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Sedation/analgesia practices in neonatal intensive care units
Sedation/analgesia practices in neonatal intensive care units

... regression adjustment, confirmed the analyses conducted in matched pairs12. Stratification based on propensity score quintiles divided the tracheally ventilated group into five strata. Within each stratum, infants treated or not treated with O-SH-GA were compared. Previous research found that this t ...
Vitamin B15 A Review and Update
Vitamin B15 A Review and Update

... In order for DMG to be legally sold as a food additive, extensive safety studies must be submitted to FDA to ensure that regulatory body that the substance is non-toxic. Da Vinci Laboratories currently has such studies underway, but they must be submitted before the approval process can begin. The c ...
NCPDP Recommendations for Improved Prescription Container Labels for Medicines Containing Acetaminophen
NCPDP Recommendations for Improved Prescription Container Labels for Medicines Containing Acetaminophen

... iii. The Institute of Safe Medication Practices (ISMP) added ―APAP‖ to its ―ISMP‘s List of Error Prone Abbreviations, Symbols, and Dose Designations‖, which have been reported to ISMP through the National Medication Errors Reporting Program as being frequently misinterpreted and involved in harmful ...
Blood Agents
Blood Agents

... reduces the elevated total peripheral resistance caused by the acidosis and cyanide. This should be used only until the IV drugs can be given. Inhalation of amyl nitrite will cause orthostatic hypotension. However, if the patient can stand, he or she does not need the antidote. Sodium nitrite Sodium ...
Eszopiclone
Eszopiclone

... The primary endpoint was the average sleep latency over the last three months of the first six months of the study. The secondary endpoint was total sleep time over the same time period. These data were not presented ordiscussed. The authors stated that seven other time points (weekone, and monthly ...
Seasonal Affective Disorder (SAD) - CMHA-NL
Seasonal Affective Disorder (SAD) - CMHA-NL

... reduced libido, and feelings of inadequacy. People with the most severe cases of the  winter form of SAD can suffer from September until April, while others find symptoms  are only present during the harshest winter months, setting in around Christmas and  subsiding in March. Rosenthal and his colle ...
Ritalin LA
Ritalin LA

... of absorption were unchanged after food relative to the fasting state, although the second peak was approximately 25% lower. The effect of a high fat lunch was not examined. There were no differences in the pharmacokinetics of Ritalin LA when administered with applesauce, compared to administration ...
Management Perspectives Polled or Scurred: Do You Know the
Management Perspectives Polled or Scurred: Do You Know the

... Testing for polled should be considered There are many reasons mistakes could happen in classifying a calf as polled or horned. The scur gene, human error, poor judgment, and a varying degree of genetic influence on horn growth strongly suggest testing for the polled gene should be a mandatory when ...
Keppra, INN-Levetiracetam
Keppra, INN-Levetiracetam

... onset seizures with or without secondary generalisation in patients with epilepsy. The daily dose is to be administered in two equally divided doses. As adjunctive therapy, the initial therapeutic recommended dose is 500 mg twice daily. Depending upon the clinical response and tolerance, the daily d ...
O R I G I N A L A R T I C L E
O R I G I N A L A R T I C L E

... brain. Normally the H2O2 is then inactivated by glutathione peroxidase but it can be converted, chemically, by Fe2+ ions (Fenton reaction) into the highly reactive hydroxyl radical. This radical has widespread deleterious effects, which can cause neuronal damage and death and may account for associa ...
Aprepitant Emend™ — Merck Frosst Canada Ltd.
Aprepitant Emend™ — Merck Frosst Canada Ltd.

... Review Report (a critique of the submitted pharmacoeconomic evaluation). These reports were prepared by the CDR Directorate to support the Canadian Expert Drug Advisory Committee (CEDAC) in making a formulary listing recommendation to participating publicly funded drug plans. The reviews are an asse ...
ERY-PED - Arbor Pharmaceuticals
ERY-PED - Arbor Pharmaceuticals

... and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible. Drug Interactions Theophylline: Erythromycin use in patients who are receiving high doses of theophylline may be associated w ...
Coccidiosis or Coccidiasis?
Coccidiosis or Coccidiasis?

... The anticoccidial drug is changed every 3, 4 or 6 months resulting in 4, 3 or 2 rotations per year. ...
Unit II presentation
Unit II presentation

... Diagnosis of G6PD deficiency • The definitive diagnosis of G6PD deficiency is based on the estimation of enzyme activity,by quantitative spectrophotometric analysis of the rate of NADPH production from NADP • Several screening test are available ...
Lithium Carbonate Extended-Release Tablets 300mg
Lithium Carbonate Extended-Release Tablets 300mg

... did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly pati ...
Analgesia dose prescribing and estimated glomerular filtration rate
Analgesia dose prescribing and estimated glomerular filtration rate

... ▪ General practice patients with a wide spectrum of chronic kidney disease (CKD) and non-CKD were included in this study. ▪ Analgesia dose prescribing was standardised using the WHO defined daily dose method. ▪ The outcome of estimated glomerular filtration rate decline is based on current clinical ...
one  that I'm not aware
one that I'm not aware

... taking a control ...
An Update on the Hereditary Spastic Paraplegias: New Genes and
An Update on the Hereditary Spastic Paraplegias: New Genes and

... pathogenicity, requiring further investigations, including family studies, expression studies, and so on. Furthermore, there are ethical issues related to the identification of “incidental findings,” such as the detection of mutations in cancer-predisposing genes, highlighting the importance of care ...
pharmacology_2
pharmacology_2

... 27.Clonidine hydrochloride (clofeline) lowers blood pressure by reducing sympathetic tone. It is believed to act by inhibiting sympathetic outflow from the vasomotor center in the medulla. A potentially serious adverse reaction that has been reported is: A. myelosuppression B. anemia C. irreversible ...
NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS)
NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS)

... generation of a protective barrier of mucous and bicarbonate, and promoting adequate blood flow to the gastric muscosal cells. Since NSAIDs block PG biosynthesis in the GI tract, they block these cytoprotective processes. The primary toxicity seen with the NSAIDs is GI irritation which may lead to t ...
10k
10k

... malignancies and solid tumor indications. The results of these studies suggest that Pracinostat has potential best-inclass pharmacokinetic properties when compared to other oral HDAC inhibitors, with side effects often associated with drugs of this class, the most frequent of which is fatigue. Praci ...
Asthma drug ratios and exacerbations: claims data from universal health coverage systems
Asthma drug ratios and exacerbations: claims data from universal health coverage systems

... the French national claims data. After excluding null ratios, two groups were defined according to ratio values in 2007: low-ratio group (0%,ratio,50%) and high-ratio group (ratio o50%). For both ratios, asthma-related outcomes and medical-resource utilisation were compared between groups. Of 2162 p ...
Genetic variation at RYR1, IGF2, FUT1, MUC13, and KPL2
Genetic variation at RYR1, IGF2, FUT1, MUC13, and KPL2

... IGF2. At the IGF2 intron3 g.3072 G>A locus, the favourable A allele increasing lean production was almost fixed in Duroc pigs and it was present at high frequencies in Landrace and Large White pigs. Duroc pigs have the highest frequency of 0.932, followed by 0.756, 0.767, and 0.788 in Landrace, Larg ...
Evaluation of the efficacy of albendazole sulphoxide and
Evaluation of the efficacy of albendazole sulphoxide and

... The morphological alterations on the parasites of T. crassiceps after the different drug treatments were observed by light microscopy. We found that the control cysts remained unaltered during the experiment, showing the classical movements and normal appearance. The first effects of the treatment w ...
Viagra - Pfizer
Viagra - Pfizer

... cardiomyopathy), or those with the rare syndrome of multiple system atrophy manifesting as severely impaired autonomic control of blood pressure. Agents for the treatment of erectile dysfunction should be used with caution in patients with anatomical deformation of the penis (such as angulation, cav ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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