Targeting the dopamine D receptor in schizophrenia
... well known, they block the effects of accumulated 5-hydroxytryptamine’ [10]. In other words, these authors proposed that antipsychotics might block all three types of receptors for noradrenaline, dopamine and serotonin, but they did not identify which receptor was selectively blocked or how to ident ...
... well known, they block the effects of accumulated 5-hydroxytryptamine’ [10]. In other words, these authors proposed that antipsychotics might block all three types of receptors for noradrenaline, dopamine and serotonin, but they did not identify which receptor was selectively blocked or how to ident ...
5-Fluorouracil encapsulated alginate beads for the treatment of
... Alginate beads containing 5-fluorouracil (5-FU) were prepared by the gelation of alginate with calcium cations. Alginate beads loaded with 5-FU were prepared at 1.0 and 2.0% (w/v) polymers. The effect of polymer concentration and the drug loading (1.0, 5.0 and 10%) on the release profile of 5-FU was ...
... Alginate beads containing 5-fluorouracil (5-FU) were prepared by the gelation of alginate with calcium cations. Alginate beads loaded with 5-FU were prepared at 1.0 and 2.0% (w/v) polymers. The effect of polymer concentration and the drug loading (1.0, 5.0 and 10%) on the release profile of 5-FU was ...
Newer Immunosuppressive Drugs: A Review
... (0.75 mg/kg per d) and MMF (10 mg/kg per d) produced at least an additive effect with a graft survival over 50 d. Either drug alone resulted in a graft survival of only 10 to 11 d (32,33). In a cynomolgus monkey heart allograft model with MMF doses between 70 and 175 mg/kg per d, prolongation of gra ...
... (0.75 mg/kg per d) and MMF (10 mg/kg per d) produced at least an additive effect with a graft survival over 50 d. Either drug alone resulted in a graft survival of only 10 to 11 d (32,33). In a cynomolgus monkey heart allograft model with MMF doses between 70 and 175 mg/kg per d, prolongation of gra ...
Inhaled loop diuretics as potential ... asthmatic drugs - *
... These findings suggest that ion transport mechanisms participate in the control of bronchial reactivity in asthma, but they do not provide sufficient infonnation to detennine the exact mechanism(s) involved. As ion transport pathways are present in virtually every cell type, all cells suspected to b ...
... These findings suggest that ion transport mechanisms participate in the control of bronchial reactivity in asthma, but they do not provide sufficient infonnation to detennine the exact mechanism(s) involved. As ion transport pathways are present in virtually every cell type, all cells suspected to b ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights
... There has been no evaluation of KADIAN as an initial opioid analgesic in the management of pain. Because it may be more difficult to titrate a patient to adequate analgesia using an extended-release morphine, begin treatment using an immediate-release morphine formulation and then convert patients t ...
... There has been no evaluation of KADIAN as an initial opioid analgesic in the management of pain. Because it may be more difficult to titrate a patient to adequate analgesia using an extended-release morphine, begin treatment using an immediate-release morphine formulation and then convert patients t ...
AusPAR: Prednisone
... According to the Product Information document (PI), the initial daily dose is 10 mg and this may be titrated down in steps of 1 mg. In some cases short-term higher treatments of 12, 15 or 20 mg are required and thus the maximum daily dose is 20 mg. It follows from this and the tablets strengths bein ...
... According to the Product Information document (PI), the initial daily dose is 10 mg and this may be titrated down in steps of 1 mg. In some cases short-term higher treatments of 12, 15 or 20 mg are required and thus the maximum daily dose is 20 mg. It follows from this and the tablets strengths bein ...
PHARMACEUTICAL BENEFITS ADVISORY COMMITTEE (PBAC
... Consumers will have the opportunity to provide comments on new drug submissions (item 5), changes to listings (item 6) and resubmissions (item 7). In many circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be list ...
... Consumers will have the opportunity to provide comments on new drug submissions (item 5), changes to listings (item 6) and resubmissions (item 7). In many circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be list ...
product monograph including patient
... Nitroglycerin overdose may result in severe hypotension, persistent throbbing headache, vertigo, palpitations, visual disturbances, flushing, and perspiring skin (later becoming cold and cyanotic), nausea and vomiting (possibly with colic and even bloody diarrhea), syncope (especially in the upright ...
... Nitroglycerin overdose may result in severe hypotension, persistent throbbing headache, vertigo, palpitations, visual disturbances, flushing, and perspiring skin (later becoming cold and cyanotic), nausea and vomiting (possibly with colic and even bloody diarrhea), syncope (especially in the upright ...
Master-Thesis
... aim of a large number of analytical tests is to eliminate all compounds with unfavourable properties like toxicity or inappropriate pharmacokinetic profiles as early as possible. Traditional HTS often includes a high rate of false-positive and false-negative results. Therefore for enhancing the perf ...
... aim of a large number of analytical tests is to eliminate all compounds with unfavourable properties like toxicity or inappropriate pharmacokinetic profiles as early as possible. Traditional HTS often includes a high rate of false-positive and false-negative results. Therefore for enhancing the perf ...
WORLD HEALTH ORGANIZATION ORGANISATION MONDIALE DE LA SANTE 31ST EXPERT COMMITTEE
... to public health, it would go to Schedule IV, regardless of its therapeutic usefulness. If the degree of risk to public health is “substantial”, it would go either to Schedule Ii or III, depending on its therapeutic usefulness. Theoretically, the possibility of a therapeutically useful substance mee ...
... to public health, it would go to Schedule IV, regardless of its therapeutic usefulness. If the degree of risk to public health is “substantial”, it would go either to Schedule Ii or III, depending on its therapeutic usefulness. Theoretically, the possibility of a therapeutically useful substance mee ...
Positive Selection of Deleterious Alleles through Interaction with a
... (linkage to a gene undergoing positive selection, i.e. indirect positive selection) [3,4]. The role of deleterious alleles in natural populations can be studied by looking at correlations between observed heterozygosity of autosomal microsatellites and various traits that are expected to affect fitn ...
... (linkage to a gene undergoing positive selection, i.e. indirect positive selection) [3,4]. The role of deleterious alleles in natural populations can be studied by looking at correlations between observed heterozygosity of autosomal microsatellites and various traits that are expected to affect fitn ...
Pediatric Moderate Sedation - Loyola University Medical Center
... sedation Recognize and manage complications of one level deeper than intended sedation Be trained/capable of providing (at minimum) bag mask ventilation and, ultimately, endotracheal intubation Understand pharmacology of sedating medications, as well as role of reversal agents for opioids and benzod ...
... sedation Recognize and manage complications of one level deeper than intended sedation Be trained/capable of providing (at minimum) bag mask ventilation and, ultimately, endotracheal intubation Understand pharmacology of sedating medications, as well as role of reversal agents for opioids and benzod ...
Needle Free Injection Systems - The Pharma Innovation Journal
... Needle-free injection systems are novel ways to introduce various medicines into patients without piercing the skin with a conventional needle. Needle-free technology offers the very obvious benefit of reducing patient concern about the use of needle. Needle free injection gives very effective injec ...
... Needle-free injection systems are novel ways to introduce various medicines into patients without piercing the skin with a conventional needle. Needle-free technology offers the very obvious benefit of reducing patient concern about the use of needle. Needle free injection gives very effective injec ...
Personalized Medicine - Scientific and Commercial Aspects Brochure
... treatment. Pharmacogenomics, a term that overlaps with pharmacogenetics but is distinct, deals with the application of genomics to drug discovery and development. It involves the mechanism of action of drugs on cells as revealed by gene expression patterns. Pharmacoproteomics is an important contrib ...
... treatment. Pharmacogenomics, a term that overlaps with pharmacogenetics but is distinct, deals with the application of genomics to drug discovery and development. It involves the mechanism of action of drugs on cells as revealed by gene expression patterns. Pharmacoproteomics is an important contrib ...
Asthma
... within the past decade Guidelines for the Diagnosis and Management of Asthma—Update on Selected Topics 2002. NIH, NHLBI. June 2002. NIH publication no. 02-5075. ...
... within the past decade Guidelines for the Diagnosis and Management of Asthma—Update on Selected Topics 2002. NIH, NHLBI. June 2002. NIH publication no. 02-5075. ...
WEST VIRGINIA LEGISLATURE Senate Bill 454
... (A) Restrict the subdivision or development of a tract for any more intense or higher density occupancy than a single-family dwelling unit; (B) Propose or enforce rules applicable to single-family dwelling units for single-family dwelling unit sanitary sewerage disposal systems; or (C) Restrict any ...
... (A) Restrict the subdivision or development of a tract for any more intense or higher density occupancy than a single-family dwelling unit; (B) Propose or enforce rules applicable to single-family dwelling units for single-family dwelling unit sanitary sewerage disposal systems; or (C) Restrict any ...
Page 1 of 9 Clinical Policy: aflibercept (Eylea), ranibizumab
... Corrected Lucentis product availability to 0.5 mg/0.05 mL ...
... Corrected Lucentis product availability to 0.5 mg/0.05 mL ...
What is Methamphetamine? Pushback Fact Sheet
... “Meth Mouth” is a phenomenon that is caused by a decrease in saliva around the teeth due to the drug, as well as increased use of sugary drinks, neglected personal hygiene, and the grinding or clenching teeth. Is Meth a Prescription Drug?2 Methamphetamine can be prescribed by a doctor to treat atten ...
... “Meth Mouth” is a phenomenon that is caused by a decrease in saliva around the teeth due to the drug, as well as increased use of sugary drinks, neglected personal hygiene, and the grinding or clenching teeth. Is Meth a Prescription Drug?2 Methamphetamine can be prescribed by a doctor to treat atten ...
Express Scripts 2015 Drug Trend Report
... recent years. Compared to 2014, brand prices in 2015 were 16% higher. Brand medications have increased in price by 164% between 2008 and 2015. Consider the case of Gleevec: In 2015, Novartis, the exclusive manufacturer, engaged in the prevalent practice of increasing the price of a medication in the ...
... recent years. Compared to 2014, brand prices in 2015 were 16% higher. Brand medications have increased in price by 164% between 2008 and 2015. Consider the case of Gleevec: In 2015, Novartis, the exclusive manufacturer, engaged in the prevalent practice of increasing the price of a medication in the ...
10117sgp02
... The primary endpoint was the average sleep latency over the last three months of the first six months of the study. The secondary endpoint was total sleep time over the same time period. These data were not presented ordiscussed. The authors stated that seven other time points (weekone, and monthly ...
... The primary endpoint was the average sleep latency over the last three months of the first six months of the study. The secondary endpoint was total sleep time over the same time period. These data were not presented ordiscussed. The authors stated that seven other time points (weekone, and monthly ...
Eszopiclone
... The primary endpoint was the average sleep latency over the last three months of the first six months of the study. The secondary endpoint was total sleep time over the same time period. These data were not presented ordiscussed. The authors stated that seven other time points (weekone, and monthly ...
... The primary endpoint was the average sleep latency over the last three months of the first six months of the study. The secondary endpoint was total sleep time over the same time period. These data were not presented ordiscussed. The authors stated that seven other time points (weekone, and monthly ...
Sedation/analgesia practices in neonatal intensive care units
... regression adjustment, confirmed the analyses conducted in matched pairs12. Stratification based on propensity score quintiles divided the tracheally ventilated group into five strata. Within each stratum, infants treated or not treated with O-SH-GA were compared. Previous research found that this t ...
... regression adjustment, confirmed the analyses conducted in matched pairs12. Stratification based on propensity score quintiles divided the tracheally ventilated group into five strata. Within each stratum, infants treated or not treated with O-SH-GA were compared. Previous research found that this t ...
An open-label, randomized, controlled, multicenter study exploring
... antiplatelet therapy up to 12 months, after which lifelong treatment with VKA should be continued. 14 In North America, The American College of Chest Physician provided recommendations based on (1) the risk of bleeding, (2) the syndrome (ACS or stable angina), and (3) the type of stent deployed (dru ...
... antiplatelet therapy up to 12 months, after which lifelong treatment with VKA should be continued. 14 In North America, The American College of Chest Physician provided recommendations based on (1) the risk of bleeding, (2) the syndrome (ACS or stable angina), and (3) the type of stent deployed (dru ...
Blood Agents
... reduces the elevated total peripheral resistance caused by the acidosis and cyanide. This should be used only until the IV drugs can be given. Inhalation of amyl nitrite will cause orthostatic hypotension. However, if the patient can stand, he or she does not need the antidote. Sodium nitrite Sodium ...
... reduces the elevated total peripheral resistance caused by the acidosis and cyanide. This should be used only until the IV drugs can be given. Inhalation of amyl nitrite will cause orthostatic hypotension. However, if the patient can stand, he or she does not need the antidote. Sodium nitrite Sodium ...