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Syeda Bushra Yunus
Syeda Bushra Yunus

... effects of various excipients generally present in the tablet dosage form of Clopidogrel bisulphate were investigated. The results indicated that they did not interfere in the assay in amounts far in excess of their normal occurrence in it. The proposed method was validated as per the ICH guidelines ...
View PDF
View PDF

... outbreaks in a variety of clinical settings. It showing resistance to glycopeptides have now been reported from many parts of the world and show heterogeneity, both phenotypic and genotypic [2]. Emerging risk factors for a massive bacterial colonization include the increased life expectancy of the g ...
The Diagnosis and Treatment of ADHD in a Primary Care Setting
The Diagnosis and Treatment of ADHD in a Primary Care Setting

... Mayo Clinic 18 year study (2008) of >5,000 children from birth (370 with ADHD, 277 boys & 93 girls) found that treatment with prescription stimulants is associated with improved long-term academic success of children with ADHD.  Girls and boys with untreated ADHD were equally vulnerable to poor sch ...
Pan London Guidelines for the Safe Prescribing, Handling and
Pan London Guidelines for the Safe Prescribing, Handling and

... With the kind permission of the authors, this document has been based around the Policy and Guidelines for the Safe Prescribing and Handling and Administration of Cytotoxic Drugs produced by the North and North East London Cancer Network (May 2005), and built upon using existing Guidelines and Polic ...
prescribing information xylocaine viscous 2%
prescribing information xylocaine viscous 2%

... It is reasonable to assume that a large number of pregnant women and women of child-bearing age have been given lidocaine. No specific disturbances to the reproductive process have so far been reported, e.g. no increased incidence of malformations. However, care should be given during early pregnanc ...
Apotex Launches First Generic Plavix®
Apotex Launches First Generic Plavix®

... Weston, Fl (August 8, 2006) - Apotex Corp. announced that it has today launched clopidogrel bisulfate 75 mg tablets. Clopidogrel is the generic equivalent of Sanofi's Plavix®, which is marketed in the U.S. by Bristol Myers Squibb. As the first generic company to file an Abbreviated New Drug Applicat ...
Chemotherapy-induced lung disease
Chemotherapy-induced lung disease

... bleomycin toxicity. In particular, exposures within the previous 6 months should be considered highly risky, although the hazard may extend for month or years beyond this period. High-inspired oxygen concentrations should be avoided whenever possible. In addition, there seems to be synergistic toxic ...
7. Mendelian Genetics
7. Mendelian Genetics

... sized offspring. (Today we know these heritable units are genes; however, Mendel did not know of the concept of a gene.) Mendel noted that plants in the monastery gardens sometimes gave rise to plants that were not exactly like the parent plants, nor were they a “mix” of the parents. He also noted t ...
HIGHLIGHTS OF PRESCRIBING INFORMATION --------------------------WARNINGS AND PRECAUTIONS---------------------------
HIGHLIGHTS OF PRESCRIBING INFORMATION --------------------------WARNINGS AND PRECAUTIONS---------------------------

... years, mean weight loss from baseline to endpoint was -2.7, -4.3, and -4.8 lbs., respectively, for patients receiving 30 mg, 50 mg, and 70 mg of Vyvanse, compared to a 2.0 pound weight gain for patients receiving placebo. Careful follow-up of weight and height in children ages 7 to 10 years who were ...
Document
Document

... DXM comparable to standard sedation when light sedation target DXM less effective when deep sedation target (RASS -4) ↑ delirium in DXM group but more CAM-ICU assessments in this group Average DEX dose 0.8mcg/kg/hr Average duration 40 h (Max duration 14 days) ...
NIDA Research Report - MDMA
NIDA Research Report - MDMA

... deceptive reputation as a “safe” drug among its users. This illegal drug, which has both stimulant and psychedelic properties, is often taken for the feelings of well-being, stimulation, and the distortions in time and sensory perceptions that it produces. MDMA first became popular in the “rave” and ...
Clinician`s Guide to Prevention and Treatment of Osteoporosis
Clinician`s Guide to Prevention and Treatment of Osteoporosis

... unique concerns and expectations of individual patients considered in any final therapeutic decision. Risk assessment All postmenopausal women and men age 50 and older should be evaluated for osteoporosis risk in order to determine the need for BMD testing and/or vertebral imaging. In general, the m ...
Information for patients and healthcare providers
Information for patients and healthcare providers

... normal functions; they are seen only after administration of large therapeutic doses of the drug. The pharmacological effects of prednisolone which are due to its glucocorticoid properties include: promotion of gluconeogenesis; increased deposition of glycogen in the liver; inhibition of the utiliza ...
fosrenol - Shire Canada
fosrenol - Shire Canada

... lanthanum and six commonly used medications (warfarin, digoxin, furosemide, phenytoin, metoprolol and enalapril) was investigated in simulated gastric fluid. The results suggest that precipitation in the stomach of insoluble complexes of these drugs with lanthanum is unlikely. In Vivo Drug Interacti ...
An Overview of the Treatment of Tourette`s Disorder and Tics
An Overview of the Treatment of Tourette`s Disorder and Tics

... which showed a mean percentage decrease of symptoms at the endpoint of 71% for pimozide and 62% for HAL. Penfluridol was used with significant symptomatic improvement and fewer adverse effects compared with HAL, but concerns about its carcinogenic potential limited its use (Parihk et al. 1979; Shapi ...
The Genetic Basis of Lateralization
The Genetic Basis of Lateralization

... It is important to emphasize that the RS genetic model was not developed by fitting parameters to studies of family handedness. Rather, it was discovered that parameters derived from studies of aphasics representative of the general population (Annett, 1975) could be applied to family data, using st ...
Product Monograph
Product Monograph

... lanthanum and six commonly used medications (warfarin, digoxin, furosemide, phenytoin, metoprolol and enalapril) was investigated in simulated gastric fluid. The results suggest that precipitation in the stomach of insoluble complexes of these drugs with lanthanum is unlikely. In Vivo Drug Interacti ...
MAXIDOL® Liquid Gels
MAXIDOL® Liquid Gels

... Adults (12-65 years): 1 caplet/capsule every 8 - 12 hours. For individuals over 65 years, 1 capsule every 12 hours. Do not take more than 2 capsules in a 24 hour period. Drink a full glass of water with each dose. Under 12 years: Children under 12 should not take this drug. The safety in pediatric u ...
Lipids - National Medical Research Council
Lipids - National Medical Research Council

... In that time, numerous studies have been published that have confirmed the benefits of statin therapy for the prevention of cardiovascular disease. In particular, the role of high intensity statins for individuals at the highest risk of coronary artery disease, and the roles of non-statin lipid lowe ...
Hepatitis C Drug Development - HIV Research Catalyst Forum
Hepatitis C Drug Development - HIV Research Catalyst Forum

... Drug Resistance the ability of an organism to grow in the presence of a drug that would normally kill it or limit its growth; drug resistance can develop or emerge within days With HCV, no one knows how long resistance mutations will last, and if they will compromise future TX options ...
Grapefruit juice–drug interactions
Grapefruit juice–drug interactions

... for substrate metabolism. Since small bowel CYP3A4 mRNA was not changed [14], grapefruit juice likely decreased CYP3A4 protein content by a post-transcriptional mechanism, possibly involving accelerated CYP3A4 degradation through mechanism-based enzyme inhibition. Thus, the return of CYP3A4 activity ...
DRUG NAME: Tamoxifen
DRUG NAME: Tamoxifen

... in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective). ...
concerta - Janssen
concerta - Janssen

... Administration of stimulants may exacerbate symptoms of behaviour disturbance and thought disorder in patients with a pre-existing psychotic disorder. Screening Patients for Bipolar Disorder Particular care should be taken in using stimulants to treat ADHD in patients with comorbid bipolar disorder ...
Hidden Dangers: Herbal and Dietary Supplement Induced
Hidden Dangers: Herbal and Dietary Supplement Induced

... hepatocellular jaundice is a serious lesion” resulting in 10-50% mortality. This observation has been validated throughout the years and is known as “Hy’s Law.” When evaluating new drugs, the FDA uses Hy’s law (aminotransferases > 3 x ULN with bilirubin > 2 x ULN with normal alkaline phosphatase pro ...
Determine by Doctor
Determine by Doctor

... achieved somewhat higher concentrations for one or the other tablet formulation. Two to 4 days of therapy may be required to achieve steady-state plasma concentrations. Although optimal therapeutic plasma concentrations suitable for all patients have not yet been determined, therapeutic plasma conc ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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