Platelet granule exocytosis: a comparison with chromaffin cells
... also have a dense tubular system (DTS), which is a membrane system thought to be derived from the megakaryocytic endoplasmic reticulum. The DTS serves as an intracellular calcium storage site, but is not directly connected to either the plasma membrane or the OCS (van Nispen tot Pannerden et al., 20 ...
... also have a dense tubular system (DTS), which is a membrane system thought to be derived from the megakaryocytic endoplasmic reticulum. The DTS serves as an intracellular calcium storage site, but is not directly connected to either the plasma membrane or the OCS (van Nispen tot Pannerden et al., 20 ...
The Tobacco Mosaic Virus 126-Kilodalton Protein
... results from a recent study where the MT array was disrupted in situ with pharmacological agents or by silencing of the a-tubulin gene indicated that disruption of the MTs did not alter TMV cell-to-cell spread (Gillespie et al., 2002). These authors suggested that MTs function to transport TMV MP to ...
... results from a recent study where the MT array was disrupted in situ with pharmacological agents or by silencing of the a-tubulin gene indicated that disruption of the MTs did not alter TMV cell-to-cell spread (Gillespie et al., 2002). These authors suggested that MTs function to transport TMV MP to ...
Protein quality control and elimination of protein waste: The role of
... ATP-independent chaperones. In yeast, the two most prominent members are Hsp42 and Hsp26. Hsp42 functions both in stressed and unstressed cells and prevents protein aggregation [70], but is also involved in targeting of misfolded proteins to peripheral aggregate deposits in cells [71]. Hsp26 is stre ...
... ATP-independent chaperones. In yeast, the two most prominent members are Hsp42 and Hsp26. Hsp42 functions both in stressed and unstressed cells and prevents protein aggregation [70], but is also involved in targeting of misfolded proteins to peripheral aggregate deposits in cells [71]. Hsp26 is stre ...
Computational optogenetics: A novel continuum framework for the
... heart, which are outside the reach of experimental measurements in humans. Fig. 3 illustrates the underlying approach in which the different physical fields interact across the different scales. On the molecular level, optical stimulation opens the cation channel channelrhodopsin initiating a photocu ...
... heart, which are outside the reach of experimental measurements in humans. Fig. 3 illustrates the underlying approach in which the different physical fields interact across the different scales. On the molecular level, optical stimulation opens the cation channel channelrhodopsin initiating a photocu ...
D. Malpighian tubules play similar function as tubular parts of the
... tubules develop from ectodermal and mesodermal cell lineages, it provides opportunity to identify novel genes involved in the integration of cells from different origins that makes mature and functional structure. Different segments of tubules are specialized to perform different functions that prov ...
... tubules develop from ectodermal and mesodermal cell lineages, it provides opportunity to identify novel genes involved in the integration of cells from different origins that makes mature and functional structure. Different segments of tubules are specialized to perform different functions that prov ...
Mystery Detectives Unit One – Living Systems
... Question 46 – During______, duplicated chromosomes in the cell’s nucleus separate and the cell pinches in two. *meiosis* ...
... Question 46 – During______, duplicated chromosomes in the cell’s nucleus separate and the cell pinches in two. *meiosis* ...
Viability and Cytotoxicity Assay Kits for Diverse Cell Types
... discrimination is reduced but can still be detected, even after 24 hours (Figure 15.29). Independence from enzymatic activity. Because it relies on two nucleic acid stains that differ in their membrane permeability, this assay equates loss of cell viability with loss of membrane integrity. Consequen ...
... discrimination is reduced but can still be detected, even after 24 hours (Figure 15.29). Independence from enzymatic activity. Because it relies on two nucleic acid stains that differ in their membrane permeability, this assay equates loss of cell viability with loss of membrane integrity. Consequen ...
A Role in Migration for the v 1 Integrin Expressed on
... (Paterson et al., 1973) and migrates during development to produce the widespread distribution of differentiated oligodendrocytes seen in the mature animal. Direct evidence for this migration has come from two sets of in vivo studies. First, cells labeled with a lac-Z reporter gene while in the subv ...
... (Paterson et al., 1973) and migrates during development to produce the widespread distribution of differentiated oligodendrocytes seen in the mature animal. Direct evidence for this migration has come from two sets of in vivo studies. First, cells labeled with a lac-Z reporter gene while in the subv ...
The Cytoplasm-to-Vacuole Targeting Pathway: A Historical
... the ER by a unique mechanism. This seemed to add some additional interest to the analysis, as the idea of analyzing yet one more vacuolar hydrolase was getting somewhat tedious. When I discussed the idea of analyzing the targeting of prApe1 with Scott Emr, however, he was not interested. After all, ...
... the ER by a unique mechanism. This seemed to add some additional interest to the analysis, as the idea of analyzing yet one more vacuolar hydrolase was getting somewhat tedious. When I discussed the idea of analyzing the targeting of prApe1 with Scott Emr, however, he was not interested. After all, ...
Linköping University Post Print
... Over the last decade, the lysosome has emerged as a significant component of the cellular death machinery. Lysosomes, which were first described by de Duve and colleagues in 1955 [1], are acidic, single-membrane bound organelles that are present in all eukaryotic cells [2]. The primary function of l ...
... Over the last decade, the lysosome has emerged as a significant component of the cellular death machinery. Lysosomes, which were first described by de Duve and colleagues in 1955 [1], are acidic, single-membrane bound organelles that are present in all eukaryotic cells [2]. The primary function of l ...
Manuscrit en préparation (soumission prévue à Int - HAL
... Several epidemiological studies have indicated that populations consuming high amounts of omega-3 (n-3) fatty acids, display a lower breast cancer risk [1, 2]. This effect seems to be related to specific n-3 polyunsaturated fatty acids and/or to the ratio of n-6 to n-3 fatty acids [3-6]. Long-chain ...
... Several epidemiological studies have indicated that populations consuming high amounts of omega-3 (n-3) fatty acids, display a lower breast cancer risk [1, 2]. This effect seems to be related to specific n-3 polyunsaturated fatty acids and/or to the ratio of n-6 to n-3 fatty acids [3-6]. Long-chain ...
FABRICATING AND CHARACTERIZATION OF Cu2O/TiO2
... Use of oxide semiconductors such as Cu2O and TiO2 as alternatives to silicon for solar cells attract much attention among the researchers. Cu2O is a p-type semiconductor with a direct band gap of 2.1 eV and is regarded as a suitable material for high-efficiency solar cells [1-4]. TiO2 is an n-type s ...
... Use of oxide semiconductors such as Cu2O and TiO2 as alternatives to silicon for solar cells attract much attention among the researchers. Cu2O is a p-type semiconductor with a direct band gap of 2.1 eV and is regarded as a suitable material for high-efficiency solar cells [1-4]. TiO2 is an n-type s ...
ATM and - Cancer Research
... A-T cell line (AT5BIVA), and DNA-PKcs-deficient M059J cells. Although the foci formed with slightly slower kinetics in the three A-T cell lines, by 30 min postirradiation, a similar number of foci were observed in A-T and control cell lines (Fig. 1A). M059J (DNA-PKcs⫺/⫺) and the parental line, M059K ...
... A-T cell line (AT5BIVA), and DNA-PKcs-deficient M059J cells. Although the foci formed with slightly slower kinetics in the three A-T cell lines, by 30 min postirradiation, a similar number of foci were observed in A-T and control cell lines (Fig. 1A). M059J (DNA-PKcs⫺/⫺) and the parental line, M059K ...
Lim, K et al Science 2015
... the target cells (1–4). However, many of these chemokines are derived from newly recruited innate immune cells during the initial infection (1, 5–7) and little is known about how these innate immunederived chemotactic signals are present in the tissue microenvironment and how they act to recruit T c ...
... the target cells (1–4). However, many of these chemokines are derived from newly recruited innate immune cells during the initial infection (1, 5–7) and little is known about how these innate immunederived chemotactic signals are present in the tissue microenvironment and how they act to recruit T c ...
Patterning the Xenopus blastula - Development
... 1994b). This indicates that, as in Drosophila, β-catenin may lie This wingless-initiated pathway has been shown to be of downstream of a Wnt signal. critical importance in the patterning of the Drosophila (c) Molecules upstream of β-catenin embryonic epidermis (DiNardo et al., 1988; Martinez-Arias e ...
... 1994b). This indicates that, as in Drosophila, β-catenin may lie This wingless-initiated pathway has been shown to be of downstream of a Wnt signal. critical importance in the patterning of the Drosophila (c) Molecules upstream of β-catenin embryonic epidermis (DiNardo et al., 1988; Martinez-Arias e ...
A Novel Recombinant Plasma Membrane
... (P2X7R). Both cell types release large amounts of ATP (100 –200 M) in response to P2X7R activation. This novel approach unveils a hitherto unsuspected nonlytic pathway for the release of large amounts of ATP that might contribute to spreading activation and recruitment of immune cells at inflammato ...
... (P2X7R). Both cell types release large amounts of ATP (100 –200 M) in response to P2X7R activation. This novel approach unveils a hitherto unsuspected nonlytic pathway for the release of large amounts of ATP that might contribute to spreading activation and recruitment of immune cells at inflammato ...
Electron Microscopy of Intermediate Filaments: Teaming up with
... their association with the thick, i.e., myosin filaments. Interestingly, it was noted that the diameter of these new filaments varied between 8 and 11 nm with a prominent peak at 10 nm, for which reason they were referred to as 10 nm filaments or ‘intermediate filaments,’ i.e., being in diameter bet ...
... their association with the thick, i.e., myosin filaments. Interestingly, it was noted that the diameter of these new filaments varied between 8 and 11 nm with a prominent peak at 10 nm, for which reason they were referred to as 10 nm filaments or ‘intermediate filaments,’ i.e., being in diameter bet ...
Lipid II: A central component in bacterial cell wall synthesis and a
... type, which strikingly resembles the bactoprenol chain. Thus in both peptidoglycan synthesis and N-glycosylation the precursors are minor-polyprenol-anchored (pyro)phosphate-coupled membrane components. These examples suggest that building a carbohydrate containing biopolymer from a membrane is best ...
... type, which strikingly resembles the bactoprenol chain. Thus in both peptidoglycan synthesis and N-glycosylation the precursors are minor-polyprenol-anchored (pyro)phosphate-coupled membrane components. These examples suggest that building a carbohydrate containing biopolymer from a membrane is best ...
Drug resistance patterns and susceptibility to
... of protoplasts in comparison to parent strains (Tiwari et al., 1984) suggested the cell membrane as a possible target-site for the action of aflatoxin B,. Bacterial resistance to antibiotics has been assoTable 111. Binding of aflatoxin BI to cell suspenciated with decreased permeability (Okamoto and ...
... of protoplasts in comparison to parent strains (Tiwari et al., 1984) suggested the cell membrane as a possible target-site for the action of aflatoxin B,. Bacterial resistance to antibiotics has been assoTable 111. Binding of aflatoxin BI to cell suspenciated with decreased permeability (Okamoto and ...
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... Mutations in spon-1 disrupt morphogenesis and affect a C. elegans spondin To identify genes required for muscle-epidermal interactions, we screened for mutations causing late arrest in elongation and muscle detachment. From a screen of approximately 8000 haploid genomes, we identified three mutation ...
... Mutations in spon-1 disrupt morphogenesis and affect a C. elegans spondin To identify genes required for muscle-epidermal interactions, we screened for mutations causing late arrest in elongation and muscle detachment. From a screen of approximately 8000 haploid genomes, we identified three mutation ...
Suppressor analysis of the protein kinase Elm1p, an enzyme
... Filamentous Growth in S. cerevisiae Knowledge of the fundamental mechanisms that dictate cell shape and polarity is a critical aspect of imderstanding how cells respond appropriately to their environment. The budding yeast S. cerevisiae has proven to be a very useful genetically tractable eukaryotic ...
... Filamentous Growth in S. cerevisiae Knowledge of the fundamental mechanisms that dictate cell shape and polarity is a critical aspect of imderstanding how cells respond appropriately to their environment. The budding yeast S. cerevisiae has proven to be a very useful genetically tractable eukaryotic ...
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... widespread candidature. The question papers are closely related and the relationships between them have been thoroughly established using our assessment expertise. All versions of the paper give assessment of equal standard. The content assessed by the examination papers and the type of questions is ...
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... disinfection of water with plants extracts (Sunda et al., 2008). Aqueous extract of Lantana camara, Cymbogon citratus and Hibiscus rosa-sinensis have shown a bactericidal effect in aquatic milieu (Sunda et al., 2008). The results obtained by Voss-Rech (2011) indicated that the vegetal extracts teste ...
... disinfection of water with plants extracts (Sunda et al., 2008). Aqueous extract of Lantana camara, Cymbogon citratus and Hibiscus rosa-sinensis have shown a bactericidal effect in aquatic milieu (Sunda et al., 2008). The results obtained by Voss-Rech (2011) indicated that the vegetal extracts teste ...
Protein S-nitrosylation in photosynthetic organisms: A
... NO is a free radical with an unpaired electron shared between the nitrogen and the oxygen atom. As a radical, NO is relatively unreactive. It does not react with itself nor it reacts with most biological molecules that have no unpaired electrons, but it tends to combine with other radicals and trans ...
... NO is a free radical with an unpaired electron shared between the nitrogen and the oxygen atom. As a radical, NO is relatively unreactive. It does not react with itself nor it reacts with most biological molecules that have no unpaired electrons, but it tends to combine with other radicals and trans ...
The advantages of being small Stockholm University
... Mycoplasmas are known to have the ability to fuse with, invade the cell or live in close contact with the host cell, being obligate parasites (Baseman et al., 1995; Dimitrov et al., 1993). They are able to incorporate essential components such as fatty acids and amino acids from the host cell to sav ...
... Mycoplasmas are known to have the ability to fuse with, invade the cell or live in close contact with the host cell, being obligate parasites (Baseman et al., 1995; Dimitrov et al., 1993). They are able to incorporate essential components such as fatty acids and amino acids from the host cell to sav ...
Cytokinesis
Cytokinesis (cyto- + kinesis) is the process during cell division in which the cytoplasm of a single eukaryotic cell is divided to form two daughter cells. It usually initiates during the early stages of mitosis, and sometimes meiosis, splitting a mitotic cell in two, to ensure that chromosome number is maintained from one generation to the next. After cytokinesis two (daughter) cells will be formed that are exact copies of the (parent) original cell. After cytokinesis, each daughter cell is in the interphase portion of the cell cycle. In animal cells, one notable exception to the normal process of cytokinesis is oogenesis (the creation of an ovum in the ovarian follicle of the ovary), where the ovum takes almost all the cytoplasm and organelles, leaving very little for the resulting polar bodies, which then die. Another form of mitosis without cytokinesis occurs in the liver, yielding multinucleate cells. In plant cells, a dividing structure known as the cell plate forms within the centre of the cytoplasm and a new cell wall forms between the two daughter cells.Cytokinesis is distinguished from the prokaryotic process of binary fission.