Therapeutic approaches to Lysosomal Storage Disorders
... Lysosomes are organelles delimited by a single membrane and filled with digestive enzymes that are able to degrade molecules and structures into their elementary constituents. Therefore they represent the final destination for many endocytic and autophagic secretion molecules targeted for degradatio ...
... Lysosomes are organelles delimited by a single membrane and filled with digestive enzymes that are able to degrade molecules and structures into their elementary constituents. Therefore they represent the final destination for many endocytic and autophagic secretion molecules targeted for degradatio ...
AMP-activated/SNF1 protein kinases: conserved guardians of
... Regulation and structure of AMPK All AMPK/SNF1 kinases appear to exist as hetero trimeric complexes comprising catalytic α-subunits and regulatory β- and γ-subunits (FIG. 3). The mamma lian kinases are activated by AMP in two ways. First, the kinase activity that resides in the α-subunit is stimul ...
... Regulation and structure of AMPK All AMPK/SNF1 kinases appear to exist as hetero trimeric complexes comprising catalytic α-subunits and regulatory β- and γ-subunits (FIG. 3). The mamma lian kinases are activated by AMP in two ways. First, the kinase activity that resides in the α-subunit is stimul ...
Identification of proteins localized to the contractile vacuole of
... wide range of environments as it progresses through its life cycle. Fluctuations in osmolarity occur within the gut of the vector and as the parasite moves from the insect gut to the bloodstream, acidic phagolysosomes, and host cell cytosol. Thus, the parasites have mechanisms to respond to both hyp ...
... wide range of environments as it progresses through its life cycle. Fluctuations in osmolarity occur within the gut of the vector and as the parasite moves from the insect gut to the bloodstream, acidic phagolysosomes, and host cell cytosol. Thus, the parasites have mechanisms to respond to both hyp ...
3 Adhesion and Adhesives of Fungi and Oomycetes
... Osherov and May 2001; Tucker and Talbot 2001). Observational studies with microscopy indicate that many fungi adhere tenaciously onto inert surfaces such as polystyrene in addition to host substrata. This is perhaps not surprising since, for example, the aerial surfaces of plants are hydrophobic and ...
... Osherov and May 2001; Tucker and Talbot 2001). Observational studies with microscopy indicate that many fungi adhere tenaciously onto inert surfaces such as polystyrene in addition to host substrata. This is perhaps not surprising since, for example, the aerial surfaces of plants are hydrophobic and ...
Use of Phenylboronic Acids to Investigate Boron
... disrupt boron diester cross-links by forming monoester linkages at positions normally occupied by boron. Given the structural differences between borate and boronates, and the inability of boronates to act as bridging molecules, the resulting boronate-diol complex would not replace putative boron di ...
... disrupt boron diester cross-links by forming monoester linkages at positions normally occupied by boron. Given the structural differences between borate and boronates, and the inability of boronates to act as bridging molecules, the resulting boronate-diol complex would not replace putative boron di ...
Some unanswered questions in radiation biology
... Carbon ions for early lung cancer (Japan): using Monte Carlo computer simulation of hypoxic and oxic (repopulating) with re-oxygenation flux, reduced oxygen dependency of ion cell kill with typical RBE [see Dale and Jones, Radiobiological Modelling in radiation Oncology] ...
... Carbon ions for early lung cancer (Japan): using Monte Carlo computer simulation of hypoxic and oxic (repopulating) with re-oxygenation flux, reduced oxygen dependency of ion cell kill with typical RBE [see Dale and Jones, Radiobiological Modelling in radiation Oncology] ...
Phage adsorption and lytic propagation in
... under starvation conditions in comparison to the one obtained in MRS broth. Adsorption efficiencies of > 99 % were observed on the starved L. plantarum ATCC 8014 cells. Finally, the influence of cell starvation conditions in phage propagation was investigated through one-step growth curves. In this ...
... under starvation conditions in comparison to the one obtained in MRS broth. Adsorption efficiencies of > 99 % were observed on the starved L. plantarum ATCC 8014 cells. Finally, the influence of cell starvation conditions in phage propagation was investigated through one-step growth curves. In this ...
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... Par3/Bazooka and the lipid phosphatase Pten are specifically lost from cell-cell junctions at epithelial edges. This results in a localized accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3), which promotes the formation of actin protrusions along the epithelial edge. Depleting PIP3 res ...
... Par3/Bazooka and the lipid phosphatase Pten are specifically lost from cell-cell junctions at epithelial edges. This results in a localized accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3), which promotes the formation of actin protrusions along the epithelial edge. Depleting PIP3 res ...
Micromechanical studies of mitotic chromosomes
... diameter, possibly with a helical structure. However, little else about supranucleosomal organization (‘higherorder chromatin structure’) is solidly understood. This is a result of the relative softness of chromatin fiber, which leads to chromatin’s apparent flexible-polymer properties (Cui and Bustam ...
... diameter, possibly with a helical structure. However, little else about supranucleosomal organization (‘higherorder chromatin structure’) is solidly understood. This is a result of the relative softness of chromatin fiber, which leads to chromatin’s apparent flexible-polymer properties (Cui and Bustam ...
Developmental Control of Telomere Lengths and Telomerase
... TRF elongation probably was caused by a telomerase-independent mechanism. However, high telomerase activity in M. album callus cultures indicates that TRF elongation was ...
... TRF elongation probably was caused by a telomerase-independent mechanism. However, high telomerase activity in M. album callus cultures indicates that TRF elongation was ...
A Cellular Hypothesis for the Induction of Blossom
... Paiva et al., 1998). As a cell expands, its plasma membrane and cell wall must increase in area. The incorporation of new material into the plasma membrane and cell wall is also a Ca2+dependent process and an elevated [Ca2+]cyt has been associated with expansion growth in several cell types (White, ...
... Paiva et al., 1998). As a cell expands, its plasma membrane and cell wall must increase in area. The incorporation of new material into the plasma membrane and cell wall is also a Ca2+dependent process and an elevated [Ca2+]cyt has been associated with expansion growth in several cell types (White, ...
Type III secretion: The bacteria-eukaryotic cell
... chaperone, helps the hydrophobic translocators to integrate in the eukaryotic plasma membrane and to form there a pore (Fig. 2). This model is supported by similar observations made in P. aeruginosa [25], Shigella [26,27] and EPEC [28], but different aspects still need to be challenged. Firstly, the ...
... chaperone, helps the hydrophobic translocators to integrate in the eukaryotic plasma membrane and to form there a pore (Fig. 2). This model is supported by similar observations made in P. aeruginosa [25], Shigella [26,27] and EPEC [28], but different aspects still need to be challenged. Firstly, the ...
Biochemical characterization of the vanilloid receptor 1 expressed in
... dorsal root ganglion-derived F-11 cells provide a powerful experimental system for the study of VR1 biochemistry. ...
... dorsal root ganglion-derived F-11 cells provide a powerful experimental system for the study of VR1 biochemistry. ...
ABSTRACT Title of Dissertation: GENETIC REGULATION OF AUTOPHAGIC CELL... Sudeshna Dutta, Doctor of Philosophy, 2008
... multiple cellular processes during metamorphosis in Drosophila, including cell differentiation, morphogenesis and death. E93 is necessary and sufficient for larval tissue cell death during metamorphosis, including autophagic cell death of salivary glands. Here we characterize new mutant alleles of ...
... multiple cellular processes during metamorphosis in Drosophila, including cell differentiation, morphogenesis and death. E93 is necessary and sufficient for larval tissue cell death during metamorphosis, including autophagic cell death of salivary glands. Here we characterize new mutant alleles of ...
Localization of Ptr ToxA Produced by Pyrenophora tritici
... function (Meinhardt et al., 2002b; Manning et al., 2004). Vitronectin relays environmental cues to cells via RGD-mediated interactions with integrin receptors with or without the internalization of the receptor and its ligand (Cherny et al., 1993; Memmo and McKeown-Longo, 1998; Hynes, 2002). Interna ...
... function (Meinhardt et al., 2002b; Manning et al., 2004). Vitronectin relays environmental cues to cells via RGD-mediated interactions with integrin receptors with or without the internalization of the receptor and its ligand (Cherny et al., 1993; Memmo and McKeown-Longo, 1998; Hynes, 2002). Interna ...
An Early Tobacco Mosaic Virus-Induced Oxidative Burst in Tobacco
... A–E). The E50Q mutation stabilizes the helical aggregates inhibiting viral disassembly, so apparently induction of ROS requires some degree of disassembly. In addition, there was no apparent difference in response between tobacco tissue that carried the N⬘ gene (cultivar EN; Fig. 5F) and nn/n⬘n⬘, as ...
... A–E). The E50Q mutation stabilizes the helical aggregates inhibiting viral disassembly, so apparently induction of ROS requires some degree of disassembly. In addition, there was no apparent difference in response between tobacco tissue that carried the N⬘ gene (cultivar EN; Fig. 5F) and nn/n⬘n⬘, as ...
Immune complexes formed following the binding of
... arterial and venular circulation. This can lead to limb- and life-threatening complications. Although the precise mechanism(s) of thrombosis is yet unestablished, evidence in literature supports a role for activated platelets, resulting procoagulants, and microparticles.13 Immune complexes also bind ...
... arterial and venular circulation. This can lead to limb- and life-threatening complications. Although the precise mechanism(s) of thrombosis is yet unestablished, evidence in literature supports a role for activated platelets, resulting procoagulants, and microparticles.13 Immune complexes also bind ...
Synergize Product Data.pub - PED portal on the Alberta Pork website
... formulation is extremely user-friendly. It has a pleasant pine fragrance and at recommended 1:256 dilutions yields a neutral pH, making it non-irritating to personnel and animals, and non-corrosive to buildings, equipment, and vehicles. This combination of power and safety make it ideally suited for ...
... formulation is extremely user-friendly. It has a pleasant pine fragrance and at recommended 1:256 dilutions yields a neutral pH, making it non-irritating to personnel and animals, and non-corrosive to buildings, equipment, and vehicles. This combination of power and safety make it ideally suited for ...
Hemoglobin Receptor in Leishmania Is a Hexokinase Located in the
... essential for targeting the protein-bound Hb to the late compartment (9), probably to generate intracellular heme. Moreover, a few receptor systems have been identified on trypanosomatid parasites such as Trypanosoma and Leishmania that mediate the uptake of low density lipoprotein and transferrin, ...
... essential for targeting the protein-bound Hb to the late compartment (9), probably to generate intracellular heme. Moreover, a few receptor systems have been identified on trypanosomatid parasites such as Trypanosoma and Leishmania that mediate the uptake of low density lipoprotein and transferrin, ...
Protein 4.2 interaction with hereditary spherocytosis mutants of the
... The locations of the three HS mutations are indicated and do not cluster together. We have previously shown that these mutations have little or no effect on the oligomerization, stability or folded structure of the isolated domain, other than a slight destabilization caused by the P327R mutation [7] ...
... The locations of the three HS mutations are indicated and do not cluster together. We have previously shown that these mutations have little or no effect on the oligomerization, stability or folded structure of the isolated domain, other than a slight destabilization caused by the P327R mutation [7] ...
Inflammation and proliferation – a causal event of host response to
... The development of chronic gastritis associated with H. pylori is a multifactorial process and is characterized by gastric epithelial cell injury and infiltration of the mucosa with both acute and chronic inflammatory cells (Smoot et al., 1999; Yang et al., 2012a). The virulence factors produced by ...
... The development of chronic gastritis associated with H. pylori is a multifactorial process and is characterized by gastric epithelial cell injury and infiltration of the mucosa with both acute and chronic inflammatory cells (Smoot et al., 1999; Yang et al., 2012a). The virulence factors produced by ...
CURRICULUM VITAE
... 15. DiLuzio NR, Knook DL, Lasskin DL, Nolan JP, Pereira CA, Wake K, Decker D. - What is kupffer cell activation? (round table). In: Cells of the hepatic sinusoid. A. Kirn, DL Knook, E Wisse, eds. Proceedings of the International Kupffer cell symposium held in Strasbourg, France, 1985,363,364. 16. Ke ...
... 15. DiLuzio NR, Knook DL, Lasskin DL, Nolan JP, Pereira CA, Wake K, Decker D. - What is kupffer cell activation? (round table). In: Cells of the hepatic sinusoid. A. Kirn, DL Knook, E Wisse, eds. Proceedings of the International Kupffer cell symposium held in Strasbourg, France, 1985,363,364. 16. Ke ...
video slide
... Would this organelle/ structure also be found in prokaryotes? If so, are there any important differences in structure or function? Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings ...
... Would this organelle/ structure also be found in prokaryotes? If so, are there any important differences in structure or function? Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings ...
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... (see supplementary material Fig. S1K,L) and the motoneuronspecific D42-Gal4 (Parkes et al., 1998), when used to target Gαo through expression of RNAi or Ptx, also led to a substantial decrease in bouton numbers (Fig. 2B). The Wg-secreting type Ib boutons (Packard et al., 2002) appeared more severely ...
... (see supplementary material Fig. S1K,L) and the motoneuronspecific D42-Gal4 (Parkes et al., 1998), when used to target Gαo through expression of RNAi or Ptx, also led to a substantial decrease in bouton numbers (Fig. 2B). The Wg-secreting type Ib boutons (Packard et al., 2002) appeared more severely ...
Approach to the interpretation of endometrial biopsies and curettings
... endometrial hyperplasia and disordered proliferative endometrium . In complex hyperplasia There is an increase in the gland to stroma ratio , glandular crowding. The glands are often closely packed although some stroma usually remains between individual glands. The glands show proliferative activity ...
... endometrial hyperplasia and disordered proliferative endometrium . In complex hyperplasia There is an increase in the gland to stroma ratio , glandular crowding. The glands are often closely packed although some stroma usually remains between individual glands. The glands show proliferative activity ...
Cytokinesis
Cytokinesis (cyto- + kinesis) is the process during cell division in which the cytoplasm of a single eukaryotic cell is divided to form two daughter cells. It usually initiates during the early stages of mitosis, and sometimes meiosis, splitting a mitotic cell in two, to ensure that chromosome number is maintained from one generation to the next. After cytokinesis two (daughter) cells will be formed that are exact copies of the (parent) original cell. After cytokinesis, each daughter cell is in the interphase portion of the cell cycle. In animal cells, one notable exception to the normal process of cytokinesis is oogenesis (the creation of an ovum in the ovarian follicle of the ovary), where the ovum takes almost all the cytoplasm and organelles, leaving very little for the resulting polar bodies, which then die. Another form of mitosis without cytokinesis occurs in the liver, yielding multinucleate cells. In plant cells, a dividing structure known as the cell plate forms within the centre of the cytoplasm and a new cell wall forms between the two daughter cells.Cytokinesis is distinguished from the prokaryotic process of binary fission.