Advances in Lung Cancer 2016: a year in review
... Immune checkpoint inhibitors for NSCLC (squamous cell carcinomas and adenocarcinomas) anti-PD-1 pembrolizumab (1st line PD-L1 IHC ≥50%, 2nd line PD-L1 IHC >1%) anti-PD-1 nivolumab (2nd line, irrespective of biomarker PD-L1 IHC) anti-PD-L1 atezolizumab (2nd line, irrespective of biomarker PD-L1 IHC) ...
... Immune checkpoint inhibitors for NSCLC (squamous cell carcinomas and adenocarcinomas) anti-PD-1 pembrolizumab (1st line PD-L1 IHC ≥50%, 2nd line PD-L1 IHC >1%) anti-PD-1 nivolumab (2nd line, irrespective of biomarker PD-L1 IHC) anti-PD-L1 atezolizumab (2nd line, irrespective of biomarker PD-L1 IHC) ...
Product Information for sofosbuvir
... Sofosbuvir is a pan-genotypic inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which is essential for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), which can be incorp ...
... Sofosbuvir is a pan-genotypic inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which is essential for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), which can be incorp ...
Cocaine - South Carolina Department of Alcohol and Other Drug
... blood tests? The time period during which cocaine use can be detected varies according to the type of test (or “screen”) being used and the limits assigned to each individual test. Generally, cocaine use can be detected for as long as 10 days to five weeks after use by high-dose abusers, and from tw ...
... blood tests? The time period during which cocaine use can be detected varies according to the type of test (or “screen”) being used and the limits assigned to each individual test. Generally, cocaine use can be detected for as long as 10 days to five weeks after use by high-dose abusers, and from tw ...
QA199.2 - Specialist Pharmacy Service
... Intrapleural administration of sclerosing agents may be painful. Discomfort can be reduced by administering a local anaesthetic via the drain prior to pleurodesis. The most frequently studied local anaesthetic for intrapleural administration is lidocaine. Analgesia should also be given to the patien ...
... Intrapleural administration of sclerosing agents may be painful. Discomfort can be reduced by administering a local anaesthetic via the drain prior to pleurodesis. The most frequently studied local anaesthetic for intrapleural administration is lidocaine. Analgesia should also be given to the patien ...
of EZN-2208, a novel anticancer agent, in patients
... The median age of the treated pts was 58 y (range: 39-85 y) (Table 1). Of the 18 treated pts, 10 (56%) were female and 8 (44%) were male; 12 pts (76%) had an ECOG performance status of 1 (Table 1). All pts were white. The UGT1A1 genotype was *1/*28 for 10 pts, *1 for 6 pts, and *28/*28 for 2 pts ...
... The median age of the treated pts was 58 y (range: 39-85 y) (Table 1). Of the 18 treated pts, 10 (56%) were female and 8 (44%) were male; 12 pts (76%) had an ECOG performance status of 1 (Table 1). All pts were white. The UGT1A1 genotype was *1/*28 for 10 pts, *1 for 6 pts, and *28/*28 for 2 pts ...
Acute coronary syndrome secondary to methylphenidate overdose
... Keywords: Amphetamine, cocaine, myocardial ischemia, substance-related disorders ...
... Keywords: Amphetamine, cocaine, myocardial ischemia, substance-related disorders ...
![[2] N 1 - Millennium Organization](http://s1.studyres.com/store/data/008288277_1-0665503fd422e99cbf1c3315d8760630-300x300.png)
SUPERGEN INC (Form: DEFA14A, Received: 04/12
... Injection 12 SuperGen, Inc. Revenue Generating Partnerships: Eisai and Johnson & Johnson Royalties: $52.5 M in 2010 Royalty Guidance 2011: Up to $55 M Approved in more than 29 countries Global 2010 hypomethylator sales exceeded $900 M Phase III elderly AML patient trial outcome reported Randomized A ...
... Injection 12 SuperGen, Inc. Revenue Generating Partnerships: Eisai and Johnson & Johnson Royalties: $52.5 M in 2010 Royalty Guidance 2011: Up to $55 M Approved in more than 29 countries Global 2010 hypomethylator sales exceeded $900 M Phase III elderly AML patient trial outcome reported Randomized A ...
BN-83495
... This presentation includes only summary information and does not purport to be comprehensive. Forward-looking statements, targets and estimates contained herein are for illustrative purposes only and are based on management’s current views and assumptions. Such statements involve known and unknown r ...
... This presentation includes only summary information and does not purport to be comprehensive. Forward-looking statements, targets and estimates contained herein are for illustrative purposes only and are based on management’s current views and assumptions. Such statements involve known and unknown r ...
1 Anish et al Journal of Drug Delivery & Therapeutics; 2012, 2(1)
... of both the body and the mind. However dedicated research from scientists all over the world has made it possible to treat, prevent and eradicate many of these diseases that plague man. The field of pharmaceutical science has been developing steadily over the years, and has today become invaluable i ...
... of both the body and the mind. However dedicated research from scientists all over the world has made it possible to treat, prevent and eradicate many of these diseases that plague man. The field of pharmaceutical science has been developing steadily over the years, and has today become invaluable i ...
Lipid Treatment Algorithm - The Center for Cholesterol Management
... Statin/Niaspan or Statin/ezetimibe (depending on statin and dose: 50-60%) Statin/colesevelam: with potent statin: ~40-45% with glycemic benefit if needed Statin plus fenofibric acid: ~5% additional apoB but no additional LDL-P lowering Statin/high dose OM 3 FA: ~ 5-7% apoB with no additional LDL-P l ...
... Statin/Niaspan or Statin/ezetimibe (depending on statin and dose: 50-60%) Statin/colesevelam: with potent statin: ~40-45% with glycemic benefit if needed Statin plus fenofibric acid: ~5% additional apoB but no additional LDL-P lowering Statin/high dose OM 3 FA: ~ 5-7% apoB with no additional LDL-P l ...
Genetics
... (1) If the F1 self-pollinated, what is the expected ratio between purple to white color plants in the F2 population? Purple : white = (1) If F1 is backcrossed to Parent 1, what is the expected ratio between purple to white color plants in BC1F1(P1) population? Purple : white = (1) If F1 is backcross ...
... (1) If the F1 self-pollinated, what is the expected ratio between purple to white color plants in the F2 population? Purple : white = (1) If F1 is backcrossed to Parent 1, what is the expected ratio between purple to white color plants in BC1F1(P1) population? Purple : white = (1) If F1 is backcross ...
formulation and evaluation of meloxicam gels
... percutaneous absorption of drugs on the basis of the combined effect of both the lipophilic and hydrophlilic domains of microemulsion. The lipophilic domain of the microemulsion can interact with the stratum corneum in many ways. The drug dissolved in the lipid domain of a microemulsion can directly ...
... percutaneous absorption of drugs on the basis of the combined effect of both the lipophilic and hydrophlilic domains of microemulsion. The lipophilic domain of the microemulsion can interact with the stratum corneum in many ways. The drug dissolved in the lipid domain of a microemulsion can directly ...
Pharmaceutical Administration and Regulations in Japan
... http://www.jpma.or.jp/about/issue/gratis/index2.html (Japanese) http://www.jpma.or.jp/english/parj/1003.html (English) ...
... http://www.jpma.or.jp/about/issue/gratis/index2.html (Japanese) http://www.jpma.or.jp/english/parj/1003.html (English) ...
HICON® Kit for the Preparation of Sodium Iodide I 131
... Instruct patients to fast at least 2 hours before and 2 hours after administration to ensure absorption. Instruct patients to hydrate before and after administration of sodium iodide I 131 and to void frequently to enhance urinary elimination of the radioiodide that is not absorbed by the thyr ...
... Instruct patients to fast at least 2 hours before and 2 hours after administration to ensure absorption. Instruct patients to hydrate before and after administration of sodium iodide I 131 and to void frequently to enhance urinary elimination of the radioiodide that is not absorbed by the thyr ...
Newer Immunosuppressive Drugs: A Review
... (0.75 mg/kg per d) and MMF (10 mg/kg per d) produced at least an additive effect with a graft survival over 50 d. Either drug alone resulted in a graft survival of only 10 to 11 d (32,33). In a cynomolgus monkey heart allograft model with MMF doses between 70 and 175 mg/kg per d, prolongation of gra ...
... (0.75 mg/kg per d) and MMF (10 mg/kg per d) produced at least an additive effect with a graft survival over 50 d. Either drug alone resulted in a graft survival of only 10 to 11 d (32,33). In a cynomolgus monkey heart allograft model with MMF doses between 70 and 175 mg/kg per d, prolongation of gra ...
Inhaled loop diuretics as potential ... asthmatic drugs - *
... These findings suggest that ion transport mechanisms participate in the control of bronchial reactivity in asthma, but they do not provide sufficient infonnation to detennine the exact mechanism(s) involved. As ion transport pathways are present in virtually every cell type, all cells suspected to b ...
... These findings suggest that ion transport mechanisms participate in the control of bronchial reactivity in asthma, but they do not provide sufficient infonnation to detennine the exact mechanism(s) involved. As ion transport pathways are present in virtually every cell type, all cells suspected to b ...
Annex 1 - Emcdda
... difficult to be sure that rare, but clinically significant, severe effects are not associated with methoxetamine use. There is one user report on a user website of self-reported “addiction” to methoxetamine. There are no other data from animal or human studies on the dependence liability of methoxet ...
... difficult to be sure that rare, but clinically significant, severe effects are not associated with methoxetamine use. There is one user report on a user website of self-reported “addiction” to methoxetamine. There are no other data from animal or human studies on the dependence liability of methoxet ...
Chapter 11 section 2 notes
... Mendel realized that the principles of probability could be used to explain the results of his genetic crosses. Probability is the likelihood that a particular event will occur. For example, there are two possible outcomes of a coin flip: The coin may land either heads up or tails up. The chance, or ...
... Mendel realized that the principles of probability could be used to explain the results of his genetic crosses. Probability is the likelihood that a particular event will occur. For example, there are two possible outcomes of a coin flip: The coin may land either heads up or tails up. The chance, or ...
Targeting the dopamine D receptor in schizophrenia
... well known, they block the effects of accumulated 5-hydroxytryptamine’ [10]. In other words, these authors proposed that antipsychotics might block all three types of receptors for noradrenaline, dopamine and serotonin, but they did not identify which receptor was selectively blocked or how to ident ...
... well known, they block the effects of accumulated 5-hydroxytryptamine’ [10]. In other words, these authors proposed that antipsychotics might block all three types of receptors for noradrenaline, dopamine and serotonin, but they did not identify which receptor was selectively blocked or how to ident ...
FLOVENT DISKUS (fluticasone propionate inhalation
... fatal course in susceptible children or adults using corticosteroids. In such children or adults who have not had these diseases or been properly immunized, particular care should be taken to avoid exposure. How the dose, route, and duration of corticosteroid administration affect the risk of develo ...
... fatal course in susceptible children or adults using corticosteroids. In such children or adults who have not had these diseases or been properly immunized, particular care should be taken to avoid exposure. How the dose, route, and duration of corticosteroid administration affect the risk of develo ...
Transdermal Buprenorphine, Opioid Rotation to Sublingual
... patients.29,30 In the United States, Lanier et al31 demonstrated the feasibility of a different proprietary transdermal buprenorphine technology for the detoxification of heroin addicts. Although they did not directly address the issue of the avoidance of precipitated withdrawal, it is notable from ...
... patients.29,30 In the United States, Lanier et al31 demonstrated the feasibility of a different proprietary transdermal buprenorphine technology for the detoxification of heroin addicts. Although they did not directly address the issue of the avoidance of precipitated withdrawal, it is notable from ...
5-Fluorouracil encapsulated alginate beads for the treatment of
... Alginate beads containing 5-fluorouracil (5-FU) were prepared by the gelation of alginate with calcium cations. Alginate beads loaded with 5-FU were prepared at 1.0 and 2.0% (w/v) polymers. The effect of polymer concentration and the drug loading (1.0, 5.0 and 10%) on the release profile of 5-FU was ...
... Alginate beads containing 5-fluorouracil (5-FU) were prepared by the gelation of alginate with calcium cations. Alginate beads loaded with 5-FU were prepared at 1.0 and 2.0% (w/v) polymers. The effect of polymer concentration and the drug loading (1.0, 5.0 and 10%) on the release profile of 5-FU was ...
Short Tandem Repeat Polymorphism and Cancer Risk: Influence of
... in CA repeats between the two methods, including 5 samples with two-repeat difference, 3 with three-repeat difference, 3 with four-repeat difference, and 1 with fiverepeat difference. Of the 12 samples that had the same allelic difference in CA repeats, only 8 had exactly the same number of repeats ...
... in CA repeats between the two methods, including 5 samples with two-repeat difference, 3 with three-repeat difference, 3 with four-repeat difference, and 1 with fiverepeat difference. Of the 12 samples that had the same allelic difference in CA repeats, only 8 had exactly the same number of repeats ...
Serevent - GlaxoSmithKline
... Long-acting beta2-adrenergic agonists (LABA), such as salmeterol, the active ingredient in SEREVENT® DISKUS® and SEREVENT® DISKHALER® Disk, increase the risk of asthma-related death. Data from a large placebo controlled US study that compared the safety of salmeterol (SEREVENT® Inhalation Aerosol) o ...
... Long-acting beta2-adrenergic agonists (LABA), such as salmeterol, the active ingredient in SEREVENT® DISKUS® and SEREVENT® DISKHALER® Disk, increase the risk of asthma-related death. Data from a large placebo controlled US study that compared the safety of salmeterol (SEREVENT® Inhalation Aerosol) o ...