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Ritalin LA - Novartis Pharmaceuticals Corporation
Ritalin LA - Novartis Pharmaceuticals Corporation

... of absorption were unchanged after food relative to the fasting state, although the second peak was approximately 25% lower. The effect of a high fat lunch was not examined. There were no differences in the pharmacokinetics of Ritalin LA when administered with applesauce, compared to administration ...
F Part 7.2: Management of Cardiac Arrest
F Part 7.2: Management of Cardiac Arrest

... Administration of resuscitation drugs into the trachea, however, results in lower blood concentrations than the same dose given intravascularly. Furthermore, recent animal studies24 –27 suggest that the lower epinephrine concentrations achieved when the drug is delivered by the endotracheal route ma ...
National Conference on “Recent Advances in Herbal Drug Technology”
National Conference on “Recent Advances in Herbal Drug Technology”

... heptapeptide unit Boc-L-ser-L-leu-L-pro-L-pro-L-ile-L-phe-gly-OMe which was in turn, prepared via carbodiimide coupling of tripeptide unit Boc-L-ser-L-leu-L-pro-OMe and tetrapeptide unit Boc-L-pro-L-ile-L-phe-gly-OMe after suitable deprotection at carboxyl and amino terminals using LiOH and TFA resp ...
Psychomotor Stimulants (part 1)
Psychomotor Stimulants (part 1)

... – offered the beneficial effects of coca without the deleterious effects of alcohol – intellectual beverage and temperance drink that cured all nervous afflictions – 1903: Coca-Cola admits cocaine is present in their soft drink, shortly thereafter they elected to quietly remove it – 1906: government ...
Physostigmine
Physostigmine

... More Mixed Overdose • 83 unconscious or severely disoriented patients • 2 mg doses repeated until maximal effect • Followed vital signs and level of consciousness  Nilsson: Ann Clin Research 1982;14:165 ...
Effect of Short-term Treatment With Gaboxadol on Sleep
Effect of Short-term Treatment With Gaboxadol on Sleep

... Efficacy analyses (PSG and LSEQ) were performed on the per-protocol set (PPS) as described in a predefined analysis plan. The PPS consisted of all randomized patients who received active treatment up to and including the second treatment night of the third treatment session and who did not violate a ...
meth_presentation
meth_presentation

... [6] Stimulant Medications and Attention Deficit–Hyperactivity Disorder, N Engl J Med 2006; 354:2294-2295May 25, 2006DOI: 10.1056/NEJMc060860 [7] http://www.nhtsa.gov/people/injury/research/job185drugs/methamphetamine.htm [8]Drug characterization/impurity profiling, with special focus on methamphetam ...
Reappraisal of European guidelines on hypertension management
Reappraisal of European guidelines on hypertension management

... those that can be identified by relatively simple and cheap procedures [electrocardiogram, serum creatinine, estimated glomerular filtration rate (eGFR), and measurement of urinary protein excretion in order to detect microalbuminuria or proteinuria], which were thus regarded as suitable for routine ...
Buprenorphine: Everything You Need to Know
Buprenorphine: Everything You Need to Know

... of patients on high-dose opioids transitioned to sublingual or buccal buprenorphine have shown improved pain control, improved control of psychiatric symptoms, and much lower risk of overdose death.12,13 Patients commonly start buprenorphine in a clinician’s office after 12 to 48 hours of withdrawal ...
Methadone and Buprenorphine: Clinical Practice Guideline for
Methadone and Buprenorphine: Clinical Practice Guideline for

... For the purposes of this document, the term buprenorphine is used to represent any formulation containing buprenorphine for use in treatment of opioid use disorder, including the combination of buprenorphine-naloxone. The benefits of opioid substitution treatment extend beyond reduction of illicit o ...
Chapter 14
Chapter 14

... in six other pea plant characters, each represented by two traits • What Mendel called a “heritable factor” is what we now call a gene Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings ...
Vitamin D dosing for vitamin D deficiency?
Vitamin D dosing for vitamin D deficiency?

... Anticonvulsants (phenytoin, barbiturates or primidone) may reduce effect of vitamin D by accelerating its metabolism. Colestyramine, colestipol, laxatives, liquid paraffin and sucralfate may reduce intestinal absorption of vitamin D. When taken with digoxin, caution is advised as hypercalcaemia caus ...
Retrospective Review of Trend in Modafinil Overexposures
Retrospective Review of Trend in Modafinil Overexposures

... norepinephrine, serotonin, glutamate, and histamine (11). However, unlike the amphetamines, modafinil does not have an effect on spontaneous dopamine release. The standard therapeutic dose of modafinil in adult patients is 200-400 mg daily. A search of the medical literature revealed limited informa ...
MS_349Formated - University of Alberta
MS_349Formated - University of Alberta

... At low temperatures in aqueous solutions, a hydration layer surrounds PF-127 molecules. However, when the temperature is raised, the hydrophilic chains of the copolymer become desolvated as a result of the breakage of the hydrogen bonds that had been established between the solvent and these chains. ...
Genomic dissection of plant development and its
Genomic dissection of plant development and its

... We applied Model B on trait BLUEs as outlined in detail by Liu et al. (2011). This model was found to be most suited for carrying out genome-wide association study (GWAS) with multiple families (Würschum et al., 2012) and has already been shown to work properly in HEB-25 (Maurer et al., 2015). It is ...
Quality Control, Screening, Toxicity, and Regulation of Herbal Drugs 2
Quality Control, Screening, Toxicity, and Regulation of Herbal Drugs 2

... A herb might be considered a “diluted” drug. To achieve the desired benefit, an individual must take an adequate amount over a certain length of time. Each herb is different. While some are safe and effective for specific uses, others are not. The general perception that herbal drugs are very safe a ...
Chapter 12: Emergency Medications
Chapter 12: Emergency Medications

... • Category B − Either: • Animal studies have not demonstrated a fetal risk but there are no controlled studies in women or • Animal reproductive studies have shown an adverse effect that was not confirmed in controlled studies on women in the first trimester ...
SNPs for individual identification
SNPs for individual identification

... concerns over identifying high likelihood of an individual developing a cancer, Alzheimer disease, or Huntington disease does preclude using SNPs that would convey such information. However, from a scientific perspective that does not generalize to precluding all SNPs from even those genes, much les ...
NIDA Research Report - MDMA
NIDA Research Report - MDMA

... their problems. It was also during this time that MDMA first started becoming available on the street. In 1985, the U.S. Drug Enforcement Administration (DEA) banned the drug, placing it on its list of Schedule I drugs, corresponding to those substances with no proven therapeutic value. ...
Mifepristone: Expanding Women`s Options for Early Abortion in the
Mifepristone: Expanding Women`s Options for Early Abortion in the

... The Clinton administration, in one of its first administrative actions in January 1993, asked the FDA to reexamine the import ban. Subsequently, an FDA deputy commissioner indicated that the agency might consider clinical trials in Europe as evidence in determining the drug’s safety, an important st ...
TRIDURAL Product Monograph
TRIDURAL Product Monograph

... Following a single IV 100 mg dose of tramadol, the cumulative excretion in breast milk within 16 hours postdose was 100 µg of tramadol (0.1% of the maternal dose) and 27 µg of M1. Pediatrics (< 18 years of age): The safety and use of TRIDURAL® in patients under 18 years of age has not been establish ...
Monohybrid Practice
Monohybrid Practice

... for pink plants as possible? Explain why or why not. If not, explain which genotype would be best. ...
Thyroid medication (desiccated )
Thyroid medication (desiccated )

View Presentation Document
View Presentation Document

... [Posted 11/17/2009] FDA notified healthcare professionals of new safety information concerning an interaction between  clopidogrel (Plavix), an anti‐clotting medication, and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to  reduce stomach acid. New data show that when clopid ...
Pathophysiology of Aspirin Poisoning
Pathophysiology of Aspirin Poisoning

... Aspirin (salicylic acid) is a non-steroidal anti-inflammatory. It is one of the most popular drugs in the world today, and with good reason. It is effective as an analgesic, as an anti-inflammatory, and as an antipyretic. It also acts to inhibit platelet aggregation (a significant contributor to thr ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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