large
... glycophorin-containing vesicles with the pure lipid vesicles, clearly shows that incorporation of glycophorin induces a largely increased permeability for glucose as well as for raffinose. This confirms earlier results with reconstituted systems using 18 : lc,18 : lc phosphatidylcholine [1,7], and s ...
... glycophorin-containing vesicles with the pure lipid vesicles, clearly shows that incorporation of glycophorin induces a largely increased permeability for glucose as well as for raffinose. This confirms earlier results with reconstituted systems using 18 : lc,18 : lc phosphatidylcholine [1,7], and s ...
Eucalyptus Arabidopsis grandis thaliana
... SuSy amino acid residue determines its cellular distribution. In order to elucidate the role of SuSy in cellulose biosynthesis a number of questions surrounding the function and regulation of SuSy need to be addressed. These questions include: What is the nature of the association between SuSy and ...
... SuSy amino acid residue determines its cellular distribution. In order to elucidate the role of SuSy in cellulose biosynthesis a number of questions surrounding the function and regulation of SuSy need to be addressed. These questions include: What is the nature of the association between SuSy and ...
The contribution of the Trp/Met/Phe residues to physical interactions
... discovered as a tumor suppressor protein [1, 2]. After 26 years of study, it is now clear that the p53 protein not only operates ...
... discovered as a tumor suppressor protein [1, 2]. After 26 years of study, it is now clear that the p53 protein not only operates ...
PKC modulates NF-B and AP-1 via mitogen
... (MAPKs), the p44/p42 MAPKs, the p38 MAPKs, and the p54/p46 c-Jun NH2-terminal kinases (JNKs), are important upstream regulators for the induction of various transcription factors (12, 37, 44). The role of each MAPK subfamily in the activation of transcription factors appears to be cell-type specific ...
... (MAPKs), the p44/p42 MAPKs, the p38 MAPKs, and the p54/p46 c-Jun NH2-terminal kinases (JNKs), are important upstream regulators for the induction of various transcription factors (12, 37, 44). The role of each MAPK subfamily in the activation of transcription factors appears to be cell-type specific ...
Isoform 5 of PIPKIc regulates the endosomal trafficking and
... required for EGFR degradation (Sun et al., 2013). Therefore, further studies focused on how these two proteins might regulate the sorting of E-cadherin for degradation. In polarized epithelial cells, the majority of E-cadherin localizes at cell–cell contacts, with the exception of the fraction of E- ...
... required for EGFR degradation (Sun et al., 2013). Therefore, further studies focused on how these two proteins might regulate the sorting of E-cadherin for degradation. In polarized epithelial cells, the majority of E-cadherin localizes at cell–cell contacts, with the exception of the fraction of E- ...
The effect of short chain fatty acids on glucose homeostasis
... 2008). This improves welfare and reduces abnormal oral behaviour by providing the opportunity to ruminate (Veissier et al., 1997). Rumen papillae growth is increased as a response to short chain fatty acid (SCFA) production from roughages by rumen microbes (Flatt et al., 1958). The physical structur ...
... 2008). This improves welfare and reduces abnormal oral behaviour by providing the opportunity to ruminate (Veissier et al., 1997). Rumen papillae growth is increased as a response to short chain fatty acid (SCFA) production from roughages by rumen microbes (Flatt et al., 1958). The physical structur ...
Physiology Review Sheet
... releases ADP and Pi (enhanced by actin binding) and undergoes power stroke (still linked to actin = rigor link) binds fresh ATP and dissociates from actin Muscle Metabolism o Fenn effect: isotonic contraction releases more energy than isometric contraction – feedback between mechanical constrain ...
... releases ADP and Pi (enhanced by actin binding) and undergoes power stroke (still linked to actin = rigor link) binds fresh ATP and dissociates from actin Muscle Metabolism o Fenn effect: isotonic contraction releases more energy than isometric contraction – feedback between mechanical constrain ...
Mammalian Mitogen-Activated Protein Kinase Signal
... proteins. Given the extraordinary complexity and diversity of MAPK regulation and function, it is critical that the efficiency and selectivity of MAPK pathways be preserved. Scaffold proteins bind and sequester select MAPK pathway components, and thereby help to maintain pathway integrity and to per ...
... proteins. Given the extraordinary complexity and diversity of MAPK regulation and function, it is critical that the efficiency and selectivity of MAPK pathways be preserved. Scaffold proteins bind and sequester select MAPK pathway components, and thereby help to maintain pathway integrity and to per ...
Dissociation of a ll0-kD Peripheral Membrane Protein from the Golgi
... of membrane-bounded compartmentalization. One potential mechanism by which BFA could act is through the disruption of underlying structural elements of the Golgi apparatus, To explore this possibility further we examined the effect of BFA on several cytoplasmically oriented proteins associated with ...
... of membrane-bounded compartmentalization. One potential mechanism by which BFA could act is through the disruption of underlying structural elements of the Golgi apparatus, To explore this possibility further we examined the effect of BFA on several cytoplasmically oriented proteins associated with ...
Article Title Authors Author affiliation Correspondence information
... injured cellular components which might become toxic. Such cellular maintenance is important, especially in resting cells and terminally differentiated cells where injured ...
... injured cellular components which might become toxic. Such cellular maintenance is important, especially in resting cells and terminally differentiated cells where injured ...
Arpp19 and Cdc6, two major regulators of the meiotic division
... always made herself available to help and support me even when nothing seemed to be working. She was the best supervisor I could hope for (and surely a better “supervisor” than a “ping pong player ...
... always made herself available to help and support me even when nothing seemed to be working. She was the best supervisor I could hope for (and surely a better “supervisor” than a “ping pong player ...
FtsZ - Cytoskeleton, Inc.
... cell division. FtsZ inactivation inhibits cell division, making them attractive targets for novel anti-microbial drugs. Although FtsZ proteins exhibit a degree of homology, inhibitors of the proteins show differential affinities and efficacies. Thus, improved targeting can be achieved by screening s ...
... cell division. FtsZ inactivation inhibits cell division, making them attractive targets for novel anti-microbial drugs. Although FtsZ proteins exhibit a degree of homology, inhibitors of the proteins show differential affinities and efficacies. Thus, improved targeting can be achieved by screening s ...
Micronuclei and the Cytoplasm of Growing Tetrahymena Contain a
... Acetylates 1-14as a Free Histone, but Fails to Acetylate Any Histone in a Chromatin Form Having established that micronuclear histones can be acetylated with a macronuclear acetylase (Fig. 1), we were interested to see whether purified micronuclei contain any extractable activity that could acetylat ...
... Acetylates 1-14as a Free Histone, but Fails to Acetylate Any Histone in a Chromatin Form Having established that micronuclear histones can be acetylated with a macronuclear acetylase (Fig. 1), we were interested to see whether purified micronuclei contain any extractable activity that could acetylat ...
Technical Bulletin Fructose Intolerance
... • Minimal effect on Insulin: Fructose is metabolized in a unique manner to produce mostly glucose, lactate and uric acid. Unlike glucose, fructose does not require insulin to enter cells and it has only a minimal effect on the stimulation of insulin secretion. For these reasons, fructose is recomme ...
... • Minimal effect on Insulin: Fructose is metabolized in a unique manner to produce mostly glucose, lactate and uric acid. Unlike glucose, fructose does not require insulin to enter cells and it has only a minimal effect on the stimulation of insulin secretion. For these reasons, fructose is recomme ...
Requirements for CPC localization during anaphase
... Figure 4. A model for CPC regulation and its effects in S. cerevisiae. A) Before anaphase the CPC is located at the centromeres. Sli15p is phosphorylated by Cdk1p and Ipl1p, contributing to this localization. The CPC regulates proper chromosome segregation in this phase. B) At the start of anaphase ...
... Figure 4. A model for CPC regulation and its effects in S. cerevisiae. A) Before anaphase the CPC is located at the centromeres. Sli15p is phosphorylated by Cdk1p and Ipl1p, contributing to this localization. The CPC regulates proper chromosome segregation in this phase. B) At the start of anaphase ...
Identification of Saccharomyces cerevisiae proteins that bind to
... The following individuals and institutions are hereby acknowledged and thanked for their contribution to this project. Dr Gabre Kemp, thank you for your support and sacrifice in the completion of this project. Your willingness to help and guide me along the way is greatly appreciated. Thank you for ...
... The following individuals and institutions are hereby acknowledged and thanked for their contribution to this project. Dr Gabre Kemp, thank you for your support and sacrifice in the completion of this project. Your willingness to help and guide me along the way is greatly appreciated. Thank you for ...
A Personal Account of Chaperonin History
... these observations were made immediately after Anfinsen’s seminal work (1) that provided the dominating intellectual framework in the 1970s and 1980s in all matters related to protein folding. By then the prevailing dogma was that protein folding was a spontaneous event and suggesting that the foldi ...
... these observations were made immediately after Anfinsen’s seminal work (1) that provided the dominating intellectual framework in the 1970s and 1980s in all matters related to protein folding. By then the prevailing dogma was that protein folding was a spontaneous event and suggesting that the foldi ...
- Wiley Online Library
... Keywords: p53; apoptosis; cell cycle arrest; transcription; cellular stress EMBO reports (2013) 14, 414–421; published online 16 April 2013; doi:10.1038/embor.2013.25 ...
... Keywords: p53; apoptosis; cell cycle arrest; transcription; cellular stress EMBO reports (2013) 14, 414–421; published online 16 April 2013; doi:10.1038/embor.2013.25 ...
Effects of Macromolecular Crowding on Protein Folding
... Macromolecular crowding generates excluded volume effects and also increases the importance of non-specific interactions between molecules. It should favor reactions that reduce the total volume occupied by all molecules within the cytoplasm, such as folding reactions. Theoretical models have predic ...
... Macromolecular crowding generates excluded volume effects and also increases the importance of non-specific interactions between molecules. It should favor reactions that reduce the total volume occupied by all molecules within the cytoplasm, such as folding reactions. Theoretical models have predic ...
Role of adiponectin in the regulation of carbohydrate and lipid
... necessary for adiponectin effects on fatty acid oxidation in skeletal muscle cells (27, 31, 35). AMPK activation triggers many metabolic changes that act to restore energy balance in muscle cells, such as increased glucose uptake and metabolism, and increased oxidation of fatty acids (36). Regulatio ...
... necessary for adiponectin effects on fatty acid oxidation in skeletal muscle cells (27, 31, 35). AMPK activation triggers many metabolic changes that act to restore energy balance in muscle cells, such as increased glucose uptake and metabolism, and increased oxidation of fatty acids (36). Regulatio ...
Cell regulation by the Apc protein Apc as master regulator of epithelia
... phosphorylated state may be important to fine tune the Apc/b-catenin interactions that occur not only in the destruction complex, but also at other sites in the cell including the nucleus (see below), the cortex [20,21], and at the centrosome [22]. Further dissection of the repeats using a wide rang ...
... phosphorylated state may be important to fine tune the Apc/b-catenin interactions that occur not only in the destruction complex, but also at other sites in the cell including the nucleus (see below), the cortex [20,21], and at the centrosome [22]. Further dissection of the repeats using a wide rang ...
Microtubules
... Other proteins that promote microtubule disassembly: Stathmin is a microtubule destabilizing protein that increases in abundance in some cancer cells. It binds to tubulin heterodimers, decreasing their availability for polymerization. Stathmin is inhibited by phosphorylation. Katanin severs mic ...
... Other proteins that promote microtubule disassembly: Stathmin is a microtubule destabilizing protein that increases in abundance in some cancer cells. It binds to tubulin heterodimers, decreasing their availability for polymerization. Stathmin is inhibited by phosphorylation. Katanin severs mic ...
The Role of Mitochondria in Cholestatic Liver Injury
... key modulator of hepatic gluconeogenesis and is a central target of the insulin-cAMP axis in the liver.(16) Once PGC-1α is activated, it powerfully induces and coordinates gene expression stimulating mitochondrial oxidative metabolism,(17) and mitochondrial content.(18) The mitochondrial numbers and ...
... key modulator of hepatic gluconeogenesis and is a central target of the insulin-cAMP axis in the liver.(16) Once PGC-1α is activated, it powerfully induces and coordinates gene expression stimulating mitochondrial oxidative metabolism,(17) and mitochondrial content.(18) The mitochondrial numbers and ...
Roles of maltodextrin and glycogen phosphorylases in maltose
... phosphorylases were assumed to be involved in glycogen degradation, forming a-glucose 1phosphate from glycogen and from maltodextrins. We show here that C. glutamicum in fact possesses two a-glucan phosphorylases, which act as a glycogen phosphorylase (GlgP) and as a maltodextrin phosphorylase (MalP ...
... phosphorylases were assumed to be involved in glycogen degradation, forming a-glucose 1phosphate from glycogen and from maltodextrins. We show here that C. glutamicum in fact possesses two a-glucan phosphorylases, which act as a glycogen phosphorylase (GlgP) and as a maltodextrin phosphorylase (MalP ...
Phosphorylation
Phosphorylation is the addition of a phosphate (PO43−) group to a protein or other organic molecule. Phosphorylation and its counterpart, dephosphorylation, turn many protein enzymes on and off, thereby altering their function and activity. Protein phosphorylation is one type of post-translational modification.Protein phosphorylation in particular plays a significant role in a wide range of cellular processes. Its prominent role in biochemistry is the subject of a very large body of research (as of March 2015, the Medline database returns over 240,000 articles on the subject, largely on protein phosphorylation).