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Cocaine - Youville
Cocaine - Youville

... altogether. There is no antidote to cocaine overdose. Snorting cocaine can cause sinus infections and loss of smell. It can damage tissues in the nose and cause holes in the bony separation between the nostrils inside the nose. Smoking cocaine can damage the lungs and cause "crack lung." Symptoms in ...
PRODUCT MONOGRAPH Pr ZYLOPRIM® Allopurinol Tablets USP
PRODUCT MONOGRAPH Pr ZYLOPRIM® Allopurinol Tablets USP

... mechanism of the interaction may be explained by xanthine oxidase being involved in the ...
Unknown - Skin Therapy Letter
Unknown - Skin Therapy Letter

... water loss. Humectants attract and bind water, drawing it up from the dermis into the epidermis. The acid mantle of the skin plays an integral role in skin barrier function as well as regulating bacterial ßora.4 Studies have shown that skin barrier regeneration/repair proceeds more slowly at neutral ...
13: Skin - Gateshead Health NHS Foundation Trust
13: Skin - Gateshead Health NHS Foundation Trust

... - Yellow soft paraffin (yellow petroleum jelly): apply as often as required. Prescribing notes ...
Herb -Drug Interactions –An Update on Synergistic Interactions
Herb -Drug Interactions –An Update on Synergistic Interactions

... the form of dietary supplements are being consumed along with modern allopathic drugs [1,2]. This is particularly true for geriatric patients who consume a number of medications simultaneously. The consumption of herbal drugs is often associated with a general belief that these drugs are relatively ...
Diapositive 1
Diapositive 1

... - The hypothesis is that uncoupling of oxidative phosphorylation led to decreased ATP, cell death and liver cytolysis. - Thus, some individuals may have partial enzymatic deficiency in the mitochondrial respiratory chain which remains entirely asymptomatic life long, unless submitted to an additiona ...
Poor - American Thoracic Society
Poor - American Thoracic Society

... both infected persons and susceptible persons in their communities. Until recently, isoniazid was the only drug proven effective and thus recommended for treatment of LTBI. Shortly after isoniazid was found to be effective for the treatment of TB, clinical trials were begun to assess the ability of ...
PDF - Santen Inc.
PDF - Santen Inc.

... is an important element in that strategy,” says Schalon Newton, EDM, Santen’s Vice President of Strategic Marketing & Business Development. “We are committed to expanding our current pipeline and identifying the next generation of compounds to develop and market. We also are actively pursuing new, e ...
American Thoracic Society
American Thoracic Society

... both infected persons and susceptible persons in their communities. Until recently, isoniazid was the only drug proven effective and thus recommended for treatment of LTBI. Shortly after isoniazid was found to be effective for the treatment of TB, clinical trials were begun to assess the ability of ...
Treatment of opioid-induced gut dysfunction
Treatment of opioid-induced gut dysfunction

... activity [13,21,22]. Transmission can be blocked both via presynaptic and postsynaptic sites of action on enteric neurons, whereby the release of acetylcholine and other transmitters is attenuated [6,21]. It has previously been believed that opiates inhibit GI propulsion in some species such as the ...
Selegiline transdermal system in major depressive disorder
Selegiline transdermal system in major depressive disorder

Acetaminophen: Old Drug, New Issues
Acetaminophen: Old Drug, New Issues

... (1). Because PARA is not widely recognized in the United States, in this article acetaminophen will be used. Acetaminophen is a member of the aniline family of analgesics, and it is the only such drug available in the United States. A January 13, 2011, Food and Drug Administration (FDA) Drug Safety ...
Dopamine Hypothesis of Mania
Dopamine Hypothesis of Mania

... Wellcome Laboratories in London. It is a cathecholamine and in the 1940s Blaschko in Cambridge proposed that DA was a precursor in synthesis of the cat-echolamine neurotransmitters noradrenaline (norepinephrine) and adrenaline (epinephrine). In 1957 it was shown to be present in the brain with other ...
highlights of prescribing information
highlights of prescribing information

... Anemia has been reported with peginterferon alfa and ribavirin therapy. The addition of VICTRELIS to peginterferon alfa and ribavirin is associated with an additional decrease in hemoglobin concentrations. Complete blood counts (with white blood cell differential counts) should be obtained pretreatm ...
Epidural Certification Course for Nurses 2010 - West
Epidural Certification Course for Nurses 2010 - West

... Local anesthetics block the conduction of nerve impulses while narcotics only interfere with pain impulses. (Hosking and Welchew 1985). The most common drugs used in epidural analgesia are Morphine and Fentanyl. At Greymouth Hospital Fentanyl is usually combined with a local anaesthetic, such as Bup ...
study of formulation, characterisation and wound healing potential of
study of formulation, characterisation and wound healing potential of

... The aim of this study was to investigate the feasibility of Curcumin patches formulation (CPF) as a transdermal therapeutic system for wound healing potential. A combination of Poly Vinyl Pyrrolidone (PVP) and Ethyl Cellulose (EC) most strongly enhanced the permeation of Curcumin patch which permeat ...
2. tablets
2. tablets

... 6. They must be free from all microbial contamination. 7. They do not alter the bioavailability of drug. 8. They must be color compatible. ...
Renerve P - SR
Renerve P - SR

... Adverse reactions were usually mild to moderate in intensity. In all controlled studies, the discontinuation rate due to adverse reactions was 12% for patients receiving pregabalin and 5% for patients receiving placebo. The most common adverse reactions resulting in discontinuation from pregabalin t ...
COMPARITIVE STUDIES OF GLUTATHIONE-S-TRANSFERASE KINETICS IN CONTROL,
COMPARITIVE STUDIES OF GLUTATHIONE-S-TRANSFERASE KINETICS IN CONTROL,

... reported decreased reduced glutathione (GSH) level and increase in lipid peroxidation compared to controls. In present studies we have attempted to study the kinetics of Glutathione-S-Transferase (GST) after cisplatin and etoposide treatment in male wistar rat. GST is a enzyme that metabolizes vario ...
Dipeptidyl peptidase4 inhibitors in the treatment of type 2
Dipeptidyl peptidase4 inhibitors in the treatment of type 2

Saving Lives, Saving Money - The Network For Excellence In Health
Saving Lives, Saving Money - The Network For Excellence In Health

... annual savings for the hospitals and payers could be approximately $170 million and 55,000 adverse drug events could be prevented every year. The study recommends that all Massachusetts hospitals complete implementation of CPOE systems with clinical decision support by 2011; that the Hospital CPOE I ...
“Squirt, Sniff, Burn”1 Introduction Zinc is a vital nutrient that serves
“Squirt, Sniff, Burn”1 Introduction Zinc is a vital nutrient that serves

... nasal anatomy. It is also important to note that no scientific studies have ever shown that use of Zicam Cold Remedy intranasal products or zinc gluconate applied instranasally can cause loss of smell. (“FDA Questions”) Unfortunately, the company’s arguments do not sufficiently prove that Zicam has ...
PREMEDICATION OF THE CHILD UNDERGOING SURGERY C. A
PREMEDICATION OF THE CHILD UNDERGOING SURGERY C. A

... potentially dangerous in the presence of eye trauma since increase in intraocular pressure has been documented with its use. Studies in mice and rats have correlated ketamine treatment with increased neuronal apoptosis during rapid synaptogenesis after birth. The clinical importance of these finding ...
Simultaneous Inhibition of Fatty Acid Amide Hydrolase and
Simultaneous Inhibition of Fatty Acid Amide Hydrolase and

... Response rate was averaged (6 S.E.M.) among mice and plotted as a function of dose. Response rate for an individual mouse was calculated by expressing the response rate during a test as a percentage of control; the control response rate was defined as the average response rate for the five preceding ...
Pain genetics: past, present and future
Pain genetics: past, present and future

... analogs of these genes in clinical and/or human experimental pain states. Little attention has been paid to comparative genetics among animal species, but a few findings are noteworthy. First, the insensitivity to capsaicin pain and thermal hyperalgesia (i.e. increased sensitivity to noxious thermal ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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